Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07

AUTHORS

Bernhard M. Kaess, Tonia de las Heras Gala, Astrid Zierer, Christa Meisinger, Simone Wahl, Annette Peters, John Todd, Christian Herder, Cornelia Huth, Barbara Thorand, Wolfgang Koenig

ABSTRACT

Troponins are sensitive markers of myocardial injury and predictive of cardiovascular events, but conventional assays fail to detect slightly elevated troponins in a considerable proportion of the general population. Using a novel ultrasensitive assay, we explored the relationship of troponin levels with the incidence of coronary heart disease (CHD) in a case-cohort sample (mean age 52.5 ± 0.2 years, 51.5% women) comprising 803 CHD cases and 1942 non-cases. Ultrasensitive troponin I was detectable in 99.9% of available case-cohort samples. In an age- and sex-adjusted model, individuals in the highest quartile of the troponin distribution had a more than threefold increased risk for CHD events compared to those in the bottom quartile [hazard ratio, HR, 3.11; 95% confidence interval (CI) 2.15-4.49]. In a model adjusting for cardiovascular risk factors including C-reactive protein, cystatin C and N-terminal pro brain natriuretic peptide, individuals in the highest troponin I quartile still showed a hazard ratio of 2.58 (95% CI 1.66-4.00) for incident CHD as compared to those in the lowest quartile. Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD. More... »

PAGES

583-591

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10654-017-0266-7

DOI

http://dx.doi.org/10.1007/s10654-017-0266-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085862326

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28585121


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