Current aspects of DNA damage and repair in ecotoxicology: a mini-review View Full Text


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Article Info

DATE

2021-10-08

AUTHORS

Pedro M. Costa

ABSTRACT

The preservation of genomic stability against environmental stressors is a major adaptive feature that is well-conserved among both prokaryotes and eukaryotes. The complex and fine-tuned mechanisms that evolved to repair DNA following exposure to radiation and chemical insult are also the first line of defence against genotoxicants. Consequently, impairing the DNA damage response leads to accumulation of genomic lesions that may ultimately lead to cell death, mutagenesis and even teratogenesis and neoplasia. Understanding how pollutants affect DNA repair machinery is thus paramount to interpret the often unclear or contradictory findings from genotoxicity assessment. The main purpose of the present mini-review is to contribute to the slowly-growing awareness among ecotoxicologists that DNA damage is not limited to direct interactions of noxious compounds with the DNA molecule. Despite the limited number of studies addressing this issue in the field, special modifications of methods for genotoxicity assessment, combined with state-of-the-art molecular tools, are beginning to show promising results in the unravelling of DNA repair proteins, genes and networks in non-conventional model organisms. I will review the essentials of the most important DNA repair pathways and discuss methods and approaches that can assist steering ecotoxicologists towards a better understanding of genotoxic hazard and risk. More... »

PAGES

1-11

References to SciGraph publications

  • 1999-12-13. Regulation of p53 in response to DNA damage in ONCOGENE
  • 2017-09-15. Cadmium effects on DNA and protein metabolism in oyster (Crassostrea gigas) revealed by proteomic analyses in SCIENTIFIC REPORTS
  • 2010-01-05. QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology in ECOTOXICOLOGY
  • 2015. Fluorescent In Situ Hybridization on Comets: FISH Comet in CHROMATIN PROTOCOLS
  • 1953-04-25. Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid in NATURE
  • 2015-10-06. DNA oxidation and DNA repair in gills of zebra mussels exposed to cadmium and benzo(a)pyrene in ECOTOXICOLOGY
  • 2017-05-17. Non-homologous DNA end joining and alternative pathways to double-strand break repair in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2018-02-26. Co-exposure to environmental carcinogens in vivo induces neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult in SCIENTIFIC REPORTS
  • 2007-12-24. A brief history of the DNA repair field in CELL RESEARCH
  • 2014-06-23. Understanding nucleotide excision repair and its roles in cancer and ageing in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-12-24. Mechanisms and functions of DNA mismatch repair in CELL RESEARCH
  • 2017-11-17. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? in CELL DEATH & DIFFERENTIATION
  • 2016-12-20. Protecting DNA from errors and damage: an overview of DNA repair mechanisms in plants compared to mammals in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2011-05-03. The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance in ARCHIVES OF TOXICOLOGY
  • 2010-02-04. γH2AX: a sensitive molecular marker of DNA damage and repair in LEUKEMIA
  • 2019-11-11. DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens in PARASITES & VECTORS
  • 2018-12-05. Formation of UV-induced DNA damage contributing to skin cancer development in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10646-021-02487-2

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    http://dx.doi.org/10.1007/s10646-021-02487-2

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    https://www.ncbi.nlm.nih.gov/pubmed/34623548


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