DPP-4 Inhibition Leads to Decreased Pancreatic Inflammatory Profile and Increased Frequency of Regulatory T Cells in Experimental Type 1 Diabetes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Mariana Rodrigues Davanso, Carolina Caliari-Oliveira, Carlos Eduardo Barra Couri, Dimas Tadeu Covas, Angela Merice de Oliveira Leal, Júlio César Voltarelli, Kelen Cristina Ribeiro Malmegrim, Juliana Navarro Ueda Yaochite

ABSTRACT

Sitagliptin is a dipeptidyl peptidase-4 inhibitor (iDPP-4), which has been used for type 2 diabetes treatment. Recently, iDPP-4 has been described as a promising treatment of type 1 diabetes (T1D) but is still necessary to evaluate immune effects of sitagliptin. C57BL/6 mice were induced by multiple low doses of streptozotocin. Diabetes incidence, insulin, glucagon, glucagon-like peptide-1 (GLP-1) serum levels, and inflammatory cytokine levels were quantified in pancreas homogenate after 30 and 90 days of treatment. In addition, frequencies of inflammatory and regulatory T cell subsets were determined in the spleen and in the pancreatic lymph nodes. iDPP-4 decreased blood glucose level while increased GLP-1 and insulin levels. After long-term treatment, treated diabetic mice presented decreased frequency of CD4+CD26+ T cells and increased percentage of CD4+CD25hiFoxp3+ T cells in the spleen. Besides, pancreatic lymph nodes from diabetic mice treated with iDPP-4 presented lower percentage of CD11b+ cells and decreased levels of inflammatory cytokines in the pancreas. Treatment of type 1 diabetic mice with iDPP-4 improved metabolic control, decreased inflammatory profile in the pancreatic microenvironment, and increased systemic regulatory T cell frequency. Therefore, we suggest the long-term use of sitagliptin as a feasible and effective therapy for T1D. More... »

PAGES

1-14

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-018-00954-3

DOI

http://dx.doi.org/10.1007/s10753-018-00954-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111840559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30707388


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