Juniperonic Acid Incorporation into the Phospholipids of Murine Macrophage Cells Modulates Pro-Inflammatory Mediator Production View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Po-Jung Tsai, Wen-Cheng Huang, Shao-Wei Lin, Sung-Nien Chen, Hung-Jing Shen, Hsiang Chang, Lu-Te Chuang

ABSTRACT

Juniperonic acid (JPA; Δ5,11,14,17-20:4), originally identified in certain gymnosperm seeds, is a rare n-3 polyunsaturated fatty acid (PUFA) with lipid-modulating effects on rats and anti-proliferative effects on fibroblast cell proliferation. However, little is known how JPA exerted its immunosuppressive effect. The objective of this study was to investigate whether JPA inhibited the production of inflammatory mediators through the modulation of cellular phospholipid fatty acid compositions. Using standard lipid chemistry techniques in conjunction with argentated column chromatography, high-purity JPA (> 98%) was extracted, isolated, and purified from Biota kernels. When murine RAW264.7 macrophages were incubated with increasing concentrations of JPA, amounts of cellular phospholipid total PUFA, JPA, and Δ7-docosatetraenoic acid (Δ7-DTA; elongation product of JPA) increased in a dose-dependent manner; however, the proportions of total monounsaturated fatty acid (MUFA) and arachidonic acid (AA) decreased. JPA suppressed the production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and the expression of inducible nitric oxide synthase (iNOS) up to 21, 75, 30, and 44%, respectively. The induction of cyclooxygenase-2 (COX-2) over-expression by JPA could account for the doubling of the PGE2 level. Furthermore, JPA suppressed the expression of phosphorylated mitogen-activated protein kinases (MAPK). In a separate study using the mouse ear edema model, we demonstrated that JPA also significantly suppressed inflammation, as measured by ear thickness and biopsy weight. The anti-inflammatory properties of JPA could be due, in part, to the incorporation of JPA into cellular phospholipids with subsequent modulation of membrane-mediated MAPK signaling. More... »

PAGES

1200-1214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-018-0767-x

DOI

http://dx.doi.org/10.1007/s10753-018-0767-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101776231

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29589254


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Edema", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Monounsaturated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Unsaturated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide Synthase Type II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RAW 264.7 Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Taiwan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.412090.e", 
          "name": [
            "Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan", 
            "Program of Nutritional Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsai", 
        "givenName": "Po-Jung", 
        "id": "sg:person.0656211542.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656211542.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.412090.e", 
          "name": [
            "Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Wen-Cheng", 
        "id": "sg:person.01151140642.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151140642.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yuanpei University", 
          "id": "https://www.grid.ac/institutes/grid.413051.2", 
          "name": [
            "Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, 300, Hsinchu, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Shao-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yuanpei University", 
          "id": "https://www.grid.ac/institutes/grid.413051.2", 
          "name": [
            "Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, 300, Hsinchu, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Sung-Nien", 
        "id": "sg:person.01056546416.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056546416.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.412090.e", 
          "name": [
            "Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Hung-Jing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yuanpei University", 
          "id": "https://www.grid.ac/institutes/grid.413051.2", 
          "name": [
            "Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, 300, Hsinchu, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Hsiang", 
        "id": "sg:person.016533044415.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016533044415.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yuanpei University", 
          "id": "https://www.grid.ac/institutes/grid.413051.2", 
          "name": [
            "Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, 300, Hsinchu, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chuang", 
        "givenName": "Lu-Te", 
        "id": "sg:person.0704262453.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704262453.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/bbrc.1999.1559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000098778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(96)04382-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004231017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02662254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005513383", 
          "https://doi.org/10.1007/bf02662254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.plefa.2006.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006650126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2014.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011649996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.nutr.19.1.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011700688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.31.1786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012777965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19940079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013422247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2007.05807.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014063415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-011-3550-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014261917", 
          "https://doi.org/10.1007/s11745-011-3550-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014341787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(82)90118-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015674611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsre.1999.5684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018352515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.p031260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021254790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biochi.2004.09.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021584711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02540092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023731439", 
          "https://doi.org/10.1007/bf02540092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10753-014-9960-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023879211", 
          "https://doi.org/10.1007/s10753-014-9960-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1011023632564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024105239", 
          "https://doi.org/10.1023/a:1011023632564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-008-3276-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027216283", 
          "https://doi.org/10.1007/s11745-008-3276-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0458-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031299072", 
          "https://doi.org/10.1186/s12974-015-0458-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m300455-jlr200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032875504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02530966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033056582", 
          "https://doi.org/10.1007/bf02530966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r000015200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035226697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-511x-1-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040263598", 
          "https://doi.org/10.1186/1476-511x-1-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(75)90067-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041054909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(75)90067-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041054909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-2760(98)00084-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041820254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02536130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041822749", 
          "https://doi.org/10.1007/bf02536130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2012.07.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041908180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(91)90254-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043977979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(91)90254-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043977979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-005-1424-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045444395", 
          "https://doi.org/10.1007/s11745-005-1424-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-999-0460-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046102319", 
          "https://doi.org/10.1007/s11745-999-0460-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11746-997-0174-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046890404", 
          "https://doi.org/10.1007/s11746-997-0174-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.plipres.2010.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052942966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-1097.2004.tb00076.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053424262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jmf.2012.2577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059283145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074645528", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075727656", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/84.1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077265816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/83.6.1505s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077269424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0903282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078141595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078441269", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1502135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079272912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083071022", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cphy.c170011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091607265"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08", 
    "datePublishedReg": "2018-08-01", 
    "description": "Juniperonic acid (JPA; \u03945,11,14,17-20:4), originally identified in certain gymnosperm seeds, is a rare n-3 polyunsaturated fatty acid (PUFA) with lipid-modulating effects on rats and anti-proliferative effects on fibroblast cell proliferation. However, little is known how JPA exerted its immunosuppressive effect. The objective of this study was to investigate whether JPA inhibited the production of inflammatory mediators through the modulation of cellular phospholipid fatty acid compositions. Using standard lipid chemistry techniques in conjunction with argentated column chromatography, high-purity JPA (>\u200998%) was extracted, isolated, and purified from Biota kernels. When murine RAW264.7 macrophages were incubated with increasing concentrations of JPA, amounts of cellular phospholipid total PUFA, JPA, and \u03947-docosatetraenoic acid (\u03947-DTA; elongation product of JPA) increased in a dose-dependent manner; however, the proportions of total monounsaturated fatty acid (MUFA) and arachidonic acid (AA) decreased. JPA suppressed the production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-\u03b1 (TNF-\u03b1) and the expression of inducible nitric oxide synthase (iNOS) up to 21, 75, 30, and 44%, respectively. The induction of cyclooxygenase-2 (COX-2) over-expression by JPA could account for the doubling of the PGE2 level. Furthermore, JPA suppressed the expression of phosphorylated mitogen-activated protein kinases (MAPK). In a separate study using the mouse ear edema model, we demonstrated that JPA also significantly suppressed inflammation, as measured by ear thickness and biopsy weight. The anti-inflammatory properties of JPA could be due, in part, to the incorporation of JPA into cellular phospholipids with subsequent modulation of membrane-mediated MAPK signaling.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10753-018-0767-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1084792", 
        "issn": [
          "0360-3997", 
          "1573-2576"
        ], 
        "name": "Inflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Juniperonic Acid Incorporation into the Phospholipids of Murine Macrophage Cells Modulates Pro-Inflammatory Mediator Production", 
    "pagination": "1200-1214", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a611bd36bec6213ad5fd235302057352f14f46b50d979df89ae11bee06abe310"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29589254"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7600105"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10753-018-0767-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101776231"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10753-018-0767-x", 
      "https://app.dimensions.ai/details/publication/pub.1101776231"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88253_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10753-018-0767-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0767-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0767-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0767-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10753-018-0767-x'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      85 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10753-018-0767-x schema:about N11ce2df6461b4c8a9a949b20d7acbe96
2 N243182ca9d9040778dec7ba3e4c825d5
3 N2692b9f09c5b4afb90243ae150ef19bf
4 N4862750ae7d347c99b4d64c0df772631
5 N6c0f6ab51ca349c68d6faafce1767f9f
6 N6efc24fd55344ddfbf6b02c8ea284e93
7 N99a62cf051044bf59bb4b01de24090ee
8 N9c7e5070bcd14c5daae68e67f44006e3
9 Nbb854ace586447f7b18448734329469d
10 Nf5651a7e26f444a0b8b03510a0425eea
11 Nf962a3aa90fb476ea32321f42d2535f9
12 Nfbe56fdee16f40219c4b3ba98eb74b0c
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author N35287fc35df44addbaf052c9fc33d0d6
16 schema:citation sg:pub.10.1007/bf02530966
17 sg:pub.10.1007/bf02536130
18 sg:pub.10.1007/bf02540092
19 sg:pub.10.1007/bf02662254
20 sg:pub.10.1007/s10753-014-9960-8
21 sg:pub.10.1007/s11745-005-1424-y
22 sg:pub.10.1007/s11745-008-3276-0
23 sg:pub.10.1007/s11745-011-3550-4
24 sg:pub.10.1007/s11745-999-0460-y
25 sg:pub.10.1007/s11746-997-0174-1
26 sg:pub.10.1023/a:1011023632564
27 sg:pub.10.1186/1476-511x-1-5
28 sg:pub.10.1186/s12974-015-0458-6
29 https://app.dimensions.ai/details/publication/pub.1074645528
30 https://app.dimensions.ai/details/publication/pub.1075727656
31 https://app.dimensions.ai/details/publication/pub.1078441269
32 https://app.dimensions.ai/details/publication/pub.1083071022
33 https://doi.org/10.1002/cphy.c170011
34 https://doi.org/10.1002/jcp.20678
35 https://doi.org/10.1006/bbrc.1999.1559
36 https://doi.org/10.1006/jsre.1999.5684
37 https://doi.org/10.1016/0003-2697(82)90118-x
38 https://doi.org/10.1016/0005-2760(75)90067-3
39 https://doi.org/10.1016/0005-2760(91)90254-f
40 https://doi.org/10.1016/j.biochi.2004.09.019
41 https://doi.org/10.1016/j.fct.2012.07.057
42 https://doi.org/10.1016/j.fct.2014.01.031
43 https://doi.org/10.1016/j.plefa.2006.05.012
44 https://doi.org/10.1016/j.plipres.2010.01.002
45 https://doi.org/10.1016/s0005-2760(98)00084-8
46 https://doi.org/10.1016/s0304-3835(96)04382-0
47 https://doi.org/10.1074/jbc.r000015200
48 https://doi.org/10.1079/bjn19940079
49 https://doi.org/10.1089/jmf.2012.2577
50 https://doi.org/10.1093/ajcn/83.6.1505s
51 https://doi.org/10.1093/ajcn/84.1.5
52 https://doi.org/10.1111/j.1742-4658.2007.05807.x
53 https://doi.org/10.1111/j.1751-1097.2004.tb00076.x
54 https://doi.org/10.1146/annurev.nutr.19.1.63
55 https://doi.org/10.1194/jlr.m300455-jlr200
56 https://doi.org/10.1194/jlr.p031260
57 https://doi.org/10.1248/bpb.31.1786
58 https://doi.org/10.4049/jimmunol.0903282
59 https://doi.org/10.4049/jimmunol.1502135
60 schema:datePublished 2018-08
61 schema:datePublishedReg 2018-08-01
62 schema:description Juniperonic acid (JPA; Δ5,11,14,17-20:4), originally identified in certain gymnosperm seeds, is a rare n-3 polyunsaturated fatty acid (PUFA) with lipid-modulating effects on rats and anti-proliferative effects on fibroblast cell proliferation. However, little is known how JPA exerted its immunosuppressive effect. The objective of this study was to investigate whether JPA inhibited the production of inflammatory mediators through the modulation of cellular phospholipid fatty acid compositions. Using standard lipid chemistry techniques in conjunction with argentated column chromatography, high-purity JPA (&gt; 98%) was extracted, isolated, and purified from Biota kernels. When murine RAW264.7 macrophages were incubated with increasing concentrations of JPA, amounts of cellular phospholipid total PUFA, JPA, and Δ7-docosatetraenoic acid (Δ7-DTA; elongation product of JPA) increased in a dose-dependent manner; however, the proportions of total monounsaturated fatty acid (MUFA) and arachidonic acid (AA) decreased. JPA suppressed the production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and the expression of inducible nitric oxide synthase (iNOS) up to 21, 75, 30, and 44%, respectively. The induction of cyclooxygenase-2 (COX-2) over-expression by JPA could account for the doubling of the PGE<sub>2</sub> level. Furthermore, JPA suppressed the expression of phosphorylated mitogen-activated protein kinases (MAPK). In a separate study using the mouse ear edema model, we demonstrated that JPA also significantly suppressed inflammation, as measured by ear thickness and biopsy weight. The anti-inflammatory properties of JPA could be due, in part, to the incorporation of JPA into cellular phospholipids with subsequent modulation of membrane-mediated MAPK signaling.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree false
66 schema:isPartOf N1f5c2b599dd044caa598e161cc0db990
67 Nf17e6604a8a449a9ac45d2197e85cb83
68 sg:journal.1084792
69 schema:name Juniperonic Acid Incorporation into the Phospholipids of Murine Macrophage Cells Modulates Pro-Inflammatory Mediator Production
70 schema:pagination 1200-1214
71 schema:productId N1cb80341bb7041d8a5fd8ad75b596df6
72 N1cf8bace8af7469796482576de4ebc69
73 N6ac862c5743e4b16bf230a620309be7c
74 N8cfeade5650c40379e58e7e31e774433
75 Na148b10dc77c4a5d8960e4be0e141335
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101776231
77 https://doi.org/10.1007/s10753-018-0767-x
78 schema:sdDatePublished 2019-04-11T13:11
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N525e5fc2dc7542fcb2d4b773bdf06683
81 schema:url https://link.springer.com/10.1007%2Fs10753-018-0767-x
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N077f5b63514a45e7ad8ce26e7eee514f rdf:first N175bcab6ae1240eda6e40f93006ea1d3
86 rdf:rest N9c5726ce962f4b2295cdc74a4aff1b68
87 N0975fbde83a5492198d2f420c299eff8 rdf:first sg:person.016533044415.08
88 rdf:rest N2e381159eb5444159ac04e640707506a
89 N11ce2df6461b4c8a9a949b20d7acbe96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mice
91 rdf:type schema:DefinedTerm
92 N175bcab6ae1240eda6e40f93006ea1d3 schema:affiliation https://www.grid.ac/institutes/grid.413051.2
93 schema:familyName Lin
94 schema:givenName Shao-Wei
95 rdf:type schema:Person
96 N1cb80341bb7041d8a5fd8ad75b596df6 schema:name readcube_id
97 schema:value a611bd36bec6213ad5fd235302057352f14f46b50d979df89ae11bee06abe310
98 rdf:type schema:PropertyValue
99 N1cf8bace8af7469796482576de4ebc69 schema:name doi
100 schema:value 10.1007/s10753-018-0767-x
101 rdf:type schema:PropertyValue
102 N1f5c2b599dd044caa598e161cc0db990 schema:issueNumber 4
103 rdf:type schema:PublicationIssue
104 N243182ca9d9040778dec7ba3e4c825d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Edema
106 rdf:type schema:DefinedTerm
107 N2692b9f09c5b4afb90243ae150ef19bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Animals
109 rdf:type schema:DefinedTerm
110 N2e381159eb5444159ac04e640707506a rdf:first sg:person.0704262453.37
111 rdf:rest rdf:nil
112 N35287fc35df44addbaf052c9fc33d0d6 rdf:first sg:person.0656211542.82
113 rdf:rest Nf474c7e41ac74938abd067b440d352fc
114 N4862750ae7d347c99b4d64c0df772631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cyclooxygenase 2
116 rdf:type schema:DefinedTerm
117 N525e5fc2dc7542fcb2d4b773bdf06683 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N6ac862c5743e4b16bf230a620309be7c schema:name nlm_unique_id
120 schema:value 7600105
121 rdf:type schema:PropertyValue
122 N6c0f6ab51ca349c68d6faafce1767f9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Macrophages
124 rdf:type schema:DefinedTerm
125 N6efc24fd55344ddfbf6b02c8ea284e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Phospholipids
127 rdf:type schema:DefinedTerm
128 N78b874216e674b9585e8a5cd8357d6d3 schema:affiliation https://www.grid.ac/institutes/grid.412090.e
129 schema:familyName Shen
130 schema:givenName Hung-Jing
131 rdf:type schema:Person
132 N8cfeade5650c40379e58e7e31e774433 schema:name pubmed_id
133 schema:value 29589254
134 rdf:type schema:PropertyValue
135 N99a62cf051044bf59bb4b01de24090ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name RAW 264.7 Cells
137 rdf:type schema:DefinedTerm
138 N9c5726ce962f4b2295cdc74a4aff1b68 rdf:first sg:person.01056546416.91
139 rdf:rest Nd4c4c203ab9740c092d2064c26edeb58
140 N9c7e5070bcd14c5daae68e67f44006e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Inflammation
142 rdf:type schema:DefinedTerm
143 Na148b10dc77c4a5d8960e4be0e141335 schema:name dimensions_id
144 schema:value pub.1101776231
145 rdf:type schema:PropertyValue
146 Nbb854ace586447f7b18448734329469d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mitogen-Activated Protein Kinases
148 rdf:type schema:DefinedTerm
149 Nd4c4c203ab9740c092d2064c26edeb58 rdf:first N78b874216e674b9585e8a5cd8357d6d3
150 rdf:rest N0975fbde83a5492198d2f420c299eff8
151 Nf17e6604a8a449a9ac45d2197e85cb83 schema:volumeNumber 41
152 rdf:type schema:PublicationVolume
153 Nf474c7e41ac74938abd067b440d352fc rdf:first sg:person.01151140642.47
154 rdf:rest N077f5b63514a45e7ad8ce26e7eee514f
155 Nf5651a7e26f444a0b8b03510a0425eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Fatty Acids, Monounsaturated
157 rdf:type schema:DefinedTerm
158 Nf962a3aa90fb476ea32321f42d2535f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Fatty Acids, Unsaturated
160 rdf:type schema:DefinedTerm
161 Nfbe56fdee16f40219c4b3ba98eb74b0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Nitric Oxide Synthase Type II
163 rdf:type schema:DefinedTerm
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
168 schema:name Immunology
169 rdf:type schema:DefinedTerm
170 sg:journal.1084792 schema:issn 0360-3997
171 1573-2576
172 schema:name Inflammation
173 rdf:type schema:Periodical
174 sg:person.01056546416.91 schema:affiliation https://www.grid.ac/institutes/grid.413051.2
175 schema:familyName Chen
176 schema:givenName Sung-Nien
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056546416.91
178 rdf:type schema:Person
179 sg:person.01151140642.47 schema:affiliation https://www.grid.ac/institutes/grid.412090.e
180 schema:familyName Huang
181 schema:givenName Wen-Cheng
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151140642.47
183 rdf:type schema:Person
184 sg:person.016533044415.08 schema:affiliation https://www.grid.ac/institutes/grid.413051.2
185 schema:familyName Chang
186 schema:givenName Hsiang
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016533044415.08
188 rdf:type schema:Person
189 sg:person.0656211542.82 schema:affiliation https://www.grid.ac/institutes/grid.412090.e
190 schema:familyName Tsai
191 schema:givenName Po-Jung
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656211542.82
193 rdf:type schema:Person
194 sg:person.0704262453.37 schema:affiliation https://www.grid.ac/institutes/grid.413051.2
195 schema:familyName Chuang
196 schema:givenName Lu-Te
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704262453.37
198 rdf:type schema:Person
199 sg:pub.10.1007/bf02530966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033056582
200 https://doi.org/10.1007/bf02530966
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf02536130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041822749
203 https://doi.org/10.1007/bf02536130
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf02540092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023731439
206 https://doi.org/10.1007/bf02540092
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf02662254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005513383
209 https://doi.org/10.1007/bf02662254
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s10753-014-9960-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023879211
212 https://doi.org/10.1007/s10753-014-9960-8
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/s11745-005-1424-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1045444395
215 https://doi.org/10.1007/s11745-005-1424-y
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/s11745-008-3276-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027216283
218 https://doi.org/10.1007/s11745-008-3276-0
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s11745-011-3550-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014261917
221 https://doi.org/10.1007/s11745-011-3550-4
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s11745-999-0460-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1046102319
224 https://doi.org/10.1007/s11745-999-0460-y
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/s11746-997-0174-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046890404
227 https://doi.org/10.1007/s11746-997-0174-1
228 rdf:type schema:CreativeWork
229 sg:pub.10.1023/a:1011023632564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024105239
230 https://doi.org/10.1023/a:1011023632564
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/1476-511x-1-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040263598
233 https://doi.org/10.1186/1476-511x-1-5
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/s12974-015-0458-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031299072
236 https://doi.org/10.1186/s12974-015-0458-6
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1074645528 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1075727656 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1078441269 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1083071022 schema:CreativeWork
242 https://doi.org/10.1002/cphy.c170011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091607265
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/jcp.20678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014341787
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1006/bbrc.1999.1559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000098778
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1006/jsre.1999.5684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018352515
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0003-2697(82)90118-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015674611
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0005-2760(75)90067-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041054909
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/0005-2760(91)90254-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1043977979
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.biochi.2004.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021584711
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.fct.2012.07.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041908180
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.fct.2014.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011649996
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.plefa.2006.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006650126
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.plipres.2010.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052942966
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0005-2760(98)00084-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041820254
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0304-3835(96)04382-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004231017
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1074/jbc.r000015200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035226697
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1079/bjn19940079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013422247
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1089/jmf.2012.2577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059283145
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1093/ajcn/83.6.1505s schema:sameAs https://app.dimensions.ai/details/publication/pub.1077269424
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/ajcn/84.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077265816
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1742-4658.2007.05807.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014063415
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1751-1097.2004.tb00076.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053424262
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1146/annurev.nutr.19.1.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011700688
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1194/jlr.m300455-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032875504
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1194/jlr.p031260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021254790
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1248/bpb.31.1786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012777965
291 rdf:type schema:CreativeWork
292 https://doi.org/10.4049/jimmunol.0903282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078141595
293 rdf:type schema:CreativeWork
294 https://doi.org/10.4049/jimmunol.1502135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079272912
295 rdf:type schema:CreativeWork
296 https://www.grid.ac/institutes/grid.412090.e schema:alternateName National Taiwan Normal University
297 schema:name Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan
298 Program of Nutritional Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.413051.2 schema:alternateName Yuanpei University
301 schema:name Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, 300, Hsinchu, Taiwan
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...