Multimodal imaging including optical coherence tomography angiography in patients with type B Niemann-Pick disease. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-11

AUTHORS

Selim Bolukbasi, Cezmi Dogan, Ertugrul Kiykim, Akin Cakir, Burak Erden, Alper Halil Bayat, Mustafa Nuri Elcioglu, Ayse Cigdem Aktuglu Zeybek

ABSTRACT

PURPOSE: To evaluate accumulation patterns of deposits in retinal layers of type B Niemann-Pick patients by multimodal imaging. METHODS: Seven patients with type B Niemann-Pick disease were included in this study. All participants underwent a complete ophthalmologic evaluation, high-resolution digital colour imaging, spectral-domain optical coherence tomography, blue light fundus autofluorescence and optical coherence tomography angiography (OCTA). RESULTS: We demonstrated different accumulation patterns in the retinal ganglion cell layer, the retinal nerve fibre layer and the subfoveolar region by multimodal imaging. Local retinal capillary nonflow areas in the superficial plexus, increased vascular tortuosity and deformed foveal avascular areas were shown in OCTA scans. CONCLUSION: Multimodal imaging including OCTA is a useful technique for the identification of different types of accumulation patterns, diagnosis and follow-up of type B Niemann-Pick patients. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10792-019-01102-y

DOI

http://dx.doi.org/10.1007/s10792-019-01102-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113378620

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30977024


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