Acute exposure of embryo, larvae and adults of Danio rerio to fipronil commercial formulation reveals effects on development and motor ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-08

AUTHORS

André L. R. Cuenca, Juliana D. Simonato, Paulo C. Meletti

ABSTRACT

The insecticide fipronil, one of the main pesticides used in Brazil, is often detected in natural aquatic environments, and causes neuronal hyperexcitation by inhibiting GABAergic neurotransmission, leading to putative alterations in behaviour and development. This work sought to analyse the toxicity of formulated Regent® 800WG (80% fipronil) on development (fish embryo toxicity test, FET), morphology, and swimming behaviour of larvae and adults of zebrafish (Danio rerio). FET was performed following OECD236 guidelines at concentrations ranging from 0.002 to 1600 μg.L−1 of formulated Regent® 800WG. Adults were exposed to 0.2, 2 and 20 μg.L−1 of the product for 24 and 96 h, and were submitted to the light-dark, novel tank and swimming endurance tests No lethal parameters were observed in larvae, but in concentrations above 400 µg.L−1, there was shortening of the body axis and decreased swimming behavior. In adults, exposure to the pesticide did not lead to changes in free swimming parameters. However, a marked decrease of swimming endurance was observed at all experimental treatments, although probably not in consequence of energetic depletion, since baseline blood glucose levels and condition factor were similar at all conditions. Furthermore, zebrafish adults did not show their natural preference for the dark environment. The pesticide likely has anxiolytic effects on zebrafish, as well as a compromising effect on locomotor control, illustrating that behavioural changes, which could affect activities on the natural environment, such as escape and predation, may occur even in environmentally relevant concentrations of this pollutant. More... »

PAGES

114-123

References to SciGraph publications

  • 2014-09-19. Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2010-07-08. Behavioural ecotoxicology, an “early warning” signal to assess environmental quality in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2019-12-21. A mixture of fipronil and fungicides induces alterations on behavioral and oxidative stress parameters in zebrafish in ECOTOXICOLOGY
  • 2016-04-05. Effect of diphenyl diselenide diet supplementation on oxidative stress biomarkers in two species of freshwater fish exposed to the insecticide fipronil in FISH PHYSIOLOGY AND BIOCHEMISTRY
  • 2010-01-14. Scototaxis as anxiety-like behavior in fish in NATURE PROTOCOLS
  • 2010-08-02. Adult zebrafish as a model organism for behavioural genetics in BMC NEUROSCIENCE
  • 2013-06-28. Haemato-biochemical Responses in Cyprinus carpio (Linnaeus, 1758) Fry Exposed to Sub-lethal Concentration of a Phenylpyrazole Insecticide, Fipronil in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, INDIA SECTION B: BIOLOGICAL SCIENCES
  • 2005-03. Comparison of behavioral responses to a novel environment between three teleosts, bluegill Lepomis macrochirus, crucian carp Carassius langsdorfii, and goldfish Carassius auratus in FISHERIES SCIENCE
  • 2019-06-12. Glyphosate- and Fipronil-Based Agrochemicals and Their Mixtures Change Zebrafish Behavior in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2020-08-29. Acute and chronic toxicity of 2,4-D and fipronil formulations (individually and in mixture) to the Neotropical cladoceran Ceriodaphnia silvestrii in ECOTOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10646-021-02497-0

    DOI

    http://dx.doi.org/10.1007/s10646-021-02497-0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34748160


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