Vitellogenin-like gene expression in freshwater amphipod Gammarus fossarum (Koch, 1835): functional characterization in females and potential for use as an ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-06-24

AUTHORS

Benoît Xuereb, Laurent Bezin, Arnaud Chaumot, Hélène Budzinski, Sylvie Augagneur, Renaud Tutundjian, Jeanne Garric, Olivier Geffard

ABSTRACT

The induction of vitellogenin (Vtg) synthesis is widely accepted as a biomarker of estrogenic exposure in male and juvenile fish. Vtg synthesis has emerged as an interesting endpoint to assess endocrine disruptor (ED) effects in crustaceans. However, studies reporting induction of Vtg in male crustaceans are lacking. This study investigated the expression of the Vtg gene in a freshwater amphipod, Gammarus fossarum, using calibrated real-time reverse transcription polymerase chain reaction (real-time RT PCR). First, we described the basal pattern of expression in healthy male and female organisms at different reproductive moult stages, in order to validate the function of this gene. Females expressed from 200 to 700 times more Vtg transcripts than males, depending on the female reproductive stage. Females displayed significant elevation of VtgmRNA levels at the end of the inter-moult phase and at the beginning of the pre-moult phase. Second, male gammarids were exposed to the estrogenic compound nonylphenol (NP) (0.05, 0.5, 5 and 50 μg L−1) and to the anti-androgen cyproterone (1, 10, 100 and 1000 μg L−1) for 2, 4, 8 and 16 days. Both chemicals altered the pattern of interindividual variability of Vtg gene expression in males with strong induction in some individuals. Finally, the impact of urban wastewater treatment plants (WWTP) on male Vtg gene expression was assessed in organisms transplanted in the field during in situ bioassay campaigns in three different watersheds. Induction of the Vtg mRNA level was observed in males transplanted downstream from WWTP effluent discharge in two of the three study sites. More... »

PAGES

1286-1299

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10646-011-0685-2

DOI

http://dx.doi.org/10.1007/s10646-011-0685-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051252348

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21701845


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79 freshwater amphipod
80 freshwater amphipod Gammarus fossarum
81 function
82 functional characterization
83 gammarids
84 gene expression
85 genes
86 impact
87 individuals
88 induction
89 induction of Vtg
90 inter-moult phase
91 interesting endpoint
92 interindividual variability
93 juvenile fish
94 levels
95 mRNA levels
96 male Vtg gene expression
97 male crustaceans
98 male gammarids
99 males
100 molt stage
101 more Vtg transcripts
102 nonylphenol
103 order
104 organisms
105 patterns
106 phase
107 plants
108 polymerase chain reaction
109 potential
110 pre-moult phase
111 reaction
112 real-time reverse transcription-polymerase chain reaction
113 reproductive moult stages
114 reproductive stage
115 reverse transcription-polymerase chain reaction
116 significant elevation
117 sites
118 situ bioassay campaigns
119 stage
120 strong induction
121 study
122 study sites
123 synthesis
124 times more Vtg transcripts
125 transcription-polymerase chain reaction
126 transcripts
127 treatment plants
128 urban wastewater treatment plants
129 use
130 variability
131 vitellogenin synthesis
132 vtg transcripts
133 wastewater treatment plants
134 watersheds
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