Phase II trial of sunitinib in patients with metastatic non-clear cell renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Ana M. Molina, Darren R. Feldman, Michelle S. Ginsberg, Glenn Kroog, Satish K. Tickoo, Xiaoyu Jia, Murielle Georges, Sujata Patil, Michael S. Baum, Victor E. Reuter, Robert J. Motzer

ABSTRACT

Sunitinib is associated with a robust objective response rate in patients with metastatic clear cell renal cell carcinoma (RCC). The primary objective of this phase II clinical trial was to assess the overall response rate for sunitinib in patients with papillary metastatic RCC as well as other non-clear cell histologies. A Simon 2-stage design was used to determine the number of papillary metastatic RCC patients for enrollment, and allowed for descriptive response data for other non-clear cell histologies. Twenty-three patients were enrolled, including 8 with papillary renal cell carcinoma (RCC) and the remainder with other non-clear cell histologies (unclassified in 5 patients). All patients received 50 mg of oral sunitinib in cycles of 4 weeks followed by 2 weeks of rest (4/2). The trial was stopped early because of slow accrual; no responses were observed in the 8 patients with papillary RCC. In the 22 evaluable patients, best response to sunitinib included a partial response in 1 patient with unclassified RCC, stable disease in 15, and progression in 6. The median progression-free survival was 5.5 months (95% CI, 2.5-7.1) in all 23 patients, and 5.6 months for the 8 papillary patients (95% CI, 1.4-7.1). The robust objective responses sunitinib had produced in clear cell RCC could not be demonstrated in this study comprised of patients with non-clear cell histologies. More... »

PAGES

335-340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10637-010-9491-6

DOI

http://dx.doi.org/10.1007/s10637-010-9491-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018648494

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20711632


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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10637-010-9491-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10637-010-9491-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10637-010-9491-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10637-010-9491-6'


 

This table displays all metadata directly associated to this object as RDF triples.

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