Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Thayne L. Sweeten, Lisa A. Croen, Gayle C. Windham, J. Dennis Odell, E. Gene Stubbs, Anthony R. Torres

ABSTRACT

Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. More... »

PAGES

410-414

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10803-018-3691-x

DOI

http://dx.doi.org/10.1007/s10803-018-3691-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105830487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30047098


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