Stimulation of the Angiotensin II AT2 Receptor is Anti-inflammatory in Human Lipopolysaccharide-Activated Monocytic Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08

AUTHORS

Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Marco Sifringer, David Schwaiberger, Thomas Unger, Ulrike Steckelings, Claudia D. Spies

ABSTRACT

Recently, AT2 receptors have been discovered on the surface of human immunocompetent cells such as monocytes. Data on regulative properties of this receptor on the cellular immune response are poor. We hypothesized that direct stimulation of the AT2 receptor mediates anti-inflammatory responses in these cells. Human monocytic THP-1 and U937 cells were stimulated with lipopolysaccharide (LPS) and the selective AT2 receptor agonist Compound 21 (C21). Expression of pro- and anti-inflammatory cytokines IL-6, IL-10, tumor necrosis factor-α (TNFα), and IL-1β were analyzed on both the transcriptional and the translational level over course of time. Treatment with C21 attenuated the expression of TNFα, IL-6, and IL-10 after LPS challenge in both cell lines in a time- and dose-dependent manner. We conclude that selective AT2 receptor stimulation acts anti-inflammatory in human monocytes. Modulation of cytokine response by AT2 receptor activation might be a beneficial and novel treatment concept in inflammatory conditions. More... »

PAGES

1690-1699

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-015-0146-9

DOI

http://dx.doi.org/10.1007/s10753-015-0146-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045551003

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25758542


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278 https://www.grid.ac/institutes/grid.5012.6 schema:alternateName Maastricht University
279 schema:name CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
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281 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
282 schema:name Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité—Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
283 rdf:type schema:Organization
 




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