Pharmacology of vasopressin antagonists View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-09-03

AUTHORS

Lisa C. Costello-Boerrigter, Guido Boerrigter, John C. Burnett

ABSTRACT

Congestive heart failure (CHF) is characterized by fluid and water retention, which frequently is a therapeutic challenge. Most conventional diuretics act primarily as saluretics, i.e. they inhibit renal tubular electrolyte reabsorption, which due to osmotic pressure promotes excretion of isotonic fluid. Arginine vasopressin (AVP) via the V1A receptor vasoconstricts and via the V2 receptor promotes water reabsorption in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane. Novel V2 receptor antagonists act as powerful aquaretics, i.e. they excrete free water. We review the pharmacology of non-selective V1A/V2 receptor antagonists and selective V2 receptor antagonists currently in clinical development. More... »

PAGES

75-82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10741-008-9108-8

DOI

http://dx.doi.org/10.1007/s10741-008-9108-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036753985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18766438


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