A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-09

AUTHORS

Lillian M. Smyth, Kelsey R. Monson, Komal Jhaveri, Alexander Drilon, Bob T. Li, Wassim Abida, Gopa Iyer, John F. Gerecitano, Mrinal Gounder, James J. Harding, Martin H. Voss, Vicky Makker, Alan L. Ho, Pedram Razavi, Alexia Iasonos, Philip Bialer, Mario E. Lacouture, Jerrold B. Teitcher, Joseph P. Erinjeri, Nora Katabi, Matthew G. Fury, David M. Hyman

ABSTRACT

Purpose We previously reported the phase I dose escalation study of buparlisib, a pan-class 1A PI3K inhibitor, combined with platinum/taxane-based chemotherapy in patients with advanced solid tumors. The combination was well tolerated and promising preliminary efficacy was observed in PTEN deficient tumors. This phase I dose expansion study now evaluates buparlisib plus high dose carboplatin and paclitaxel in unselected patients with advanced solid tumors and buparlisib plus standard dose carboplatin and paclitaxel in patients with PTEN deficient tumors (ClinicalTrials.gov, NCT01297452). Methods There were two expansion cohorts: Cohort A received continuous buparlisib (100 mg/daily) orally plus high dose carboplatin AUC 6 and paclitaxel 200 mg/m2; Cohort B treated patients with PTEN deficient tumors only and they received the recommended phase II dose (RP2D) of continuous buparlisib (100 mg/daily) orally plus standard dose carboplatin AUC 5 and paclitaxel 175 mg/m2. Both cohorts received chemotherapy intravenously on day 1 of the 21-day cycle with pegfilgrastim support. Primary endpoint in Cohort A was to evaluate the safety and tolerability of chemotherapy dose intensification with buparlisib and in Cohort B was to describe preliminary efficacy of the combination among patients with tumors harboring a PTEN mutation or homozygous deletion. Results 14 subjects were enrolled, 7 in Cohort A and 7 in Cohort B. Dose reductions were required in 5 (71%) and 3 (43%) patients, in cohort A and B respectively. Grade 3 adverse events in Cohort A included lymphopenia (n = 5 [71%]), hyperglycemia (n = 2, [29%]), diarrhea (n = 2, [29%]) and rash (n = 2, [29%]) and in cohort B included lymphopenia (n = 5 [71%]), hyperglycemia (n = 4 [57%]) and neutropenia (n = 2 [29%]. The mean number of cycles on protocol was 6. The overall objective response rate was 14% (2 /14). No objective responses were observed in the PTEN deficient cohort. Four out of 6 patients with stable disease (SD) had SD or better for ≥6 cycles, 2 of which had PTEN deficient tumors. Conclusion The addition of buparlisib to high dose carboplatin and paclitaxel was not tolerable. The combination did not reveal significant clinical activity amongst a small and heterogenous group of PTEN deficient tumors, More... »

PAGES

742-750

Journal

TITLE

Investigational New Drugs

ISSUE

6

VOLUME

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10637-017-0445-0

DOI

http://dx.doi.org/10.1007/s10637-017-0445-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084025947

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28281183


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aminopyridines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carboplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maximum Tolerated Dose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Morpholines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paclitaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoinositide-3 Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smyth", 
        "givenName": "Lillian M.", 
        "id": "sg:person.012202131030.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012202131030.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monson", 
        "givenName": "Kelsey R.", 
        "id": "sg:person.01317656002.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317656002.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jhaveri", 
        "givenName": "Komal", 
        "id": "sg:person.01115006020.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115006020.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drilon", 
        "givenName": "Alexander", 
        "id": "sg:person.01355654660.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355654660.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Bob T.", 
        "id": "sg:person.01270325306.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270325306.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abida", 
        "givenName": "Wassim", 
        "id": "sg:person.0762116241.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762116241.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iyer", 
        "givenName": "Gopa", 
        "id": "sg:person.014635271363.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014635271363.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gerecitano", 
        "givenName": "John F.", 
        "id": "sg:person.0731357515.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731357515.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gounder", 
        "givenName": "Mrinal", 
        "id": "sg:person.0676140273.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676140273.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harding", 
        "givenName": "James J.", 
        "id": "sg:person.01154466504.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154466504.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voss", 
        "givenName": "Martin H.", 
        "id": "sg:person.0577111044.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577111044.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Makker", 
        "givenName": "Vicky", 
        "id": "sg:person.01365124571.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365124571.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ho", 
        "givenName": "Alan L.", 
        "id": "sg:person.011024272057.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011024272057.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Razavi", 
        "givenName": "Pedram", 
        "id": "sg:person.01352541065.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352541065.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iasonos", 
        "givenName": "Alexia", 
        "id": "sg:person.01331724606.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331724606.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bialer", 
        "givenName": "Philip", 
        "id": "sg:person.01272234306.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272234306.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacouture", 
        "givenName": "Mario E.", 
        "id": "sg:person.01105036134.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105036134.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teitcher", 
        "givenName": "Jerrold B.", 
        "id": "sg:person.01077731164.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077731164.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erinjeri", 
        "givenName": "Joseph P.", 
        "id": "sg:person.01365111477.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365111477.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katabi", 
        "givenName": "Nora", 
        "id": "sg:person.0653035177.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653035177.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.418961.3", 
          "name": [
            "Oncology Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fury", 
        "givenName": "Matthew G.", 
        "id": "sg:person.01262212677.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262212677.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hyman", 
        "givenName": "David M.", 
        "id": "sg:person.01147411161.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147411161.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00280-015-2693-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044021272", 
          "https://doi.org/10.1007/s00280-015-2693-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-011-1572-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042247302", 
          "https://doi.org/10.1007/s10549-011-1572-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1525-1497.2001.016009606.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002964461", 
          "https://doi.org/10.1046/j.1525-1497.2001.016009606.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014023118", 
          "https://doi.org/10.1038/nrc839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-010-0492-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027836042", 
          "https://doi.org/10.1007/s11060-010-0492-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034861855", 
          "https://doi.org/10.1038/nature07091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008398399", 
          "https://doi.org/10.1038/onc.2008.241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2015.194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001580074", 
          "https://doi.org/10.1038/nrclinonc.2015.194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040868228", 
          "https://doi.org/10.1038/nrm3330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016821519", 
          "https://doi.org/10.1038/nrc2664"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03-09", 
    "datePublishedReg": "2017-03-09", 
    "description": "Purpose We previously reported the phase I dose escalation study of buparlisib, a pan-class 1A PI3K inhibitor, combined with platinum/taxane-based chemotherapy in patients with advanced solid tumors. The combination was well tolerated and promising preliminary efficacy was observed in PTEN deficient tumors. This phase I dose expansion study now evaluates buparlisib plus high dose carboplatin and paclitaxel in unselected patients with advanced solid tumors and buparlisib plus standard dose carboplatin and paclitaxel in patients with PTEN deficient tumors (ClinicalTrials.gov, NCT01297452). Methods There were two expansion cohorts: Cohort A received continuous buparlisib (100\u00a0mg/daily) orally plus high dose carboplatin AUC 6 and paclitaxel 200\u00a0mg/m2; Cohort B treated patients with PTEN deficient tumors only and they received the recommended phase II dose (RP2D) of continuous buparlisib (100\u00a0mg/daily) orally plus standard dose carboplatin AUC 5 and paclitaxel 175\u00a0mg/m2. Both cohorts received chemotherapy intravenously on day 1 of the 21-day cycle with pegfilgrastim support. Primary endpoint in Cohort A was to evaluate the safety and tolerability of chemotherapy dose intensification with buparlisib and in Cohort B was to describe preliminary efficacy of the combination among patients with tumors harboring a PTEN mutation or homozygous deletion. Results 14 subjects were enrolled, 7 in Cohort A and 7 in Cohort B. Dose reductions were required in 5 (71%) and 3 (43%) patients, in cohort A and B respectively. Grade 3 adverse events in Cohort A included lymphopenia (n\u00a0=\u00a05 [71%]), hyperglycemia (n\u00a0=\u00a02, [29%]), diarrhea (n\u00a0=\u00a02, [29%]) and rash (n\u00a0=\u00a02, [29%]) and in cohort B included lymphopenia (n\u00a0=\u00a05 [71%]), hyperglycemia (n\u00a0=\u00a04 [57%]) and neutropenia (n\u00a0=\u00a02 [29%]. The mean number of cycles on protocol was 6. The overall objective response rate was 14% (2 /14). No objective responses were observed in the PTEN deficient cohort. Four out of 6 patients with stable disease (SD) had SD or better for \u22656\u00a0cycles, 2 of which had PTEN deficient tumors. Conclusion The addition of buparlisib to high dose carboplatin and paclitaxel was not tolerable. The combination did not reveal significant clinical activity amongst a small and heterogenous group of PTEN deficient tumors,", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10637-017-0445-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094201", 
        "issn": [
          "0167-6997", 
          "1573-0646"
        ], 
        "name": "Investigational New Drugs", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "PTEN-deficient tumors", 
      "advanced solid tumors", 
      "cohort A", 
      "cohort B", 
      "deficient tumors", 
      "dose carboplatin", 
      "preliminary efficacy", 
      "platinum/taxane-based chemotherapy", 
      "solid tumors", 
      "grade 3 adverse events", 
      "phase I", 
      "standard dose carboplatin", 
      "carboplatin AUC 6", 
      "carboplatin AUC 5", 
      "chemotherapy dose intensification", 
      "high-dose carboplatin", 
      "phase II dose", 
      "taxane-based chemotherapy", 
      "PI3K inhibitors", 
      "AUC 6", 
      "paclitaxel 200", 
      "AUC 5", 
      "paclitaxel 175", 
      "pegfilgrastim support", 
      "expansion cohort", 
      "primary endpoint", 
      "dose intensification", 
      "escalation study", 
      "unselected patients", 
      "adverse events", 
      "dose reduction", 
      "patients", 
      "day 1", 
      "buparlisib", 
      "tumors", 
      "K inhibitors", 
      "PTEN mutations", 
      "lymphopenia", 
      "chemotherapy", 
      "hyperglycemia", 
      "carboplatin", 
      "cohort", 
      "homozygous deletion", 
      "paclitaxel", 
      "efficacy", 
      "tolerability", 
      "neutropenia", 
      "rash", 
      "diarrhea", 
      "dose", 
      "endpoint", 
      "inhibitors", 
      "study", 
      "subjects", 
      "safety", 
      "m2", 
      "mutations", 
      "combination", 
      "deletion", 
      "expansion studies", 
      "events", 
      "reduction", 
      "purpose", 
      "support", 
      "cycle", 
      "method", 
      "intensification"
    ], 
    "name": "A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel", 
    "pagination": "742-750", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084025947"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10637-017-0445-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28281183"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10637-017-0445-0", 
      "https://app.dimensions.ai/details/publication/pub.1084025947"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_731.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10637-017-0445-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10637-017-0445-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10637-017-0445-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10637-017-0445-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10637-017-0445-0'


 

This table displays all metadata directly associated to this object as RDF triples.

410 TRIPLES      21 PREDICATES      122 URIs      104 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10637-017-0445-0 schema:about N0104431cb5ba43e1bd645a1c1c856140
2 N180f53d17c424e1685ae1d63cce96c7a
3 N2f23b7f0d6114193ab0274db395d3328
4 N2f75ed6aa6814a7dba7902f6f48429c8
5 N3741878aed0d43d8817e1d43d658329f
6 N40cfc90f2b0d43e0a5425ffea29eccfb
7 N44a339141eae47059a0a26f089c3bc45
8 N456d97379b434845ad61ed7699779871
9 N4fbb31b0bc404198941967ceb4d95db6
10 N5fffb8cd461c40fabde43ce215625bc5
11 N6f2e2eaa18b145fc9061c92cdef66df5
12 N72c26bafcc554976acdf0c258a508308
13 N79e81d42498a4f12ba74aaa9d91916a6
14 N8c6448960760430ca7d9b6eeae2581a2
15 N9ea116abbf204440a1f2611531e4f523
16 Na3eecb03242b430e8486a9166e85a8af
17 Nb137d901ece54b4987ece38b59185e9d
18 Nb408c64f2e994ae9b00a71113583bf32
19 Nf4c6d5d5957644779a2c12efca32bdfb
20 Nf8d66dfab5744a9a92cf9ff5fb2f76b2
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Na0186fb13357468dbdb658c488090037
24 schema:citation sg:pub.10.1007/s00280-015-2693-z
25 sg:pub.10.1007/s10549-011-1572-5
26 sg:pub.10.1007/s11060-010-0492-2
27 sg:pub.10.1038/nature07091
28 sg:pub.10.1038/nrc2664
29 sg:pub.10.1038/nrc839
30 sg:pub.10.1038/nrclinonc.2015.194
31 sg:pub.10.1038/nrm3330
32 sg:pub.10.1038/onc.2008.241
33 sg:pub.10.1046/j.1525-1497.2001.016009606.x
34 schema:datePublished 2017-03-09
35 schema:datePublishedReg 2017-03-09
36 schema:description Purpose We previously reported the phase I dose escalation study of buparlisib, a pan-class 1A PI3K inhibitor, combined with platinum/taxane-based chemotherapy in patients with advanced solid tumors. The combination was well tolerated and promising preliminary efficacy was observed in PTEN deficient tumors. This phase I dose expansion study now evaluates buparlisib plus high dose carboplatin and paclitaxel in unselected patients with advanced solid tumors and buparlisib plus standard dose carboplatin and paclitaxel in patients with PTEN deficient tumors (ClinicalTrials.gov, NCT01297452). Methods There were two expansion cohorts: Cohort A received continuous buparlisib (100 mg/daily) orally plus high dose carboplatin AUC 6 and paclitaxel 200 mg/m2; Cohort B treated patients with PTEN deficient tumors only and they received the recommended phase II dose (RP2D) of continuous buparlisib (100 mg/daily) orally plus standard dose carboplatin AUC 5 and paclitaxel 175 mg/m2. Both cohorts received chemotherapy intravenously on day 1 of the 21-day cycle with pegfilgrastim support. Primary endpoint in Cohort A was to evaluate the safety and tolerability of chemotherapy dose intensification with buparlisib and in Cohort B was to describe preliminary efficacy of the combination among patients with tumors harboring a PTEN mutation or homozygous deletion. Results 14 subjects were enrolled, 7 in Cohort A and 7 in Cohort B. Dose reductions were required in 5 (71%) and 3 (43%) patients, in cohort A and B respectively. Grade 3 adverse events in Cohort A included lymphopenia (n = 5 [71%]), hyperglycemia (n = 2, [29%]), diarrhea (n = 2, [29%]) and rash (n = 2, [29%]) and in cohort B included lymphopenia (n = 5 [71%]), hyperglycemia (n = 4 [57%]) and neutropenia (n = 2 [29%]. The mean number of cycles on protocol was 6. The overall objective response rate was 14% (2 /14). No objective responses were observed in the PTEN deficient cohort. Four out of 6 patients with stable disease (SD) had SD or better for ≥6 cycles, 2 of which had PTEN deficient tumors. Conclusion The addition of buparlisib to high dose carboplatin and paclitaxel was not tolerable. The combination did not reveal significant clinical activity amongst a small and heterogenous group of PTEN deficient tumors,
37 schema:genre article
38 schema:isAccessibleForFree true
39 schema:isPartOf Ncd5f84ee31224558894cc5e297e24c8e
40 Neec4161612e94146a79b0ca19033cdef
41 sg:journal.1094201
42 schema:keywords AUC 5
43 AUC 6
44 K inhibitors
45 PI3K inhibitors
46 PTEN mutations
47 PTEN-deficient tumors
48 advanced solid tumors
49 adverse events
50 buparlisib
51 carboplatin
52 carboplatin AUC 5
53 carboplatin AUC 6
54 chemotherapy
55 chemotherapy dose intensification
56 cohort
57 cohort A
58 cohort B
59 combination
60 cycle
61 day 1
62 deficient tumors
63 deletion
64 diarrhea
65 dose
66 dose carboplatin
67 dose intensification
68 dose reduction
69 efficacy
70 endpoint
71 escalation study
72 events
73 expansion cohort
74 expansion studies
75 grade 3 adverse events
76 high-dose carboplatin
77 homozygous deletion
78 hyperglycemia
79 inhibitors
80 intensification
81 lymphopenia
82 m2
83 method
84 mutations
85 neutropenia
86 paclitaxel
87 paclitaxel 175
88 paclitaxel 200
89 patients
90 pegfilgrastim support
91 phase I
92 phase II dose
93 platinum/taxane-based chemotherapy
94 preliminary efficacy
95 primary endpoint
96 purpose
97 rash
98 reduction
99 safety
100 solid tumors
101 standard dose carboplatin
102 study
103 subjects
104 support
105 taxane-based chemotherapy
106 tolerability
107 tumors
108 unselected patients
109 schema:name A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel
110 schema:pagination 742-750
111 schema:productId N7074e35f1578412582e03d550a18b810
112 Nbbe3d1e71397410a9b47cac1f93b3d96
113 Ncdad82299636438cb9283df9f11094f0
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084025947
115 https://doi.org/10.1007/s10637-017-0445-0
116 schema:sdDatePublished 2022-09-02T16:00
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher Na7d2ac674089408ea7fa9f14ce36ec33
119 schema:url https://doi.org/10.1007/s10637-017-0445-0
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N0104431cb5ba43e1bd645a1c1c856140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Carboplatin
125 rdf:type schema:DefinedTerm
126 N08d8db37fad94b3d870f5e511ebd572e rdf:first sg:person.011024272057.19
127 rdf:rest Nc5ec192282e94bc7a85574b5134795be
128 N0c91a38e51f4487e8005fea6f0687f21 rdf:first sg:person.01355654660.61
129 rdf:rest N9686dbeec9404946a5c508ad70aa9c7b
130 N11bb3a90217a4cb59296e91115a84369 rdf:first sg:person.01365111477.00
131 rdf:rest N612719a552fb4d2fbfe6f72fc32c1b85
132 N1222a12ab6b748c1928a404bdf7bb62d rdf:first sg:person.01365124571.46
133 rdf:rest N08d8db37fad94b3d870f5e511ebd572e
134 N180f53d17c424e1685ae1d63cce96c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Tissue Distribution
136 rdf:type schema:DefinedTerm
137 N1ad83b78d5c247af81d5f2d9b9256136 rdf:first sg:person.0731357515.28
138 rdf:rest Na30ae28bf5904193855131350408849a
139 N2f23b7f0d6114193ab0274db395d3328 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Male
141 rdf:type schema:DefinedTerm
142 N2f75ed6aa6814a7dba7902f6f48429c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 N3741878aed0d43d8817e1d43d658329f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Dose-Response Relationship, Drug
147 rdf:type schema:DefinedTerm
148 N3f9dde5ff7de4aa2a8abd4ee14112727 rdf:first sg:person.01115006020.77
149 rdf:rest N0c91a38e51f4487e8005fea6f0687f21
150 N40cfc90f2b0d43e0a5425ffea29eccfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Neoplasms
152 rdf:type schema:DefinedTerm
153 N44a339141eae47059a0a26f089c3bc45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Follow-Up Studies
155 rdf:type schema:DefinedTerm
156 N456d97379b434845ad61ed7699779871 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Aged
158 rdf:type schema:DefinedTerm
159 N4fbb31b0bc404198941967ceb4d95db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Morpholines
161 rdf:type schema:DefinedTerm
162 N5fffb8cd461c40fabde43ce215625bc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Female
164 rdf:type schema:DefinedTerm
165 N612719a552fb4d2fbfe6f72fc32c1b85 rdf:first sg:person.0653035177.24
166 rdf:rest Na6b08fdc357f46a9889873c4b95903f4
167 N6f2e2eaa18b145fc9061c92cdef66df5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Middle Aged
169 rdf:type schema:DefinedTerm
170 N7074e35f1578412582e03d550a18b810 schema:name pubmed_id
171 schema:value 28281183
172 rdf:type schema:PropertyValue
173 N72c26bafcc554976acdf0c258a508308 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Prognosis
175 rdf:type schema:DefinedTerm
176 N79e81d42498a4f12ba74aaa9d91916a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name PTEN Phosphohydrolase
178 rdf:type schema:DefinedTerm
179 N7f610a9421714eed8ae60b23d4fc9430 rdf:first sg:person.014635271363.05
180 rdf:rest N1ad83b78d5c247af81d5f2d9b9256136
181 N87b3fc7574084c469de43236366c4a7f rdf:first sg:person.01331724606.93
182 rdf:rest Ne185ed4540b34ce986bd6d0d5c7c4a9e
183 N8c6448960760430ca7d9b6eeae2581a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Antineoplastic Combined Chemotherapy Protocols
185 rdf:type schema:DefinedTerm
186 N8d847875c79a4b7c8439ee325ae5bb5e rdf:first sg:person.01154466504.00
187 rdf:rest Nf3259bbb5f454866b94d911e1095ec5d
188 N9598ec4aaf0148b782e931505f340818 rdf:first sg:person.01105036134.18
189 rdf:rest N9cc9e33082f44290878546d44506f4b4
190 N9686dbeec9404946a5c508ad70aa9c7b rdf:first sg:person.01270325306.04
191 rdf:rest Ne4d71ca9ad634038828a097ab8801371
192 N9cc9e33082f44290878546d44506f4b4 rdf:first sg:person.01077731164.75
193 rdf:rest N11bb3a90217a4cb59296e91115a84369
194 N9ea116abbf204440a1f2611531e4f523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Paclitaxel
196 rdf:type schema:DefinedTerm
197 Na0186fb13357468dbdb658c488090037 rdf:first sg:person.012202131030.61
198 rdf:rest Ndbad7a5c5f4a4a15ba3b6a9c42747e2d
199 Na30ae28bf5904193855131350408849a rdf:first sg:person.0676140273.55
200 rdf:rest N8d847875c79a4b7c8439ee325ae5bb5e
201 Na3eecb03242b430e8486a9166e85a8af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Maximum Tolerated Dose
203 rdf:type schema:DefinedTerm
204 Na6b08fdc357f46a9889873c4b95903f4 rdf:first sg:person.01262212677.52
205 rdf:rest Nf351c63b7d564a72ad01268d2eac1782
206 Na7d2ac674089408ea7fa9f14ce36ec33 schema:name Springer Nature - SN SciGraph project
207 rdf:type schema:Organization
208 Nb137d901ece54b4987ece38b59185e9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Cohort Studies
210 rdf:type schema:DefinedTerm
211 Nb408c64f2e994ae9b00a71113583bf32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Adult
213 rdf:type schema:DefinedTerm
214 Nbbe3d1e71397410a9b47cac1f93b3d96 schema:name dimensions_id
215 schema:value pub.1084025947
216 rdf:type schema:PropertyValue
217 Nc5ec192282e94bc7a85574b5134795be rdf:first sg:person.01352541065.20
218 rdf:rest N87b3fc7574084c469de43236366c4a7f
219 Ncd5f84ee31224558894cc5e297e24c8e schema:issueNumber 6
220 rdf:type schema:PublicationIssue
221 Ncdad82299636438cb9283df9f11094f0 schema:name doi
222 schema:value 10.1007/s10637-017-0445-0
223 rdf:type schema:PropertyValue
224 Ndbad7a5c5f4a4a15ba3b6a9c42747e2d rdf:first sg:person.01317656002.95
225 rdf:rest N3f9dde5ff7de4aa2a8abd4ee14112727
226 Ne185ed4540b34ce986bd6d0d5c7c4a9e rdf:first sg:person.01272234306.86
227 rdf:rest N9598ec4aaf0148b782e931505f340818
228 Ne4d71ca9ad634038828a097ab8801371 rdf:first sg:person.0762116241.88
229 rdf:rest N7f610a9421714eed8ae60b23d4fc9430
230 Neec4161612e94146a79b0ca19033cdef schema:volumeNumber 35
231 rdf:type schema:PublicationVolume
232 Nf3259bbb5f454866b94d911e1095ec5d rdf:first sg:person.0577111044.36
233 rdf:rest N1222a12ab6b748c1928a404bdf7bb62d
234 Nf351c63b7d564a72ad01268d2eac1782 rdf:first sg:person.01147411161.34
235 rdf:rest rdf:nil
236 Nf4c6d5d5957644779a2c12efca32bdfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Phosphoinositide-3 Kinase Inhibitors
238 rdf:type schema:DefinedTerm
239 Nf8d66dfab5744a9a92cf9ff5fb2f76b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Aminopyridines
241 rdf:type schema:DefinedTerm
242 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
243 schema:name Medical and Health Sciences
244 rdf:type schema:DefinedTerm
245 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
246 schema:name Oncology and Carcinogenesis
247 rdf:type schema:DefinedTerm
248 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1007/s10637-017-0445-0
249 rdf:type schema:MonetaryGrant
250 sg:journal.1094201 schema:issn 0167-6997
251 1573-0646
252 schema:name Investigational New Drugs
253 schema:publisher Springer Nature
254 rdf:type schema:Periodical
255 sg:person.01077731164.75 schema:affiliation grid-institutes:grid.51462.34
256 schema:familyName Teitcher
257 schema:givenName Jerrold B.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077731164.75
259 rdf:type schema:Person
260 sg:person.011024272057.19 schema:affiliation grid-institutes:grid.51462.34
261 schema:familyName Ho
262 schema:givenName Alan L.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011024272057.19
264 rdf:type schema:Person
265 sg:person.01105036134.18 schema:affiliation grid-institutes:grid.51462.34
266 schema:familyName Lacouture
267 schema:givenName Mario E.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105036134.18
269 rdf:type schema:Person
270 sg:person.01115006020.77 schema:affiliation grid-institutes:grid.51462.34
271 schema:familyName Jhaveri
272 schema:givenName Komal
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115006020.77
274 rdf:type schema:Person
275 sg:person.01147411161.34 schema:affiliation grid-institutes:grid.51462.34
276 schema:familyName Hyman
277 schema:givenName David M.
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147411161.34
279 rdf:type schema:Person
280 sg:person.01154466504.00 schema:affiliation grid-institutes:grid.51462.34
281 schema:familyName Harding
282 schema:givenName James J.
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154466504.00
284 rdf:type schema:Person
285 sg:person.012202131030.61 schema:affiliation grid-institutes:grid.51462.34
286 schema:familyName Smyth
287 schema:givenName Lillian M.
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012202131030.61
289 rdf:type schema:Person
290 sg:person.01262212677.52 schema:affiliation grid-institutes:grid.418961.3
291 schema:familyName Fury
292 schema:givenName Matthew G.
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262212677.52
294 rdf:type schema:Person
295 sg:person.01270325306.04 schema:affiliation grid-institutes:grid.51462.34
296 schema:familyName Li
297 schema:givenName Bob T.
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270325306.04
299 rdf:type schema:Person
300 sg:person.01272234306.86 schema:affiliation grid-institutes:grid.51462.34
301 schema:familyName Bialer
302 schema:givenName Philip
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272234306.86
304 rdf:type schema:Person
305 sg:person.01317656002.95 schema:affiliation grid-institutes:grid.51462.34
306 schema:familyName Monson
307 schema:givenName Kelsey R.
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317656002.95
309 rdf:type schema:Person
310 sg:person.01331724606.93 schema:affiliation grid-institutes:grid.51462.34
311 schema:familyName Iasonos
312 schema:givenName Alexia
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331724606.93
314 rdf:type schema:Person
315 sg:person.01352541065.20 schema:affiliation grid-institutes:grid.51462.34
316 schema:familyName Razavi
317 schema:givenName Pedram
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352541065.20
319 rdf:type schema:Person
320 sg:person.01355654660.61 schema:affiliation grid-institutes:grid.51462.34
321 schema:familyName Drilon
322 schema:givenName Alexander
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355654660.61
324 rdf:type schema:Person
325 sg:person.01365111477.00 schema:affiliation grid-institutes:grid.51462.34
326 schema:familyName Erinjeri
327 schema:givenName Joseph P.
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365111477.00
329 rdf:type schema:Person
330 sg:person.01365124571.46 schema:affiliation grid-institutes:grid.51462.34
331 schema:familyName Makker
332 schema:givenName Vicky
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365124571.46
334 rdf:type schema:Person
335 sg:person.014635271363.05 schema:affiliation grid-institutes:grid.51462.34
336 schema:familyName Iyer
337 schema:givenName Gopa
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014635271363.05
339 rdf:type schema:Person
340 sg:person.0577111044.36 schema:affiliation grid-institutes:grid.51462.34
341 schema:familyName Voss
342 schema:givenName Martin H.
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577111044.36
344 rdf:type schema:Person
345 sg:person.0653035177.24 schema:affiliation grid-institutes:grid.51462.34
346 schema:familyName Katabi
347 schema:givenName Nora
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653035177.24
349 rdf:type schema:Person
350 sg:person.0676140273.55 schema:affiliation grid-institutes:grid.51462.34
351 schema:familyName Gounder
352 schema:givenName Mrinal
353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676140273.55
354 rdf:type schema:Person
355 sg:person.0731357515.28 schema:affiliation grid-institutes:grid.51462.34
356 schema:familyName Gerecitano
357 schema:givenName John F.
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731357515.28
359 rdf:type schema:Person
360 sg:person.0762116241.88 schema:affiliation grid-institutes:grid.51462.34
361 schema:familyName Abida
362 schema:givenName Wassim
363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762116241.88
364 rdf:type schema:Person
365 sg:pub.10.1007/s00280-015-2693-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044021272
366 https://doi.org/10.1007/s00280-015-2693-z
367 rdf:type schema:CreativeWork
368 sg:pub.10.1007/s10549-011-1572-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042247302
369 https://doi.org/10.1007/s10549-011-1572-5
370 rdf:type schema:CreativeWork
371 sg:pub.10.1007/s11060-010-0492-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027836042
372 https://doi.org/10.1007/s11060-010-0492-2
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/nature07091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034861855
375 https://doi.org/10.1038/nature07091
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/nrc2664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016821519
378 https://doi.org/10.1038/nrc2664
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/nrc839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014023118
381 https://doi.org/10.1038/nrc839
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/nrclinonc.2015.194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001580074
384 https://doi.org/10.1038/nrclinonc.2015.194
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/nrm3330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040868228
387 https://doi.org/10.1038/nrm3330
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/onc.2008.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008398399
390 https://doi.org/10.1038/onc.2008.241
391 rdf:type schema:CreativeWork
392 sg:pub.10.1046/j.1525-1497.2001.016009606.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002964461
393 https://doi.org/10.1046/j.1525-1497.2001.016009606.x
394 rdf:type schema:CreativeWork
395 grid-institutes:grid.418961.3 schema:alternateName Oncology Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, NY, USA
396 schema:name Oncology Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, NY, USA
397 rdf:type schema:Organization
398 grid-institutes:grid.51462.34 schema:alternateName Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
399 Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA
400 Department of Pathology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
401 Department of Psychiatry, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
402 Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
403 Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
404 schema:name Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
405 Department of Medicine, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY, USA
406 Department of Pathology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
407 Department of Psychiatry, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
408 Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
409 Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA
410 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...