Hyperserotonemia in Adults with Autistic Disorder View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-11

AUTHORS

Dubravka Hranilovic, Zorana Bujas-Petkovic, Renata Vragovic, Tomislav Vuk, Karlo Hock, Branimir Jernej

ABSTRACT

Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 +/- 37.4 ng/microL) was significantly higher than the control sample (59.2 +/- 16.2 ng/microL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects. More... »

PAGES

1934-1940

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10803-006-0324-6

DOI

http://dx.doi.org/10.1007/s10803-006-0324-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052071259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17165147


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