Novel thiosemicarbazones induce high toxicity in estrogen-receptor-positive breast cancer cells (MCF7) and exacerbate cisplatin effectiveness in triple-negative breast (MDA-MB231) and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06-08

AUTHORS

Estefany Ingrid Medina-Reyes, Marco Antonio Mancera-Rodríguez, Norma Laura Delgado-Buenrostro, Adriana Moreno-Rodríguez, Juan Luis Bautista-Martínez, Clara Estela Díaz-Velásquez, Stefanía Andrea Martínez-Alarcón, Hugo Torrens, María de los Ángeles Godínez-Rodríguez, Luis Ignacio Terrazas-Valdés, Yolanda Irasema Chirino, Felipe Vaca-Paniagua

ABSTRACT

Cis-diamminedichloroplatinum(II) (CDDP), known as cisplatin, has been extensively used against breast cancer, which is the most frequent cancer among women, and lung cancer, the leading cancer that causes death worldwide. Novel compounds such as thiazole derivatives have exhibited antiproliferative activity, suggesting they could be useful against cancer treatment. Herein, we synthesized two novel thiosemicarbazones and an aldehyde to combine with CDDP to enhance efficacy against ER-positive breast MCF7 cancer cells, triple-negative/basal-B mammary carcinoma cells (MDA-MB231) and lung adenocarcinoma (A549) human cells. We synthesized 2,3,5,6-tetrafluoro-4-(2-mercaptoetanothiolyl)benzaldehyde (ALD), 5-[(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC1) and 5-[(4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC2) and used them alone or in combination with subtoxic CDDP concentrations to evaluate cytotoxicity, cytoskeleton integrity and mitochondrial function. We found that none of the synthesized compounds improved CDDP activity against MCF7 cell cultures; however, TSC2 was effective in enhancing the cytotoxicity of CDDP against MDA-MB231 and A549 cancer cell cultures. We demonstrated that the cytotoxic effect is related to the TSC2 capacity to induce disruption in the cytoskeleton network and to decrease mitochondrial function. More... »

PAGES

558-573

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10637-019-00789-1

DOI

http://dx.doi.org/10.1007/s10637-019-00789-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1116997458

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31177399


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "A549 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma of Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MCF-7 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiosemicarbazones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triple Negative Breast Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Medina-Reyes", 
        "givenName": "Estefany Ingrid", 
        "id": "sg:person.0733633222.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733633222.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mancera-Rodr\u00edguez", 
        "givenName": "Marco Antonio", 
        "id": "sg:person.011354602233.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011354602233.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delgado-Buenrostro", 
        "givenName": "Norma Laura", 
        "id": "sg:person.01115757642.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115757642.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma Benito Ju\u00e1rez, Oaxaca, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.440442.2", 
          "name": [
            "Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma Benito Ju\u00e1rez, Oaxaca, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno-Rodr\u00edguez", 
        "givenName": "Adriana", 
        "id": "sg:person.0617475022.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617475022.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma Benito Ju\u00e1rez, Oaxaca, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.440442.2", 
          "name": [
            "Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma Benito Ju\u00e1rez, Oaxaca, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bautista-Mart\u00ednez", 
        "givenName": "Juan Luis", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio Nacional en Salud: Diagn\u00f3stico Molecular y Efecto Ambiental en Enfermedades Cr\u00f3nico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Laboratorio Nacional en Salud: Diagn\u00f3stico Molecular y Efecto Ambiental en Enfermedades Cr\u00f3nico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u00edaz-Vel\u00e1squez", 
        "givenName": "Clara Estela", 
        "id": "sg:person.015651151735.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015651151735.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez-Alarc\u00f3n", 
        "givenName": "Stefan\u00eda Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torrens", 
        "givenName": "Hugo", 
        "id": "sg:person.0631321406.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631321406.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Carrera de Enfermer\u00eda, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Carrera de Enfermer\u00eda, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de los \u00c1ngeles God\u00ednez-Rodr\u00edguez", 
        "givenName": "Mar\u00eda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio Nacional en Salud: Diagn\u00f3stico Molecular y Efecto Ambiental en Enfermedades Cr\u00f3nico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
            "Laboratorio Nacional en Salud: Diagn\u00f3stico Molecular y Efecto Ambiental en Enfermedades Cr\u00f3nico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terrazas-Vald\u00e9s", 
        "givenName": "Luis Ignacio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chirino", 
        "givenName": "Yolanda Irasema", 
        "id": "sg:person.01170625340.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170625340.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda, San Fernando No. 22, Tlalpan, CP 14080, Ciudad de M\u00e9xico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419167.c", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
            "Laboratorio Nacional en Salud: Diagn\u00f3stico Molecular y Efecto Ambiental en Enfermedades Cr\u00f3nico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de M\u00e9xico, Mexico", 
            "Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda, San Fernando No. 22, Tlalpan, CP 14080, Ciudad de M\u00e9xico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaca-Paniagua", 
        "givenName": "Felipe", 
        "id": "sg:person.01355004143.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355004143.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10637-007-9044-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027831604", 
          "https://doi.org/10.1007/s10637-007-9044-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/205698a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050458887", 
          "https://doi.org/10.1038/205698a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13045-016-0330-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051794356", 
          "https://doi.org/10.1186/s13045-016-0330-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-06-08", 
    "datePublishedReg": "2019-06-08", 
    "description": "Cis-diamminedichloroplatinum(II) (CDDP), known as cisplatin, has been extensively used against breast cancer, which is the most frequent cancer among women, and lung cancer, the leading cancer that causes death worldwide. Novel compounds such as thiazole derivatives have exhibited antiproliferative activity, suggesting they could be useful against cancer treatment. Herein, we synthesized two novel thiosemicarbazones and an aldehyde to combine with CDDP to enhance efficacy against ER-positive breast MCF7 cancer cells, triple-negative/basal-B mammary carcinoma cells (MDA-MB231) and lung adenocarcinoma (A549) human cells. We synthesized 2,3,5,6-tetrafluoro-4-(2-mercaptoetanothiolyl)benzaldehyde (ALD), 5-[(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC1) and 5-[(4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC2) and used them alone or in combination with subtoxic CDDP concentrations to evaluate cytotoxicity, cytoskeleton integrity and mitochondrial function. We found that none of the synthesized compounds improved CDDP activity against MCF7 cell cultures; however, TSC2 was effective in enhancing the cytotoxicity of CDDP against MDA-MB231 and A549 cancer cell cultures. We demonstrated that the cytotoxic effect is related to the TSC2 capacity to induce disruption in the cytoskeleton network and to decrease mitochondrial function.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10637-019-00789-1", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094201", 
        "issn": [
          "0167-6997", 
          "1573-0646"
        ], 
        "name": "Investigational New Drugs", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "keywords": [
      "positive breast cancer cells", 
      "cancer cells", 
      "mitochondrial function", 
      "triple-negative breast", 
      "breast cancer cells", 
      "mammary carcinoma cells", 
      "cytotoxicity of CDDP", 
      "lung adenocarcinoma cells", 
      "frequent cancer", 
      "lung cancer", 
      "MCF7 cell cultures", 
      "breast cancer", 
      "CDDP concentrations", 
      "cell cultures", 
      "cancer cell cultures", 
      "cancer", 
      "cancer treatment", 
      "adenocarcinoma cells", 
      "carcinoma cells", 
      "MDA-MB231", 
      "cisplatin effectiveness", 
      "cytotoxic effects", 
      "novel thiosemicarbazones", 
      "CDDP activity", 
      "CDDP", 
      "MCF7 cancer cells", 
      "antiproliferative activity", 
      "cells", 
      "novel compounds", 
      "cytotoxicity", 
      "human cells", 
      "cytoskeleton integrity", 
      "breast", 
      "cisplatin", 
      "women", 
      "efficacy", 
      "death", 
      "treatment", 
      "high toxicity", 
      "activity", 
      "toxicity", 
      "TSC2", 
      "culture", 
      "thiazole derivatives", 
      "disruption", 
      "function", 
      "cytoskeleton network", 
      "effect", 
      "concentration", 
      "cis", 
      "compounds", 
      "combination", 
      "integrity", 
      "effectiveness", 
      "Herein", 
      "capacity", 
      "thiosemicarbazone", 
      "derivatives", 
      "tetrafluoro-4", 
      "aldehydes", 
      "network"
    ], 
    "name": "Novel thiosemicarbazones induce high toxicity in estrogen-receptor-positive breast cancer cells (MCF7) and exacerbate cisplatin effectiveness in triple-negative breast (MDA-MB231) and lung adenocarcinoma (A549) cells", 
    "pagination": "558-573", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1116997458"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10637-019-00789-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31177399"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10637-019-00789-1", 
      "https://app.dimensions.ai/details/publication/pub.1116997458"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_830.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10637-019-00789-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10637-019-00789-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10637-019-00789-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10637-019-00789-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10637-019-00789-1'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      103 URIs      92 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10637-019-00789-1 schema:about N1baf04d835de4a32af36923e2bb841ac
2 N2b99186861924904aa453bd6f8893d0d
3 N30a8378f36b64a0da2ec539584e200c9
4 N3c1e924de4624048b56f3301fd58320a
5 N447f96314ca742d8a9540c7e693a8f51
6 N459e62ad62a646ca947dab5bd992dbba
7 N577ea47242034aeb95d8fd137de092a5
8 N647b4c396c274b0ebd3cacbe9656971a
9 N705ea59534e44609af58786bcbcf52e6
10 N97cb9c4707b9495c8e925a445c4b1844
11 Na0abef7a411548c188b3c64c3a7c39fd
12 Nc4b3dbee72a94d7587071639e870530c
13 Nd9e176427ec34df6bf3b63204fbb89f7
14 Nf1633bc08fb1432ca6c1fc7ff5d26148
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N3f6470e9bc7342a9afe7384931dd5a10
18 schema:citation sg:pub.10.1007/s10637-007-9044-9
19 sg:pub.10.1038/205698a0
20 sg:pub.10.1186/s13045-016-0330-x
21 schema:datePublished 2019-06-08
22 schema:datePublishedReg 2019-06-08
23 schema:description Cis-diamminedichloroplatinum(II) (CDDP), known as cisplatin, has been extensively used against breast cancer, which is the most frequent cancer among women, and lung cancer, the leading cancer that causes death worldwide. Novel compounds such as thiazole derivatives have exhibited antiproliferative activity, suggesting they could be useful against cancer treatment. Herein, we synthesized two novel thiosemicarbazones and an aldehyde to combine with CDDP to enhance efficacy against ER-positive breast MCF7 cancer cells, triple-negative/basal-B mammary carcinoma cells (MDA-MB231) and lung adenocarcinoma (A549) human cells. We synthesized 2,3,5,6-tetrafluoro-4-(2-mercaptoetanothiolyl)benzaldehyde (ALD), 5-[(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC1) and 5-[(4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC2) and used them alone or in combination with subtoxic CDDP concentrations to evaluate cytotoxicity, cytoskeleton integrity and mitochondrial function. We found that none of the synthesized compounds improved CDDP activity against MCF7 cell cultures; however, TSC2 was effective in enhancing the cytotoxicity of CDDP against MDA-MB231 and A549 cancer cell cultures. We demonstrated that the cytotoxic effect is related to the TSC2 capacity to induce disruption in the cytoskeleton network and to decrease mitochondrial function.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf Nb50537b6547f45f1ad09b4d620c28634
27 Nd5e542b65fa34f83b219f34bd5802c0e
28 sg:journal.1094201
29 schema:keywords CDDP
30 CDDP activity
31 CDDP concentrations
32 Herein
33 MCF7 cancer cells
34 MCF7 cell cultures
35 MDA-MB231
36 TSC2
37 activity
38 adenocarcinoma cells
39 aldehydes
40 antiproliferative activity
41 breast
42 breast cancer
43 breast cancer cells
44 cancer
45 cancer cell cultures
46 cancer cells
47 cancer treatment
48 capacity
49 carcinoma cells
50 cell cultures
51 cells
52 cis
53 cisplatin
54 cisplatin effectiveness
55 combination
56 compounds
57 concentration
58 culture
59 cytoskeleton integrity
60 cytoskeleton network
61 cytotoxic effects
62 cytotoxicity
63 cytotoxicity of CDDP
64 death
65 derivatives
66 disruption
67 effect
68 effectiveness
69 efficacy
70 frequent cancer
71 function
72 high toxicity
73 human cells
74 integrity
75 lung adenocarcinoma cells
76 lung cancer
77 mammary carcinoma cells
78 mitochondrial function
79 network
80 novel compounds
81 novel thiosemicarbazones
82 positive breast cancer cells
83 tetrafluoro-4
84 thiazole derivatives
85 thiosemicarbazone
86 toxicity
87 treatment
88 triple-negative breast
89 women
90 schema:name Novel thiosemicarbazones induce high toxicity in estrogen-receptor-positive breast cancer cells (MCF7) and exacerbate cisplatin effectiveness in triple-negative breast (MDA-MB231) and lung adenocarcinoma (A549) cells
91 schema:pagination 558-573
92 schema:productId N049a9ad568c943efb542489a2b2ebc8e
93 N25f5f6eedef142d59f559c2683053c40
94 N32cd26874ba144268acbdc1f14f6b7d6
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1116997458
96 https://doi.org/10.1007/s10637-019-00789-1
97 schema:sdDatePublished 2022-10-01T06:46
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher Nd7f7debbe1394a809ad0fb62aaccbd6c
100 schema:url https://doi.org/10.1007/s10637-019-00789-1
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N049a9ad568c943efb542489a2b2ebc8e schema:name dimensions_id
105 schema:value pub.1116997458
106 rdf:type schema:PropertyValue
107 N1baf04d835de4a32af36923e2bb841ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Receptors, Estrogen
109 rdf:type schema:DefinedTerm
110 N1df7e490a6be46529b8516d32fa66ed4 rdf:first sg:person.01115757642.88
111 rdf:rest Nbb275fcc311a460dbb353f9913acc7cb
112 N22d759beed1c47c5aac0d7389f473a16 rdf:first N973ee3a7a1834fab9180f9274d3161b4
113 rdf:rest Na14228a116bb431bb23b93a51e00cac4
114 N25f5f6eedef142d59f559c2683053c40 schema:name pubmed_id
115 schema:value 31177399
116 rdf:type schema:PropertyValue
117 N2a880729b3764ffb930c0f8a73258143 schema:affiliation grid-institutes:grid.9486.3
118 schema:familyName Martínez-Alarcón
119 schema:givenName Stefanía Andrea
120 rdf:type schema:Person
121 N2b99186861924904aa453bd6f8893d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N30a8378f36b64a0da2ec539584e200c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Estrogens
126 rdf:type schema:DefinedTerm
127 N32cd26874ba144268acbdc1f14f6b7d6 schema:name doi
128 schema:value 10.1007/s10637-019-00789-1
129 rdf:type schema:PropertyValue
130 N3c1e924de4624048b56f3301fd58320a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Antineoplastic Agents
132 rdf:type schema:DefinedTerm
133 N3f6470e9bc7342a9afe7384931dd5a10 rdf:first sg:person.0733633222.06
134 rdf:rest N695dabeb36cb426ca121d0bc4d6587f4
135 N447f96314ca742d8a9540c7e693a8f51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adenocarcinoma of Lung
137 rdf:type schema:DefinedTerm
138 N459e62ad62a646ca947dab5bd992dbba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Thiosemicarbazones
140 rdf:type schema:DefinedTerm
141 N577ea47242034aeb95d8fd137de092a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name A549 Cells
143 rdf:type schema:DefinedTerm
144 N57f033f2f8c94204a3b578046b64e127 rdf:first sg:person.01355004143.55
145 rdf:rest rdf:nil
146 N647b4c396c274b0ebd3cacbe9656971a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Lung Neoplasms
148 rdf:type schema:DefinedTerm
149 N695dabeb36cb426ca121d0bc4d6587f4 rdf:first sg:person.011354602233.09
150 rdf:rest N1df7e490a6be46529b8516d32fa66ed4
151 N705ea59534e44609af58786bcbcf52e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name MCF-7 Cells
153 rdf:type schema:DefinedTerm
154 N74990fa63b56422badca117302dc01fe rdf:first sg:person.01170625340.45
155 rdf:rest N57f033f2f8c94204a3b578046b64e127
156 N8a01310f8b3c45c7b630c02eb533e618 rdf:first sg:person.0631321406.92
157 rdf:rest N22d759beed1c47c5aac0d7389f473a16
158 N95182b28ebcd46a4971801350335620d rdf:first N2a880729b3764ffb930c0f8a73258143
159 rdf:rest N8a01310f8b3c45c7b630c02eb533e618
160 N973ee3a7a1834fab9180f9274d3161b4 schema:affiliation grid-institutes:grid.9486.3
161 schema:familyName de los Ángeles Godínez-Rodríguez
162 schema:givenName María
163 rdf:type schema:Person
164 N97cb9c4707b9495c8e925a445c4b1844 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Line, Tumor
166 rdf:type schema:DefinedTerm
167 N98c6854ffc5a4b55a1e73c007ffed6ae rdf:first Nf7ea5a7bc1e14e679b3e0836710c6a2e
168 rdf:rest Na5fd7123976b43ae8533ecb1e151b466
169 Na0abef7a411548c188b3c64c3a7c39fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Female
171 rdf:type schema:DefinedTerm
172 Na14228a116bb431bb23b93a51e00cac4 rdf:first Nfe514f3c66ab45d99fa349fdb5154648
173 rdf:rest N74990fa63b56422badca117302dc01fe
174 Na5fd7123976b43ae8533ecb1e151b466 rdf:first sg:person.015651151735.08
175 rdf:rest N95182b28ebcd46a4971801350335620d
176 Nb50537b6547f45f1ad09b4d620c28634 schema:volumeNumber 38
177 rdf:type schema:PublicationVolume
178 Nbb275fcc311a460dbb353f9913acc7cb rdf:first sg:person.0617475022.34
179 rdf:rest N98c6854ffc5a4b55a1e73c007ffed6ae
180 Nc4b3dbee72a94d7587071639e870530c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Cell Proliferation
182 rdf:type schema:DefinedTerm
183 Nd5e542b65fa34f83b219f34bd5802c0e schema:issueNumber 3
184 rdf:type schema:PublicationIssue
185 Nd7f7debbe1394a809ad0fb62aaccbd6c schema:name Springer Nature - SN SciGraph project
186 rdf:type schema:Organization
187 Nd9e176427ec34df6bf3b63204fbb89f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Cisplatin
189 rdf:type schema:DefinedTerm
190 Nf1633bc08fb1432ca6c1fc7ff5d26148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Triple Negative Breast Neoplasms
192 rdf:type schema:DefinedTerm
193 Nf7ea5a7bc1e14e679b3e0836710c6a2e schema:affiliation grid-institutes:grid.440442.2
194 schema:familyName Bautista-Martínez
195 schema:givenName Juan Luis
196 rdf:type schema:Person
197 Nfe514f3c66ab45d99fa349fdb5154648 schema:affiliation grid-institutes:grid.9486.3
198 schema:familyName Terrazas-Valdés
199 schema:givenName Luis Ignacio
200 rdf:type schema:Person
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
205 schema:name Oncology and Carcinogenesis
206 rdf:type schema:DefinedTerm
207 sg:journal.1094201 schema:issn 0167-6997
208 1573-0646
209 schema:name Investigational New Drugs
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01115757642.88 schema:affiliation grid-institutes:grid.9486.3
213 schema:familyName Delgado-Buenrostro
214 schema:givenName Norma Laura
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115757642.88
216 rdf:type schema:Person
217 sg:person.011354602233.09 schema:affiliation grid-institutes:grid.9486.3
218 schema:familyName Mancera-Rodríguez
219 schema:givenName Marco Antonio
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011354602233.09
221 rdf:type schema:Person
222 sg:person.01170625340.45 schema:affiliation grid-institutes:grid.9486.3
223 schema:familyName Chirino
224 schema:givenName Yolanda Irasema
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170625340.45
226 rdf:type schema:Person
227 sg:person.01355004143.55 schema:affiliation grid-institutes:grid.419167.c
228 schema:familyName Vaca-Paniagua
229 schema:givenName Felipe
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355004143.55
231 rdf:type schema:Person
232 sg:person.015651151735.08 schema:affiliation grid-institutes:grid.9486.3
233 schema:familyName Díaz-Velásquez
234 schema:givenName Clara Estela
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015651151735.08
236 rdf:type schema:Person
237 sg:person.0617475022.34 schema:affiliation grid-institutes:grid.440442.2
238 schema:familyName Moreno-Rodríguez
239 schema:givenName Adriana
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617475022.34
241 rdf:type schema:Person
242 sg:person.0631321406.92 schema:affiliation grid-institutes:grid.9486.3
243 schema:familyName Torrens
244 schema:givenName Hugo
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631321406.92
246 rdf:type schema:Person
247 sg:person.0733633222.06 schema:affiliation grid-institutes:grid.9486.3
248 schema:familyName Medina-Reyes
249 schema:givenName Estefany Ingrid
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733633222.06
251 rdf:type schema:Person
252 sg:pub.10.1007/s10637-007-9044-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027831604
253 https://doi.org/10.1007/s10637-007-9044-9
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/205698a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050458887
256 https://doi.org/10.1038/205698a0
257 rdf:type schema:CreativeWork
258 sg:pub.10.1186/s13045-016-0330-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051794356
259 https://doi.org/10.1186/s13045-016-0330-x
260 rdf:type schema:CreativeWork
261 grid-institutes:grid.419167.c schema:alternateName Subdirección de Investigación Básica, Instituto Nacional de Cancerología, San Fernando No. 22, Tlalpan, CP 14080, Ciudad de México, Mexico
262 schema:name Laboratorio Nacional en Salud: Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
263 Subdirección de Investigación Básica, Instituto Nacional de Cancerología, San Fernando No. 22, Tlalpan, CP 14080, Ciudad de México, Mexico
264 Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
265 rdf:type schema:Organization
266 grid-institutes:grid.440442.2 schema:alternateName Facultad de Ciencias Químicas, Universidad Autónoma Benito Juárez, Oaxaca, Mexico
267 schema:name Facultad de Ciencias Químicas, Universidad Autónoma Benito Juárez, Oaxaca, Mexico
268 rdf:type schema:Organization
269 grid-institutes:grid.9486.3 schema:alternateName Carrera de Enfermería, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
270 Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México
271 Laboratorio Nacional en Salud: Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
272 Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
273 schema:name Carrera de Enfermería, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
274 Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México
275 Laboratorio Nacional en Salud: Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
276 Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, CP 54059, Tlalnepantla, Estado de México, Mexico
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...