Ontology type: schema:ScholarlyArticle
2014-12
AUTHORSHaiyan Zhu, Xunlong Shi, Dianwen Ju, Hai Huang, Wei Wei, Xiaoying Dong
ABSTRACTThe purpose of this study is to investigate the anti-inflammatory effect of thalidomide (Thd) on H1N1-induced acute lung injury in mice. BALB/C mice were infected intranasally with influenza A virus (H1N1) and then treated with Thd at a dose of 100 or 200 mg/kg/day for 7 days. Weight loss and survival of mice were monitored for 14 days after virus challenge, and the serum and lung tissues were collected at 4 days for histological and biochemical analysis. The results showed that Thd significantly improved the survival rate, reduced the infiltration of inflammatory cells and cytokine (e.g., IL-6, TNF-α) and chemokine (e.g., RANTES, IP-10) levels, and inhibited activated p-NFκB p65 in infected mice. These findings suggested that Thd may attenuate H1N1-induced pulmonary injury and thus may find use in the treatment of viral diseases. More... »
PAGES2091-2098
http://scigraph.springernature.com/pub.10.1007/s10753-014-9943-9
DOIhttp://dx.doi.org/10.1007/s10753-014-9943-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1011740060
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24912813
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Anti-Inflammatory Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inflammation Mediators",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Influenza A Virus, H1N1 Subtype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung Injury",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Orthomyxoviridae Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Random Allocation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thalidomide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Fudan University",
"id": "https://www.grid.ac/institutes/grid.8547.e",
"name": [
"Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Zhu",
"givenName": "Haiyan",
"id": "sg:person.0657736344.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657736344.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fudan University",
"id": "https://www.grid.ac/institutes/grid.8547.e",
"name": [
"Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Shi",
"givenName": "Xunlong",
"id": "sg:person.0755555513.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755555513.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fudan University",
"id": "https://www.grid.ac/institutes/grid.8547.e",
"name": [
"Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Ju",
"givenName": "Dianwen",
"id": "sg:person.01361572035.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361572035.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fudan University",
"id": "https://www.grid.ac/institutes/grid.8547.e",
"name": [
"Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Huang",
"givenName": "Hai",
"id": "sg:person.0764004225.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764004225.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tianjin Medical University General Hospital",
"id": "https://www.grid.ac/institutes/grid.412645.0",
"name": [
"Department of Rheumatism and Immunity, General Hospital of Tianjin Medical University, 300052, Tianjin, China"
],
"type": "Organization"
},
"familyName": "Wei",
"givenName": "Wei",
"id": "sg:person.01252466013.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252466013.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tianjin Medical University General Hospital",
"id": "https://www.grid.ac/institutes/grid.412645.0",
"name": [
"Department of Rheumatism and Immunity, General Hospital of Tianjin Medical University, 300052, Tianjin, China"
],
"type": "Organization"
},
"familyName": "Dong",
"givenName": "Xiaoying",
"id": "sg:person.01125743162.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125743162.26"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.jcv.2013.05.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002535251"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/bc.2008.148",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010839464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20030351",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014705534"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.275.12.8307",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020396075"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1743-422x-7-196",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023477656",
"https://doi.org/10.1186/1743-422x-7-196"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0264-410x(00)00275-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026864939"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.intimp.2013.06.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028775085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jviromet.2008.06.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035419308"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/cr.2013.25",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040747246",
"https://doi.org/10.1038/cr.2013.25"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m413726200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044356241"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1179/joc.2011.23.6.326",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047703052"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jcv.2013.05.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048971084"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(02)11772-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051535290"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(02)11772-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051535290"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1165/ajrcmb.18.2.2822",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052335167"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0031-1298620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1057254225"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/09298673113209990198",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069163378"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/187221310791163026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069224826"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-12",
"datePublishedReg": "2014-12-01",
"description": "The purpose of this study is to investigate the anti-inflammatory effect of thalidomide (Thd) on H1N1-induced acute lung injury in mice. BALB/C mice were infected intranasally with influenza A virus (H1N1) and then treated with Thd at a dose of 100 or 200 mg/kg/day for 7 days. Weight loss and survival of mice were monitored for 14 days after virus challenge, and the serum and lung tissues were collected at 4 days for histological and biochemical analysis. The results showed that Thd significantly improved the survival rate, reduced the infiltration of inflammatory cells and cytokine (e.g., IL-6, TNF-\u03b1) and chemokine (e.g., RANTES, IP-10) levels, and inhibited activated p-NF\u03baB p65 in infected mice. These findings suggested that Thd may attenuate H1N1-induced pulmonary injury and thus may find use in the treatment of viral diseases.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10753-014-9943-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.7018325",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1084792",
"issn": [
"0360-3997",
"1573-2576"
],
"name": "Inflammation",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "37"
}
],
"name": "Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice",
"pagination": "2091-2098",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"37ef72077a3e79d3631c0c6488cb84dcb018f3eba21c793d5547dd8280e2d182"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24912813"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7600105"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10753-014-9943-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1011740060"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10753-014-9943-9",
"https://app.dimensions.ai/details/publication/pub.1011740060"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T14:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000486.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s10753-014-9943-9"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10753-014-9943-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10753-014-9943-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10753-014-9943-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10753-014-9943-9'
This table displays all metadata directly associated to this object as RDF triples.
210 TRIPLES
21 PREDICATES
58 URIs
33 LITERALS
21 BLANK NODES