Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04-02

AUTHORS

Michael T. Koller, Christian van Delden, Nicolas J. Müller, Philippe Baumann, Christian Lovis, Hans-Peter Marti, Thomas Fehr, Isabelle Binet, Sabina De Geest, Heiner C. Bucher, Pascal Meylan, Manuel Pascual, Jürg Steiger

ABSTRACT

In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients at the national level. The features of the STCS are a flexible patient-case system that allows capturing all transplant scenarios and collection of patient-specific and allograft-specific data. Beyond comprehensive clinical data, specific focus is directed at psychosocial and behavioral factors, infectious disease development, and bio-banking. Between May 2008 and end of 2011, the six Swiss transplant centers recruited 1,677 patients involving 1,721 transplantations, and a total of 1,800 organs implanted in 15 different transplantation scenarios. 10 % of all patients underwent re-transplantation and 3% had a second transplantation, either in the past or during follow-up. 34% of all kidney allografts originated from living donation. Until the end of 2011 we observed 4,385 infection episodes in our patient population. The STCS showed operative capabilities to collect high-quality data and to adequately reflect the complexity of the post-transplantation process. The STCS represents a promising novel project for comparative effectiveness research in transplantation medicine. More... »

PAGES

347-355

Journal

TITLE

European Journal of Epidemiology

ISSUE

4

VOLUME

28

Clinical Trials linked to this publication

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10654-012-9754-y

DOI

http://dx.doi.org/10.1007/s10654-012-9754-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026952332

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23546766


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