Behavioral Correlates of Maternal Antibody Status Among Children with Autism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07

AUTHORS

Daniel Braunschweig, Paul Duncanson, Robert Boyce, Robin Hansen, Paul Ashwood, Isaac N. Pessah, Irva Hertz-Picciotto, Judy Van de Water

ABSTRACT

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes. More... »

PAGES

1435-1445

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10803-011-1378-7

DOI

http://dx.doi.org/10.1007/s10803-011-1378-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019004942

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22012245


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