Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04

AUTHORS

Ingrid P. Vogelaar, Marjolijn J. L. Ligtenberg, Rachel S. van der Post, Richarda M. de Voer, C. Marleen Kets, Trees J. G. Jansen, Liesbeth Jacobs, Gerty Schreibelt, International Gastric Cancer Genetics Group, I. Jolanda M. de Vries, Mihai G. Netea, Nicoline Hoogerbrugge

ABSTRACT

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk. More... »

PAGES

289-296

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10689-015-9859-z

DOI

http://dx.doi.org/10.1007/s10689-015-9859-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042765226

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26700889


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