Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Sheikh Fayaz Ahmad, Sabry M. Attia, Saleh A. Bakheet, Khairy M. A. Zoheir, Mushtaq Ahmad Ansari, Hesham M. Korashy, Hala E. Abdel-Hamied, Abdelkader E. Ashour, Adel R. A. Abd-Allah

ABSTRACT

Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions. More... »

PAGES

846-857

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-014-9994-y

DOI

http://dx.doi.org/10.1007/s10753-014-9994-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042249598

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25117567


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