Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10

AUTHORS

Majid Katebi, Patricia Fernandez, Edwin S. L. Chan, Bruce N. Cronstein

ABSTRACT

Peripheral blood fibrocytes are a newly identified circulating leukocyte subpopulation that migrates into injured tissue where it may display fibroblast-like properties and participate in wound healing and fibrosis of skin and other organs. Previous studies in our lab demonstrated that A(2A) receptor-deficient and A(2A) antagonist-treated mice were protected from developing bleomycin-induced dermal fibrosis, thus the aim of this study was to determine whether the adenosine A(2A) receptor regulates recruitment of fibrocytes to the dermis in this bleomycin-induced model of dermal fibrosis. Sections of skin from normal mice and bleomycin-treated wild type, A(2A) knockout and A(2A) antagonist-treated mice were stained for Procollagen alpha2 Type I and CD34 and the double stained cells, fibrocytes, were counted in the tissue sections. There were more fibrocytes in the dermis of bleomycin-treated mice than normal mice and the increase was abrogated by deletion or blockade of adenosine A(2A) receptors. Because fibrocytes play a central role in tissue fibrosis these results suggest that diminished adenosine A(2A) receptor-mediated recruitment of fibrocytes into tissue may play a role in the pathogenesis of fibrosing diseases of the skin. Moreover, these results provide further evidence that adenosine A(2A) receptors may represent a new target for the treatment of such fibrosing diseases as scleroderma or nephrogenic fibrosing dermopathy. More... »

PAGES

299-303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10753-008-9078-y

DOI

http://dx.doi.org/10.1007/s10753-008-9078-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010205416

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18709547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine A2 Receptor Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibiotics, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD34", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bleomycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Connective Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Adenosine A2A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Scleroderma, Systemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Divisions of Clinical Pharmacology and Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Ave., 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katebi", 
        "givenName": "Majid", 
        "id": "sg:person.01311746631.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311746631.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Divisions of Clinical Pharmacology and Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Ave., 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez", 
        "givenName": "Patricia", 
        "id": "sg:person.0617716153.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617716153.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Divisions of Clinical Pharmacology and Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Ave., 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Edwin S. L.", 
        "id": "sg:person.014375742202.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014375742202.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Divisions of Clinical Pharmacology and Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Ave., 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cronstein", 
        "givenName": "Bruce N.", 
        "id": "sg:person.0711105165.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711105165.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/art.21974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001412340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61151-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003320036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1014417728325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003979323", 
          "https://doi.org/10.1023/a:1014417728325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.22084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009832732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63749-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015517610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0765.2000.035002093.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016106826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/13.12.1533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017442017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017939946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00208.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019961864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.104.007807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020165175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2003.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024080528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11926-006-0055-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025937361", 
          "https://doi.org/10.1007/s11926-006-0055-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029585062", 
          "https://doi.org/10.1038/labinvest.3700654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.12.7556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030645401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00217.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031275978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0706812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031727718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.37.2.716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033503747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.107.038760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034442899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.31.4.943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035573996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2004-0103oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041386031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci27303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042274622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00258.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046209277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00258.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046209277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci26372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046753639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.051213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051980850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61170-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053477752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.186.9.1615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci16815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.8.3991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076576934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.175.3.1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077085982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.6.4035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077475247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082956383", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03403533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082956383", 
          "https://doi.org/10.1007/bf03403533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03403533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082956383", 
          "https://doi.org/10.1007/bf03403533"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-10", 
    "datePublishedReg": "2008-10-01", 
    "description": "Peripheral blood fibrocytes are a newly identified circulating leukocyte subpopulation that migrates into injured tissue where it may display fibroblast-like properties and participate in wound healing and fibrosis of skin and other organs. Previous studies in our lab demonstrated that A(2A) receptor-deficient and A(2A) antagonist-treated mice were protected from developing bleomycin-induced dermal fibrosis, thus the aim of this study was to determine whether the adenosine A(2A) receptor regulates recruitment of fibrocytes to the dermis in this bleomycin-induced model of dermal fibrosis. Sections of skin from normal mice and bleomycin-treated wild type, A(2A) knockout and A(2A) antagonist-treated mice were stained for Procollagen alpha2 Type I and CD34 and the double stained cells, fibrocytes, were counted in the tissue sections. There were more fibrocytes in the dermis of bleomycin-treated mice than normal mice and the increase was abrogated by deletion or blockade of adenosine A(2A) receptors. Because fibrocytes play a central role in tissue fibrosis these results suggest that diminished adenosine A(2A) receptor-mediated recruitment of fibrocytes into tissue may play a role in the pathogenesis of fibrosing diseases of the skin. Moreover, these results provide further evidence that adenosine A(2A) receptors may represent a new target for the treatment of such fibrosing diseases as scleroderma or nephrogenic fibrosing dermopathy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10753-008-9078-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2423992", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2515431", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2443784", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2463355", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2464878", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2465062", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1084792", 
        "issn": [
          "0360-3997", 
          "1573-2576"
        ], 
        "name": "Inflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis", 
    "pagination": "299-303", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10753-008-9078-y"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "309edefa7d4c4a508c9075cd447c81f8d037839d7b45e6d6f1dea6ad9b504ce4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010205416"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7600105"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18709547"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10753-008-9078-y", 
      "https://app.dimensions.ai/details/publication/pub.1010205416"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56185_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10753-008-9078-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10753-008-9078-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10753-008-9078-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10753-008-9078-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10753-008-9078-y'


 

This table displays all metadata directly associated to this object as RDF triples.

268 TRIPLES      21 PREDICATES      78 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10753-008-9078-y schema:about N1535bc0a295d474e86d5790b706a951a
2 N1dbd57e0cdcd42b4b52a01872767f003
3 N2f8e6df7a59246669cbb245c23aedae2
4 N3f45452c220e42fd9971112e7ca178f6
5 N61366b14623647c1b443de71ce6cd927
6 N652d86d3d4624343af15e6f69d87a2a4
7 N79f3313145d44d00ba61ea5e6900a594
8 N9448581c034f48219ae97c2ee3a3b86e
9 N9c92eff6ece54e0e8951e18ed67e77d6
10 Na8618c759de1437fb291915fd74b9eaa
11 Nb61d9943b31f4bed9eec01b8e54731f2
12 Nd3bccdd9b57f412193089de3bc2c2f67
13 Nddf36134c4854a27983b96bc26d06e3c
14 Ne81073598fb84a8d9a29e309e12f29e4
15 Nef1955e180a74c3cbe25f05ae09f6551
16 Nf04e84234da3489b9fcd2e5f417b06bc
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Ncad0cb106f8149b687afb01429519987
20 schema:citation sg:pub.10.1007/bf03403533
21 sg:pub.10.1007/s11926-006-0055-x
22 sg:pub.10.1023/a:1014417728325
23 sg:pub.10.1038/labinvest.3700654
24 https://app.dimensions.ai/details/publication/pub.1082956383
25 https://doi.org/10.1002/art.21974
26 https://doi.org/10.1002/ijc.22084
27 https://doi.org/10.1002/jcp.21182
28 https://doi.org/10.1016/j.biocel.2003.10.005
29 https://doi.org/10.1016/s0002-9440(10)61151-0
30 https://doi.org/10.1016/s0002-9440(10)61170-4
31 https://doi.org/10.1016/s0002-9440(10)63749-2
32 https://doi.org/10.1034/j.1600-0765.2000.035002093.x
33 https://doi.org/10.1038/sj.bjp.0706812
34 https://doi.org/10.1084/jem.186.9.1615
35 https://doi.org/10.1093/intimm/13.12.1533
36 https://doi.org/10.1124/mol.104.007807
37 https://doi.org/10.1124/mol.107.038760
38 https://doi.org/10.1152/ajpgi.00208.2006
39 https://doi.org/10.1152/ajpheart.00217.2004
40 https://doi.org/10.1152/ajplung.00258.2005
41 https://doi.org/10.1161/01.hyp.31.4.943
42 https://doi.org/10.1161/01.hyp.37.2.716
43 https://doi.org/10.1165/rcmb.2004-0103oc
44 https://doi.org/10.1172/jci16815
45 https://doi.org/10.1172/jci20997
46 https://doi.org/10.1172/jci26372
47 https://doi.org/10.1172/jci27303
48 https://doi.org/10.2353/ajpath.2007.051213
49 https://doi.org/10.4049/jimmunol.166.12.7556
50 https://doi.org/10.4049/jimmunol.171.8.3991
51 https://doi.org/10.4049/jimmunol.175.3.1937
52 https://doi.org/10.4049/jimmunol.179.6.4035
53 schema:datePublished 2008-10
54 schema:datePublishedReg 2008-10-01
55 schema:description Peripheral blood fibrocytes are a newly identified circulating leukocyte subpopulation that migrates into injured tissue where it may display fibroblast-like properties and participate in wound healing and fibrosis of skin and other organs. Previous studies in our lab demonstrated that A(2A) receptor-deficient and A(2A) antagonist-treated mice were protected from developing bleomycin-induced dermal fibrosis, thus the aim of this study was to determine whether the adenosine A(2A) receptor regulates recruitment of fibrocytes to the dermis in this bleomycin-induced model of dermal fibrosis. Sections of skin from normal mice and bleomycin-treated wild type, A(2A) knockout and A(2A) antagonist-treated mice were stained for Procollagen alpha2 Type I and CD34 and the double stained cells, fibrocytes, were counted in the tissue sections. There were more fibrocytes in the dermis of bleomycin-treated mice than normal mice and the increase was abrogated by deletion or blockade of adenosine A(2A) receptors. Because fibrocytes play a central role in tissue fibrosis these results suggest that diminished adenosine A(2A) receptor-mediated recruitment of fibrocytes into tissue may play a role in the pathogenesis of fibrosing diseases of the skin. Moreover, these results provide further evidence that adenosine A(2A) receptors may represent a new target for the treatment of such fibrosing diseases as scleroderma or nephrogenic fibrosing dermopathy.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N7cb397a03456433092ea827b83267464
60 Nb0b006fad26a48dfbb307360f5ef403a
61 sg:journal.1084792
62 schema:name Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis
63 schema:pagination 299-303
64 schema:productId N0bf1efed592c490a94992f5222a171ce
65 N6f138c71278e4eb3b0a147774a18123c
66 Nae9c363b2c1d4f8ebc43d175f4f6d159
67 Nbe06417655e14229aa49fd7f9a099634
68 Nffd4c3bbbfca4ea1ba765528348087b5
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010205416
70 https://doi.org/10.1007/s10753-008-9078-y
71 schema:sdDatePublished 2019-04-15T09:22
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N49d0b947534d4b3d99aa277e46018a02
74 schema:url https://link.springer.com/10.1007%2Fs10753-008-9078-y
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0bf1efed592c490a94992f5222a171ce schema:name readcube_id
79 schema:value 309edefa7d4c4a508c9075cd447c81f8d037839d7b45e6d6f1dea6ad9b504ce4
80 rdf:type schema:PropertyValue
81 N1535bc0a295d474e86d5790b706a951a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Adenosine A2 Receptor Antagonists
83 rdf:type schema:DefinedTerm
84 N1dbd57e0cdcd42b4b52a01872767f003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Disease Models, Animal
86 rdf:type schema:DefinedTerm
87 N2f8e6df7a59246669cbb245c23aedae2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Receptor, Adenosine A2A
89 rdf:type schema:DefinedTerm
90 N3f45452c220e42fd9971112e7ca178f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Bleomycin
92 rdf:type schema:DefinedTerm
93 N43f51fc3e1a1449cada721be09dfb8d3 rdf:first sg:person.0617716153.05
94 rdf:rest Nf2738d781ed44fffa436f3acd12a37d5
95 N49d0b947534d4b3d99aa277e46018a02 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N61366b14623647c1b443de71ce6cd927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Antibiotics, Antineoplastic
99 rdf:type schema:DefinedTerm
100 N652d86d3d4624343af15e6f69d87a2a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Animals
102 rdf:type schema:DefinedTerm
103 N6f138c71278e4eb3b0a147774a18123c schema:name dimensions_id
104 schema:value pub.1010205416
105 rdf:type schema:PropertyValue
106 N79f3313145d44d00ba61ea5e6900a594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Connective Tissue
108 rdf:type schema:DefinedTerm
109 N7cb397a03456433092ea827b83267464 schema:issueNumber 5
110 rdf:type schema:PublicationIssue
111 N9448581c034f48219ae97c2ee3a3b86e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Antigens, CD34
113 rdf:type schema:DefinedTerm
114 N9c92eff6ece54e0e8951e18ed67e77d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Scleroderma, Systemic
116 rdf:type schema:DefinedTerm
117 Na8618c759de1437fb291915fd74b9eaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Fibroblasts
119 rdf:type schema:DefinedTerm
120 Nae9c363b2c1d4f8ebc43d175f4f6d159 schema:name doi
121 schema:value 10.1007/s10753-008-9078-y
122 rdf:type schema:PropertyValue
123 Nb0b006fad26a48dfbb307360f5ef403a schema:volumeNumber 31
124 rdf:type schema:PublicationVolume
125 Nb61d9943b31f4bed9eec01b8e54731f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice
127 rdf:type schema:DefinedTerm
128 Nbe06417655e14229aa49fd7f9a099634 schema:name nlm_unique_id
129 schema:value 7600105
130 rdf:type schema:PropertyValue
131 Ncad0cb106f8149b687afb01429519987 rdf:first sg:person.01311746631.42
132 rdf:rest N43f51fc3e1a1449cada721be09dfb8d3
133 Nd3bccdd9b57f412193089de3bc2c2f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Skin
135 rdf:type schema:DefinedTerm
136 Nddf36134c4854a27983b96bc26d06e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Collagen
138 rdf:type schema:DefinedTerm
139 Ne81073598fb84a8d9a29e309e12f29e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Gene Deletion
141 rdf:type schema:DefinedTerm
142 Nef1955e180a74c3cbe25f05ae09f6551 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Fibrosis
144 rdf:type schema:DefinedTerm
145 Nf04e84234da3489b9fcd2e5f417b06bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Models, Biological
147 rdf:type schema:DefinedTerm
148 Nf2738d781ed44fffa436f3acd12a37d5 rdf:first sg:person.014375742202.01
149 rdf:rest Nf8b08063c60f4d77a68380468635d0c6
150 Nf8b08063c60f4d77a68380468635d0c6 rdf:first sg:person.0711105165.79
151 rdf:rest rdf:nil
152 Nffd4c3bbbfca4ea1ba765528348087b5 schema:name pubmed_id
153 schema:value 18709547
154 rdf:type schema:PropertyValue
155 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
156 schema:name Medical and Health Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
159 schema:name Clinical Sciences
160 rdf:type schema:DefinedTerm
161 sg:grant.2423992 http://pending.schema.org/fundedItem sg:pub.10.1007/s10753-008-9078-y
162 rdf:type schema:MonetaryGrant
163 sg:grant.2443784 http://pending.schema.org/fundedItem sg:pub.10.1007/s10753-008-9078-y
164 rdf:type schema:MonetaryGrant
165 sg:grant.2463355 http://pending.schema.org/fundedItem sg:pub.10.1007/s10753-008-9078-y
166 rdf:type schema:MonetaryGrant
167 sg:grant.2464878 http://pending.schema.org/fundedItem sg:pub.10.1007/s10753-008-9078-y
168 rdf:type schema:MonetaryGrant
169 sg:grant.2465062 http://pending.schema.org/fundedItem sg:pub.10.1007/s10753-008-9078-y
170 rdf:type schema:MonetaryGrant
171 sg:grant.2515431 http://pending.schema.org/fundedItem sg:pub.10.1007/s10753-008-9078-y
172 rdf:type schema:MonetaryGrant
173 sg:journal.1084792 schema:issn 0360-3997
174 1573-2576
175 schema:name Inflammation
176 rdf:type schema:Periodical
177 sg:person.01311746631.42 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
178 schema:familyName Katebi
179 schema:givenName Majid
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311746631.42
181 rdf:type schema:Person
182 sg:person.014375742202.01 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
183 schema:familyName Chan
184 schema:givenName Edwin S. L.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014375742202.01
186 rdf:type schema:Person
187 sg:person.0617716153.05 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
188 schema:familyName Fernandez
189 schema:givenName Patricia
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617716153.05
191 rdf:type schema:Person
192 sg:person.0711105165.79 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
193 schema:familyName Cronstein
194 schema:givenName Bruce N.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711105165.79
196 rdf:type schema:Person
197 sg:pub.10.1007/bf03403533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082956383
198 https://doi.org/10.1007/bf03403533
199 rdf:type schema:CreativeWork
200 sg:pub.10.1007/s11926-006-0055-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025937361
201 https://doi.org/10.1007/s11926-006-0055-x
202 rdf:type schema:CreativeWork
203 sg:pub.10.1023/a:1014417728325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003979323
204 https://doi.org/10.1023/a:1014417728325
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/labinvest.3700654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029585062
207 https://doi.org/10.1038/labinvest.3700654
208 rdf:type schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1082956383 schema:CreativeWork
210 https://doi.org/10.1002/art.21974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001412340
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/ijc.22084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009832732
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/jcp.21182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017939946
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.biocel.2003.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024080528
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0002-9440(10)61151-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003320036
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0002-9440(10)61170-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053477752
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0002-9440(10)63749-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015517610
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1034/j.1600-0765.2000.035002093.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016106826
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1038/sj.bjp.0706812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031727718
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1084/jem.186.9.1615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438643
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1093/intimm/13.12.1533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017442017
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1124/mol.104.007807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020165175
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1124/mol.107.038760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034442899
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1152/ajpgi.00208.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019961864
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1152/ajpheart.00217.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031275978
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1152/ajplung.00258.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046209277
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1161/01.hyp.31.4.943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035573996
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1161/01.hyp.37.2.716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033503747
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1165/rcmb.2004-0103oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1041386031
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1172/jci16815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416235
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1172/jci20997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416579
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1172/jci26372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046753639
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1172/jci27303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042274622
255 rdf:type schema:CreativeWork
256 https://doi.org/10.2353/ajpath.2007.051213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051980850
257 rdf:type schema:CreativeWork
258 https://doi.org/10.4049/jimmunol.166.12.7556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030645401
259 rdf:type schema:CreativeWork
260 https://doi.org/10.4049/jimmunol.171.8.3991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076576934
261 rdf:type schema:CreativeWork
262 https://doi.org/10.4049/jimmunol.175.3.1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077085982
263 rdf:type schema:CreativeWork
264 https://doi.org/10.4049/jimmunol.179.6.4035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077475247
265 rdf:type schema:CreativeWork
266 https://www.grid.ac/institutes/grid.137628.9 schema:alternateName New York University
267 schema:name Divisions of Clinical Pharmacology and Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Ave., 10016, New York, NY, USA
268 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...