Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-04

AUTHORS

Ida Juul Rasmussen, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G. Nordestgaard, Ruth Frikke-Schmidt

ABSTRACT

To test whether genetic variants in PICALM, BIN1, CD2AP, and RIN3-suggested to be involved in blood-brain barrier amyloid-β transcytosis pathways-associate with Alzheimer's disease, all dementia, suggested vascular dementia, and stroke, and whether such associations are independent of the strong ε4 APOE risk allele. In a prospective cohort study of 74,754 individuals from the general population we genotyped PICALM (rs10792832), BIN1 (rs6733839), CD2AP (rs10948363), and RIN3 (rs10498633), and generated a weighted and a simple allele score. Multifactorially adjusted hazard ratios for the fourth quartile versus the first quartile of the weighted allele score were 1.42 (95% confidence interval 1.22-1.64) for Alzheimer's disease, and 1.33 (1.19-1.48) for all dementia. For suggested vascular dementia and stroke the corresponding estimates were 1.71 (1.18-2.49) and 1.12 (1.04-1.22), respectively. Hazard ratios were similar after APOE adjustment. Genetic variants in PICALM, BIN1, CD2AP, and RIN3 are associated with increased risk of Alzheimer's disease, all dementia, and suggested vascular dementia independent of the strong APOE ε4 allele. These findings may suggest that clathrin-mediated endocytosis in clearance of amyloid-β across the blood-brain barrier is important for the integrity of both brain tissue and cerebral vessels. More... »

PAGES

1-12

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10654-019-00498-2

DOI

http://dx.doi.org/10.1007/s10654-019-00498-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112514008

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30830563


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gentofte Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411646.0", 
          "name": [
            "Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen \u00d8, Denmark", 
            "The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juul Rasmussen", 
        "givenName": "Ida", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen \u00d8, Denmark", 
            "The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark", 
            "The Copenhagen City Heart Study, Frederiksberg Hospital, 2000, Frederiksberg, Denmark", 
            "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tybj\u00e6rg-Hansen", 
        "givenName": "Anne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gentofte Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411646.0", 
          "name": [
            "Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen \u00d8, Denmark", 
            "The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rasmussen", 
        "givenName": "Katrine Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gentofte Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411646.0", 
          "name": [
            "The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark", 
            "The Copenhagen City Heart Study, Frederiksberg Hospital, 2000, Frederiksberg, Denmark", 
            "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark", 
            "Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nordestgaard", 
        "givenName": "B\u00f8rge G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen \u00d8, Denmark", 
            "The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark", 
            "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frikke-Schmidt", 
        "givenName": "Ruth", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1308027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000463047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.26.16700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001059606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1997.03540340047031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002377012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.10.4804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003471963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2013.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003926021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wad.0000000000000034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005189835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wad.0000000000000034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005189835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006423654", 
          "https://doi.org/10.1038/ng.801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007929967", 
          "https://doi.org/10.1038/ng.440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007929967", 
          "https://doi.org/10.1038/ng.440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009790540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1004606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010418040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000107084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012373687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90316-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012923782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014685397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10654-015-0082-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014920697", 
          "https://doi.org/10.1007/s10654-015-0082-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10654-015-0082-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014920697", 
          "https://doi.org/10.1007/s10654-015-0082-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015460770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00109.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015796196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90306-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016052471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.10.8.2687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017284802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018560935", 
          "https://doi.org/10.1038/ng.439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018560935", 
          "https://doi.org/10.1038/ng.439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81608-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019052978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.299.21.2524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019284777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1197623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019286527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/kisup.2012.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020397537", 
          "https://doi.org/10.1038/kisup.2012.73"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1213210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020576816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2015.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024086499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.34.7.939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024664401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025133227", 
          "https://doi.org/10.1038/nature08185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025133227", 
          "https://doi.org/10.1038/nature08185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2015.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025815613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4061/2011/501862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026774249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(91)90609-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028134537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(91)90609-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028134537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000285518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028660641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031397264", 
          "https://doi.org/10.1038/ng.2802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031397264", 
          "https://doi.org/10.1038/ng.2802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci10498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031916105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2014.05.1757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033293224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2014.05.1757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033293224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033899527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arr.2010.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033980788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037025366", 
          "https://doi.org/10.1038/nature11087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)00475-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037507194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.135.4.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038164437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.10.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040180265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040381982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041370090", 
          "https://doi.org/10.1038/nn.4018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.102913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041981797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.8.10.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042762270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044022105", 
          "https://doi.org/10.1038/ng.803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1753-4887.2010.00352.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044787060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1753-4887.2010.00352.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044787060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046181123", 
          "https://doi.org/10.1038/nn.4025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.24326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049093974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(98)01264-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049340285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2013.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049367334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050137360", 
          "https://doi.org/10.1038/nature11133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0909142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050272107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052597019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053009946", 
          "https://doi.org/10.1038/nrn3114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m115.637207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058213470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1999.10474144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058305593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1566067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062491586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.286.5438.312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062566890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8346443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1403494811399958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064001916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1403494811399958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064001916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1403494811401482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064001927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1403494811401482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064001927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.43.2.250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064371394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080284174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2017.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090995762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acn3.506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099710431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2018.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101296883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2018.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101296883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-018-1029-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101491443", 
          "https://doi.org/10.1186/s12916-018-1029-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-018-1029-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101491443", 
          "https://doi.org/10.1186/s12916-018-1029-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-018-1029-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101491443", 
          "https://doi.org/10.1186/s12916-018-1029-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-018-1029-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101491443", 
          "https://doi.org/10.1186/s12916-018-1029-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-04", 
    "datePublishedReg": "2019-03-04", 
    "description": "To test whether genetic variants in PICALM, BIN1, CD2AP, and RIN3-suggested to be involved in blood-brain barrier amyloid-\u03b2 transcytosis pathways-associate with Alzheimer's disease, all dementia, suggested vascular dementia, and stroke, and whether such associations are independent of the strong \u03b54 APOE risk allele. In a prospective cohort study of 74,754 individuals from the general population we genotyped PICALM (rs10792832), BIN1 (rs6733839), CD2AP (rs10948363), and RIN3 (rs10498633), and generated a weighted and a simple allele score. Multifactorially adjusted hazard ratios for the fourth quartile versus the first quartile of the weighted allele score were 1.42 (95% confidence interval 1.22-1.64) for Alzheimer's disease, and 1.33 (1.19-1.48) for all dementia. For suggested vascular dementia and stroke the corresponding estimates were 1.71 (1.18-2.49) and 1.12 (1.04-1.22), respectively. Hazard ratios were similar after APOE adjustment. Genetic variants in PICALM, BIN1, CD2AP, and RIN3 are associated with increased risk of Alzheimer's disease, all dementia, and suggested vascular dementia independent of the strong APOE \u03b54 allele. These findings may suggest that clathrin-mediated endocytosis in clearance of amyloid-\u03b2 across the blood-brain barrier is important for the integrity of both brain tissue and cerebral vessels.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10654-019-00498-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095636", 
        "issn": [
          "0393-2990", 
          "1573-7284"
        ], 
        "name": "European Journal of Epidemiology", 
        "type": "Periodical"
      }
    ], 
    "name": "Blood\u2013brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals", 
    "pagination": "1-12", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "eb283fc31ef165a03ab7941591f96b8ccaa127448e7252e58f51fbc2cded6c63"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30830563"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8508062"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10654-019-00498-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112514008"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10654-019-00498-2", 
      "https://app.dimensions.ai/details/publication/pub.1112514008"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60335_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10654-019-00498-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10654-019-00498-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10654-019-00498-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10654-019-00498-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10654-019-00498-2'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      21 PREDICATES      93 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10654-019-00498-2 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N7e27fbc7e2af4ad48393719f9ff77e00
4 schema:citation sg:pub.10.1007/s10654-015-0082-x
5 sg:pub.10.1038/kisup.2012.73
6 sg:pub.10.1038/nature08185
7 sg:pub.10.1038/nature11087
8 sg:pub.10.1038/nature11133
9 sg:pub.10.1038/ng.2802
10 sg:pub.10.1038/ng.439
11 sg:pub.10.1038/ng.440
12 sg:pub.10.1038/ng.801
13 sg:pub.10.1038/ng.803
14 sg:pub.10.1038/nn.4018
15 sg:pub.10.1038/nn.4025
16 sg:pub.10.1038/nrn3114
17 sg:pub.10.1186/s12916-018-1029-3
18 https://app.dimensions.ai/details/publication/pub.1080284174
19 https://doi.org/10.1001/jama.1997.03540340047031
20 https://doi.org/10.1001/jama.2010.574
21 https://doi.org/10.1001/jama.299.21.2524
22 https://doi.org/10.1002/acn3.506
23 https://doi.org/10.1002/ana.24326
24 https://doi.org/10.1016/0092-8674(91)90316-q
25 https://doi.org/10.1016/0092-8674(92)90306-w
26 https://doi.org/10.1016/0165-6147(91)90609-v
27 https://doi.org/10.1016/j.arr.2010.04.002
28 https://doi.org/10.1016/j.cell.2011.10.038
29 https://doi.org/10.1016/j.cell.2013.10.037
30 https://doi.org/10.1016/j.jalz.2011.03.005
31 https://doi.org/10.1016/j.jalz.2014.05.1757
32 https://doi.org/10.1016/j.jalz.2015.04.006
33 https://doi.org/10.1016/j.jalz.2015.05.016
34 https://doi.org/10.1016/j.jalz.2017.05.006
35 https://doi.org/10.1016/j.jalz.2018.01.005
36 https://doi.org/10.1016/j.molmed.2013.06.004
37 https://doi.org/10.1016/j.neuron.2013.10.008
38 https://doi.org/10.1016/s0092-8674(00)81608-6
39 https://doi.org/10.1016/s0166-2236(98)01264-8
40 https://doi.org/10.1016/s0896-6273(01)00475-5
41 https://doi.org/10.1056/nejmoa1308027
42 https://doi.org/10.1056/nejmra0909142
43 https://doi.org/10.1073/pnas.93.10.4804
44 https://doi.org/10.1074/jbc.272.26.16700
45 https://doi.org/10.1074/jbc.m115.637207
46 https://doi.org/10.1080/01621459.1999.10474144
47 https://doi.org/10.1083/jcb.135.4.913
48 https://doi.org/10.1091/mbc.10.8.2687
49 https://doi.org/10.1091/mbc.8.10.2003
50 https://doi.org/10.1097/wad.0000000000000034
51 https://doi.org/10.1111/j.1753-4887.2010.00352.x
52 https://doi.org/10.1126/science.1072994
53 https://doi.org/10.1126/science.1197623
54 https://doi.org/10.1126/science.1213210
55 https://doi.org/10.1126/science.1566067
56 https://doi.org/10.1126/science.286.5438.312
57 https://doi.org/10.1126/science.8346443
58 https://doi.org/10.1152/ajpcell.00109.2012
59 https://doi.org/10.1159/000107084
60 https://doi.org/10.1159/000285518
61 https://doi.org/10.1172/jci10498
62 https://doi.org/10.1177/1403494811399958
63 https://doi.org/10.1177/1403494811401482
64 https://doi.org/10.1212/wnl.34.7.939
65 https://doi.org/10.1212/wnl.43.2.250
66 https://doi.org/10.1242/jcs.00718
67 https://doi.org/10.1242/jcs.102913
68 https://doi.org/10.1371/journal.pgen.1004606
69 https://doi.org/10.1371/journal.ppat.1002383
70 https://doi.org/10.4061/2011/501862
71 schema:datePublished 2019-03-04
72 schema:datePublishedReg 2019-03-04
73 schema:description To test whether genetic variants in PICALM, BIN1, CD2AP, and RIN3-suggested to be involved in blood-brain barrier amyloid-β transcytosis pathways-associate with Alzheimer's disease, all dementia, suggested vascular dementia, and stroke, and whether such associations are independent of the strong ε4 APOE risk allele. In a prospective cohort study of 74,754 individuals from the general population we genotyped PICALM (rs10792832), BIN1 (rs6733839), CD2AP (rs10948363), and RIN3 (rs10498633), and generated a weighted and a simple allele score. Multifactorially adjusted hazard ratios for the fourth quartile versus the first quartile of the weighted allele score were 1.42 (95% confidence interval 1.22-1.64) for Alzheimer's disease, and 1.33 (1.19-1.48) for all dementia. For suggested vascular dementia and stroke the corresponding estimates were 1.71 (1.18-2.49) and 1.12 (1.04-1.22), respectively. Hazard ratios were similar after APOE adjustment. Genetic variants in PICALM, BIN1, CD2AP, and RIN3 are associated with increased risk of Alzheimer's disease, all dementia, and suggested vascular dementia independent of the strong APOE ε4 allele. These findings may suggest that clathrin-mediated endocytosis in clearance of amyloid-β across the blood-brain barrier is important for the integrity of both brain tissue and cerebral vessels.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf sg:journal.1095636
78 schema:name Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals
79 schema:pagination 1-12
80 schema:productId N1b34d653b56c49f4ab7a5aec5eaf083f
81 N1eb539e34cdb44d4b1d77f3627efec86
82 N225b38380d164943b89fe6655bc34237
83 N7781ea9b9f36406c98473fbf458cf1ae
84 Ndc291a6f355741d3a06d8793cfb0a072
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112514008
86 https://doi.org/10.1007/s10654-019-00498-2
87 schema:sdDatePublished 2019-04-11T10:59
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N09bc565858574df88df00bb2ae31a440
90 schema:url https://link.springer.com/10.1007%2Fs10654-019-00498-2
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N09bc565858574df88df00bb2ae31a440 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N0bfd43f453c94129a3863c1345948f95 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
97 schema:familyName Frikke-Schmidt
98 schema:givenName Ruth
99 rdf:type schema:Person
100 N137f76319ff14a44b5a6cf12084c11de schema:affiliation https://www.grid.ac/institutes/grid.411646.0
101 schema:familyName Nordestgaard
102 schema:givenName Børge G.
103 rdf:type schema:Person
104 N1b34d653b56c49f4ab7a5aec5eaf083f schema:name pubmed_id
105 schema:value 30830563
106 rdf:type schema:PropertyValue
107 N1eb539e34cdb44d4b1d77f3627efec86 schema:name dimensions_id
108 schema:value pub.1112514008
109 rdf:type schema:PropertyValue
110 N225b38380d164943b89fe6655bc34237 schema:name doi
111 schema:value 10.1007/s10654-019-00498-2
112 rdf:type schema:PropertyValue
113 N634945be43174365a322d60ac90d1d2b schema:affiliation https://www.grid.ac/institutes/grid.411646.0
114 schema:familyName Juul Rasmussen
115 schema:givenName Ida
116 rdf:type schema:Person
117 N6ff07af70d96484a8958d5c08a1329f7 rdf:first Neec68577640348348386a1ec005e1730
118 rdf:rest Nb206bc3c72494574bdeb543e84cf531e
119 N7781ea9b9f36406c98473fbf458cf1ae schema:name readcube_id
120 schema:value eb283fc31ef165a03ab7941591f96b8ccaa127448e7252e58f51fbc2cded6c63
121 rdf:type schema:PropertyValue
122 N7e27fbc7e2af4ad48393719f9ff77e00 rdf:first N634945be43174365a322d60ac90d1d2b
123 rdf:rest N6ff07af70d96484a8958d5c08a1329f7
124 N9c1727d76a314e18bee61eed5ffe6a67 rdf:first N137f76319ff14a44b5a6cf12084c11de
125 rdf:rest Ncd5ae6dacf3c47f18519bab00922b870
126 Nb206bc3c72494574bdeb543e84cf531e rdf:first Nc864a5281de94d329d9165df138b9748
127 rdf:rest N9c1727d76a314e18bee61eed5ffe6a67
128 Nc864a5281de94d329d9165df138b9748 schema:affiliation https://www.grid.ac/institutes/grid.411646.0
129 schema:familyName Rasmussen
130 schema:givenName Katrine Laura
131 rdf:type schema:Person
132 Ncd5ae6dacf3c47f18519bab00922b870 rdf:first N0bfd43f453c94129a3863c1345948f95
133 rdf:rest rdf:nil
134 Ndc291a6f355741d3a06d8793cfb0a072 schema:name nlm_unique_id
135 schema:value 8508062
136 rdf:type schema:PropertyValue
137 Neec68577640348348386a1ec005e1730 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
138 schema:familyName Tybjærg-Hansen
139 schema:givenName Anne
140 rdf:type schema:Person
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
145 schema:name Neurosciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1095636 schema:issn 0393-2990
148 1573-7284
149 schema:name European Journal of Epidemiology
150 rdf:type schema:Periodical
151 sg:pub.10.1007/s10654-015-0082-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014920697
152 https://doi.org/10.1007/s10654-015-0082-x
153 rdf:type schema:CreativeWork
154 sg:pub.10.1038/kisup.2012.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020397537
155 https://doi.org/10.1038/kisup.2012.73
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/nature08185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025133227
158 https://doi.org/10.1038/nature08185
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/nature11087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037025366
161 https://doi.org/10.1038/nature11087
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nature11133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050137360
164 https://doi.org/10.1038/nature11133
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/ng.2802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031397264
167 https://doi.org/10.1038/ng.2802
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/ng.439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018560935
170 https://doi.org/10.1038/ng.439
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/ng.440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007929967
173 https://doi.org/10.1038/ng.440
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/ng.801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006423654
176 https://doi.org/10.1038/ng.801
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/ng.803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044022105
179 https://doi.org/10.1038/ng.803
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nn.4018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041370090
182 https://doi.org/10.1038/nn.4018
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nn.4025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046181123
185 https://doi.org/10.1038/nn.4025
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nrn3114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053009946
188 https://doi.org/10.1038/nrn3114
189 rdf:type schema:CreativeWork
190 sg:pub.10.1186/s12916-018-1029-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101491443
191 https://doi.org/10.1186/s12916-018-1029-3
192 rdf:type schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1080284174 schema:CreativeWork
194 https://doi.org/10.1001/jama.1997.03540340047031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002377012
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1001/jama.2010.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014685397
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1001/jama.299.21.2524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019284777
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/acn3.506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099710431
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/ana.24326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049093974
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/0092-8674(91)90316-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1012923782
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0092-8674(92)90306-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1016052471
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0165-6147(91)90609-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1028134537
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.arr.2010.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033980788
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.cell.2011.10.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009790540
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.cell.2013.10.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040180265
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.jalz.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015460770
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.jalz.2014.05.1757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033293224
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.jalz.2015.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025815613
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.jalz.2015.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024086499
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.jalz.2017.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090995762
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.jalz.2018.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101296883
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.molmed.2013.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003926021
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.neuron.2013.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049367334
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0092-8674(00)81608-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019052978
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0166-2236(98)01264-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049340285
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0896-6273(01)00475-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037507194
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1056/nejmoa1308027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000463047
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1056/nejmra0909142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050272107
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1073/pnas.93.10.4804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003471963
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1074/jbc.272.26.16700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001059606
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1074/jbc.m115.637207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058213470
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1080/01621459.1999.10474144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058305593
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1083/jcb.135.4.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038164437
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1091/mbc.10.8.2687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017284802
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1091/mbc.8.10.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042762270
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/wad.0000000000000034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005189835
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1753-4887.2010.00352.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044787060
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1126/science.1072994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052597019
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.1197623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019286527
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1126/science.1213210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020576816
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1126/science.1566067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062491586
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/science.286.5438.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062566890
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1126/science.8346443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654771
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1152/ajpcell.00109.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015796196
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1159/000107084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012373687
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1159/000285518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028660641
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1172/jci10498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031916105
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1177/1403494811399958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064001916
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1177/1403494811401482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064001927
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1212/wnl.34.7.939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024664401
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1212/wnl.43.2.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064371394
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1242/jcs.00718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033899527
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1242/jcs.102913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041981797
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1371/journal.pgen.1004606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010418040
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1371/journal.ppat.1002383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040381982
295 rdf:type schema:CreativeWork
296 https://doi.org/10.4061/2011/501862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026774249
297 rdf:type schema:CreativeWork
298 https://www.grid.ac/institutes/grid.411646.0 schema:alternateName Gentofte Hospital
299 schema:name Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
300 Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark
301 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
302 The Copenhagen City Heart Study, Frederiksberg Hospital, 2000, Frederiksberg, Denmark
303 The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
306 schema:name Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
307 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
308 The Copenhagen City Heart Study, Frederiksberg Hospital, 2000, Frederiksberg, Denmark
309 The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...