Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06

AUTHORS

Ashley D. Staton, Allison W. Kurian, Kristin Cobb, Meredith A. Mills, James M. Ford

ABSTRACT

BACKGROUND: Women with mutations in the BRCA1 or BRCA2 cancer susceptibility genes face unique choices regarding management of their high risk for breast and ovarian cancer that impact their reproductive options. In order to explore women's preferences for management of elevated cancer risk, we evaluated the decisions of BRCA1/2 mutation carriers about contraception, prophylactic surgery, and family planning. METHODS: An internet-based questionnaire assessing high-risk women's preferences about cancer risk management and reproductive options was designed, pilot-tested and administered electronically to 284 participants of an internet-based advocacy group for women with BRCA1/2 mutations. RESULTS: Two hundred and thirteen eligible participants completed the majority of the survey. Mean age was 34 years; 66% were BRCA1 mutation carriers and 34% were BRCA2 mutation carriers. Most women (92%) had used oral contraceptive pills. About 88% of responders reported frequent or extreme worry about transmitting the mutation to their children. Despite their high level of worry, few responders said they would likely consider using assisted reproduction technologies such as a pregnancy surrogate (3%), cryopreservation of oocytes or embryos (8%), or pre-implantation genetic diagnosis (PGD) to select embryos without BRCA1/2 mutations (13%). CONCLUSIONS: Although they expressed substantial concern about transmitting BRCA1/2 mutations to their children, only a minority of the high-risk women surveyed were likely to consider currently available assisted reproductive strategies. Further research is necessary to explore the risk management preferences of patients with inherited cancer predisposition, and to incorporate these preferences into clinical care. More... »

PAGES

179-186

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10689-007-9171-7

DOI

http://dx.doi.org/10.1007/s10689-007-9171-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005613430

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18026853


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "California", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Contraceptives, Oral, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Decision Making", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Internet", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mastectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovariectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproductive Techniques, Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Reduction Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 1115, 269 Campus Drive, 94305-5151, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staton", 
        "givenName": "Ashley D.", 
        "id": "sg:person.0641702121.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641702121.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 1115, 269 Campus Drive, 94305-5151, Stanford, CA, USA", 
            "Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurian", 
        "givenName": "Allison W.", 
        "id": "sg:person.01253367536.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253367536.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cobb", 
        "givenName": "Kristin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 1115, 269 Campus Drive, 94305-5151, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "Meredith A.", 
        "id": "sg:person.01121772371.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121772371.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 1115, 269 Campus Drive, 94305-5151, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ford", 
        "givenName": "James M.", 
        "id": "sg:person.0666602023.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666602023.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10689-005-4215-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001947092", 
          "https://doi.org/10.1007/s10689-005-4215-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-005-4215-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001947092", 
          "https://doi.org/10.1007/s10689-005-4215-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-005-4215-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001947092", 
          "https://doi.org/10.1007/s10689-005-4215-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002331489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002331489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.23.1773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002610944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.10.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007153700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008483652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008483652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.6100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011061631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-04-0376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017239862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/13.5.1125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020290652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pon.533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020774711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.37.11.883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026271056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.1066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026376945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028611272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70983-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028972777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029472865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.1708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029886915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006842-197905000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029900423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006842-197905000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029900423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dem055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030979522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032006320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0278-6133.16.1.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033306169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.a.30265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037908123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7545954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041365117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)03258-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043230962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-005-0343-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045043673", 
          "https://doi.org/10.1007/s10552-005-0343-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-005-0343-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045043673", 
          "https://doi.org/10.1007/s10552-005-0343-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1369-7625.2005.00333.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048582167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1369-7625.2005.00333.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048582167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-004-1446-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050127142", 
          "https://doi.org/10.1007/s10689-004-1446-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-004-1446-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050127142", 
          "https://doi.org/10.1007/s10689-004-1446-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-004-1446-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050127142", 
          "https://doi.org/10.1007/s10689-004-1446-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.01.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050143266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0029-7844(95)00405-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054545827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jncimonographs/lgi012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059821933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075037265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077141702", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2014.0127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078966981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2014.0127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078966981"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-06", 
    "datePublishedReg": "2008-06-01", 
    "description": "BACKGROUND: Women with mutations in the BRCA1 or BRCA2 cancer susceptibility genes face unique choices regarding management of their high risk for breast and ovarian cancer that impact their reproductive options. In order to explore women's preferences for management of elevated cancer risk, we evaluated the decisions of BRCA1/2 mutation carriers about contraception, prophylactic surgery, and family planning.\nMETHODS: An internet-based questionnaire assessing high-risk women's preferences about cancer risk management and reproductive options was designed, pilot-tested and administered electronically to 284 participants of an internet-based advocacy group for women with BRCA1/2 mutations.\nRESULTS: Two hundred and thirteen eligible participants completed the majority of the survey. Mean age was 34 years; 66% were BRCA1 mutation carriers and 34% were BRCA2 mutation carriers. Most women (92%) had used oral contraceptive pills. About 88% of responders reported frequent or extreme worry about transmitting the mutation to their children. Despite their high level of worry, few responders said they would likely consider using assisted reproduction technologies such as a pregnancy surrogate (3%), cryopreservation of oocytes or embryos (8%), or pre-implantation genetic diagnosis (PGD) to select embryos without BRCA1/2 mutations (13%).\nCONCLUSIONS: Although they expressed substantial concern about transmitting BRCA1/2 mutations to their children, only a minority of the high-risk women surveyed were likely to consider currently available assisted reproductive strategies. Further research is necessary to explore the risk management preferences of patients with inherited cancer predisposition, and to incorporate these preferences into clinical care.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10689-007-9171-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021923", 
        "issn": [
          "1389-9600", 
          "1573-7292"
        ], 
        "name": "Familial Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriers", 
    "pagination": "179-186", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10689-007-9171-7"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1abef863645e7686cc94ffd1c84fc19fefea1889b3e5b26919068e0c6b0c6a5a"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005613430"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100898211"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18026853"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10689-007-9171-7", 
      "https://app.dimensions.ai/details/publication/pub.1005613430"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56185_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10689-007-9171-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10689-007-9171-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10689-007-9171-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10689-007-9171-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10689-007-9171-7'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      79 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10689-007-9171-7 schema:about N0c3e7d60eb2a47189068be5804208480
2 N123dead1f6224ad68640291a06f4fc6c
3 N1c381c0d74194642b9c56187069e1843
4 N42dc481a998743dd80189f214674b62b
5 N5117af6920e24d849a3c36d6577aabeb
6 N51c7de41e95f42c496aef4e126f25e32
7 N57ed9b2aa5014e998170522d59f632dd
8 N5bcf02024a814fc79aa694cec66292f3
9 N5ef5563258b145fd93afe373892c6616
10 N6a2c46a49575446cb5c69b2d71c5e888
11 N6dd75615851940bb828b48372f577372
12 N856860735cf3411d9e52d6ad1fba192d
13 N8d44628a02374d63b55fe288244625dc
14 N9562cfbe3daa4a168d7b4f1bfc687b21
15 N95c2d1dd2a424f9fae42230ca0d0cf4d
16 Na093080dddb04eaeb093bf06974c5f65
17 Na4701c48b11d40b69212d05230971aa9
18 Nde07d385587a4c74928ee85b7b14c0c1
19 Ne9341eb5c808471bbfe0884e937a2041
20 anzsrc-for:11
21 anzsrc-for:1114
22 schema:author N5bfd22715e6947658039880ee109eb7a
23 schema:citation sg:pub.10.1007/s10552-005-0343-1
24 sg:pub.10.1007/s10689-004-1446-7
25 sg:pub.10.1007/s10689-005-4215-3
26 https://app.dimensions.ai/details/publication/pub.1075037265
27 https://app.dimensions.ai/details/publication/pub.1077141702
28 https://doi.org/10.1002/ajmg.a.30265
29 https://doi.org/10.1002/ijc.21273
30 https://doi.org/10.1002/ijc.21536
31 https://doi.org/10.1002/pd.1708
32 https://doi.org/10.1002/pon.533
33 https://doi.org/10.1016/0029-7844(95)00405-x
34 https://doi.org/10.1016/s0140-6736(00)03258-x
35 https://doi.org/10.1016/s1470-2045(06)70983-4
36 https://doi.org/10.1037/0278-6133.16.1.63
37 https://doi.org/10.1086/375033
38 https://doi.org/10.1093/humrep/13.5.1125
39 https://doi.org/10.1093/humrep/dem055
40 https://doi.org/10.1093/jnci/94.23.1773
41 https://doi.org/10.1093/jnci/djh211
42 https://doi.org/10.1093/jncimonographs/lgi012
43 https://doi.org/10.1097/00006842-197905000-00004
44 https://doi.org/10.1111/j.1369-7625.2005.00333.x
45 https://doi.org/10.1126/science.7545954
46 https://doi.org/10.1136/jmg.37.11.883
47 https://doi.org/10.1158/1055-9965.epi-04-0376
48 https://doi.org/10.1200/jco.2004.01.159
49 https://doi.org/10.1200/jco.2005.04.050
50 https://doi.org/10.1200/jco.2005.10.035
51 https://doi.org/10.1200/jco.2006.06.6100
52 https://doi.org/10.1200/jco.2006.09.1066
53 https://doi.org/10.6004/jnccn.2014.0127
54 schema:datePublished 2008-06
55 schema:datePublishedReg 2008-06-01
56 schema:description BACKGROUND: Women with mutations in the BRCA1 or BRCA2 cancer susceptibility genes face unique choices regarding management of their high risk for breast and ovarian cancer that impact their reproductive options. In order to explore women's preferences for management of elevated cancer risk, we evaluated the decisions of BRCA1/2 mutation carriers about contraception, prophylactic surgery, and family planning. METHODS: An internet-based questionnaire assessing high-risk women's preferences about cancer risk management and reproductive options was designed, pilot-tested and administered electronically to 284 participants of an internet-based advocacy group for women with BRCA1/2 mutations. RESULTS: Two hundred and thirteen eligible participants completed the majority of the survey. Mean age was 34 years; 66% were BRCA1 mutation carriers and 34% were BRCA2 mutation carriers. Most women (92%) had used oral contraceptive pills. About 88% of responders reported frequent or extreme worry about transmitting the mutation to their children. Despite their high level of worry, few responders said they would likely consider using assisted reproduction technologies such as a pregnancy surrogate (3%), cryopreservation of oocytes or embryos (8%), or pre-implantation genetic diagnosis (PGD) to select embryos without BRCA1/2 mutations (13%). CONCLUSIONS: Although they expressed substantial concern about transmitting BRCA1/2 mutations to their children, only a minority of the high-risk women surveyed were likely to consider currently available assisted reproductive strategies. Further research is necessary to explore the risk management preferences of patients with inherited cancer predisposition, and to incorporate these preferences into clinical care.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N2ef0786ea8774ea494281a5844b9f197
61 Nfcc6e3a43b084bee90062dc297edb681
62 sg:journal.1021923
63 schema:name Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriers
64 schema:pagination 179-186
65 schema:productId N0fe30651a1ac44aca9141d7212b33e76
66 N18387c4fc06f42f0bf4b00acc2642b5a
67 N2282ef76fb444d3481b65efeefb68a36
68 N44d081e818e949c6b1a446aa793e16c2
69 N80efe79edf204a31a86caf0434d267b8
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005613430
71 https://doi.org/10.1007/s10689-007-9171-7
72 schema:sdDatePublished 2019-04-15T09:22
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N22734fcf93824be39004097234567da2
75 schema:url http://link.springer.com/10.1007/s10689-007-9171-7
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0c3e7d60eb2a47189068be5804208480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Risk Factors
81 rdf:type schema:DefinedTerm
82 N0fe30651a1ac44aca9141d7212b33e76 schema:name dimensions_id
83 schema:value pub.1005613430
84 rdf:type schema:PropertyValue
85 N123dead1f6224ad68640291a06f4fc6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Decision Making
87 rdf:type schema:DefinedTerm
88 N18387c4fc06f42f0bf4b00acc2642b5a schema:name pubmed_id
89 schema:value 18026853
90 rdf:type schema:PropertyValue
91 N1c381c0d74194642b9c56187069e1843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Genes, BRCA1
93 rdf:type schema:DefinedTerm
94 N22734fcf93824be39004097234567da2 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N2282ef76fb444d3481b65efeefb68a36 schema:name doi
97 schema:value 10.1007/s10689-007-9171-7
98 rdf:type schema:PropertyValue
99 N2e66b4a74233480590eb9d967aee16f9 rdf:first sg:person.0666602023.87
100 rdf:rest rdf:nil
101 N2ef0786ea8774ea494281a5844b9f197 schema:issueNumber 2
102 rdf:type schema:PublicationIssue
103 N42dc481a998743dd80189f214674b62b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mastectomy
105 rdf:type schema:DefinedTerm
106 N44d081e818e949c6b1a446aa793e16c2 schema:name readcube_id
107 schema:value 1abef863645e7686cc94ffd1c84fc19fefea1889b3e5b26919068e0c6b0c6a5a
108 rdf:type schema:PropertyValue
109 N5117af6920e24d849a3c36d6577aabeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Reproduction
111 rdf:type schema:DefinedTerm
112 N51c7de41e95f42c496aef4e126f25e32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name California
114 rdf:type schema:DefinedTerm
115 N57ed9b2aa5014e998170522d59f632dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mutation
117 rdf:type schema:DefinedTerm
118 N5bcf02024a814fc79aa694cec66292f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Surveys and Questionnaires
120 rdf:type schema:DefinedTerm
121 N5bfd22715e6947658039880ee109eb7a rdf:first sg:person.0641702121.91
122 rdf:rest Nbf5f9324c7e94cbcaf9e7ccd30570c98
123 N5ef5563258b145fd93afe373892c6616 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Internet
125 rdf:type schema:DefinedTerm
126 N6a2c46a49575446cb5c69b2d71c5e888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Ovarian Neoplasms
128 rdf:type schema:DefinedTerm
129 N6dd75615851940bb828b48372f577372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Ovariectomy
131 rdf:type schema:DefinedTerm
132 N80efe79edf204a31a86caf0434d267b8 schema:name nlm_unique_id
133 schema:value 100898211
134 rdf:type schema:PropertyValue
135 N856860735cf3411d9e52d6ad1fba192d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Breast Neoplasms
137 rdf:type schema:DefinedTerm
138 N8d44628a02374d63b55fe288244625dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 N9562cfbe3daa4a168d7b4f1bfc687b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Risk Reduction Behavior
143 rdf:type schema:DefinedTerm
144 N95c2d1dd2a424f9fae42230ca0d0cf4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Contraceptives, Oral, Hormonal
146 rdf:type schema:DefinedTerm
147 Na093080dddb04eaeb093bf06974c5f65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Genes, BRCA2
149 rdf:type schema:DefinedTerm
150 Na4701c48b11d40b69212d05230971aa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Adult
152 rdf:type schema:DefinedTerm
153 Nabafe569401047729b97b2991a7a434a rdf:first Nb3769e7ca78448f09324e28a53ef3b97
154 rdf:rest Ndca649d009ff41b6a1923b1ecf667fb1
155 Nb3769e7ca78448f09324e28a53ef3b97 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
156 schema:familyName Cobb
157 schema:givenName Kristin
158 rdf:type schema:Person
159 Nbf5f9324c7e94cbcaf9e7ccd30570c98 rdf:first sg:person.01253367536.51
160 rdf:rest Nabafe569401047729b97b2991a7a434a
161 Ndca649d009ff41b6a1923b1ecf667fb1 rdf:first sg:person.01121772371.18
162 rdf:rest N2e66b4a74233480590eb9d967aee16f9
163 Nde07d385587a4c74928ee85b7b14c0c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Reproductive Techniques, Assisted
165 rdf:type schema:DefinedTerm
166 Ne9341eb5c808471bbfe0884e937a2041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Humans
168 rdf:type schema:DefinedTerm
169 Nfcc6e3a43b084bee90062dc297edb681 schema:volumeNumber 7
170 rdf:type schema:PublicationVolume
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
175 schema:name Paediatrics and Reproductive Medicine
176 rdf:type schema:DefinedTerm
177 sg:journal.1021923 schema:issn 1389-9600
178 1573-7292
179 schema:name Familial Cancer
180 rdf:type schema:Periodical
181 sg:person.01121772371.18 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
182 schema:familyName Mills
183 schema:givenName Meredith A.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121772371.18
185 rdf:type schema:Person
186 sg:person.01253367536.51 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
187 schema:familyName Kurian
188 schema:givenName Allison W.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253367536.51
190 rdf:type schema:Person
191 sg:person.0641702121.91 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
192 schema:familyName Staton
193 schema:givenName Ashley D.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641702121.91
195 rdf:type schema:Person
196 sg:person.0666602023.87 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
197 schema:familyName Ford
198 schema:givenName James M.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666602023.87
200 rdf:type schema:Person
201 sg:pub.10.1007/s10552-005-0343-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045043673
202 https://doi.org/10.1007/s10552-005-0343-1
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s10689-004-1446-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050127142
205 https://doi.org/10.1007/s10689-004-1446-7
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/s10689-005-4215-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001947092
208 https://doi.org/10.1007/s10689-005-4215-3
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1075037265 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1077141702 schema:CreativeWork
212 https://doi.org/10.1002/ajmg.a.30265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037908123
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/ijc.21273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029472865
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/ijc.21536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008483652
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/pd.1708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029886915
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/pon.533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020774711
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0029-7844(95)00405-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1054545827
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0140-6736(00)03258-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043230962
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s1470-2045(06)70983-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028972777
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1037/0278-6133.16.1.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033306169
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1086/375033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002331489
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/humrep/13.5.1125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020290652
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1093/humrep/dem055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030979522
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/jnci/94.23.1773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002610944
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/jnci/djh211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032006320
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/jncimonographs/lgi012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059821933
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/00006842-197905000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029900423
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1369-7625.2005.00333.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048582167
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.7545954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041365117
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1136/jmg.37.11.883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026271056
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1158/1055-9965.epi-04-0376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017239862
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1200/jco.2004.01.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050143266
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1200/jco.2005.04.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028611272
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1200/jco.2005.10.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007153700
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1200/jco.2006.06.6100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011061631
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1200/jco.2006.09.1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026376945
261 rdf:type schema:CreativeWork
262 https://doi.org/10.6004/jnccn.2014.0127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078966981
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
265 schema:name Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA
266 Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 1115, 269 Campus Drive, 94305-5151, Stanford, CA, USA
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...