Head Circumferences in Twins With and Without Autism Spectrum Disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

Wendy Froehlich, Sue Cleveland, Andrea Torres, Jennifer Phillips, Brianne Cohen, Tiffany Torigoe, Janet Miller, Angie Fedele, Jack Collins, Karen Smith, Linda Lotspeich, Lisa A. Croen, Sally Ozonoff, Clara Lajonchere, Judith K. Grether, Joachim Hallmayer

ABSTRACT

To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. More... »

PAGES

2026-2037

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10803-012-1751-1

DOI

http://dx.doi.org/10.1007/s10803-012-1751-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008612976

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23321801


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