Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07

AUTHORS

Stacey E. Alexeeff, Vincent Yau, Yinge Qian, Meghan Davignon, Frances Lynch, Phillip Crawford, Robert Davis, Lisa A. Croen

ABSTRACT

This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0-23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1-3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis. More... »

PAGES

2067-2079

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10803-017-3130-4

DOI

http://dx.doi.org/10.1007/s10803-017-3130-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085044157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28434058


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