Characterization of two novel sialyl N-acetyllactosaminyl nucleotides separated from ovine colostrum View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10

AUTHORS

Masashi Sasaki, Tadashi Nakamura, Kentaro Hirayama, Kenji Fukuda, Tadao Saito, Tadasu Urashima, Sadaki Asakuma

ABSTRACT

The milk/colostrum of some mammalian species is known to contain sugar nucleotides including uridine diphosphate (UDP) oligosaccharides in addition to lactose and milk oligosaccharides, but the detailed structures of these UDP oligosaccharides have not so far been clarified. In this study we isolated two UDP-sialyl N-acetyllactosamines from ovine colostrum and characterized them using (1)H-NMR and MALDI-TOFMS spectroscopies. Their structures were found to be Neu5Gc(α2-3)Gal(β1-4)GlcNAcα1-UDP and Neu5Gc(α2-6)Gal(β1-4)GlcNAcα1-UDP. More... »

PAGES

789-796

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10719-016-9672-4

DOI

http://dx.doi.org/10.1007/s10719-016-9672-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036372599

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27206414


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