Liposomal Amphotericin B Fosters the Corticosteroids’ Anti-inflammatory Effect on Murine Allergic Bronchopulmonary Aspergillosis Model Airways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-08-08

AUTHORS

Chizu Fukushima, Hiroto Matsuse, Yasushi Obase, Susumu Fukahori, Tomoko Tsuchida, Tetsuya Kawano, Shigeru Kohno, Hiroshi Mukae

ABSTRACT

Fungus is an antigen for bronchial asthma causing allergic bronchopulmonary mycosis (ABPM). As a therapy other than corticosteroids, itraconazole (ITCZ) is known to suppress the allergic inflammation induced by Aspergillus fumigatus (Af). However, the efficacy of liposomal amphotericin B (LAMB) with/without corticosteroid on ABPM is unknown. Mice sensitized to Dermatophagoides farinae (Df) allergen were intranasally infected with Af (DfAf group). After the infection, corticosteroid (dexamethasone (Dex)) was administered for 5 days (DfAf/Dex group). The effects of ITCZ or LAMB with/without Dex were also evaluated. Pathologically, Dex and LAMB combination treatment decreased the allergic inflammation evidently. The bronchoalveolar lavage fluid (BALF) concentrations of IL-5, IL-13, and MIP-2 were significantly elevated in DfAf mice compared with control mice (p < 0.05, each). In DfAf mice, ITCZ and LAMB significantly decreased the elevation of MIP-2 (p < 0.05 vs the DfAf group). The addition of both Dex and LAMB suppressed the MIP-2 elevation in DfAf mice (p < 0.05 vs the Df/Af/Dex/LAMB group), but the addition of Dex and ITCZ did not (DfAf/Dex/ITCZ group). None of Dex, ITCZ, or LAMB decreased pulmonary IL-13 concentration. It was suggested that combination of antifungal drugs and corticosteroid enhanced the suppressing effect of airway inflammations. This finding will give a hope for the treatment of severe fungus-related asthma. More... »

PAGES

2065-2071

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-019-01069-z

DOI

http://dx.doi.org/10.1007/s10753-019-01069-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120198424

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31396817


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenal Cortex Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amphotericin B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antifungal Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspergillosis, Allergic Bronchopulmonary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspergillus fumigatus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dexamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Itraconazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411873.8", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
            "Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukushima", 
        "givenName": "Chizu", 
        "id": "sg:person.01226570717.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226570717.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.470115.6", 
          "name": [
            "Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuse", 
        "givenName": "Hiroto", 
        "id": "sg:person.01161550342.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161550342.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obase", 
        "givenName": "Yasushi", 
        "id": "sg:person.01045143143.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045143143.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukahori", 
        "givenName": "Susumu", 
        "id": "sg:person.0777651441.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777651441.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuchida", 
        "givenName": "Tomoko", 
        "id": "sg:person.01066650121.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066650121.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawano", 
        "givenName": "Tetsuya", 
        "id": "sg:person.01203076521.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203076521.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohno", 
        "givenName": "Shigeru", 
        "id": "sg:person.01311530576.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311530576.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01143125277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2019-08-08", 
    "datePublishedReg": "2019-08-08", 
    "description": "Fungus is an antigen for bronchial asthma causing allergic bronchopulmonary mycosis (ABPM). As a therapy other than corticosteroids, itraconazole (ITCZ) is known to suppress the allergic inflammation induced by Aspergillus fumigatus (Af). However, the efficacy of liposomal amphotericin B (LAMB) with/without corticosteroid on ABPM is unknown. Mice sensitized to Dermatophagoides farinae (Df) allergen were intranasally infected with Af (DfAf group). After the infection, corticosteroid (dexamethasone (Dex)) was administered for 5\u00a0days (DfAf/Dex group). The effects of ITCZ or LAMB with/without Dex were also evaluated. Pathologically, Dex and LAMB combination treatment decreased the allergic inflammation evidently. The bronchoalveolar lavage fluid (BALF) concentrations of IL-5, IL-13, and MIP-2 were significantly elevated in DfAf mice compared with control mice (p\u2009<\u20090.05, each). In DfAf mice, ITCZ and LAMB significantly decreased the elevation of MIP-2 (p\u2009<\u20090.05 vs the DfAf group). The addition of both Dex and LAMB suppressed the MIP-2 elevation in DfAf mice (p\u2009<\u20090.05 vs the Df/Af/Dex/LAMB group), but the addition of Dex and ITCZ did not (DfAf/Dex/ITCZ group). None of Dex, ITCZ, or LAMB decreased pulmonary IL-13 concentration. It was suggested that combination of antifungal drugs and corticosteroid enhanced the suppressing effect of airway inflammations. This finding will give a hope for the treatment of severe fungus-related asthma.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10753-019-01069-z", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1084792", 
        "issn": [
          "0360-3997", 
          "1573-2576"
        ], 
        "name": "Inflammation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "keywords": [
      "liposomal amphotericin B", 
      "allergic bronchopulmonary mycosis", 
      "anti-inflammatory effects", 
      "allergic inflammation", 
      "MIP-2", 
      "bronchoalveolar lavage fluid concentrations", 
      "lavage fluid concentrations", 
      "IL-13 concentrations", 
      "effect of itraconazole", 
      "Dermatophagoides farinae allergens", 
      "addition of Dex", 
      "bronchopulmonary mycosis", 
      "airway inflammation", 
      "bronchial asthma", 
      "control mice", 
      "IL-13", 
      "IL-5", 
      "farinae allergens", 
      "corticosteroids", 
      "combination treatment", 
      "amphotericin B", 
      "fluid concentrations", 
      "inflammation", 
      "itraconazole", 
      "mice", 
      "antifungal drugs", 
      "asthma", 
      "Aspergillus fumigatus", 
      "treatment", 
      "Dex", 
      "elevation", 
      "model airway", 
      "suppressing effect", 
      "airway", 
      "therapy", 
      "allergens", 
      "infection", 
      "antigen", 
      "mycosis", 
      "drugs", 
      "efficacy", 
      "effect", 
      "days", 
      "fumigatus", 
      "concentration", 
      "findings", 
      "AF", 
      "addition", 
      "hope", 
      "combination", 
      "fungi", 
      "fosters"
    ], 
    "name": "Liposomal Amphotericin B Fosters the Corticosteroids\u2019 Anti-inflammatory Effect on Murine Allergic Bronchopulmonary Aspergillosis Model Airways", 
    "pagination": "2065-2071", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1120198424"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10753-019-01069-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31396817"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10753-019-01069-z", 
      "https://app.dimensions.ai/details/publication/pub.1120198424"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_833.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10753-019-01069-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10753-019-01069-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10753-019-01069-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10753-019-01069-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10753-019-01069-z'


 

This table displays all metadata directly associated to this object as RDF triples.

217 TRIPLES      20 PREDICATES      89 URIs      81 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10753-019-01069-z schema:about N0511ae35aecb46be8d0e57268daadbce
2 N0fd09967dc0042b488c2f6ccb9b53978
3 N3d7098f3396e4bc9a907413e220077f7
4 N4095867c8f99444383c2684ac23b437f
5 N4cdf0f35328943b2b7efc8f60eddffca
6 N60a143344dca4b8f9f0e85fa94366d3b
7 N6bcccb596a32412baf97ba07f77e9fc6
8 N6fe506a0799d4279b41992a7a9a2f8db
9 N7a398462c34d45f2850345d85bb91834
10 Na90780221ac344a9b642585b293e1c3d
11 Ncb032c35ed4b4366b762e2f846873be6
12 Ncbd6fd4731e1400c8c035bd36eee967c
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author Nedad2d95c8e64c5fb7916d6a4b02cd9d
16 schema:datePublished 2019-08-08
17 schema:datePublishedReg 2019-08-08
18 schema:description Fungus is an antigen for bronchial asthma causing allergic bronchopulmonary mycosis (ABPM). As a therapy other than corticosteroids, itraconazole (ITCZ) is known to suppress the allergic inflammation induced by Aspergillus fumigatus (Af). However, the efficacy of liposomal amphotericin B (LAMB) with/without corticosteroid on ABPM is unknown. Mice sensitized to Dermatophagoides farinae (Df) allergen were intranasally infected with Af (DfAf group). After the infection, corticosteroid (dexamethasone (Dex)) was administered for 5 days (DfAf/Dex group). The effects of ITCZ or LAMB with/without Dex were also evaluated. Pathologically, Dex and LAMB combination treatment decreased the allergic inflammation evidently. The bronchoalveolar lavage fluid (BALF) concentrations of IL-5, IL-13, and MIP-2 were significantly elevated in DfAf mice compared with control mice (p < 0.05, each). In DfAf mice, ITCZ and LAMB significantly decreased the elevation of MIP-2 (p < 0.05 vs the DfAf group). The addition of both Dex and LAMB suppressed the MIP-2 elevation in DfAf mice (p < 0.05 vs the Df/Af/Dex/LAMB group), but the addition of Dex and ITCZ did not (DfAf/Dex/ITCZ group). None of Dex, ITCZ, or LAMB decreased pulmonary IL-13 concentration. It was suggested that combination of antifungal drugs and corticosteroid enhanced the suppressing effect of airway inflammations. This finding will give a hope for the treatment of severe fungus-related asthma.
19 schema:genre article
20 schema:isAccessibleForFree false
21 schema:isPartOf N14e885bec2ee4d22976122a5a5b176ee
22 Nf3414c15d0b54331b920883103bc32d6
23 sg:journal.1084792
24 schema:keywords AF
25 Aspergillus fumigatus
26 Dermatophagoides farinae allergens
27 Dex
28 IL-13
29 IL-13 concentrations
30 IL-5
31 MIP-2
32 addition
33 addition of Dex
34 airway
35 airway inflammation
36 allergens
37 allergic bronchopulmonary mycosis
38 allergic inflammation
39 amphotericin B
40 anti-inflammatory effects
41 antifungal drugs
42 antigen
43 asthma
44 bronchial asthma
45 bronchoalveolar lavage fluid concentrations
46 bronchopulmonary mycosis
47 combination
48 combination treatment
49 concentration
50 control mice
51 corticosteroids
52 days
53 drugs
54 effect
55 effect of itraconazole
56 efficacy
57 elevation
58 farinae allergens
59 findings
60 fluid concentrations
61 fosters
62 fumigatus
63 fungi
64 hope
65 infection
66 inflammation
67 itraconazole
68 lavage fluid concentrations
69 liposomal amphotericin B
70 mice
71 model airway
72 mycosis
73 suppressing effect
74 therapy
75 treatment
76 schema:name Liposomal Amphotericin B Fosters the Corticosteroids’ Anti-inflammatory Effect on Murine Allergic Bronchopulmonary Aspergillosis Model Airways
77 schema:pagination 2065-2071
78 schema:productId N07f83fb6dc714cf08b079fc105ffacb3
79 N4405c8c05fc3400dae5a023b80b64dd2
80 Na5a660a88a7047fcb64415a62ef7f013
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120198424
82 https://doi.org/10.1007/s10753-019-01069-z
83 schema:sdDatePublished 2022-10-01T06:46
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N38f3d4bef25c4954bb7229df773a1b86
86 schema:url https://doi.org/10.1007/s10753-019-01069-z
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0511ae35aecb46be8d0e57268daadbce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Aspergillus fumigatus
92 rdf:type schema:DefinedTerm
93 N07f83fb6dc714cf08b079fc105ffacb3 schema:name doi
94 schema:value 10.1007/s10753-019-01069-z
95 rdf:type schema:PropertyValue
96 N0e55e28a45db4f499f81316434106990 rdf:first sg:person.01161550342.23
97 rdf:rest N5bbc1bc366be4a6e816aa6efbcd775aa
98 N0fd09967dc0042b488c2f6ccb9b53978 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Dexamethasone
100 rdf:type schema:DefinedTerm
101 N14e885bec2ee4d22976122a5a5b176ee schema:issueNumber 6
102 rdf:type schema:PublicationIssue
103 N38f3d4bef25c4954bb7229df773a1b86 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N3d7098f3396e4bc9a907413e220077f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Animals
107 rdf:type schema:DefinedTerm
108 N3fea3324d2b642d68c643064dd00d399 rdf:first sg:person.0777651441.52
109 rdf:rest Nb904d57eeb354ad3b068b3d79903ae9c
110 N4095867c8f99444383c2684ac23b437f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Anti-Inflammatory Agents
112 rdf:type schema:DefinedTerm
113 N4405c8c05fc3400dae5a023b80b64dd2 schema:name dimensions_id
114 schema:value pub.1120198424
115 rdf:type schema:PropertyValue
116 N4ca1755381c746da9b5ccee99752fa01 rdf:first sg:person.01143125277.28
117 rdf:rest rdf:nil
118 N4cdf0f35328943b2b7efc8f60eddffca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Amphotericin B
120 rdf:type schema:DefinedTerm
121 N5bbc1bc366be4a6e816aa6efbcd775aa rdf:first sg:person.01045143143.47
122 rdf:rest N3fea3324d2b642d68c643064dd00d399
123 N60a143344dca4b8f9f0e85fa94366d3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Aspergillosis, Allergic Bronchopulmonary
125 rdf:type schema:DefinedTerm
126 N6bcccb596a32412baf97ba07f77e9fc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Antifungal Agents
128 rdf:type schema:DefinedTerm
129 N6fe506a0799d4279b41992a7a9a2f8db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease Models, Animal
131 rdf:type schema:DefinedTerm
132 N7a398462c34d45f2850345d85bb91834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Drug Therapy, Combination
134 rdf:type schema:DefinedTerm
135 Na5a660a88a7047fcb64415a62ef7f013 schema:name pubmed_id
136 schema:value 31396817
137 rdf:type schema:PropertyValue
138 Na90780221ac344a9b642585b293e1c3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Itraconazole
140 rdf:type schema:DefinedTerm
141 Nb904d57eeb354ad3b068b3d79903ae9c rdf:first sg:person.01066650121.35
142 rdf:rest Nbd0162d9d8554381846f7d32b90a2791
143 Nbd0162d9d8554381846f7d32b90a2791 rdf:first sg:person.01203076521.29
144 rdf:rest Ndea8da4102514a31a4423778893285c0
145 Ncb032c35ed4b4366b762e2f846873be6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Mice
147 rdf:type schema:DefinedTerm
148 Ncbd6fd4731e1400c8c035bd36eee967c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adrenal Cortex Hormones
150 rdf:type schema:DefinedTerm
151 Ndea8da4102514a31a4423778893285c0 rdf:first sg:person.01311530576.67
152 rdf:rest N4ca1755381c746da9b5ccee99752fa01
153 Nedad2d95c8e64c5fb7916d6a4b02cd9d rdf:first sg:person.01226570717.43
154 rdf:rest N0e55e28a45db4f499f81316434106990
155 Nf3414c15d0b54331b920883103bc32d6 schema:volumeNumber 42
156 rdf:type schema:PublicationVolume
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
161 schema:name Cardiorespiratory Medicine and Haematology
162 rdf:type schema:DefinedTerm
163 sg:journal.1084792 schema:issn 0360-3997
164 1573-2576
165 schema:name Inflammation
166 schema:publisher Springer Nature
167 rdf:type schema:Periodical
168 sg:person.01045143143.47 schema:affiliation grid-institutes:grid.174567.6
169 schema:familyName Obase
170 schema:givenName Yasushi
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045143143.47
172 rdf:type schema:Person
173 sg:person.01066650121.35 schema:affiliation grid-institutes:grid.174567.6
174 schema:familyName Tsuchida
175 schema:givenName Tomoko
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066650121.35
177 rdf:type schema:Person
178 sg:person.01143125277.28 schema:affiliation grid-institutes:grid.174567.6
179 schema:familyName Mukae
180 schema:givenName Hiroshi
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28
182 rdf:type schema:Person
183 sg:person.01161550342.23 schema:affiliation grid-institutes:grid.470115.6
184 schema:familyName Matsuse
185 schema:givenName Hiroto
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161550342.23
187 rdf:type schema:Person
188 sg:person.01203076521.29 schema:affiliation grid-institutes:grid.174567.6
189 schema:familyName Kawano
190 schema:givenName Tetsuya
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203076521.29
192 rdf:type schema:Person
193 sg:person.01226570717.43 schema:affiliation grid-institutes:grid.411873.8
194 schema:familyName Fukushima
195 schema:givenName Chizu
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226570717.43
197 rdf:type schema:Person
198 sg:person.01311530576.67 schema:affiliation grid-institutes:grid.174567.6
199 schema:familyName Kohno
200 schema:givenName Shigeru
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311530576.67
202 rdf:type schema:Person
203 sg:person.0777651441.52 schema:affiliation grid-institutes:grid.174567.6
204 schema:familyName Fukahori
205 schema:givenName Susumu
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777651441.52
207 rdf:type schema:Person
208 grid-institutes:grid.174567.6 schema:alternateName Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
209 schema:name Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
210 rdf:type schema:Organization
211 grid-institutes:grid.411873.8 schema:alternateName Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan
212 schema:name Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan
213 Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
214 rdf:type schema:Organization
215 grid-institutes:grid.470115.6 schema:alternateName Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
216 schema:name Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
217 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...