Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

Haiyan Zhu, Xunlong Shi, Dianwen Ju, Hai Huang, Wei Wei, Xiaoying Dong

ABSTRACT

The purpose of this study is to investigate the anti-inflammatory effect of thalidomide (Thd) on H1N1-induced acute lung injury in mice. BALB/C mice were infected intranasally with influenza A virus (H1N1) and then treated with Thd at a dose of 100 or 200 mg/kg/day for 7 days. Weight loss and survival of mice were monitored for 14 days after virus challenge, and the serum and lung tissues were collected at 4 days for histological and biochemical analysis. The results showed that Thd significantly improved the survival rate, reduced the infiltration of inflammatory cells and cytokine (e.g., IL-6, TNF-α) and chemokine (e.g., RANTES, IP-10) levels, and inhibited activated p-NFκB p65 in infected mice. These findings suggested that Thd may attenuate H1N1-induced pulmonary injury and thus may find use in the treatment of viral diseases. More... »

PAGES

2091-2098

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-014-9943-9

DOI

http://dx.doi.org/10.1007/s10753-014-9943-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011740060

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24912813


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