Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Linlin Wang, Meng Shi, Lin Tong, Jian Wang, Shimeng Ji, Jing Bi, Cuicui Chen, Jinjun Jiang, Chunxue Bai, Jian Zhou, Yuanlin Song

ABSTRACT

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Mesenchymal stem cells (MSCs) have been shown to improve ALI, and the imbalance of regulatory T cells (Tregs) and Th17 cells is associated with mortality in ALI/ARDS patients. However, whether administration of lung-resident MSC (LRMSC) improves lung injury and regulates the balance of Tregs and Th17 cells remains unknown. An ALI animal model was induced by LPS, and PBS or LRMSC were administered via tail vein after 4 h. LRMSC were subsequently detected in the lungs by a live imaging system (Berthold LB983, Germany). Lung morphology; lung wet-to-dry weight ratio; and total protein concentration, inflammatory cells, and cytokines in bronchoalveolar lavage fluid (BALF) and plasma were determined. The percentage of Tregs in lung and spleen, and of Th17 cells in lung and blood, were also evaluated. The results showed that LRMSC not only attenuated histopathological damage but also mediated the downregulation of lung wet-to-dry weight ratio and the reduction of total protein concentration and inflammatory cells in BALF. LRMSC also decreased inflammatory cytokines in both BALF and plasma and increased KGF-2 and surfactant protein C (SPC) expression in the lung. Flow cytometry revealed the upregulation of Tregs and the downregulation of Th17 cells, and the increase in the ratio of Tregs and Th17 cells. The live imaging system showed that LRMSC migrated to and were retained in the injured area. In conclusion, the results indicated that administration of LRMSC attenuates LPS-induced ALI via upregulating the balance of Tregs and Th17 cells. More... »

PAGES

199-210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-018-0884-6

DOI

http://dx.doi.org/10.1007/s10753-018-0884-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106679654

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30187337


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Linlin", 
        "id": "sg:person.015403306354.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015403306354.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Meng", 
        "id": "sg:person.010620103054.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010620103054.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tong", 
        "givenName": "Lin", 
        "id": "sg:person.01151553421.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151553421.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Shimeng", 
        "id": "sg:person.011070556554.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011070556554.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bi", 
        "givenName": "Jing", 
        "id": "sg:person.01103440221.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103440221.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Cuicui", 
        "id": "sg:person.01233305437.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233305437.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Jinjun", 
        "id": "sg:person.0724036361.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724036361.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bai", 
        "givenName": "Chunxue", 
        "id": "sg:person.0674141325.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674141325.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Jian", 
        "id": "sg:person.0651754002.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651754002.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Public Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.470110.3", 
          "name": [
            "Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China", 
            "Shanghai Public Health Clinical Center, 201508, Shanghai, China", 
            "Zhongshan Hospital, Qingpu Branch, Fudan University, 201700, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Yuanlin", 
        "id": "sg:person.015333604474.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015333604474.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1164/rccm.201001-0010oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004910158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009423330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009423330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci60331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010135385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010516860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010516860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00431.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012787733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013122874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00309.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014551813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2012-0198oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015093942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0902007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015598537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2010.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017531585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-010-0849-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019092072", 
          "https://doi.org/10.1007/s00262-010-0849-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-010-0849-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019092072", 
          "https://doi.org/10.1007/s00262-010-0849-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0040269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021056630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1432929100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023425732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2015-0006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024601179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0045272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026084036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027044744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-12-108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027973330", 
          "https://doi.org/10.1186/1465-9921-12-108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep21642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029404211", 
          "https://doi.org/10.1038/srep21642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0704421104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031989813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200425405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036595685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/scrt216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038492833", 
          "https://doi.org/10.1186/scrt216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0811-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038960533", 
          "https://doi.org/10.1186/s13054-015-0811-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0811-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038960533", 
          "https://doi.org/10.1186/s13054-015-0811-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200005043421806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046585288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.06-1743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048035114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0907996106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050188727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2008-0428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052993129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2006.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.3.1855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077447904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms18040689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084435986"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Mesenchymal stem cells (MSCs) have been shown to improve ALI, and the imbalance of regulatory T cells (Tregs) and Th17 cells is associated with mortality in ALI/ARDS patients. However, whether administration of lung-resident MSC (LRMSC) improves lung injury and regulates the balance of Tregs and Th17 cells remains unknown. An ALI animal model was induced by LPS, and PBS or LRMSC were administered via tail vein after 4\u00a0h. LRMSC were subsequently detected in the lungs by a live imaging system (Berthold LB983, Germany). Lung morphology; lung wet-to-dry weight ratio; and total protein concentration, inflammatory cells, and cytokines in bronchoalveolar lavage fluid (BALF) and plasma were determined. The percentage of Tregs in lung and spleen, and of Th17 cells in lung and blood, were also evaluated. The results showed that LRMSC not only attenuated histopathological damage but also mediated the downregulation of lung wet-to-dry weight ratio and the reduction of total protein concentration and inflammatory cells in BALF. LRMSC also decreased inflammatory cytokines in both BALF and plasma and increased KGF-2 and surfactant protein C (SPC) expression in the lung. Flow cytometry revealed the upregulation of Tregs and the downregulation of Th17 cells, and the increase in the ratio of Tregs and Th17 cells. The live imaging system showed that LRMSC migrated to and were retained in the injured area. In conclusion, the results indicated that administration of LRMSC attenuates LPS-induced ALI via upregulating the balance of Tregs and Th17 cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10753-018-0884-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1084792", 
        "issn": [
          "0360-3997", 
          "1573-2576"
        ], 
        "name": "Inflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells", 
    "pagination": "199-210", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "05965ae04212f50caae7ef0339d07d993849a11fe25a452f21f30851b0354639"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30187337"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7600105"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10753-018-0884-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106679654"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10753-018-0884-6", 
      "https://app.dimensions.ai/details/publication/pub.1106679654"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99818_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10753-018-0884-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0884-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0884-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0884-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0884-6'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      58 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10753-018-0884-6 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Nb16dfb541dd44722802577c625d894a5
4 schema:citation sg:pub.10.1007/s00262-010-0849-6
5 sg:pub.10.1038/srep21642
6 sg:pub.10.1186/1465-9921-12-108
7 sg:pub.10.1186/s13054-015-0811-2
8 sg:pub.10.1186/scrt216
9 https://doi.org/10.1002/eji.200425405
10 https://doi.org/10.1002/path.2302
11 https://doi.org/10.1016/j.yexcr.2010.05.009
12 https://doi.org/10.1056/nejm200005043421806
13 https://doi.org/10.1056/nejmoa050333
14 https://doi.org/10.1073/pnas.0704421104
15 https://doi.org/10.1073/pnas.0907996106
16 https://doi.org/10.1073/pnas.1432929100
17 https://doi.org/10.1089/hum.2006.137
18 https://doi.org/10.1146/annurev.immunol.21.120601.141122
19 https://doi.org/10.1152/ajplung.00309.2003
20 https://doi.org/10.1152/ajplung.00431.2006
21 https://doi.org/10.1164/rccm.201001-0010oc
22 https://doi.org/10.1165/rcmb.2012-0198oc
23 https://doi.org/10.1172/jci36498
24 https://doi.org/10.1172/jci60331
25 https://doi.org/10.1371/journal.pmed.0040269
26 https://doi.org/10.1371/journal.pone.0045272
27 https://doi.org/10.1378/chest.06-1743
28 https://doi.org/10.1634/stemcells.2008-0428
29 https://doi.org/10.3390/ijms18040689
30 https://doi.org/10.4049/jimmunol.0902007
31 https://doi.org/10.4049/jimmunol.179.3.1855
32 https://doi.org/10.5966/sctm.2015-0006
33 schema:datePublished 2019-02
34 schema:datePublishedReg 2019-02-01
35 schema:description Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Mesenchymal stem cells (MSCs) have been shown to improve ALI, and the imbalance of regulatory T cells (Tregs) and Th17 cells is associated with mortality in ALI/ARDS patients. However, whether administration of lung-resident MSC (LRMSC) improves lung injury and regulates the balance of Tregs and Th17 cells remains unknown. An ALI animal model was induced by LPS, and PBS or LRMSC were administered via tail vein after 4 h. LRMSC were subsequently detected in the lungs by a live imaging system (Berthold LB983, Germany). Lung morphology; lung wet-to-dry weight ratio; and total protein concentration, inflammatory cells, and cytokines in bronchoalveolar lavage fluid (BALF) and plasma were determined. The percentage of Tregs in lung and spleen, and of Th17 cells in lung and blood, were also evaluated. The results showed that LRMSC not only attenuated histopathological damage but also mediated the downregulation of lung wet-to-dry weight ratio and the reduction of total protein concentration and inflammatory cells in BALF. LRMSC also decreased inflammatory cytokines in both BALF and plasma and increased KGF-2 and surfactant protein C (SPC) expression in the lung. Flow cytometry revealed the upregulation of Tregs and the downregulation of Th17 cells, and the increase in the ratio of Tregs and Th17 cells. The live imaging system showed that LRMSC migrated to and were retained in the injured area. In conclusion, the results indicated that administration of LRMSC attenuates LPS-induced ALI via upregulating the balance of Tregs and Th17 cells.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N9e5f95a9da254799bc64da1d62c9ecaa
40 Nd50ba26de8c34287a51e7620ffd8dc49
41 sg:journal.1084792
42 schema:name Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells
43 schema:pagination 199-210
44 schema:productId N17226b58e7a74fc6886d34c1b4061fdd
45 N315b615f469d449396e0e69b99e8aa2d
46 N7de4e74c78d34867af4336fb81b30965
47 Nb5100221505c44409dea2f3d6b934cb1
48 Ndaf76dba4f4e4899bdb466db6a6309f1
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106679654
50 https://doi.org/10.1007/s10753-018-0884-6
51 schema:sdDatePublished 2019-04-11T09:35
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N96f51f49dbbd493d8eef6f1e5c31b2a0
54 schema:url https://link.springer.com/10.1007%2Fs10753-018-0884-6
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N01c6d355ff834f84be1e4127cb2ebe7e schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
59 rdf:type schema:Organization
60 N0a2ed3a4baf94503a62cef0a8959e338 schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
61 rdf:type schema:Organization
62 N0fd9278170184269a9b9a842ad67e15e rdf:first sg:person.015333604474.20
63 rdf:rest rdf:nil
64 N17226b58e7a74fc6886d34c1b4061fdd schema:name readcube_id
65 schema:value 05965ae04212f50caae7ef0339d07d993849a11fe25a452f21f30851b0354639
66 rdf:type schema:PropertyValue
67 N2164d1f33e294f5f885c0318e31d9a7e schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
68 rdf:type schema:Organization
69 N311cc3b27dd844ef8688f977a53b65ff schema:affiliation N99024bfa3d0e4150aeeb23f011eab23b
70 schema:familyName Wang
71 schema:givenName Jian
72 rdf:type schema:Person
73 N315b615f469d449396e0e69b99e8aa2d schema:name dimensions_id
74 schema:value pub.1106679654
75 rdf:type schema:PropertyValue
76 N381c74361dbb4871b6fa13947ae71510 schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
77 rdf:type schema:Organization
78 N406dd2f3639e4668808dfcfcc0739a2e schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
79 rdf:type schema:Organization
80 N4608b41d48f94bd38aedd58f211d1a07 schema:name Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, 200032, Shanghai, China
81 rdf:type schema:Organization
82 N4d990c5391ed4327a843c928bd16b19c rdf:first sg:person.01233305437.42
83 rdf:rest N5e80f9ba29ee48308b130830a712ccd6
84 N5e80f9ba29ee48308b130830a712ccd6 rdf:first sg:person.0724036361.80
85 rdf:rest Na58c468583ad4d60a24e11c872d93a57
86 N797b11e44c4245c496b71a87dc5f26cc schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
87 rdf:type schema:Organization
88 N7de4e74c78d34867af4336fb81b30965 schema:name nlm_unique_id
89 schema:value 7600105
90 rdf:type schema:PropertyValue
91 N8b8ea96cea8247dca0ff99e2f7157f21 schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
92 rdf:type schema:Organization
93 N9117e44fe5ea4117a973ede1d2542dca rdf:first sg:person.01151553421.75
94 rdf:rest Nb8722134da854157901b81ffdd785986
95 N96f51f49dbbd493d8eef6f1e5c31b2a0 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N989d14c85c7140c1b9548c0277f6bbc0 schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
98 rdf:type schema:Organization
99 N99024bfa3d0e4150aeeb23f011eab23b schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
100 rdf:type schema:Organization
101 N9e5f95a9da254799bc64da1d62c9ecaa schema:issueNumber 1
102 rdf:type schema:PublicationIssue
103 Na4e7a9fadaea46e7b2fea4fcd42c970c rdf:first sg:person.0651754002.31
104 rdf:rest N0fd9278170184269a9b9a842ad67e15e
105 Na58c468583ad4d60a24e11c872d93a57 rdf:first sg:person.0674141325.81
106 rdf:rest Na4e7a9fadaea46e7b2fea4fcd42c970c
107 Naa1a0870ce06466db31b7a0b8b62058f rdf:first sg:person.01103440221.60
108 rdf:rest N4d990c5391ed4327a843c928bd16b19c
109 Nb16dfb541dd44722802577c625d894a5 rdf:first sg:person.015403306354.15
110 rdf:rest Nfccdd0123f9f4cca82d65b52a4dc10ac
111 Nb5100221505c44409dea2f3d6b934cb1 schema:name doi
112 schema:value 10.1007/s10753-018-0884-6
113 rdf:type schema:PropertyValue
114 Nb8722134da854157901b81ffdd785986 rdf:first N311cc3b27dd844ef8688f977a53b65ff
115 rdf:rest Nef4d1f43d5034d1688a2e4e3ee2a164c
116 Nd50ba26de8c34287a51e7620ffd8dc49 schema:volumeNumber 42
117 rdf:type schema:PublicationVolume
118 Ndaf76dba4f4e4899bdb466db6a6309f1 schema:name pubmed_id
119 schema:value 30187337
120 rdf:type schema:PropertyValue
121 Nef4d1f43d5034d1688a2e4e3ee2a164c rdf:first sg:person.011070556554.30
122 rdf:rest Naa1a0870ce06466db31b7a0b8b62058f
123 Nfccdd0123f9f4cca82d65b52a4dc10ac rdf:first sg:person.010620103054.55
124 rdf:rest N9117e44fe5ea4117a973ede1d2542dca
125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
126 schema:name Medical and Health Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
129 schema:name Cardiorespiratory Medicine and Haematology
130 rdf:type schema:DefinedTerm
131 sg:journal.1084792 schema:issn 0360-3997
132 1573-2576
133 schema:name Inflammation
134 rdf:type schema:Periodical
135 sg:person.010620103054.55 schema:affiliation N4608b41d48f94bd38aedd58f211d1a07
136 schema:familyName Shi
137 schema:givenName Meng
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010620103054.55
139 rdf:type schema:Person
140 sg:person.01103440221.60 schema:affiliation N2164d1f33e294f5f885c0318e31d9a7e
141 schema:familyName Bi
142 schema:givenName Jing
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103440221.60
144 rdf:type schema:Person
145 sg:person.011070556554.30 schema:affiliation N797b11e44c4245c496b71a87dc5f26cc
146 schema:familyName Ji
147 schema:givenName Shimeng
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011070556554.30
149 rdf:type schema:Person
150 sg:person.01151553421.75 schema:affiliation N989d14c85c7140c1b9548c0277f6bbc0
151 schema:familyName Tong
152 schema:givenName Lin
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151553421.75
154 rdf:type schema:Person
155 sg:person.01233305437.42 schema:affiliation N406dd2f3639e4668808dfcfcc0739a2e
156 schema:familyName Chen
157 schema:givenName Cuicui
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233305437.42
159 rdf:type schema:Person
160 sg:person.015333604474.20 schema:affiliation https://www.grid.ac/institutes/grid.470110.3
161 schema:familyName Song
162 schema:givenName Yuanlin
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015333604474.20
164 rdf:type schema:Person
165 sg:person.015403306354.15 schema:affiliation N01c6d355ff834f84be1e4127cb2ebe7e
166 schema:familyName Wang
167 schema:givenName Linlin
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015403306354.15
169 rdf:type schema:Person
170 sg:person.0651754002.31 schema:affiliation N381c74361dbb4871b6fa13947ae71510
171 schema:familyName Zhou
172 schema:givenName Jian
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651754002.31
174 rdf:type schema:Person
175 sg:person.0674141325.81 schema:affiliation N8b8ea96cea8247dca0ff99e2f7157f21
176 schema:familyName Bai
177 schema:givenName Chunxue
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674141325.81
179 rdf:type schema:Person
180 sg:person.0724036361.80 schema:affiliation N0a2ed3a4baf94503a62cef0a8959e338
181 schema:familyName Jiang
182 schema:givenName Jinjun
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724036361.80
184 rdf:type schema:Person
185 sg:pub.10.1007/s00262-010-0849-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019092072
186 https://doi.org/10.1007/s00262-010-0849-6
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/srep21642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029404211
189 https://doi.org/10.1038/srep21642
190 rdf:type schema:CreativeWork
191 sg:pub.10.1186/1465-9921-12-108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027973330
192 https://doi.org/10.1186/1465-9921-12-108
193 rdf:type schema:CreativeWork
194 sg:pub.10.1186/s13054-015-0811-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038960533
195 https://doi.org/10.1186/s13054-015-0811-2
196 rdf:type schema:CreativeWork
197 sg:pub.10.1186/scrt216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038492833
198 https://doi.org/10.1186/scrt216
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/eji.200425405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036595685
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/path.2302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013122874
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.yexcr.2010.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017531585
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1056/nejm200005043421806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046585288
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1056/nejmoa050333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010516860
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1073/pnas.0704421104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031989813
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1073/pnas.0907996106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050188727
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.1432929100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023425732
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1089/hum.2006.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272702
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1146/annurev.immunol.21.120601.141122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027044744
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1152/ajplung.00309.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014551813
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1152/ajplung.00431.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012787733
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1164/rccm.201001-0010oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1004910158
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1165/rcmb.2012-0198oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1015093942
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1172/jci36498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009423330
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1172/jci60331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010135385
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1371/journal.pmed.0040269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021056630
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1371/journal.pone.0045272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026084036
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1378/chest.06-1743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048035114
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1634/stemcells.2008-0428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052993129
239 rdf:type schema:CreativeWork
240 https://doi.org/10.3390/ijms18040689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084435986
241 rdf:type schema:CreativeWork
242 https://doi.org/10.4049/jimmunol.0902007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015598537
243 rdf:type schema:CreativeWork
244 https://doi.org/10.4049/jimmunol.179.3.1855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077447904
245 rdf:type schema:CreativeWork
246 https://doi.org/10.5966/sctm.2015-0006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024601179
247 rdf:type schema:CreativeWork
248 https://www.grid.ac/institutes/grid.470110.3 schema:alternateName Shanghai Public Health Clinical Center
249 schema:name Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China
250 Shanghai Public Health Clinical Center, 201508, Shanghai, China
251 Zhongshan Hospital, Qingpu Branch, Fudan University, 201700, Shanghai, China
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...