Generational sensitivity alteration in Chironomus yoshimatsui to carbamate and pharmaceutical chemicals and the effect on Catalase, CYP450, and hemoglobin gene ... View Full Text


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Article Info

DATE

2021-10-08

AUTHORS

Makoto Ishimota, Naruto Tomiyama

ABSTRACT

To ascertain the tolerance mechanisms of aquatic organisms to artificial chemicals, intergenerational sensitivity changes of Chironomus yoshimatsui to a carbamate pesticide (pirimicarb) and pharmaceutical chemical (diazepam) were investigated. The larvae (<48-h-old) in each generation were exposed to both chemicals for 48 h and then the surviving chironomids were cultured until the fifth generation (F0–F4) without chemical addition. The 48-h 50% effective concentration (EC50) value of chironomids was determined for each generation. In the pirimicarb treatment group, the EC50 values significantly increased in F3 and F4, and those in the diazepam treatment group slightly increased. Catalase, Cytochrome P450 and hemoglobin (Hb) mRNA levels were monitored to see whether these were related to the trans-generational sensitivity. Although the generalized linear model results showed that the sensitivity to diazepam was slightly increased in the diazepam treatment, we could not find any mRNA levels related to sensitivity alteration. In contrast, the model approach showed that the chironomids exposed to pirimicarb trans-generationally became tolerant with increasing Hb mRNA levels. Therefore, they might decrease their chemical stress by modifying Hb gene transcription. More... »

PAGES

2119-2131

References to SciGraph publications

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  • 1995-11. Alterations in life-history traits of Chironomus riparius (diptera) obtained from metal contaminated rivers in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
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  • 2012-05. Peculiarities of structural organization of hemoglobin of Chiromonus plumosus L. (Diptera: Chironomidae) in JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
  • 2018-03-15. Acute and Chronic Effects of Three Pharmaceutical Drugs on the Tropical Freshwater Cladoceran Ceriodaphnia silvestrii in WATER, AIR, & SOIL POLLUTION
  • 2020-06-03. Long-Term Tolerance Acquisition and Changes in Acetylcholinesterase Activity in Three Cladoceran Species After a 48-H Pulsed Exposure to Pirimicarb in WATER, AIR, & SOIL POLLUTION
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    http://scigraph.springernature.com/pub.10.1007/s10646-021-02484-5

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    PUBMED

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