Anti-inflammatory Effect of Erdosteine in Lipopolysaccharide-Stimulated RAW 264.7 Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

Jong Sun Park, Mi-Young Park, Young-Jae Cho, Jae Ho Lee, Chul-Gyu Yoo, Choon-Taek Lee, Sang-Min Lee

ABSTRACT

Erdosteine is widely used as a mucolytic agent and also has free radical scavenging and antioxidant activities. However, little is known about the mechanisms of the anti-inflammatory effect of erdosteine. We investigated the effect of erdosteine on the activation of the nuclear factor (NF)-kB/inhibitor of NFkB (IkB), and the mitogen-activated protein kinase (MAPK) and Akt pathways in the mouse macrophage cell line RAW 264.7. Cultured RAW 264.7 cells were pretreated with erdosteine and stimulated with lipopolysaccharide (LPS). In Western blotting, pretreatment with erdosteine inhibited the IkBα degradation induced in RAW 264.7 cells by LPS. LPS-induced IkB kinase (IKK) activity and NF-kB transcription were inhibited by pretreatment with erdosteine. Production of IL-6 and IL-1β was also inhibited by erdosteine pretreatment. However, erdosteine did not inhibit LPS-induced phosphorylation of Akt and MAPKs. These results suggest that the anti-inflammatory effect of erdosteine in mouse macrophages is mediated through inhibition of LPS-induced NF-kB activation. More... »

PAGES

1573-1581

References to SciGraph publications

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  • 1999-09. NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase in NATURE
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  • 2007-11. Regulatory mechanisms of mitogen-activated kinase signaling in CELLULAR AND MOLECULAR LIFE SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10753-016-0393-4

    DOI

    http://dx.doi.org/10.1007/s10753-016-0393-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010814516

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27317418


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    HOW TO GET THIS DATA PROGRAMMATICALLY:

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