The Activation of NF-κB in Infiltrated Mononuclear Cells Negatively Correlates with Treg Cell Frequency in Oral Lichen Planus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03-12

AUTHORS

Dunfang Zhang, Jiayi Wang, Zhangwei Li, Min Zhou, Qianming Chen, Xin Zeng, Yu Chen

ABSTRACT

Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease with persistent accumulation of T cells in the lamina propria. Nuclear factor-kappa B (NF-κB) is a major regulator of immune responses, and NF-κB-dependent cytokines and pro-inflammatory mediators can be detected in higher levels in the saliva and serum from patients with OLP. CD4+CD25+Foxp3+ regulatory T (Treg) cells play an important role in the prevention of autoimmune pathology by regulating the immune response. To explore the correlation between NF-κB p65 activation and accumulation of Treg cells in patients with OLP, 40 ethnic Chinese patients with OLP and 10 healthy volunteers were recruited. The nuclear expression of NF-κB p65 in infiltrated mononuclear cells and Treg cells in the OLP lesion and the normal oral mucosa (NOM) was analyzed by immunohistochemistry assay. Our results showed that both the nuclear expression of NF-κB p65 and the number of Foxp3+ Treg were higher in the OLP lesions. Furthermore, the frequency of Treg cells was negatively correlated with NF-κB nuclear expression in subepithelial lymphocytic infiltrate of the OLP lesion. This finding provides a new insight into the pathogenesis of OLP and may contribute to novel therapeutic strategies for the treatment of OLP by modulating the immune system. More... »

PAGES

1683-1689

Journal

TITLE

Inflammation

ISSUE

4

VOLUME

38

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10753-015-0145-x

    DOI

    http://dx.doi.org/10.1007/s10753-015-0145-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014005241

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25761427


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