Plasma metabolomic profiles for colorectal cancer precursors in women View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-01-15

AUTHORS

Dong Hang, Oana A. Zeleznik, Jiayi Lu, Amit D. Joshi, Kana Wu, Zhibin Hu, Hongbing Shen, Clary B. Clish, Liming Liang, A. Heather Eliassen, Shuji Ogino, Jeffrey A. Meyerhardt, Andrew T. Chan, Mingyang Song

ABSTRACT

How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case–control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC–MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. 993), in the Nurses' Health Study (NHS) and NHSII. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). We used the permutation-based Westfall and Young approach to account for multiple testing. Subgroup analyses were performed for advanced conventional adenomas (defined as at least one adenoma of ≥ 10 mm or with high-grade dysplasia, or tubulovillous or villous histology) and high-risk serrated polyps that were located in the proximal colon or with size of ≥ 10 mm. After multiple testing correction, among 207 metabolites, higher levels of C36:3 phosphatidylcholine (PC) plasmalogen were associated with lower risk of conventional adenomas, with the OR (95% CI) comparing the 90th to the 10th percentile of 0.62 (0.48–0.81); C54:8 triglyceride (TAG) was associated with higher risk of serrated polyps (OR = 1.79, 95% CI: 1.31–2.43), and phenylacetylglutamine (PAG) was associated with lower risk (OR = 0.57, 95% CI:0.43–0.77). PAG was also inversely associated with advanced adenomas (OR = 0.57, 95% CI: 0.36–0.89) and high-risk serrated polyps (OR = 0.54, 95% CI: 0.32–0.89), although the multiple testing-corrected p value was > 0.05. Our findings suggest potential roles of lipid metabolism and phenylacetylglutamine, a microbial metabolite, in the early stage of colorectal carcinogenesis, particularly for the serrated pathway. More... »

PAGES

413-422

Journal

TITLE

European Journal of Epidemiology

ISSUE

4

VOLUME

37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10654-021-00834-5

DOI

http://dx.doi.org/10.1007/s10654-021-00834-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1144693732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35032257


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