Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08

AUTHORS

O. Bottasso, G. Docena, J. L. Stanford, J. M. Grange

ABSTRACT

Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective immunoregulatory networks or to reprogramme defective ones. In contrast to acute inflammation, chronic inflammation appears to have no beneficial role, but is a state of sustained immune reactivity in the presence or progression of a disease process. This results in an escalating cycle of tissue damage followed by unproductive tissue repair, breaks in self-tolerance, malignant transformation or deleterious changes in tissue morphology and function. Such inappropriate immune reactivity is an underlying characteristic, either in initiation or maintenance, of a diverse range of disease states including chronic infection, autoimmunity, allergy, cancer, vascular disease and metabolic alterations. Evidence is presented that the inappropriate immune reactivity is due, at least to some extent, to failures in the establishment of immunoregulatory networks as a result of hygiene-related factors. Such networks are the result of activation of antigen-presenting cells, principally dendritic cells, by molecular patterns of micro-organisms encountered sequentially during life and establishing the 'biography' of the immune system. More... »

PAGES

193-203

References to SciGraph publications

  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2007-04. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge in NATURE IMMUNOLOGY
  • 2008-07. From endoplasmic-reticulum stress to the inflammatory response in NATURE
  • 2008-07. Integration of metabolism and inflammation by lipid-activated nuclear receptors in NATURE
  • 2004-10. Toll-like receptor control of the adaptive immune responses in NATURE IMMUNOLOGY
  • 2004-02. Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders in SEMINARS IN IMMUNOPATHOLOGY
  • 2002-05. Daycare attendance and risk of childhood acute lymphoblastic leukaemia in BRITISH JOURNAL OF CANCER
  • 2008-07. Cancer-related inflammation in NATURE
  • 1999-07. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase in NATURE
  • 2007-10-18. Recognition of microorganisms and activation of the immune response in NATURE
  • 2003-01. Alternative activation of macrophages in NATURE REVIEWS IMMUNOLOGY
  • 2007-06-28. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance in NATURE
  • 2008-07. Origin and physiological roles of inflammation in NATURE
  • 2007-09. Development, cytokine profile and function of human interleukin 17–producing helper T cells in NATURE IMMUNOLOGY
  • 2007-09. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells in NATURE IMMUNOLOGY
  • 2002-04. Day-care, early common infections and childhood acute leukaemia: a multicentre French case–control study in BRITISH JOURNAL OF CANCER
  • 2008-12. Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model in LABORATORY INVESTIGATION
  • 2008-12. Significance of Toll-like Receptors Expression in Tumor Growth and Spreading: A Short Review in CANCER MICROENVIRONMENT
  • 2006. Dendritic Cells: Translating Innate to Adaptive Immunity in FROM INNATE IMMUNITY TO IMMUNOLOGICAL MEMORY
  • 2004-10. Toll-like receptors in the pathogenesis of human disease in NATURE IMMUNOLOGY
  • 1997-10. Protection from obesity-induced insulin resistance in mice lacking TNF-α function in NATURE
  • 2009-07. Is the risk of multiple sclerosis related to the ‘biography’ of the immune system? in JOURNAL OF NEUROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10787-009-0008-x

    DOI

    http://dx.doi.org/10.1007/s10787-009-0008-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041326228

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19597940


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autoimmunity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biological Products", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chronic Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infection", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National University of Rosario", 
              "id": "https://www.grid.ac/institutes/grid.10814.3c", 
              "name": [
                "Instituto de Inmunologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000, Rosario, Argentina"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bottasso", 
            "givenName": "O.", 
            "id": "sg:person.01255750555.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255750555.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of La Plata", 
              "id": "https://www.grid.ac/institutes/grid.9499.d", 
              "name": [
                "Laboratorio de Investigaciones del Sistema Inmune, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Docena", 
            "givenName": "G.", 
            "id": "sg:person.01351731513.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351731513.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College London", 
              "id": "https://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, University College London, 46, Cleveland Street, W1T 3JF, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stanford", 
            "givenName": "J. L.", 
            "id": "sg:person.0744432204.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744432204.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College London", 
              "id": "https://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, University College London, 46, Cleveland Street, W1T 3JF, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grange", 
            "givenName": "J. M.", 
            "id": "sg:person.0675664453.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664453.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ni1116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000067676", 
              "https://doi.org/10.1038/ni1116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000067676", 
              "https://doi.org/10.1038/ni1116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(99)90437-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000975571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12307-008-0005-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001715249", 
              "https://doi.org/10.1007/s12307-008-0005-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.20996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001990881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004311589", 
              "https://doi.org/10.1038/nature06246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210689200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004326439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.r700007-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004754569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000180261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004892148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006206841", 
              "https://doi.org/10.1038/sj.bjc.6600274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006206841", 
              "https://doi.org/10.1038/sj.bjc.6600274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-32636-7_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006572773", 
              "https://doi.org/10.1007/3-540-32636-7_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0307166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006595288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0954-6111(99)90155-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007695560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19990601)85:11<2359::aid-cncr10>3.0.co;2-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007895979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-1980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008161719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.299.6710.1259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009211879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009929568", 
              "https://doi.org/10.1038/sj.bjc.6600091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009929568", 
              "https://doi.org/10.1038/sj.bjc.6600091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-003-0148-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011077338", 
              "https://doi.org/10.1007/s00281-003-0148-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.1.217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012366454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-4262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012659228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0041-3879(90)90063-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012876177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2008.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014367923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00063198-200105000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014920629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00063198-200105000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014920629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016014529", 
              "https://doi.org/10.1038/nature07201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/scbi.2001.0400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017825555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019330185", 
              "https://doi.org/10.1038/ni1449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0041-3879(91)90049-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019450816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jech.56.3.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019551771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(94)90075-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019711741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(94)90075-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019711741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00607.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020264864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020978968", 
              "https://doi.org/10.1038/39335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020978968", 
              "https://doi.org/10.1038/39335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m105619200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021514939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2008/169414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022097914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(03)00072-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022248539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(03)00072-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022248539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(03)00052-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023886890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(03)00052-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023886890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(03)00384-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023945601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/22572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025963511", 
              "https://doi.org/10.1038/22572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/22572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025963511", 
              "https://doi.org/10.1038/22572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2004.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027882498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200403-406oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028493123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.09.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028606166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-009-5068-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029470862", 
              "https://doi.org/10.1007/s00415-009-5068-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-009-5068-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029470862", 
              "https://doi.org/10.1007/s00415-009-5068-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2008.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029787748", 
              "https://doi.org/10.1038/labinvest.2008.90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030692825", 
              "https://doi.org/10.1038/nri978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030692825", 
              "https://doi.org/10.1038/nri978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(03)00625-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031131188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(03)00625-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031131188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.2.896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032060710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032899443", 
              "https://doi.org/10.1038/nature07202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.2.788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034155683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(2001010)31:10<2857::aid-immu2857>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035702434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4906(02)02302-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035805474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4906(02)02302-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035805474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(99)01046-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036838263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.micinf.2008.07.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036867459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2008.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036944466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2003.12.374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037663428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgh317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038122382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m702690200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038601875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1071059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038790461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038921838", 
              "https://doi.org/10.1038/nature07203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.286.3.327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039378707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040040375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2007.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040074204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00715.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041630480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-03-006403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042225353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2003.10.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042667729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043435108", 
              "https://doi.org/10.1038/ni1497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.163.1.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044815542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)04046-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047972304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0264-410x(03)00195-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048417140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0264-410x(03)00195-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048417140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048928679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048928679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00712.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049356812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2006.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049383869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050377252", 
              "https://doi.org/10.1038/ni1496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050655831", 
              "https://doi.org/10.1038/nature05894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(95)92348-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050686504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(95)92348-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050686504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbalip.2007.04.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052717989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052724075", 
              "https://doi.org/10.1038/ni1112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052724075", 
              "https://doi.org/10.1038/ni1112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0400983101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052779374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.4.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053283990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/346134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058641392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.290.5494.1166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062572053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7678183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci16109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci19451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci20773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2005-1901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1615/critrevimmunol.v28.i2.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068131963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1900/rds.2006.3.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068727870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.41.2.s97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070736757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3184/003685001783239014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071111054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3184/003685001783239014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071111054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3184/003685001783239014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071111054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.5.2457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077011843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.3.1962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077593549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080971428", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1996.271.5.c1424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083008625"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-08", 
        "datePublishedReg": "2009-08-01", 
        "description": "Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective immunoregulatory networks or to reprogramme defective ones. In contrast to acute inflammation, chronic inflammation appears to have no beneficial role, but is a state of sustained immune reactivity in the presence or progression of a disease process. This results in an escalating cycle of tissue damage followed by unproductive tissue repair, breaks in self-tolerance, malignant transformation or deleterious changes in tissue morphology and function. Such inappropriate immune reactivity is an underlying characteristic, either in initiation or maintenance, of a diverse range of disease states including chronic infection, autoimmunity, allergy, cancer, vascular disease and metabolic alterations. Evidence is presented that the inappropriate immune reactivity is due, at least to some extent, to failures in the establishment of immunoregulatory networks as a result of hygiene-related factors. Such networks are the result of activation of antigen-presenting cells, principally dendritic cells, by molecular patterns of micro-organisms encountered sequentially during life and establishing the 'biography' of the immune system.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10787-009-0008-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1101677", 
            "issn": [
              "0925-4692", 
              "1568-5608"
            ], 
            "name": "Inflammopharmacology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products", 
        "pagination": "193-203", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10787-009-0008-x"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c4ddc9e7aedb0d51ca75fb4c00a7d6c734e9aa66bca9ab143afee7faeb0e6d37"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1041326228"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9112626"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19597940"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10787-009-0008-x", 
          "https://app.dimensions.ai/details/publication/pub.1041326228"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56159_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs10787-009-0008-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10787-009-0008-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10787-009-0008-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10787-009-0008-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10787-009-0008-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    436 TRIPLES      21 PREDICATES      132 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10787-009-0008-x schema:about N01b846a62c284dc6a65d6827bcb70334
    2 N1febf897af604cd09106391c16676fba
    3 N2d9d13d174804d78ac94931470d71ea7
    4 N56e9dbf0f4d04d5da3adff35b4863bf4
    5 N6b5d10752be34536a23ea2048bd513a4
    6 N79ecb3e9ef62493c8ff005ac12767feb
    7 N7cf5a1b38f7a4cc2b149278fdbbb50c0
    8 N8990fda2c4b342b4a7b8b28d732ea4a8
    9 Nf1846152baf74a7290dcbb6f3eb3059f
    10 anzsrc-for:11
    11 anzsrc-for:1107
    12 schema:author Nc3334158df7744bbb485fe4168b9ff2f
    13 schema:citation sg:pub.10.1007/3-540-32636-7_2
    14 sg:pub.10.1007/s00281-003-0148-9
    15 sg:pub.10.1007/s00415-009-5068-8
    16 sg:pub.10.1007/s12307-008-0005-4
    17 sg:pub.10.1038/22572
    18 sg:pub.10.1038/39335
    19 sg:pub.10.1038/labinvest.2008.90
    20 sg:pub.10.1038/nature04753
    21 sg:pub.10.1038/nature04754
    22 sg:pub.10.1038/nature05894
    23 sg:pub.10.1038/nature06246
    24 sg:pub.10.1038/nature07201
    25 sg:pub.10.1038/nature07202
    26 sg:pub.10.1038/nature07203
    27 sg:pub.10.1038/nature07205
    28 sg:pub.10.1038/ni1112
    29 sg:pub.10.1038/ni1116
    30 sg:pub.10.1038/ni1449
    31 sg:pub.10.1038/ni1496
    32 sg:pub.10.1038/ni1497
    33 sg:pub.10.1038/nri978
    34 sg:pub.10.1038/sj.bjc.6600091
    35 sg:pub.10.1038/sj.bjc.6600274
    36 https://app.dimensions.ai/details/publication/pub.1080971428
    37 https://doi.org/10.1001/archinte.163.1.93
    38 https://doi.org/10.1001/jama.286.3.327
    39 https://doi.org/10.1002/(sici)1097-0142(19990601)85:11<2359::aid-cncr10>3.0.co;2-a
    40 https://doi.org/10.1002/1521-4141(2001010)31:10<2857::aid-immu2857>3.0.co;2-x
    41 https://doi.org/10.1002/jcb.20996
    42 https://doi.org/10.1006/scbi.2001.0400
    43 https://doi.org/10.1016/0041-3879(90)90063-e
    44 https://doi.org/10.1016/0041-3879(91)90049-x
    45 https://doi.org/10.1016/0167-5699(94)90075-2
    46 https://doi.org/10.1016/j.bbalip.2007.04.021
    47 https://doi.org/10.1016/j.cell.2004.09.032
    48 https://doi.org/10.1016/j.cell.2006.01.007
    49 https://doi.org/10.1016/j.chom.2008.05.003
    50 https://doi.org/10.1016/j.ejca.2004.08.010
    51 https://doi.org/10.1016/j.ejca.2006.01.003
    52 https://doi.org/10.1016/j.gde.2008.07.016
    53 https://doi.org/10.1016/j.it.2003.10.013
    54 https://doi.org/10.1016/j.jaci.2003.12.374
    55 https://doi.org/10.1016/j.micinf.2008.07.013
    56 https://doi.org/10.1016/j.tibs.2007.09.003
    57 https://doi.org/10.1016/s0140-6736(00)04046-0
    58 https://doi.org/10.1016/s0140-6736(95)92348-9
    59 https://doi.org/10.1016/s0140-6736(99)01046-6
    60 https://doi.org/10.1016/s0140-6736(99)90437-3
    61 https://doi.org/10.1016/s0264-410x(03)00195-6
    62 https://doi.org/10.1016/s0952-7915(03)00072-4
    63 https://doi.org/10.1016/s0954-6111(99)90155-5
    64 https://doi.org/10.1016/s0959-8049(03)00625-7
    65 https://doi.org/10.1016/s1097-2765(03)00384-8
    66 https://doi.org/10.1016/s1359-6101(03)00052-2
    67 https://doi.org/10.1016/s1471-4906(02)02302-5
    68 https://doi.org/10.1073/pnas.0400983101
    69 https://doi.org/10.1073/pnas.89.1.217
    70 https://doi.org/10.1074/jbc.m105619200
    71 https://doi.org/10.1074/jbc.m210689200
    72 https://doi.org/10.1074/jbc.m702690200
    73 https://doi.org/10.1086/346134
    74 https://doi.org/10.1093/carcin/bgh317
    75 https://doi.org/10.1097/00063198-200105000-00002
    76 https://doi.org/10.1111/j.1600-065x.2008.00607.x
    77 https://doi.org/10.1111/j.1600-065x.2008.00712.x
    78 https://doi.org/10.1111/j.1600-065x.2008.00715.x
    79 https://doi.org/10.1126/science.1071059
    80 https://doi.org/10.1126/science.290.5494.1166
    81 https://doi.org/10.1126/science.7678183
    82 https://doi.org/10.1136/bmj.299.6710.1259
    83 https://doi.org/10.1136/jech.56.3.209
    84 https://doi.org/10.1152/ajpcell.1996.271.5.c1424
    85 https://doi.org/10.1155/2008/169414
    86 https://doi.org/10.1158/0008-5472.can-04-4262
    87 https://doi.org/10.1158/1078-0432.ccr-08-1980
    88 https://doi.org/10.1159/000180261
    89 https://doi.org/10.1164/rccm.200403-406oc
    90 https://doi.org/10.1172/jci16109
    91 https://doi.org/10.1172/jci19451
    92 https://doi.org/10.1172/jci20773
    93 https://doi.org/10.1172/jci35288
    94 https://doi.org/10.1182/blood-2006-03-006403
    95 https://doi.org/10.1189/jlb.0307166
    96 https://doi.org/10.1194/jlr.r700007-jlr200
    97 https://doi.org/10.1210/jc.2005-1901
    98 https://doi.org/10.1615/critrevimmunol.v28.i2.10
    99 https://doi.org/10.1900/rds.2006.3.72
    100 https://doi.org/10.2337/diab.41.2.s97
    101 https://doi.org/10.3184/003685001783239014
    102 https://doi.org/10.4049/jimmunol.174.5.2457
    103 https://doi.org/10.4049/jimmunol.175.2.788
    104 https://doi.org/10.4049/jimmunol.177.2.896
    105 https://doi.org/10.4049/jimmunol.180.3.1962
    106 https://doi.org/10.4049/jimmunol.180.4.2011
    107 schema:datePublished 2009-08
    108 schema:datePublishedReg 2009-08-01
    109 schema:description Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective immunoregulatory networks or to reprogramme defective ones. In contrast to acute inflammation, chronic inflammation appears to have no beneficial role, but is a state of sustained immune reactivity in the presence or progression of a disease process. This results in an escalating cycle of tissue damage followed by unproductive tissue repair, breaks in self-tolerance, malignant transformation or deleterious changes in tissue morphology and function. Such inappropriate immune reactivity is an underlying characteristic, either in initiation or maintenance, of a diverse range of disease states including chronic infection, autoimmunity, allergy, cancer, vascular disease and metabolic alterations. Evidence is presented that the inappropriate immune reactivity is due, at least to some extent, to failures in the establishment of immunoregulatory networks as a result of hygiene-related factors. Such networks are the result of activation of antigen-presenting cells, principally dendritic cells, by molecular patterns of micro-organisms encountered sequentially during life and establishing the 'biography' of the immune system.
    110 schema:genre research_article
    111 schema:inLanguage en
    112 schema:isAccessibleForFree false
    113 schema:isPartOf N018ffb1d48b24c72b868b5b6538031a5
    114 N3a2dad8ce0e548fbb8397f96b0800d56
    115 sg:journal.1101677
    116 schema:name Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products
    117 schema:pagination 193-203
    118 schema:productId Nab8bbcf28725496ebb5b8e11b66ec319
    119 Nb9fa4724309c4c30b4224455d48fb03f
    120 Nd119435a9ef144febbd18c169582b1e1
    121 Ndb9f54ec1e484d0582a3f977f0ccbbfd
    122 Nf1264145c7274bfbad813fbafbc80401
    123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041326228
    124 https://doi.org/10.1007/s10787-009-0008-x
    125 schema:sdDatePublished 2019-04-15T09:12
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher Ne84020e9af824a469520092bf75d1e98
    128 schema:url http://link.springer.com/10.1007%2Fs10787-009-0008-x
    129 sgo:license sg:explorer/license/
    130 sgo:sdDataset articles
    131 rdf:type schema:ScholarlyArticle
    132 N018ffb1d48b24c72b868b5b6538031a5 schema:issueNumber 4
    133 rdf:type schema:PublicationIssue
    134 N01b846a62c284dc6a65d6827bcb70334 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Autoimmunity
    136 rdf:type schema:DefinedTerm
    137 N1febf897af604cd09106391c16676fba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Biological Products
    139 rdf:type schema:DefinedTerm
    140 N2d9d13d174804d78ac94931470d71ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Infection
    142 rdf:type schema:DefinedTerm
    143 N3314f7a850024f2989de1558907aa955 rdf:first sg:person.0675664453.01
    144 rdf:rest rdf:nil
    145 N3a2dad8ce0e548fbb8397f96b0800d56 schema:volumeNumber 17
    146 rdf:type schema:PublicationVolume
    147 N56e9dbf0f4d04d5da3adff35b4863bf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Inflammation
    149 rdf:type schema:DefinedTerm
    150 N6b5d10752be34536a23ea2048bd513a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Animals
    152 rdf:type schema:DefinedTerm
    153 N79ecb3e9ef62493c8ff005ac12767feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Dendritic Cells
    155 rdf:type schema:DefinedTerm
    156 N7cf5a1b38f7a4cc2b149278fdbbb50c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Disease Progression
    158 rdf:type schema:DefinedTerm
    159 N8990fda2c4b342b4a7b8b28d732ea4a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Humans
    161 rdf:type schema:DefinedTerm
    162 Nab8bbcf28725496ebb5b8e11b66ec319 schema:name doi
    163 schema:value 10.1007/s10787-009-0008-x
    164 rdf:type schema:PropertyValue
    165 Nb6017d54ed584110b098915c17e7f6bb rdf:first sg:person.01351731513.02
    166 rdf:rest Nfe53bb897c914ef690810819ca36b6c9
    167 Nb9fa4724309c4c30b4224455d48fb03f schema:name readcube_id
    168 schema:value c4ddc9e7aedb0d51ca75fb4c00a7d6c734e9aa66bca9ab143afee7faeb0e6d37
    169 rdf:type schema:PropertyValue
    170 Nc3334158df7744bbb485fe4168b9ff2f rdf:first sg:person.01255750555.28
    171 rdf:rest Nb6017d54ed584110b098915c17e7f6bb
    172 Nd119435a9ef144febbd18c169582b1e1 schema:name dimensions_id
    173 schema:value pub.1041326228
    174 rdf:type schema:PropertyValue
    175 Ndb9f54ec1e484d0582a3f977f0ccbbfd schema:name nlm_unique_id
    176 schema:value 9112626
    177 rdf:type schema:PropertyValue
    178 Ne84020e9af824a469520092bf75d1e98 schema:name Springer Nature - SN SciGraph project
    179 rdf:type schema:Organization
    180 Nf1264145c7274bfbad813fbafbc80401 schema:name pubmed_id
    181 schema:value 19597940
    182 rdf:type schema:PropertyValue
    183 Nf1846152baf74a7290dcbb6f3eb3059f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Chronic Disease
    185 rdf:type schema:DefinedTerm
    186 Nfe53bb897c914ef690810819ca36b6c9 rdf:first sg:person.0744432204.27
    187 rdf:rest N3314f7a850024f2989de1558907aa955
    188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Medical and Health Sciences
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Immunology
    193 rdf:type schema:DefinedTerm
    194 sg:journal.1101677 schema:issn 0925-4692
    195 1568-5608
    196 schema:name Inflammopharmacology
    197 rdf:type schema:Periodical
    198 sg:person.01255750555.28 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
    199 schema:familyName Bottasso
    200 schema:givenName O.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255750555.28
    202 rdf:type schema:Person
    203 sg:person.01351731513.02 schema:affiliation https://www.grid.ac/institutes/grid.9499.d
    204 schema:familyName Docena
    205 schema:givenName G.
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351731513.02
    207 rdf:type schema:Person
    208 sg:person.0675664453.01 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
    209 schema:familyName Grange
    210 schema:givenName J. M.
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664453.01
    212 rdf:type schema:Person
    213 sg:person.0744432204.27 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
    214 schema:familyName Stanford
    215 schema:givenName J. L.
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744432204.27
    217 rdf:type schema:Person
    218 sg:pub.10.1007/3-540-32636-7_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006572773
    219 https://doi.org/10.1007/3-540-32636-7_2
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00281-003-0148-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011077338
    222 https://doi.org/10.1007/s00281-003-0148-9
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00415-009-5068-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029470862
    225 https://doi.org/10.1007/s00415-009-5068-8
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s12307-008-0005-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001715249
    228 https://doi.org/10.1007/s12307-008-0005-4
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/22572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025963511
    231 https://doi.org/10.1038/22572
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/39335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020978968
    234 https://doi.org/10.1038/39335
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/labinvest.2008.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029787748
    237 https://doi.org/10.1038/labinvest.2008.90
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    240 https://doi.org/10.1038/nature04753
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    243 https://doi.org/10.1038/nature04754
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature05894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050655831
    246 https://doi.org/10.1038/nature05894
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nature06246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004311589
    249 https://doi.org/10.1038/nature06246
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nature07201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016014529
    252 https://doi.org/10.1038/nature07201
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nature07202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032899443
    255 https://doi.org/10.1038/nature07202
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nature07203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038921838
    258 https://doi.org/10.1038/nature07203
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    261 https://doi.org/10.1038/nature07205
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/ni1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052724075
    264 https://doi.org/10.1038/ni1112
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ni1116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000067676
    267 https://doi.org/10.1038/ni1116
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ni1449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019330185
    270 https://doi.org/10.1038/ni1449
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/ni1496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050377252
    273 https://doi.org/10.1038/ni1496
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/ni1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043435108
    276 https://doi.org/10.1038/ni1497
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nri978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030692825
    279 https://doi.org/10.1038/nri978
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/sj.bjc.6600091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009929568
    282 https://doi.org/10.1038/sj.bjc.6600091
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/sj.bjc.6600274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006206841
    285 https://doi.org/10.1038/sj.bjc.6600274
    286 rdf:type schema:CreativeWork
    287 https://app.dimensions.ai/details/publication/pub.1080971428 schema:CreativeWork
    288 https://doi.org/10.1001/archinte.163.1.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044815542
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1001/jama.286.3.327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039378707
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1002/(sici)1097-0142(19990601)85:11<2359::aid-cncr10>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1007895979
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1002/1521-4141(2001010)31:10<2857::aid-immu2857>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035702434
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1002/jcb.20996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001990881
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1006/scbi.2001.0400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017825555
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/0041-3879(90)90063-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1012876177
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/0041-3879(91)90049-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019450816
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/0167-5699(94)90075-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019711741
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.bbalip.2007.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052717989
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.cell.2004.09.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028606166
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.cell.2006.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040040375
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.chom.2008.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014367923
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.ejca.2004.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027882498
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.ejca.2006.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049383869
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.gde.2008.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036944466
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.it.2003.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042667729
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.jaci.2003.12.374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037663428
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.micinf.2008.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036867459
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/j.tibs.2007.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040074204
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/s0140-6736(00)04046-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047972304
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/s0140-6736(95)92348-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050686504
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s0140-6736(99)01046-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036838263
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/s0140-6736(99)90437-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000975571
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/s0264-410x(03)00195-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048417140
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/s0952-7915(03)00072-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022248539
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/s0954-6111(99)90155-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007695560
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/s0959-8049(03)00625-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031131188
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1016/s1097-2765(03)00384-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023945601
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/s1359-6101(03)00052-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023886890
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/s1471-4906(02)02302-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035805474
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1073/pnas.0400983101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052779374
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1073/pnas.89.1.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012366454
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1074/jbc.m105619200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021514939
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1074/jbc.m210689200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004326439
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1074/jbc.m702690200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038601875
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1086/346134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058641392
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1093/carcin/bgh317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038122382
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1097/00063198-200105000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014920629
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1111/j.1600-065x.2008.00607.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020264864
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1600-065x.2008.00712.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049356812
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1111/j.1600-065x.2008.00715.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041630480
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1126/science.1071059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038790461
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1126/science.290.5494.1166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572053
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1126/science.7678183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648363
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1136/bmj.299.6710.1259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009211879
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1136/jech.56.3.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019551771
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1152/ajpcell.1996.271.5.c1424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083008625
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1155/2008/169414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022097914
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1158/0008-5472.can-04-4262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012659228
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1158/1078-0432.ccr-08-1980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008161719
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1159/000180261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004892148
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1164/rccm.200403-406oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1028493123
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1172/jci16109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415480
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1172/jci19451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416401
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1172/jci20773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416564
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1172/jci35288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048928679
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1182/blood-2006-03-006403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042225353
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1189/jlb.0307166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006595288
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1194/jlr.r700007-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004754569
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1210/jc.2005-1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288798
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1615/critrevimmunol.v28.i2.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131963
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1900/rds.2006.3.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068727870
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.2337/diab.41.2.s97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736757
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.3184/003685001783239014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071111054
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.4049/jimmunol.174.5.2457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077011843
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.4049/jimmunol.175.2.788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034155683
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.4049/jimmunol.177.2.896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032060710
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.4049/jimmunol.180.3.1962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077593549
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.4049/jimmunol.180.4.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053283990
    427 rdf:type schema:CreativeWork
    428 https://www.grid.ac/institutes/grid.10814.3c schema:alternateName National University of Rosario
    429 schema:name Instituto de Inmunologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000, Rosario, Argentina
    430 rdf:type schema:Organization
    431 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
    432 schema:name Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, University College London, 46, Cleveland Street, W1T 3JF, London, UK
    433 rdf:type schema:Organization
    434 https://www.grid.ac/institutes/grid.9499.d schema:alternateName National University of La Plata
    435 schema:name Laboratorio de Investigaciones del Sistema Inmune, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
    436 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...