Interaction between lifestyle and genetic susceptibility in myopia: the Generation R study. View Full Text


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Article Info

DATE

2019-04-03

AUTHORS

Clair A Enthoven, Jan Willem Lodewijk Tideman, Jan Roelof Polling, Milly S Tedja, Hein Raat, Adriana I Iglesias, Virginie J M Verhoeven, Caroline C W Klaver

ABSTRACT

Myopia is a refractive error of the eye caused by a complex interplay between nature and nurture. The aim of this study was to investigate whether environmental risk factors can influence the genetic effect in children developing myopia. A total of 3422 children participating in the birth-cohort study Generation R underwent an extensive eye examination at 9 years with measurements of refractive error and axial length corneal radius ratio (AL/CR). Environmental risk factors were evaluated using a questionnaire, and environmental risk scores (ERS) were calculated using backward regression analyses. Genetic risk scores (GRS) were calculated based on all currently known risk variants for myopia. Gene-environment interaction (G×E) was investigated using linear and logistic regression analyses. The predictive value of G×E and parental myopia was estimated using receiver operating characteristic curves. Myopia prevalence was 12%. Both GRS (P < 0.01) and ERS (P < 0.01) were significantly associated with myopia and AL/CR, as was G×E interaction (P < 0.01 for myopia; P = 0.07 for AL/CR). The predictive value of parental myopia was 0.67 (95% CI 0.65-0.70), similar to the values of GRS (0.67; 95% CI 0.64-0.70; P = 0.98) and ERS (0.69; 95% CI 0.66-0.72; P = 0.98). Adding G×E interaction significantly improved the predictive value to 0.73 (95% CI 0.70-0.75; P < 0.01). This study provides evidence that nature and nurture are equally important for myopia and AL/CR; however, the combination has the strongest influence. Since myopia genes are common in the population, adjustment of lifestyle should be a major focus in the prevention of myopia. More... »

References to SciGraph publications

  • 2013-12. Education influences the role of genetics in myopia in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2015-04. Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2015-12. Second-generation PLINK: rising to the challenge of larger and richer datasets in GIGASCIENCE
  • 2015-04. Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2011-12. pROC: an open-source package for R and S+ to analyze and compare ROC curves in BMC BIOINFORMATICS
  • 2016-12. The Generation R Study: design and cohort update 2017 in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2016-03-29. Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error in NATURE COMMUNICATIONS
  • 2016-09. Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium in SCIENTIFIC REPORTS
  • 2017-12. Phenotypic and genotypic correlation between myopia and intelligence in SCIENTIFIC REPORTS
  • 2014-12. The Generation R Study: Biobank update 2015 in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2016-05. Low serum vitamin D is associated with axial length and risk of myopia in young children in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2018-06. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error in NATURE GENETICS
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    http://scigraph.springernature.com/pub.10.1007/s10654-019-00512-7

    DOI

    http://dx.doi.org/10.1007/s10654-019-00512-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113182426

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30945054


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