Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03

AUTHORS

Vincent M. Yau, Marta Lutsky, Cathleen K. Yoshida, Bill Lasley, Martin Kharrazi, Gayle Windham, Nancy Gee, Lisa A. Croen

ABSTRACT

Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000-2001 were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12-0.91], Early Onset ASD vs. GP: 0.31 [0.10-0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18-2.04]). More... »

PAGES

719-730

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10803-014-2227-2

    DOI

    http://dx.doi.org/10.1007/s10803-014-2227-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012288569

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25178989


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