Clinical, pharmacodynamic and pharmacokinetic results of a prospective phase II study on oral metronomic vinorelbine and dexamethasone in castration-resistant prostate ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Teresa Di Desidero, Lisa Derosa, Luca Galli, Paola Orlandi, Andrea Fontana, Anna Fioravanti, Riccardo Marconcini, Mario Giorgi, Beatrice Campi, Alessandro Saba, Sara Lucchesi, Renato Felipetto, Romano Danesi, Giulio Francia, Giacomo Allegrini, Alfredo Falcone, Guido Bocci

ABSTRACT

The aim of the present study was to evaluate clinical activity, and the pharmacodynamic and pharmacokinetic profiles, of oral metronomic vinorelbine (VNR) plus dexamethasone (DEX) in metastatic castration-resistant prostate cancer (mCRPC) patients. Fourty-one patients (92 % chemotherapy-resistant) received 30 mg/day VNR p.o. thrice a week plus 1 mg/day DEX p.o. until disease progression. Plasma soluble B cell antigen 7 homolog 3 (sB7-H3), vascular endothelial growth factor (VEGF), and thrombospondin-1 (TSP-1), were measured by ELISA. Plasma VNR was detected using a LC-MS-MS system. The fraction of patients free of progression, defined by criteria of the Prostate Cancer Clinical Trials Working Group 2, at 3 months was 61 %. PSA decrease ≥50 % from baseline was observed in 35 % of patients. Median PFS and OS were 4 months (95 % CI, 2.8-6.9) and 17.5 months (95 % CI, 10.8-24.5), respectively. Toxicity was mild, and no grade 4 toxicities were found. The mean plasma VNR Cmax ranged from 1 to 2.7 ng/ml (Tmax 1.1 h) and no evidence of drug accumulation was found. A moderate relationship was found between plasma sB7-H3 and PSA values (r = 0.565; P = 0.0094) at the baseline. Increased PFS (11.3 vs. 2.8 months; P = 0.0298) was observed in patients with sB7-H3 levels <30.25 ng/mL. Plasma VEGF AUC0-24day increased in non-responders (P < 0.0001), whereas responders maintained higher plasma TSP-1 AUC0-24day (P = 0.0063). In conclusion, metronomic VNR plus DEX showed favourable activity, and a low toxicity profile, in mCRPC patients. Plasma sB7-H3, VEGF and TSP-1 levels are potential pharmacodynamic markers at the reached low plasma concentrations of vinorelbine metronomically administered. More... »

PAGES

760-770

References to SciGraph publications

  • 2012-01. A phase I trial of oral metronomic vinorelbine plus capecitabine in patients with metastatic breast cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-12. Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study in BMC CANCER
  • 2016-09. Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2016-11. Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2012-06. Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers in ANGIOGENESIS
  • 2015-12. Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial) in BMC CANCER
  • 2010-09. Metronomic Chemotherapy for Metastatic Prostate Cancer in DRUGS & AGING
  • 2016-10. Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2012-02. Evaluation of oral chemotherapy with capecitabine and cyclophosphamide plus thalidomide and prednisone in prostate cancer patients in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2012-04. Metronomic chemotherapy with cyclophosphamide and dexamethasone in patients with metastatic carcinoma of the prostate in BRITISH JOURNAL OF CANCER
  • 2010-06. Clinical outcome of patients with docetaxel-resistant hormone-refractory prostate cancer treated with second-line cyclophosphamide-based metronomic chemotherapy in MEDICAL ONCOLOGY
  • 2015. An Overview of VEGF-Mediated Signal Transduction in VEGF SIGNALING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10637-016-0385-0

    DOI

    http://dx.doi.org/10.1007/s10637-016-0385-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004229491

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27557783


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Oral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dexamethasone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Grading", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prostatic Neoplasms, Castration-Resistant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tissue Distribution", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vinblastine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vinorelbine", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Di Desidero", 
            "givenName": "Teresa", 
            "id": "sg:person.0643613626.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643613626.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Oncology Unit 2, University Hospital of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Derosa", 
            "givenName": "Lisa", 
            "id": "sg:person.0666145632.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666145632.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Oncology Unit 2, University Hospital of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Galli", 
            "givenName": "Luca", 
            "id": "sg:person.01346140542.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346140542.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Orlandi", 
            "givenName": "Paola", 
            "id": "sg:person.01355617307.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355617307.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Oncology Unit 2, University Hospital of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fontana", 
            "givenName": "Andrea", 
            "id": "sg:person.0660374013.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660374013.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fioravanti", 
            "givenName": "Anna", 
            "id": "sg:person.01307504107.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307504107.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Oncology Unit 2, University Hospital of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marconcini", 
            "givenName": "Riccardo", 
            "id": "sg:person.01002374232.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002374232.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Department of Veterinary Sciences, University of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giorgi", 
            "givenName": "Mario", 
            "id": "sg:person.01040121067.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040121067.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campi", 
            "givenName": "Beatrice", 
            "id": "sg:person.011046625165.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011046625165.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saba", 
            "givenName": "Alessandro", 
            "id": "sg:person.01034556254.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034556254.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Oncology Unit, Azienda USL Toscana Nord Ovest, Civil Hospital of Pontedera, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lucchesi", 
            "givenName": "Sara", 
            "id": "sg:person.01177116607.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177116607.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Urology Unit, Civil Hospital of Pontedera, Azienda USL Toscana Nord Ovest, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Felipetto", 
            "givenName": "Renato", 
            "id": "sg:person.01005072724.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005072724.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Danesi", 
            "givenName": "Romano", 
            "id": "sg:person.0704167507.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704167507.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas at El Paso", 
              "id": "https://www.grid.ac/institutes/grid.267324.6", 
              "name": [
                "Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Francia", 
            "givenName": "Giulio", 
            "id": "sg:person.01267155331.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267155331.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Oncology Unit, Azienda USL Toscana Nord Ovest, Civil Hospital of Pontedera, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allegrini", 
            "givenName": "Giacomo", 
            "id": "sg:person.0623002156.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623002156.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Oncology Unit 2, University Hospital of Pisa, Pisa, Italy", 
                "Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Falcone", 
            "givenName": "Alfredo", 
            "id": "sg:person.01006230145.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pisa", 
              "id": "https://www.grid.ac/institutes/grid.5395.a", 
              "name": [
                "Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bocci", 
            "givenName": "Guido", 
            "id": "sg:person.01066531307.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066531307.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/sim.721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001557237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003398646", 
              "https://doi.org/10.1038/bjc.2012.78"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fon.15.306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003870567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2007.01.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003981947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2015.3059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004119481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2015.3059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004119481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11537480-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005247826", 
              "https://doi.org/10.2165/11537480-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11537480-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005247826", 
              "https://doi.org/10.2165/11537480-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61389-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005976220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006498518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2010.01.061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007148995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-11-4570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010528964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1354-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012056344", 
              "https://doi.org/10.1186/s12885-015-1354-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1354-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012056344", 
              "https://doi.org/10.1186/s12885-015-1354-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2567.2007.02723.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012110849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cad.0000000000000319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015017239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cad.0000000000000319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015017239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1532-5415.2010.02833.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016105967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-011-1663-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017067987", 
              "https://doi.org/10.1007/s00280-011-1663-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1442-2042.2012.03017.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018234672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(15)70033-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018681126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prnil.2015.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018829341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.28953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020566407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000048411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020685317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022566141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026558254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-009-9218-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028106763", 
              "https://doi.org/10.1007/s12032-009-9218-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-009-9218-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028106763", 
              "https://doi.org/10.1007/s12032-009-9218-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2010/683875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029339844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.4487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031178629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/769790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031266321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(12)70379-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032592013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2009.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032662156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0709802104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033342157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2016.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036153321", 
              "https://doi.org/10.1038/pcan.2016.17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-011-1101-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036183602", 
              "https://doi.org/10.1007/s00432-011-1101-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.11713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038670473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2016.57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038886085", 
              "https://doi.org/10.1038/nrclinonc.2016.57"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-3317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040523235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.28474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041302925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(14)61947-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042194391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-2917-7_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042604985", 
              "https://doi.org/10.1007/978-1-4939-2917-7_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.urology.2011.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043606526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1207506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044642614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2014.12.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045290074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2014.12.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045290074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2014.12.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045290074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2014.12.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045290074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-13-263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046178967", 
              "https://doi.org/10.1186/1471-2407-13-263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-0970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047099379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2016.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049830714", 
              "https://doi.org/10.1038/nrclinonc.2016.64"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2135406100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050157278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2015.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051139986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/diagnostics6030027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051331347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-04-1422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051585696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-012-9260-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052092198", 
              "https://doi.org/10.1007/s10456-012-9260-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-012-9260-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052092198", 
              "https://doi.org/10.1007/s10456-012-9260-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1756287212440302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064076963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1756287212440302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064076963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078292396", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078424818", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1303116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078969026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079202780", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-12", 
        "datePublishedReg": "2016-12-01", 
        "description": "The aim of the present study was to evaluate clinical activity, and the pharmacodynamic and pharmacokinetic profiles, of oral metronomic vinorelbine (VNR) plus dexamethasone (DEX) in metastatic castration-resistant prostate cancer (mCRPC) patients. Fourty-one patients (92\u00a0% chemotherapy-resistant) received 30\u00a0mg/day VNR p.o. thrice a week plus 1\u00a0mg/day DEX p.o. until disease progression. Plasma soluble B cell antigen 7 homolog 3 (sB7-H3), vascular endothelial growth factor (VEGF), and thrombospondin-1 (TSP-1), were measured by ELISA. Plasma VNR was detected using a LC-MS-MS system. The fraction of patients free of progression, defined by criteria of the Prostate Cancer Clinical Trials Working Group 2, at 3\u00a0months was 61\u00a0%. PSA decrease \u226550\u00a0% from baseline was observed in 35\u00a0% of patients. Median PFS and OS were 4\u00a0months (95\u00a0% CI, 2.8-6.9) and 17.5\u00a0months (95\u00a0% CI, 10.8-24.5), respectively. Toxicity was mild, and no grade 4 toxicities were found. The mean plasma VNR Cmax ranged from 1 to 2.7\u00a0ng/ml (Tmax 1.1\u00a0h) and no evidence of drug accumulation was found. A moderate relationship was found between plasma sB7-H3 and PSA values (r\u00a0=\u00a00.565; P\u00a0=\u00a00.0094) at the baseline. Increased PFS (11.3 vs. 2.8\u00a0months; P\u00a0=\u00a00.0298) was observed in patients with sB7-H3 levels <30.25\u00a0ng/mL. Plasma VEGF AUC0-24day increased in non-responders (P\u00a0<\u00a00.0001), whereas responders maintained higher plasma TSP-1 AUC0-24day (P\u00a0=\u00a00.0063). In conclusion, metronomic VNR plus DEX showed favourable activity, and a low toxicity profile, in mCRPC patients. Plasma sB7-H3, VEGF and TSP-1 levels are potential pharmacodynamic markers at the reached low plasma concentrations of vinorelbine metronomically administered.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10637-016-0385-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094201", 
            "issn": [
              "0167-6997", 
              "1573-0646"
            ], 
            "name": "Investigational New Drugs", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "name": "Clinical, pharmacodynamic and pharmacokinetic results of a prospective phase II study on oral metronomic vinorelbine and dexamethasone in castration-resistant prostate cancer patients", 
        "pagination": "760-770", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "142782ecb735545184ceea66a7b934902860e6b34c0acc4c852f97c2d84277b8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27557783"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8309330"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10637-016-0385-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004229491"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10637-016-0385-0", 
          "https://app.dimensions.ai/details/publication/pub.1004229491"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:27", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87119_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs10637-016-0385-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10637-016-0385-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10637-016-0385-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10637-016-0385-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10637-016-0385-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    449 TRIPLES      21 PREDICATES      103 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10637-016-0385-0 schema:about N0face8c584224e1580de4e135c1b4b75
    2 N1b50cb4defdb4e728254ee36a64c678f
    3 N2cc5519eae2a4546bdd6203b90900389
    4 N2dfe7d8da6574705aaa80176e9b5ded5
    5 N3080b2573c4c4fa681af4e57cb32b3fe
    6 N53a3c72c60464e9b9329b54f24944716
    7 N544b2fdb3bda44eb82196f164c6c9d0f
    8 N597047f26ea2419885d9b3a963f647ca
    9 N5b116aef6c424e2b897c98051c46f461
    10 N62b9b5e7c00a45e1b3ad933c21bf8150
    11 N7b96261157ff45358430b99d3855c569
    12 N82c5c3d846764a31a96b2dfbbbedf113
    13 N892bb6bcc9274dc0bf5a4943bf264b7e
    14 Na9c62c2454914e6b869082e75ef63223
    15 Nb731a159d7b64789b1d9db37cf852a25
    16 Nb7981c6da294486394d959289a3a19dd
    17 Nbcaf6d802cb5418f8dc7b32fcb9e50fa
    18 Nbd6d9fe56cae4355ba5e6d6dc7c8ab51
    19 Nc9acf39e3e9d4dc99b035a2c32a23d1e
    20 Ndd03f5e266614117970f3a15f9b180da
    21 Ne73ec73afe204d3896f571fc95f734b7
    22 anzsrc-for:11
    23 anzsrc-for:1103
    24 schema:author Na1032187a2094b10bb8788950441d239
    25 schema:citation sg:pub.10.1007/978-1-4939-2917-7_7
    26 sg:pub.10.1007/s00280-011-1663-3
    27 sg:pub.10.1007/s00432-011-1101-2
    28 sg:pub.10.1007/s10456-012-9260-6
    29 sg:pub.10.1007/s12032-009-9218-8
    30 sg:pub.10.1038/bjc.2012.78
    31 sg:pub.10.1038/nrclinonc.2016.57
    32 sg:pub.10.1038/nrclinonc.2016.64
    33 sg:pub.10.1038/pcan.2016.17
    34 sg:pub.10.1186/1471-2407-13-263
    35 sg:pub.10.1186/s12885-015-1354-2
    36 sg:pub.10.2165/11537480-000000000-00000
    37 https://app.dimensions.ai/details/publication/pub.1078292396
    38 https://app.dimensions.ai/details/publication/pub.1078424818
    39 https://app.dimensions.ai/details/publication/pub.1079202780
    40 https://doi.org/10.1002/cncr.11713
    41 https://doi.org/10.1002/cncr.28953
    42 https://doi.org/10.1002/ijc.28474
    43 https://doi.org/10.1002/sim.721
    44 https://doi.org/10.1016/j.canlet.2014.12.039
    45 https://doi.org/10.1016/j.ejca.2008.10.026
    46 https://doi.org/10.1016/j.eururo.2015.07.007
    47 https://doi.org/10.1016/j.ijrobp.2010.01.061
    48 https://doi.org/10.1016/j.immuni.2013.07.012
    49 https://doi.org/10.1016/j.juro.2007.01.143
    50 https://doi.org/10.1016/j.lungcan.2009.01.017
    51 https://doi.org/10.1016/j.prnil.2015.12.003
    52 https://doi.org/10.1016/j.urology.2011.08.010
    53 https://doi.org/10.1016/s0140-6736(10)61389-x
    54 https://doi.org/10.1016/s0140-6736(14)61947-4
    55 https://doi.org/10.1016/s1470-2045(12)70379-0
    56 https://doi.org/10.1016/s1470-2045(15)70033-1
    57 https://doi.org/10.1056/nejmoa1207506
    58 https://doi.org/10.1073/pnas.0709802104
    59 https://doi.org/10.1073/pnas.2135406100
    60 https://doi.org/10.1097/cad.0000000000000319
    61 https://doi.org/10.1111/j.1365-2567.2007.02723.x
    62 https://doi.org/10.1111/j.1442-2042.2012.03017.x
    63 https://doi.org/10.1111/j.1532-5415.2010.02833.x
    64 https://doi.org/10.1155/2010/683875
    65 https://doi.org/10.1155/2014/769790
    66 https://doi.org/10.1158/0008-5472.can-07-1068
    67 https://doi.org/10.1158/1078-0432.ccr-08-3317
    68 https://doi.org/10.1158/1078-0432.ccr-09-0970
    69 https://doi.org/10.1159/000048411
    70 https://doi.org/10.1177/1756287212440302
    71 https://doi.org/10.1182/blood-2005-04-1422
    72 https://doi.org/10.1182/blood-2005-11-4570
    73 https://doi.org/10.1200/jco.2007.12.4487
    74 https://doi.org/10.2217/fon.15.306
    75 https://doi.org/10.3390/diagnostics6030027
    76 https://doi.org/10.3892/ijo.2015.3059
    77 https://doi.org/10.4049/jimmunol.1303116
    78 schema:datePublished 2016-12
    79 schema:datePublishedReg 2016-12-01
    80 schema:description The aim of the present study was to evaluate clinical activity, and the pharmacodynamic and pharmacokinetic profiles, of oral metronomic vinorelbine (VNR) plus dexamethasone (DEX) in metastatic castration-resistant prostate cancer (mCRPC) patients. Fourty-one patients (92 % chemotherapy-resistant) received 30 mg/day VNR p.o. thrice a week plus 1 mg/day DEX p.o. until disease progression. Plasma soluble B cell antigen 7 homolog 3 (sB7-H3), vascular endothelial growth factor (VEGF), and thrombospondin-1 (TSP-1), were measured by ELISA. Plasma VNR was detected using a LC-MS-MS system. The fraction of patients free of progression, defined by criteria of the Prostate Cancer Clinical Trials Working Group 2, at 3 months was 61 %. PSA decrease ≥50 % from baseline was observed in 35 % of patients. Median PFS and OS were 4 months (95 % CI, 2.8-6.9) and 17.5 months (95 % CI, 10.8-24.5), respectively. Toxicity was mild, and no grade 4 toxicities were found. The mean plasma VNR C<sub>max</sub> ranged from 1 to 2.7 ng/ml (T<sub>max</sub> 1.1 h) and no evidence of drug accumulation was found. A moderate relationship was found between plasma sB7-H3 and PSA values (r = 0.565; P = 0.0094) at the baseline. Increased PFS (11.3 vs. 2.8 months; P = 0.0298) was observed in patients with sB7-H3 levels &lt;30.25 ng/mL. Plasma VEGF AUC<sub>0-24day</sub> increased in non-responders (P &lt; 0.0001), whereas responders maintained higher plasma TSP-1 AUC<sub>0-24day</sub> (P = 0.0063). In conclusion, metronomic VNR plus DEX showed favourable activity, and a low toxicity profile, in mCRPC patients. Plasma sB7-H3, VEGF and TSP-1 levels are potential pharmacodynamic markers at the reached low plasma concentrations of vinorelbine metronomically administered.
    81 schema:genre research_article
    82 schema:inLanguage en
    83 schema:isAccessibleForFree false
    84 schema:isPartOf N629285b93e5f4fb18c6b2d3e6d9ae701
    85 Nde875963aabe4af2afd6e5ec38712494
    86 sg:journal.1094201
    87 schema:name Clinical, pharmacodynamic and pharmacokinetic results of a prospective phase II study on oral metronomic vinorelbine and dexamethasone in castration-resistant prostate cancer patients
    88 schema:pagination 760-770
    89 schema:productId N1621e45fc77f4464bfd044e02fae8d08
    90 N73b093ef0f4d4cea9ea1b97c3242ff9a
    91 Nd9256ce621da4345a4fe02d3ecdb5423
    92 Nefca3e98a60e43f692e37e7457582d97
    93 Nfe2ee1ff656b44ffb417fa432cf34e57
    94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004229491
    95 https://doi.org/10.1007/s10637-016-0385-0
    96 schema:sdDatePublished 2019-04-11T12:27
    97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    98 schema:sdPublisher Ndaf85b843e5649d189e81f87577ca47a
    99 schema:url https://link.springer.com/10.1007%2Fs10637-016-0385-0
    100 sgo:license sg:explorer/license/
    101 sgo:sdDataset articles
    102 rdf:type schema:ScholarlyArticle
    103 N0c41144283e94936b9a4b60a88fc5e3a rdf:first sg:person.01034556254.96
    104 rdf:rest N4e5c5c719ec14f9ab077d878f5ab6cdc
    105 N0face8c584224e1580de4e135c1b4b75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Vinblastine
    107 rdf:type schema:DefinedTerm
    108 N1621e45fc77f4464bfd044e02fae8d08 schema:name doi
    109 schema:value 10.1007/s10637-016-0385-0
    110 rdf:type schema:PropertyValue
    111 N1b50cb4defdb4e728254ee36a64c678f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Antineoplastic Combined Chemotherapy Protocols
    113 rdf:type schema:DefinedTerm
    114 N235844b2ff574647b6e850da33190b9e rdf:first sg:person.01002374232.05
    115 rdf:rest N2852a080ec38466387ffce10554b068b
    116 N2852a080ec38466387ffce10554b068b rdf:first sg:person.01040121067.26
    117 rdf:rest N4472b2d409724e0a9c194fac3a0ca594
    118 N2cc5519eae2a4546bdd6203b90900389 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Bone Neoplasms
    120 rdf:type schema:DefinedTerm
    121 N2dfe7d8da6574705aaa80176e9b5ded5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Aged
    123 rdf:type schema:DefinedTerm
    124 N3080b2573c4c4fa681af4e57cb32b3fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Follow-Up Studies
    126 rdf:type schema:DefinedTerm
    127 N423a297b74e646e0908174a6ae5bea18 rdf:first sg:person.01307504107.09
    128 rdf:rest N235844b2ff574647b6e850da33190b9e
    129 N4472b2d409724e0a9c194fac3a0ca594 rdf:first sg:person.011046625165.57
    130 rdf:rest N0c41144283e94936b9a4b60a88fc5e3a
    131 N482b62b5015d48e0b5ab46d28ca1a955 rdf:first sg:person.0623002156.45
    132 rdf:rest N491e26805a7049d1a5c778dde79f7924
    133 N491e26805a7049d1a5c778dde79f7924 rdf:first sg:person.01006230145.44
    134 rdf:rest Nacbc95c8773e40ee8b75eb6b76b521a0
    135 N4e5c5c719ec14f9ab077d878f5ab6cdc rdf:first sg:person.01177116607.12
    136 rdf:rest N916c05e099954786a15501f15c25b36b
    137 N4fe2d447532a45868dff67ee5e4f25c8 schema:name Oncology Unit, Azienda USL Toscana Nord Ovest, Civil Hospital of Pontedera, Pisa, Italy
    138 rdf:type schema:Organization
    139 N539973eaefd44a07b4cd224be8827de4 schema:name Oncology Unit, Azienda USL Toscana Nord Ovest, Civil Hospital of Pontedera, Pisa, Italy
    140 rdf:type schema:Organization
    141 N53a3c72c60464e9b9329b54f24944716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Survival Rate
    143 rdf:type schema:DefinedTerm
    144 N544b2fdb3bda44eb82196f164c6c9d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Lymphatic Metastasis
    146 rdf:type schema:DefinedTerm
    147 N597047f26ea2419885d9b3a963f647ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Aged, 80 and over
    149 rdf:type schema:DefinedTerm
    150 N5b116aef6c424e2b897c98051c46f461 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Middle Aged
    152 rdf:type schema:DefinedTerm
    153 N629285b93e5f4fb18c6b2d3e6d9ae701 schema:volumeNumber 34
    154 rdf:type schema:PublicationVolume
    155 N62b9b5e7c00a45e1b3ad933c21bf8150 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Male
    157 rdf:type schema:DefinedTerm
    158 N6ae09cde446f411985e486b3f98fa404 rdf:first sg:person.01267155331.10
    159 rdf:rest N482b62b5015d48e0b5ab46d28ca1a955
    160 N73b093ef0f4d4cea9ea1b97c3242ff9a schema:name pubmed_id
    161 schema:value 27557783
    162 rdf:type schema:PropertyValue
    163 N7b96261157ff45358430b99d3855c569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Administration, Oral
    165 rdf:type schema:DefinedTerm
    166 N82c5c3d846764a31a96b2dfbbbedf113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Vinorelbine
    168 rdf:type schema:DefinedTerm
    169 N892bb6bcc9274dc0bf5a4943bf264b7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Dexamethasone
    171 rdf:type schema:DefinedTerm
    172 N916c05e099954786a15501f15c25b36b rdf:first sg:person.01005072724.71
    173 rdf:rest N9202389f3d184d8b9f4403b43aeea918
    174 N9202389f3d184d8b9f4403b43aeea918 rdf:first sg:person.0704167507.01
    175 rdf:rest N6ae09cde446f411985e486b3f98fa404
    176 Na1032187a2094b10bb8788950441d239 rdf:first sg:person.0643613626.90
    177 rdf:rest Ne02eabf1ce1847d0b4a7dcd4c271aa5c
    178 Na9c62c2454914e6b869082e75ef63223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Prognosis
    180 rdf:type schema:DefinedTerm
    181 Nacbc95c8773e40ee8b75eb6b76b521a0 rdf:first sg:person.01066531307.37
    182 rdf:rest rdf:nil
    183 Nb5f7a6419eec427f98816779c4b8ae09 schema:name Urology Unit, Civil Hospital of Pontedera, Azienda USL Toscana Nord Ovest, Pisa, Italy
    184 rdf:type schema:Organization
    185 Nb731a159d7b64789b1d9db37cf852a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Prospective Studies
    187 rdf:type schema:DefinedTerm
    188 Nb7981c6da294486394d959289a3a19dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Prostatic Neoplasms, Castration-Resistant
    190 rdf:type schema:DefinedTerm
    191 Nbcaf6d802cb5418f8dc7b32fcb9e50fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Neoplasm Grading
    193 rdf:type schema:DefinedTerm
    194 Nbd6d9fe56cae4355ba5e6d6dc7c8ab51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Humans
    196 rdf:type schema:DefinedTerm
    197 Nbfa8f2b0b43e406abb79b0abe52a1d47 rdf:first sg:person.01355617307.22
    198 rdf:rest Ne7084eb07947490d98cecfd98da942af
    199 Nc9acf39e3e9d4dc99b035a2c32a23d1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Lung Neoplasms
    201 rdf:type schema:DefinedTerm
    202 Nd9256ce621da4345a4fe02d3ecdb5423 schema:name nlm_unique_id
    203 schema:value 8309330
    204 rdf:type schema:PropertyValue
    205 Ndaf85b843e5649d189e81f87577ca47a schema:name Springer Nature - SN SciGraph project
    206 rdf:type schema:Organization
    207 Ndd03f5e266614117970f3a15f9b180da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Tissue Distribution
    209 rdf:type schema:DefinedTerm
    210 Nde875963aabe4af2afd6e5ec38712494 schema:issueNumber 6
    211 rdf:type schema:PublicationIssue
    212 Ne02eabf1ce1847d0b4a7dcd4c271aa5c rdf:first sg:person.0666145632.70
    213 rdf:rest Ne23d4b3efcaa47298da802500342fb27
    214 Ne23d4b3efcaa47298da802500342fb27 rdf:first sg:person.01346140542.48
    215 rdf:rest Nbfa8f2b0b43e406abb79b0abe52a1d47
    216 Ne7084eb07947490d98cecfd98da942af rdf:first sg:person.0660374013.97
    217 rdf:rest N423a297b74e646e0908174a6ae5bea18
    218 Ne73ec73afe204d3896f571fc95f734b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Neoplasm Staging
    220 rdf:type schema:DefinedTerm
    221 Nefca3e98a60e43f692e37e7457582d97 schema:name readcube_id
    222 schema:value 142782ecb735545184ceea66a7b934902860e6b34c0acc4c852f97c2d84277b8
    223 rdf:type schema:PropertyValue
    224 Nfe2ee1ff656b44ffb417fa432cf34e57 schema:name dimensions_id
    225 schema:value pub.1004229491
    226 rdf:type schema:PropertyValue
    227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Medical and Health Sciences
    229 rdf:type schema:DefinedTerm
    230 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Clinical Sciences
    232 rdf:type schema:DefinedTerm
    233 sg:journal.1094201 schema:issn 0167-6997
    234 1573-0646
    235 schema:name Investigational New Drugs
    236 rdf:type schema:Periodical
    237 sg:person.01002374232.05 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    238 schema:familyName Marconcini
    239 schema:givenName Riccardo
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002374232.05
    241 rdf:type schema:Person
    242 sg:person.01005072724.71 schema:affiliation Nb5f7a6419eec427f98816779c4b8ae09
    243 schema:familyName Felipetto
    244 schema:givenName Renato
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005072724.71
    246 rdf:type schema:Person
    247 sg:person.01006230145.44 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    248 schema:familyName Falcone
    249 schema:givenName Alfredo
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
    251 rdf:type schema:Person
    252 sg:person.01034556254.96 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    253 schema:familyName Saba
    254 schema:givenName Alessandro
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034556254.96
    256 rdf:type schema:Person
    257 sg:person.01040121067.26 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    258 schema:familyName Giorgi
    259 schema:givenName Mario
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040121067.26
    261 rdf:type schema:Person
    262 sg:person.01066531307.37 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    263 schema:familyName Bocci
    264 schema:givenName Guido
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066531307.37
    266 rdf:type schema:Person
    267 sg:person.011046625165.57 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    268 schema:familyName Campi
    269 schema:givenName Beatrice
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011046625165.57
    271 rdf:type schema:Person
    272 sg:person.01177116607.12 schema:affiliation N4fe2d447532a45868dff67ee5e4f25c8
    273 schema:familyName Lucchesi
    274 schema:givenName Sara
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177116607.12
    276 rdf:type schema:Person
    277 sg:person.01267155331.10 schema:affiliation https://www.grid.ac/institutes/grid.267324.6
    278 schema:familyName Francia
    279 schema:givenName Giulio
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267155331.10
    281 rdf:type schema:Person
    282 sg:person.01307504107.09 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    283 schema:familyName Fioravanti
    284 schema:givenName Anna
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307504107.09
    286 rdf:type schema:Person
    287 sg:person.01346140542.48 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    288 schema:familyName Galli
    289 schema:givenName Luca
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346140542.48
    291 rdf:type schema:Person
    292 sg:person.01355617307.22 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    293 schema:familyName Orlandi
    294 schema:givenName Paola
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355617307.22
    296 rdf:type schema:Person
    297 sg:person.0623002156.45 schema:affiliation N539973eaefd44a07b4cd224be8827de4
    298 schema:familyName Allegrini
    299 schema:givenName Giacomo
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623002156.45
    301 rdf:type schema:Person
    302 sg:person.0643613626.90 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    303 schema:familyName Di Desidero
    304 schema:givenName Teresa
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643613626.90
    306 rdf:type schema:Person
    307 sg:person.0660374013.97 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    308 schema:familyName Fontana
    309 schema:givenName Andrea
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660374013.97
    311 rdf:type schema:Person
    312 sg:person.0666145632.70 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    313 schema:familyName Derosa
    314 schema:givenName Lisa
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666145632.70
    316 rdf:type schema:Person
    317 sg:person.0704167507.01 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
    318 schema:familyName Danesi
    319 schema:givenName Romano
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704167507.01
    321 rdf:type schema:Person
    322 sg:pub.10.1007/978-1-4939-2917-7_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042604985
    323 https://doi.org/10.1007/978-1-4939-2917-7_7
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1007/s00280-011-1663-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017067987
    326 https://doi.org/10.1007/s00280-011-1663-3
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1007/s00432-011-1101-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036183602
    329 https://doi.org/10.1007/s00432-011-1101-2
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1007/s10456-012-9260-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052092198
    332 https://doi.org/10.1007/s10456-012-9260-6
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1007/s12032-009-9218-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028106763
    335 https://doi.org/10.1007/s12032-009-9218-8
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/bjc.2012.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003398646
    338 https://doi.org/10.1038/bjc.2012.78
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nrclinonc.2016.57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038886085
    341 https://doi.org/10.1038/nrclinonc.2016.57
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/nrclinonc.2016.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049830714
    344 https://doi.org/10.1038/nrclinonc.2016.64
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/pcan.2016.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036153321
    347 https://doi.org/10.1038/pcan.2016.17
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1186/1471-2407-13-263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046178967
    350 https://doi.org/10.1186/1471-2407-13-263
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1186/s12885-015-1354-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012056344
    353 https://doi.org/10.1186/s12885-015-1354-2
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.2165/11537480-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005247826
    356 https://doi.org/10.2165/11537480-000000000-00000
    357 rdf:type schema:CreativeWork
    358 https://app.dimensions.ai/details/publication/pub.1078292396 schema:CreativeWork
    359 https://app.dimensions.ai/details/publication/pub.1078424818 schema:CreativeWork
    360 https://app.dimensions.ai/details/publication/pub.1079202780 schema:CreativeWork
    361 https://doi.org/10.1002/cncr.11713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038670473
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1002/cncr.28953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020566407
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1002/ijc.28474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041302925
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1002/sim.721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001557237
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.canlet.2014.12.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045290074
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/j.eururo.2015.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051139986
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/j.ijrobp.2010.01.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007148995
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.immuni.2013.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006498518
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/j.juro.2007.01.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003981947
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/j.lungcan.2009.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032662156
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/j.prnil.2015.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018829341
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/j.urology.2011.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043606526
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/s0140-6736(10)61389-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005976220
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/s0140-6736(14)61947-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042194391
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/s1470-2045(12)70379-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032592013
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/s1470-2045(15)70033-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018681126
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1056/nejmoa1207506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044642614
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1073/pnas.0709802104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033342157
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1073/pnas.2135406100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050157278
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1097/cad.0000000000000319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015017239
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1111/j.1365-2567.2007.02723.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012110849
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1111/j.1442-2042.2012.03017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018234672
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1111/j.1532-5415.2010.02833.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016105967
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1155/2010/683875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029339844
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1155/2014/769790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031266321
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1158/0008-5472.can-07-1068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022566141
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1158/1078-0432.ccr-08-3317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040523235
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1158/1078-0432.ccr-09-0970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047099379
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1159/000048411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020685317
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1177/1756287212440302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064076963
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1182/blood-2005-04-1422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051585696
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1182/blood-2005-11-4570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010528964
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1200/jco.2007.12.4487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031178629
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.2217/fon.15.306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003870567
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.3390/diagnostics6030027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051331347
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.3892/ijo.2015.3059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004119481
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.4049/jimmunol.1303116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078969026
    436 rdf:type schema:CreativeWork
    437 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
    438 schema:name Oncology Unit 2, University Hospital of Pisa, Pisa, Italy
    439 rdf:type schema:Organization
    440 https://www.grid.ac/institutes/grid.267324.6 schema:alternateName The University of Texas at El Paso
    441 schema:name Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, USA
    442 rdf:type schema:Organization
    443 https://www.grid.ac/institutes/grid.5395.a schema:alternateName University of Pisa
    444 schema:name Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
    445 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
    446 Department of Veterinary Sciences, University of Pisa, Pisa, Italy
    447 Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy
    448 Oncology Unit 2, University Hospital of Pisa, Pisa, Italy
    449 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...