Hydrogen peroxide leads to cell damage and apoptosis in the gill of the freshwater crab Sinopotamon henanense (Crustacea, Decapoda) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

Jinxiang Wang, Qian Wang, Na Liu, Weixin Jing, Lan Wang, Feng Zhou

ABSTRACT

Hydrogen peroxide (H2O2), a major reactive oxygen species, has been shown to be a critical mediator of apoptosis induced by several toxic metals such as cadmium. In this study, we used the freshwater crab Sinopotamon henanense to study whether H2O2 can cause apoptosis in gill cells. The crabs were incubated in H2O2 and the DNA fragmentation, ultrastructural changes and caspase-3/8/9 activities were measured. The results showed that in freshwater crab, H2O2 was found to induce apoptosis, as confirmed by DNA fragmentation analysis and morphological observation of transmission electron microscopy. This apoptosis occurs in a concentration-dependent pattern. During the apoptotic process, caspase-3, caspase-8 and caspase-9 were activated by H2O2. In addition, multiple physiological and pathological changes of gill cells were discovered after 24 h exposure to 5 mM H2O2, including aggregation and condensation of nuclear chromatin, appearance of extremely irregular nuclei with finger-like buds, disappearance of the organelles around the nuclei, swollen and dissolved cristae of mitochondria. We propose that H2O2-induced stress leads to mitochondria lesions oxidative injury and triggers apoptotic response through the caspase pathway in freshwater crab. More... »

PAGES

13-21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10750-013-1760-x

DOI

http://dx.doi.org/10.1007/s10750-013-1760-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004041435


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanxi Datong University", 
          "id": "https://www.grid.ac/institutes/grid.440639.c", 
          "name": [
            "School of Life Science, Shanxi University, 030006, Taiyuan, China", 
            "School of Life Science, Shanxi Datong University, 037009, Datong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jinxiang", 
        "id": "sg:person.01251746615.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251746615.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanxi University", 
          "id": "https://www.grid.ac/institutes/grid.163032.5", 
          "name": [
            "School of Life Science, Shanxi University, 030006, Taiyuan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Qian", 
        "id": "sg:person.0631576630.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631576630.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanxi University", 
          "id": "https://www.grid.ac/institutes/grid.163032.5", 
          "name": [
            "School of Life Science, Shanxi University, 030006, Taiyuan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Na", 
        "id": "sg:person.01133776467.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133776467.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanxi University", 
          "id": "https://www.grid.ac/institutes/grid.163032.5", 
          "name": [
            "School of Life Science, Shanxi University, 030006, Taiyuan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jing", 
        "givenName": "Weixin", 
        "id": "sg:person.01355066174.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355066174.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanxi University", 
          "id": "https://www.grid.ac/institutes/grid.163032.5", 
          "name": [
            "School of Life Science, Shanxi University, 030006, Taiyuan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Lan", 
        "id": "sg:person.0712247506.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712247506.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanxi Datong University", 
          "id": "https://www.grid.ac/institutes/grid.440639.c", 
          "name": [
            "School of Life Science, Shanxi Datong University, 037009, Datong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Feng", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1202325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000980457", 
          "https://doi.org/10.1038/sj.onc.1202325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000980457", 
          "https://doi.org/10.1038/sj.onc.1202325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2009.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001193635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2007.01.089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001898426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chemosphere.2010.07.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003362000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-007-1100-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005214071", 
          "https://doi.org/10.1007/s00221-007-1100-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-007-1100-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005214071", 
          "https://doi.org/10.1007/s00221-007-1100-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(99)00259-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005379961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.01152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006036039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2010.08.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007831978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.1998.0743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008304662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.1999.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008359295", 
          "https://doi.org/10.1038/emm.1999.9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.1999.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008359295", 
          "https://doi.org/10.1038/emm.1999.9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/284555a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009203237", 
          "https://doi.org/10.1038/284555a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m011136200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012693166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.16.9357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013528186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2013.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014165573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4886(02)00059-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015447233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m212389200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017205504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0064020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017927981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114500001422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017968175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-326x(00)00159-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019387907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aquatox.2011.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021316513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4835(03)00023-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022723787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023092800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2011.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023889508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2008.10.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025591328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70545-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025890301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(95)00603-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027171400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aquaculture.2008.10.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027507235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.21.11233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029485889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrgentox.2008.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030670430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecoenv.2011.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031407297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12031-009-9285-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033475348", 
          "https://doi.org/10.1007/s12031-009-9285-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12031-009-9285-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033475348", 
          "https://doi.org/10.1007/s12031-009-9285-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(98)00630-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034567222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2012.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036092811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10534-010-9329-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037732668", 
          "https://doi.org/10.1007/s10534-010-9329-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10534-010-9329-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037732668", 
          "https://doi.org/10.1007/s10534-010-9329-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.10295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038112448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m201070200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041352723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20101695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041857222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20101695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041857222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2011.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042146214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81590-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042580199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(96)20008-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042654263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1383-5742(03)00017-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043535298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1383-5742(03)00017-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043535298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80430-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045716809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-005-3087-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047486709", 
          "https://doi.org/10.1007/s10495-005-3087-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-005-3087-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047486709", 
          "https://doi.org/10.1007/s10495-005-3087-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(02)00967-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047521401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(01)00591-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050420855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(96)00275-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050551204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrgentox.2008.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051851059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(00)00321-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052458957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aquatox.2011.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052745360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a002947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059959624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.282.5392.1318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062563196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/isl.1.3.9262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072305027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074691454", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074691454", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078654573", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082718489", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "Hydrogen peroxide (H2O2), a major reactive oxygen species, has been shown to be a critical mediator of apoptosis induced by several toxic metals such as cadmium. In this study, we used the freshwater crab Sinopotamon henanense to study whether H2O2 can cause apoptosis in gill cells. The crabs were incubated in H2O2 and the DNA fragmentation, ultrastructural changes and caspase-3/8/9 activities were measured. The results showed that in freshwater crab, H2O2 was found to induce apoptosis, as confirmed by DNA fragmentation analysis and morphological observation of transmission electron microscopy. This apoptosis occurs in a concentration-dependent pattern. During the apoptotic process, caspase-3, caspase-8 and caspase-9 were activated by H2O2. In addition, multiple physiological and pathological changes of gill cells were discovered after 24 h exposure to 5 mM H2O2, including aggregation and condensation of nuclear chromatin, appearance of extremely irregular nuclei with finger-like buds, disappearance of the organelles around the nuclei, swollen and dissolved cristae of mitochondria. We propose that H2O2-induced stress leads to mitochondria lesions oxidative injury and triggers apoptotic response through the caspase pathway in freshwater crab.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10750-013-1760-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5016379", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023171", 
        "issn": [
          "1037-0544", 
          "1573-8590"
        ], 
        "name": "Hydrobiologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "741"
      }
    ], 
    "name": "Hydrogen peroxide leads to cell damage and apoptosis in the gill of the freshwater crab Sinopotamon henanense (Crustacea, Decapoda)", 
    "pagination": "13-21", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "13419396b509329c493e55bdf4005e79ac560398d74ab78b7931a170558563d2"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10750-013-1760-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004041435"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10750-013-1760-x", 
      "https://app.dimensions.ai/details/publication/pub.1004041435"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000530.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10750-013-1760-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10750-013-1760-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10750-013-1760-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10750-013-1760-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10750-013-1760-x'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      83 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10750-013-1760-x schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N0915b760c8e5451a84a08a4d5a102023
4 schema:citation sg:pub.10.1007/s00221-007-1100-3
5 sg:pub.10.1007/s10495-005-3087-1
6 sg:pub.10.1007/s10534-010-9329-x
7 sg:pub.10.1007/s12031-009-9285-5
8 sg:pub.10.1038/284555a0
9 sg:pub.10.1038/emm.1999.9
10 sg:pub.10.1038/sj.onc.1202325
11 https://app.dimensions.ai/details/publication/pub.1074691454
12 https://app.dimensions.ai/details/publication/pub.1078654573
13 https://app.dimensions.ai/details/publication/pub.1082718489
14 https://doi.org/10.1002/jnr.10295
15 https://doi.org/10.1006/jmcc.1998.0743
16 https://doi.org/10.1016/0003-2697(76)90527-3
17 https://doi.org/10.1016/0014-5793(95)00603-7
18 https://doi.org/10.1016/j.aquaculture.2008.10.053
19 https://doi.org/10.1016/j.aquatox.2011.07.013
20 https://doi.org/10.1016/j.aquatox.2011.08.013
21 https://doi.org/10.1016/j.biocel.2008.10.029
22 https://doi.org/10.1016/j.cellsig.2013.02.003
23 https://doi.org/10.1016/j.chemosphere.2010.07.063
24 https://doi.org/10.1016/j.ecoenv.2011.02.018
25 https://doi.org/10.1016/j.ejphar.2007.01.089
26 https://doi.org/10.1016/j.freeradbiomed.2012.11.017
27 https://doi.org/10.1016/j.lfs.2011.12.020
28 https://doi.org/10.1016/j.mrgentox.2008.10.005
29 https://doi.org/10.1016/j.mrgentox.2008.11.012
30 https://doi.org/10.1016/j.neulet.2010.08.063
31 https://doi.org/10.1016/j.taap.2009.01.013
32 https://doi.org/10.1016/j.tox.2011.06.002
33 https://doi.org/10.1016/s0002-9343(99)00259-4
34 https://doi.org/10.1016/s0014-4835(03)00023-x
35 https://doi.org/10.1016/s0014-4886(02)00059-6
36 https://doi.org/10.1016/s0014-5793(98)00630-9
37 https://doi.org/10.1016/s0025-326x(00)00159-4
38 https://doi.org/10.1016/s0092-8674(00)80430-4
39 https://doi.org/10.1016/s0092-8674(00)81590-1
40 https://doi.org/10.1016/s0165-5728(00)00321-0
41 https://doi.org/10.1016/s0891-5849(01)00591-3
42 https://doi.org/10.1016/s0891-5849(02)00967-x
43 https://doi.org/10.1016/s0891-5849(96)00275-4
44 https://doi.org/10.1016/s0968-0004(96)20008-8
45 https://doi.org/10.1016/s1383-5742(03)00017-6
46 https://doi.org/10.1016/s1470-2045(06)70545-9
47 https://doi.org/10.1017/s0007114500001422
48 https://doi.org/10.1042/bj20101695
49 https://doi.org/10.1073/pnas.94.21.11233
50 https://doi.org/10.1074/jbc.273.16.9357
51 https://doi.org/10.1074/jbc.m011136200
52 https://doi.org/10.1074/jbc.m201070200
53 https://doi.org/10.1074/jbc.m212389200
54 https://doi.org/10.1093/oxfordjournals.jbchem.a002947
55 https://doi.org/10.1126/science.282.5392.1318
56 https://doi.org/10.1242/jeb.01152
57 https://doi.org/10.1371/journal.pone.0015808
58 https://doi.org/10.1371/journal.pone.0064020
59 https://doi.org/10.4161/isl.1.3.9262
60 schema:datePublished 2014-12
61 schema:datePublishedReg 2014-12-01
62 schema:description Hydrogen peroxide (H2O2), a major reactive oxygen species, has been shown to be a critical mediator of apoptosis induced by several toxic metals such as cadmium. In this study, we used the freshwater crab Sinopotamon henanense to study whether H2O2 can cause apoptosis in gill cells. The crabs were incubated in H2O2 and the DNA fragmentation, ultrastructural changes and caspase-3/8/9 activities were measured. The results showed that in freshwater crab, H2O2 was found to induce apoptosis, as confirmed by DNA fragmentation analysis and morphological observation of transmission electron microscopy. This apoptosis occurs in a concentration-dependent pattern. During the apoptotic process, caspase-3, caspase-8 and caspase-9 were activated by H2O2. In addition, multiple physiological and pathological changes of gill cells were discovered after 24 h exposure to 5 mM H2O2, including aggregation and condensation of nuclear chromatin, appearance of extremely irregular nuclei with finger-like buds, disappearance of the organelles around the nuclei, swollen and dissolved cristae of mitochondria. We propose that H2O2-induced stress leads to mitochondria lesions oxidative injury and triggers apoptotic response through the caspase pathway in freshwater crab.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree false
66 schema:isPartOf N8ce365f7f5f7414e96842d575d103cba
67 Nc1e8815deb794de6b2e5eef2538827e8
68 sg:journal.1023171
69 schema:name Hydrogen peroxide leads to cell damage and apoptosis in the gill of the freshwater crab Sinopotamon henanense (Crustacea, Decapoda)
70 schema:pagination 13-21
71 schema:productId N253d1d09319b4ba4920a2b3bbc2ecaad
72 N8d7961f9b1224062a364ff0910f00564
73 Ndaacfb840eab43a7993ca13a4d282add
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004041435
75 https://doi.org/10.1007/s10750-013-1760-x
76 schema:sdDatePublished 2019-04-10T17:35
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nb21c1a148590486c89f1f08ac203f701
79 schema:url http://link.springer.com/10.1007%2Fs10750-013-1760-x
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0915b760c8e5451a84a08a4d5a102023 rdf:first sg:person.01251746615.64
84 rdf:rest N411a6d6a5334483d9d57306de57ccc15
85 N0a656344ca304384b19a00d9ca2e2d98 schema:affiliation https://www.grid.ac/institutes/grid.440639.c
86 schema:familyName Zhou
87 schema:givenName Feng
88 rdf:type schema:Person
89 N0a961f609de4434eb1ec887072d9e5d5 rdf:first sg:person.01133776467.97
90 rdf:rest N62b1e812010f4b28b8247a7e52f4b76e
91 N253d1d09319b4ba4920a2b3bbc2ecaad schema:name dimensions_id
92 schema:value pub.1004041435
93 rdf:type schema:PropertyValue
94 N3b673e700ffa48d8a689f29a2008ab35 rdf:first sg:person.0712247506.17
95 rdf:rest Ne86925bb63154794903f18dda4e30176
96 N411a6d6a5334483d9d57306de57ccc15 rdf:first sg:person.0631576630.93
97 rdf:rest N0a961f609de4434eb1ec887072d9e5d5
98 N62b1e812010f4b28b8247a7e52f4b76e rdf:first sg:person.01355066174.27
99 rdf:rest N3b673e700ffa48d8a689f29a2008ab35
100 N8ce365f7f5f7414e96842d575d103cba schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N8d7961f9b1224062a364ff0910f00564 schema:name readcube_id
103 schema:value 13419396b509329c493e55bdf4005e79ac560398d74ab78b7931a170558563d2
104 rdf:type schema:PropertyValue
105 Nb21c1a148590486c89f1f08ac203f701 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Nc1e8815deb794de6b2e5eef2538827e8 schema:volumeNumber 741
108 rdf:type schema:PublicationVolume
109 Ndaacfb840eab43a7993ca13a4d282add schema:name doi
110 schema:value 10.1007/s10750-013-1760-x
111 rdf:type schema:PropertyValue
112 Ne86925bb63154794903f18dda4e30176 rdf:first N0a656344ca304384b19a00d9ca2e2d98
113 rdf:rest rdf:nil
114 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
115 schema:name Biological Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
118 schema:name Biochemistry and Cell Biology
119 rdf:type schema:DefinedTerm
120 sg:grant.5016379 http://pending.schema.org/fundedItem sg:pub.10.1007/s10750-013-1760-x
121 rdf:type schema:MonetaryGrant
122 sg:journal.1023171 schema:issn 1037-0544
123 1573-8590
124 schema:name Hydrobiologia
125 rdf:type schema:Periodical
126 sg:person.01133776467.97 schema:affiliation https://www.grid.ac/institutes/grid.163032.5
127 schema:familyName Liu
128 schema:givenName Na
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133776467.97
130 rdf:type schema:Person
131 sg:person.01251746615.64 schema:affiliation https://www.grid.ac/institutes/grid.440639.c
132 schema:familyName Wang
133 schema:givenName Jinxiang
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251746615.64
135 rdf:type schema:Person
136 sg:person.01355066174.27 schema:affiliation https://www.grid.ac/institutes/grid.163032.5
137 schema:familyName Jing
138 schema:givenName Weixin
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355066174.27
140 rdf:type schema:Person
141 sg:person.0631576630.93 schema:affiliation https://www.grid.ac/institutes/grid.163032.5
142 schema:familyName Wang
143 schema:givenName Qian
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631576630.93
145 rdf:type schema:Person
146 sg:person.0712247506.17 schema:affiliation https://www.grid.ac/institutes/grid.163032.5
147 schema:familyName Wang
148 schema:givenName Lan
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712247506.17
150 rdf:type schema:Person
151 sg:pub.10.1007/s00221-007-1100-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005214071
152 https://doi.org/10.1007/s00221-007-1100-3
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s10495-005-3087-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047486709
155 https://doi.org/10.1007/s10495-005-3087-1
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/s10534-010-9329-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037732668
158 https://doi.org/10.1007/s10534-010-9329-x
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s12031-009-9285-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033475348
161 https://doi.org/10.1007/s12031-009-9285-5
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/284555a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009203237
164 https://doi.org/10.1038/284555a0
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/emm.1999.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008359295
167 https://doi.org/10.1038/emm.1999.9
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/sj.onc.1202325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000980457
170 https://doi.org/10.1038/sj.onc.1202325
171 rdf:type schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1074691454 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1078654573 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1082718489 schema:CreativeWork
175 https://doi.org/10.1002/jnr.10295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038112448
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1006/jmcc.1998.0743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008304662
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0014-5793(95)00603-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027171400
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.aquaculture.2008.10.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027507235
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.aquatox.2011.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021316513
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.aquatox.2011.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052745360
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.biocel.2008.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025591328
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.cellsig.2013.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014165573
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.chemosphere.2010.07.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003362000
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.ecoenv.2011.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031407297
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.ejphar.2007.01.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001898426
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.freeradbiomed.2012.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036092811
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.lfs.2011.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023889508
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.mrgentox.2008.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051851059
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.mrgentox.2008.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030670430
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.neulet.2010.08.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007831978
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.taap.2009.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001193635
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.tox.2011.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042146214
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0002-9343(99)00259-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005379961
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0014-4835(03)00023-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022723787
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0014-4886(02)00059-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015447233
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0014-5793(98)00630-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034567222
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0025-326x(00)00159-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019387907
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0092-8674(00)80430-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045716809
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0092-8674(00)81590-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042580199
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0165-5728(00)00321-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052458957
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0891-5849(01)00591-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050420855
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0891-5849(02)00967-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047521401
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0891-5849(96)00275-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050551204
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0968-0004(96)20008-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042654263
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s1383-5742(03)00017-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043535298
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s1470-2045(06)70545-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025890301
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1017/s0007114500001422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017968175
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1042/bj20101695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041857222
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1073/pnas.94.21.11233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029485889
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1074/jbc.273.16.9357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013528186
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.m011136200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012693166
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.m201070200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041352723
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1074/jbc.m212389200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017205504
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/oxfordjournals.jbchem.a002947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059959624
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.282.5392.1318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563196
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1242/jeb.01152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006036039
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1371/journal.pone.0015808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023092800
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1371/journal.pone.0064020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017927981
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4161/isl.1.3.9262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305027
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.163032.5 schema:alternateName Shanxi University
268 schema:name School of Life Science, Shanxi University, 030006, Taiyuan, China
269 rdf:type schema:Organization
270 https://www.grid.ac/institutes/grid.440639.c schema:alternateName Shanxi Datong University
271 schema:name School of Life Science, Shanxi Datong University, 037009, Datong, China
272 School of Life Science, Shanxi University, 030006, Taiyuan, China
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...