ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Frankie Lam, Tracey D. Bradshaw, Hui Mao, Scott Roberts, Yuanjiang Pan, Shudong Wang

ABSTRACT

ZJU-6 was designed to enhance anti-angiogenesis and anti-tumour activity of its parent compound Erianin, a clinic anti-tumour agent. This study investigated the detailed biological mechanism of ZJU-6 in comparison with that of Erianin. Both ZJU-6 and Erianin substantially reduced cell viability and induced apoptosis in human cancer cell lines. Profound G2/M cell arrest was observed 24 h after treatment of MCF-7 cells with ZJU-6 (≥ 2.5 μM) or Erianin (≥ 0.1 μM); being consistent with mitotic collapse. 0.5 μM of Erianin or ZJU-6 failed to stabilise tubulin. Pre-G1 MCF-7 cell accumulating 24 h post treatment indicated apoptosis. Caspase-3 activity, PARP cleavage and Annexin V + ve /PI -ve populations correlate the apoptotic destiny of cells exposed to either ZJU-6 or Erianin. Furthermore ZJU-6 showed potent anti-angiogenetic property and demonstrated radical scavenging capacity. Due to its potent anti-proliferative, pro-apoptotic and anti-angiogenic activities ZJU-6 is an attractive chemotherapeutic agent to be developed. More... »

PAGES

1899-1907

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10637-011-9755-9

DOI

http://dx.doi.org/10.1007/s10637-011-9755-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015561942

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21997795


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenesis Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Annexin A5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bibenzyls", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Checkpoints", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Free Radical Scavengers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "G2 Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MCF-7 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microtubules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Poly(ADP-ribose) Polymerases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tubulin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lam", 
        "givenName": "Frankie", 
        "id": "sg:person.0715074143.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715074143.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bradshaw", 
        "givenName": "Tracey D.", 
        "id": "sg:person.01202076504.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202076504.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Zhejiang University", 
          "id": "https://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Department of Chemistry, Zhejiang University, 310027, Hangzhou, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mao", 
        "givenName": "Hui", 
        "id": "sg:person.01034637540.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034637540.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Scott", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Zhejiang University", 
          "id": "https://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Department of Chemistry, Zhejiang University, 310027, Hangzhou, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pan", 
        "givenName": "Yuanjiang", 
        "id": "sg:person.0646446001.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646446001.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Shudong", 
        "id": "sg:person.01166601440.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166601440.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejca.2004.01.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007718520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009344480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np068054v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013816917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np068054v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013816917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2005.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019305740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-011-9641-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030937142", 
          "https://doi.org/10.1007/s10637-011-9641-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81683-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031899717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(74)90316-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034788747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(97)00079-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035344394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/22.8.1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037088684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038813523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-04-1678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039586723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046190517", 
          "https://doi.org/10.1038/nrd2060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046190517", 
          "https://doi.org/10.1038/nrd2060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(98)00317-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048606995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(99)00642-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049360440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00627a037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055183212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm0309957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm0309957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074356036", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.2001.280.5.h2357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074798102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074963697", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076831331", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-10", 
    "datePublishedReg": "2012-10-01", 
    "description": "ZJU-6 was designed to enhance anti-angiogenesis and anti-tumour activity of its parent compound Erianin, a clinic anti-tumour agent. This study investigated the detailed biological mechanism of ZJU-6 in comparison with that of Erianin. Both ZJU-6 and Erianin substantially reduced cell viability and induced apoptosis in human cancer cell lines. Profound G2/M cell arrest was observed 24 h after treatment of MCF-7 cells with ZJU-6 (\u2265 2.5 \u03bcM) or Erianin (\u2265 0.1 \u03bcM); being consistent with mitotic collapse. 0.5 \u03bcM of Erianin or ZJU-6 failed to stabilise tubulin. Pre-G1 MCF-7 cell accumulating 24 h post treatment indicated apoptosis. Caspase-3 activity, PARP cleavage and Annexin V\u2009+\u2009ve /PI -ve populations correlate the apoptotic destiny of cells exposed to either ZJU-6 or Erianin. Furthermore ZJU-6 showed potent anti-angiogenetic property and demonstrated radical scavenging capacity. Due to its potent anti-proliferative, pro-apoptotic and anti-angiogenic activities ZJU-6 is an attractive chemotherapeutic agent to be developed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10637-011-9755-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094201", 
        "issn": [
          "0167-6997", 
          "1573-0646"
        ], 
        "name": "Investigational New Drugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities", 
    "pagination": "1899-1907", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4a25155718540b644023d81cfbce88d2baded8f4a88ef862262a17bf23e4a5ed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21997795"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8309330"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10637-011-9755-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015561942"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10637-011-9755-9", 
      "https://app.dimensions.ai/details/publication/pub.1015561942"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10637-011-9755-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10637-011-9755-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10637-011-9755-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10637-011-9755-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10637-011-9755-9'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      68 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10637-011-9755-9 schema:about N01cb93d67924495bbcf125444ad5af64
2 N14d5ddf6f82b498397e6f0291bc163c1
3 N2f5a4319a73044dfa2fec5b5e6804337
4 N66335c0a340d4526adb208d077b2f2cb
5 N69f3dec6eb2e4327bc1b4e2d1fa1044d
6 N6bc4fb2321ef4276a02f04bc6d55af6c
7 N896949d441444011be93e635a6f67e1e
8 N8cda9906c56946838f0276851951d2af
9 N92ef32864cc44cd3893b9b32ebade490
10 N9a3ffb9cf1a047389b54fdb22a1c0fe6
11 Na5064b5380f843228d4e6329560a32a6
12 Na679b56915d2487d958941415c1e3569
13 Nae3a396ce50a4fac9dbb8433973c7ec7
14 Nc7fc5707679d476393a557ee5e90a120
15 Nca0b54e9b73e4ced8c146195ac0a591d
16 Nca9dbf9a9a9d4195a88d287bf0fe4ee7
17 Nce06c75821994e77916b31fa7d02e794
18 Ndeeedb3256ab4d1c9b93b1ede20a70ef
19 Nef91e8632fd1426f9ff14da5acc6e264
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author N4dee3f6a639a4e20ba5bb6288c2ca1f0
23 schema:citation sg:pub.10.1007/s10637-011-9641-5
24 sg:pub.10.1038/nrd2060
25 https://app.dimensions.ai/details/publication/pub.1074356036
26 https://app.dimensions.ai/details/publication/pub.1074963697
27 https://app.dimensions.ai/details/publication/pub.1076831331
28 https://doi.org/10.1002/ijc.26127
29 https://doi.org/10.1016/0012-1606(74)90316-9
30 https://doi.org/10.1016/j.ejca.2004.01.041
31 https://doi.org/10.1016/j.ejphar.2005.01.004
32 https://doi.org/10.1016/s0024-3205(99)00642-6
33 https://doi.org/10.1016/s0092-8674(00)81683-9
34 https://doi.org/10.1016/s0360-3016(98)00317-4
35 https://doi.org/10.1016/s0891-5849(97)00079-8
36 https://doi.org/10.1021/bi00627a037
37 https://doi.org/10.1021/jm0309957
38 https://doi.org/10.1021/np068054v
39 https://doi.org/10.1093/carcin/22.8.1111
40 https://doi.org/10.1152/ajpheart.2001.280.5.h2357
41 https://doi.org/10.1172/jci118962
42 https://doi.org/10.1182/blood-2005-04-1678
43 schema:datePublished 2012-10
44 schema:datePublishedReg 2012-10-01
45 schema:description ZJU-6 was designed to enhance anti-angiogenesis and anti-tumour activity of its parent compound Erianin, a clinic anti-tumour agent. This study investigated the detailed biological mechanism of ZJU-6 in comparison with that of Erianin. Both ZJU-6 and Erianin substantially reduced cell viability and induced apoptosis in human cancer cell lines. Profound G2/M cell arrest was observed 24 h after treatment of MCF-7 cells with ZJU-6 (≥ 2.5 μM) or Erianin (≥ 0.1 μM); being consistent with mitotic collapse. 0.5 μM of Erianin or ZJU-6 failed to stabilise tubulin. Pre-G1 MCF-7 cell accumulating 24 h post treatment indicated apoptosis. Caspase-3 activity, PARP cleavage and Annexin V + ve /PI -ve populations correlate the apoptotic destiny of cells exposed to either ZJU-6 or Erianin. Furthermore ZJU-6 showed potent anti-angiogenetic property and demonstrated radical scavenging capacity. Due to its potent anti-proliferative, pro-apoptotic and anti-angiogenic activities ZJU-6 is an attractive chemotherapeutic agent to be developed.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N5731d4362dfc43b0b24e99c5923d9d9f
50 N682f1d3e4b2c4aa8a16bd553deca6697
51 sg:journal.1094201
52 schema:name ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities
53 schema:pagination 1899-1907
54 schema:productId N4e9fb3850d0a45b7b8ec2a14349b7d56
55 N61ff51d0bef84d62b91f54a60b5b99dd
56 N7f3aae899a0547548a53d2dbaf96b447
57 N9385946bcfe745d0ab141148cd5d678e
58 Nd3e72ebd6293468b840479f64f4b66e5
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015561942
60 https://doi.org/10.1007/s10637-011-9755-9
61 schema:sdDatePublished 2019-04-10T17:31
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N4f880660944c45a4969db97deb48f25e
64 schema:url http://link.springer.com/10.1007%2Fs10637-011-9755-9
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N01cb93d67924495bbcf125444ad5af64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Caspase 3
70 rdf:type schema:DefinedTerm
71 N14d5ddf6f82b498397e6f0291bc163c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Bibenzyls
73 rdf:type schema:DefinedTerm
74 N1ad70c878ef74d279630697b26a0df2d rdf:first sg:person.01202076504.83
75 rdf:rest N7916499a709e4c838fabfb28a78d9977
76 N2f5a4319a73044dfa2fec5b5e6804337 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Free Radical Scavengers
78 rdf:type schema:DefinedTerm
79 N4dee3f6a639a4e20ba5bb6288c2ca1f0 rdf:first sg:person.0715074143.78
80 rdf:rest N1ad70c878ef74d279630697b26a0df2d
81 N4e9fb3850d0a45b7b8ec2a14349b7d56 schema:name pubmed_id
82 schema:value 21997795
83 rdf:type schema:PropertyValue
84 N4f880660944c45a4969db97deb48f25e schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N5731d4362dfc43b0b24e99c5923d9d9f schema:issueNumber 5
87 rdf:type schema:PublicationIssue
88 N5d2e97ad64034216999720ee9d3df309 rdf:first N65cf6b771a0742dfb63cf2526557c75b
89 rdf:rest N654c2636437a47749433eb78098c47fe
90 N61ff51d0bef84d62b91f54a60b5b99dd schema:name doi
91 schema:value 10.1007/s10637-011-9755-9
92 rdf:type schema:PropertyValue
93 N654c2636437a47749433eb78098c47fe rdf:first sg:person.0646446001.43
94 rdf:rest N7c581b2910924db28fec266feb927ea2
95 N65cf6b771a0742dfb63cf2526557c75b schema:affiliation https://www.grid.ac/institutes/grid.4563.4
96 schema:familyName Roberts
97 schema:givenName Scott
98 rdf:type schema:Person
99 N66335c0a340d4526adb208d077b2f2cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Tubulin
101 rdf:type schema:DefinedTerm
102 N682f1d3e4b2c4aa8a16bd553deca6697 schema:volumeNumber 30
103 rdf:type schema:PublicationVolume
104 N69f3dec6eb2e4327bc1b4e2d1fa1044d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cell Division
106 rdf:type schema:DefinedTerm
107 N6bc4fb2321ef4276a02f04bc6d55af6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cell Line, Tumor
109 rdf:type schema:DefinedTerm
110 N7916499a709e4c838fabfb28a78d9977 rdf:first sg:person.01034637540.58
111 rdf:rest N5d2e97ad64034216999720ee9d3df309
112 N7c581b2910924db28fec266feb927ea2 rdf:first sg:person.01166601440.04
113 rdf:rest rdf:nil
114 N7f3aae899a0547548a53d2dbaf96b447 schema:name dimensions_id
115 schema:value pub.1015561942
116 rdf:type schema:PropertyValue
117 N896949d441444011be93e635a6f67e1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Poly(ADP-ribose) Polymerases
119 rdf:type schema:DefinedTerm
120 N8cda9906c56946838f0276851951d2af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name MCF-7 Cells
122 rdf:type schema:DefinedTerm
123 N92ef32864cc44cd3893b9b32ebade490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name G2 Phase
125 rdf:type schema:DefinedTerm
126 N9385946bcfe745d0ab141148cd5d678e schema:name readcube_id
127 schema:value 4a25155718540b644023d81cfbce88d2baded8f4a88ef862262a17bf23e4a5ed
128 rdf:type schema:PropertyValue
129 N9a3ffb9cf1a047389b54fdb22a1c0fe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Proliferation
131 rdf:type schema:DefinedTerm
132 Na5064b5380f843228d4e6329560a32a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Angiogenesis Inhibitors
134 rdf:type schema:DefinedTerm
135 Na679b56915d2487d958941415c1e3569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Antineoplastic Agents
137 rdf:type schema:DefinedTerm
138 Nae3a396ce50a4fac9dbb8433973c7ec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Survival
140 rdf:type schema:DefinedTerm
141 Nc7fc5707679d476393a557ee5e90a120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Apoptosis
143 rdf:type schema:DefinedTerm
144 Nca0b54e9b73e4ced8c146195ac0a591d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cell Cycle Checkpoints
146 rdf:type schema:DefinedTerm
147 Nca9dbf9a9a9d4195a88d287bf0fe4ee7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Microtubules
149 rdf:type schema:DefinedTerm
150 Nce06c75821994e77916b31fa7d02e794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Annexin A5
152 rdf:type schema:DefinedTerm
153 Nd3e72ebd6293468b840479f64f4b66e5 schema:name nlm_unique_id
154 schema:value 8309330
155 rdf:type schema:PropertyValue
156 Ndeeedb3256ab4d1c9b93b1ede20a70ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antioxidants
158 rdf:type schema:DefinedTerm
159 Nef91e8632fd1426f9ff14da5acc6e264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Humans
161 rdf:type schema:DefinedTerm
162 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
163 schema:name Biological Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
166 schema:name Biochemistry and Cell Biology
167 rdf:type schema:DefinedTerm
168 sg:journal.1094201 schema:issn 0167-6997
169 1573-0646
170 schema:name Investigational New Drugs
171 rdf:type schema:Periodical
172 sg:person.01034637540.58 schema:affiliation https://www.grid.ac/institutes/grid.13402.34
173 schema:familyName Mao
174 schema:givenName Hui
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034637540.58
176 rdf:type schema:Person
177 sg:person.01166601440.04 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
178 schema:familyName Wang
179 schema:givenName Shudong
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166601440.04
181 rdf:type schema:Person
182 sg:person.01202076504.83 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
183 schema:familyName Bradshaw
184 schema:givenName Tracey D.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202076504.83
186 rdf:type schema:Person
187 sg:person.0646446001.43 schema:affiliation https://www.grid.ac/institutes/grid.13402.34
188 schema:familyName Pan
189 schema:givenName Yuanjiang
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646446001.43
191 rdf:type schema:Person
192 sg:person.0715074143.78 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
193 schema:familyName Lam
194 schema:givenName Frankie
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715074143.78
196 rdf:type schema:Person
197 sg:pub.10.1007/s10637-011-9641-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030937142
198 https://doi.org/10.1007/s10637-011-9641-5
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nrd2060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046190517
201 https://doi.org/10.1038/nrd2060
202 rdf:type schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1074356036 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1074963697 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1076831331 schema:CreativeWork
206 https://doi.org/10.1002/ijc.26127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009344480
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0012-1606(74)90316-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034788747
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ejca.2004.01.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007718520
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.ejphar.2005.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019305740
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0024-3205(99)00642-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049360440
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0092-8674(00)81683-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031899717
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0360-3016(98)00317-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048606995
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0891-5849(97)00079-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035344394
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1021/bi00627a037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055183212
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1021/jm0309957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055948385
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1021/np068054v schema:sameAs https://app.dimensions.ai/details/publication/pub.1013816917
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/carcin/22.8.1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037088684
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1152/ajpheart.2001.280.5.h2357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074798102
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1172/jci118962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038813523
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1182/blood-2005-04-1678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039586723
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.13402.34 schema:alternateName Zhejiang University
237 schema:name Department of Chemistry, Zhejiang University, 310027, Hangzhou, People’s Republic of China
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
240 schema:name School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK
241 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...