The thiopurines: An update View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10-26

AUTHORS

Sally Coulthard, Linda Hogarth

ABSTRACT

The thiopurine drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) are commonly used cytotoxic agents. A derivative of 6-MP, azathioprine, is commonly used as an immunosuppressant. A prominent route for the metabolism of these agents is mediated by the enzyme thiopurine methyltransferase (TPMT). This enzyme exhibits considerable inter-individual variation in activity, partly due to the presence of common genetic polymorphisms, which influence cytotoxicity of the thiopurine drugs. Variations in the number of tandem repeats in the 5′ promoter region have also been shown to influence TPMT expression in vitro. In this article, we review the impact of variations in TPMT activity on sensitivity to the thiopurine drugs in vitro and also in vivo in terms of their clinical efficacy and toxicity. A possible relationship between TPMT and secondary malignancies is also reviewed. More... »

PAGES

523-532

References to SciGraph publications

  • 1997-12. Promoter and Intronic Sequences of the Human Thiopurine S-Methyltransferase (TPMT) Gene Isolated from a Human Pacl Genomic Library in PHARMACEUTICAL RESEARCH
  • 1981-07. Clinical pharmacology of oral thioguanine in acute myelogenous leukemia in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1982-06. Phase II evaluation and plasma pharmacokinetics of high-dose intravenous 6-thioguanine in patients with colorectal carcinoma in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2003-06-19. Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2000-12-01. Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92 in LEUKEMIA
  • 1992-10. The clinical pharmacology of 6-mercaptopurine in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1998-06. Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2001-04. Recent advances in the pharmacogenomics of thiopurine methyltransferase in THE PHARMACOGENOMICS JOURNAL
  • 1997-10-09. Olsalazine and 6‐mercaptopurine‐related bone marrow suppression: A possible drug‐drug interaction in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1998-03-01. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia in LEUKEMIA
  • 2000-09-01. Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene in JOURNAL OF HUMAN GENETICS
  • 2000-04-01. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia in LEUKEMIA
  • 1999-03. Pharmacogenetics as a Molecular Basis for Individualized Drug Therapy: The Thiopurine S-methyltransferase Paradigm in PHARMACEUTICAL RESEARCH
  • 1993-07. Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia? in BRITISH JOURNAL OF CANCER
  • 2003-06-20. A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL in LEUKEMIA
  • 1989-08-26. Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2000-08. Thiopurine methyltransferase polymorphic tandem repeat: Genotype‐phenotype correlation analysis in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1998-08. Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2001-08. Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10637-005-4020-8

    DOI

    http://dx.doi.org/10.1007/s10637-005-4020-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043851224

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16267626


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antimetabolites, Antineoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Azathioprine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Guanine Nucleotides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunosuppressive Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mercaptopurine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Methyltransferases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thioguanine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thionucleotides", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle Upon Tyne, UK", 
              "id": "http://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle Upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coulthard", 
            "givenName": "Sally", 
            "id": "sg:person.0576131213.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576131213.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle Upon Tyne, UK", 
              "id": "http://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle Upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hogarth", 
            "givenName": "Linda", 
            "id": "sg:person.01245632127.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245632127.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.leu.2400928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046488609", 
              "https://doi.org/10.1038/sj.leu.2400928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1067/mcp.2001.117284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008223166", 
              "https://doi.org/10.1067/mcp.2001.117284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011909315614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046367699", 
              "https://doi.org/10.1023/a:1011909315614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s100380070020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050031173", 
              "https://doi.org/10.1007/s100380070020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0009-9236(97)90125-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032244265", 
              "https://doi.org/10.1016/s0009-9236(97)90125-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1067/mcp.2000.108674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005506858", 
              "https://doi.org/10.1067/mcp.2000.108674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00253008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009761882", 
              "https://doi.org/10.1007/bf00253008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033249097", 
              "https://doi.org/10.1038/bjc.1993.311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.tpj.6500066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031895354", 
              "https://doi.org/10.1038/sj.tpj.6500066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004860258", 
              "https://doi.org/10.1038/sj.leu.2402981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.1989.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045694510", 
              "https://doi.org/10.1038/clpt.1989.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02220605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000863143", 
              "https://doi.org/10.1007/bf02220605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002800050816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037384717", 
              "https://doi.org/10.1007/s002800050816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1012111325397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030674820", 
              "https://doi.org/10.1023/a:1012111325397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002280050457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019665476", 
              "https://doi.org/10.1007/s002280050457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00255484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014629242", 
              "https://doi.org/10.1007/bf00255484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027135078", 
              "https://doi.org/10.1038/sj.leu.2401974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00228-003-0617-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007561734", 
              "https://doi.org/10.1007/s00228-003-0617-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018637081", 
              "https://doi.org/10.1038/sj.leu.2401723"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-10-26", 
        "datePublishedReg": "2005-10-26", 
        "description": "The thiopurine drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) are commonly used cytotoxic agents. A derivative of 6-MP, azathioprine, is commonly used as an immunosuppressant. A prominent route for the metabolism of these agents is mediated by the enzyme thiopurine methyltransferase (TPMT). This enzyme exhibits considerable inter-individual variation in activity, partly due to the presence of common genetic polymorphisms, which influence cytotoxicity of the thiopurine drugs. Variations in the number of tandem repeats in the 5\u2032 promoter region have also been shown to influence TPMT expression in vitro. In this article, we review the impact of variations in TPMT activity on sensitivity to the thiopurine drugs in vitro and also in vivo in terms of their clinical efficacy and toxicity. A possible relationship between TPMT and secondary malignancies is also reviewed.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10637-005-4020-8", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094201", 
            "issn": [
              "0167-6997", 
              "1573-0646"
            ], 
            "name": "Investigational New Drugs", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "keywords": [
          "thiopurine methyltransferase", 
          "thiopurine drugs", 
          "enzyme thiopurine methyltransferase", 
          "considerable inter-individual variation", 
          "common genetic polymorphisms", 
          "secondary malignancies", 
          "clinical efficacy", 
          "TPMT activity", 
          "cytotoxic agents", 
          "inter-individual variation", 
          "genetic polymorphisms", 
          "TPMT expression", 
          "drugs", 
          "possible relationship", 
          "azathioprine", 
          "thiopurines", 
          "immunosuppressants", 
          "malignancy", 
          "agents", 
          "promoter region", 
          "prominent route", 
          "efficacy", 
          "vitro", 
          "vivo", 
          "activity", 
          "toxicity", 
          "metabolism", 
          "cytotoxicity", 
          "polymorphism", 
          "expression", 
          "update", 
          "sensitivity", 
          "enzyme", 
          "presence", 
          "methyltransferase", 
          "impact of variations", 
          "tandem repeats", 
          "relationship", 
          "number", 
          "impact", 
          "route", 
          "variation", 
          "repeats", 
          "region", 
          "derivatives", 
          "article", 
          "terms"
        ], 
        "name": "The thiopurines: An update", 
        "pagination": "523-532", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1043851224"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10637-005-4020-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16267626"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10637-005-4020-8", 
          "https://app.dimensions.ai/details/publication/pub.1043851224"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:33", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_411.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10637-005-4020-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10637-005-4020-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10637-005-4020-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10637-005-4020-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10637-005-4020-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    243 TRIPLES      21 PREDICATES      103 URIs      76 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10637-005-4020-8 schema:about N0ac0bc38fcc943ffb8c01d08b37dd12b
    2 N1525cfd85fe3479fa29b30a582fc8baa
    3 N23e7fa6d1fd841a594e1080d075420cb
    4 N2f814f300a444f349e28c050777340e4
    5 N3dbae8316b8548a79baa2f78a15b65f0
    6 N6048b7df137a4884a3a8a5d90204ea81
    7 N62e2c8d7956944c4adc33e1afb2b6768
    8 N6d94185f804d470f8ebd9e4ee5452936
    9 N7b18ae59ca16456cad65054bebb8aaf2
    10 N8284324d04184fd7ab5451b6ca1bce90
    11 Nb9f1dc1362ee4e2f8b903dc0ce867759
    12 Nd27e2dc664a442d3b6bbd0aefbe95380
    13 Ne5fa9aba4e104f1a9844ea9ba2eb3f6f
    14 anzsrc-for:11
    15 anzsrc-for:1115
    16 schema:author N506a257b246d4c739329ef8454b7ed20
    17 schema:citation sg:pub.10.1007/bf00253008
    18 sg:pub.10.1007/bf00255484
    19 sg:pub.10.1007/bf02220605
    20 sg:pub.10.1007/s00228-003-0617-z
    21 sg:pub.10.1007/s002280050457
    22 sg:pub.10.1007/s002800050816
    23 sg:pub.10.1007/s100380070020
    24 sg:pub.10.1016/s0009-9236(97)90125-9
    25 sg:pub.10.1023/a:1011909315614
    26 sg:pub.10.1023/a:1012111325397
    27 sg:pub.10.1038/bjc.1993.311
    28 sg:pub.10.1038/clpt.1989.119
    29 sg:pub.10.1038/sj.leu.2400928
    30 sg:pub.10.1038/sj.leu.2401723
    31 sg:pub.10.1038/sj.leu.2401974
    32 sg:pub.10.1038/sj.leu.2402981
    33 sg:pub.10.1038/sj.tpj.6500066
    34 sg:pub.10.1067/mcp.2000.108674
    35 sg:pub.10.1067/mcp.2001.117284
    36 schema:datePublished 2005-10-26
    37 schema:datePublishedReg 2005-10-26
    38 schema:description The thiopurine drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) are commonly used cytotoxic agents. A derivative of 6-MP, azathioprine, is commonly used as an immunosuppressant. A prominent route for the metabolism of these agents is mediated by the enzyme thiopurine methyltransferase (TPMT). This enzyme exhibits considerable inter-individual variation in activity, partly due to the presence of common genetic polymorphisms, which influence cytotoxicity of the thiopurine drugs. Variations in the number of tandem repeats in the 5′ promoter region have also been shown to influence TPMT expression in vitro. In this article, we review the impact of variations in TPMT activity on sensitivity to the thiopurine drugs in vitro and also in vivo in terms of their clinical efficacy and toxicity. A possible relationship between TPMT and secondary malignancies is also reviewed.
    39 schema:genre article
    40 schema:isAccessibleForFree false
    41 schema:isPartOf N0eb8941a135746bcbc2b20ba4500dafc
    42 N94ecdb86cb1b4ea6824e0610415c5942
    43 sg:journal.1094201
    44 schema:keywords TPMT activity
    45 TPMT expression
    46 activity
    47 agents
    48 article
    49 azathioprine
    50 clinical efficacy
    51 common genetic polymorphisms
    52 considerable inter-individual variation
    53 cytotoxic agents
    54 cytotoxicity
    55 derivatives
    56 drugs
    57 efficacy
    58 enzyme
    59 enzyme thiopurine methyltransferase
    60 expression
    61 genetic polymorphisms
    62 immunosuppressants
    63 impact
    64 impact of variations
    65 inter-individual variation
    66 malignancy
    67 metabolism
    68 methyltransferase
    69 number
    70 polymorphism
    71 possible relationship
    72 presence
    73 prominent route
    74 promoter region
    75 region
    76 relationship
    77 repeats
    78 route
    79 secondary malignancies
    80 sensitivity
    81 tandem repeats
    82 terms
    83 thiopurine drugs
    84 thiopurine methyltransferase
    85 thiopurines
    86 toxicity
    87 update
    88 variation
    89 vitro
    90 vivo
    91 schema:name The thiopurines: An update
    92 schema:pagination 523-532
    93 schema:productId N6b9b5485ee764e75a0b80043cbbfca44
    94 Nb20d4f2d3fdc4ba09bf2142114f03d18
    95 Nd700253da49f4dcea3e56ff92ed3a011
    96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043851224
    97 https://doi.org/10.1007/s10637-005-4020-8
    98 schema:sdDatePublished 2022-10-01T06:33
    99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    100 schema:sdPublisher N372ae7bd0ae244d587b8bf035dc2fef3
    101 schema:url https://doi.org/10.1007/s10637-005-4020-8
    102 sgo:license sg:explorer/license/
    103 sgo:sdDataset articles
    104 rdf:type schema:ScholarlyArticle
    105 N0ac0bc38fcc943ffb8c01d08b37dd12b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Antimetabolites, Antineoplastic
    107 rdf:type schema:DefinedTerm
    108 N0eb8941a135746bcbc2b20ba4500dafc schema:issueNumber 6
    109 rdf:type schema:PublicationIssue
    110 N1525cfd85fe3479fa29b30a582fc8baa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Azathioprine
    112 rdf:type schema:DefinedTerm
    113 N23e7fa6d1fd841a594e1080d075420cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Immunosuppressive Agents
    115 rdf:type schema:DefinedTerm
    116 N2f814f300a444f349e28c050777340e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Polymorphism, Genetic
    118 rdf:type schema:DefinedTerm
    119 N372ae7bd0ae244d587b8bf035dc2fef3 schema:name Springer Nature - SN SciGraph project
    120 rdf:type schema:Organization
    121 N3dbae8316b8548a79baa2f78a15b65f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Guanine Nucleotides
    123 rdf:type schema:DefinedTerm
    124 N4b4d943639ba43d9991e5c2adb1e6acf rdf:first sg:person.01245632127.83
    125 rdf:rest rdf:nil
    126 N506a257b246d4c739329ef8454b7ed20 rdf:first sg:person.0576131213.97
    127 rdf:rest N4b4d943639ba43d9991e5c2adb1e6acf
    128 N6048b7df137a4884a3a8a5d90204ea81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Leukemia
    130 rdf:type schema:DefinedTerm
    131 N62e2c8d7956944c4adc33e1afb2b6768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Humans
    133 rdf:type schema:DefinedTerm
    134 N6b9b5485ee764e75a0b80043cbbfca44 schema:name pubmed_id
    135 schema:value 16267626
    136 rdf:type schema:PropertyValue
    137 N6d94185f804d470f8ebd9e4ee5452936 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Thionucleotides
    139 rdf:type schema:DefinedTerm
    140 N7b18ae59ca16456cad65054bebb8aaf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Thioguanine
    142 rdf:type schema:DefinedTerm
    143 N8284324d04184fd7ab5451b6ca1bce90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Cell Line, Tumor
    145 rdf:type schema:DefinedTerm
    146 N94ecdb86cb1b4ea6824e0610415c5942 schema:volumeNumber 23
    147 rdf:type schema:PublicationVolume
    148 Nb20d4f2d3fdc4ba09bf2142114f03d18 schema:name doi
    149 schema:value 10.1007/s10637-005-4020-8
    150 rdf:type schema:PropertyValue
    151 Nb9f1dc1362ee4e2f8b903dc0ce867759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Methyltransferases
    153 rdf:type schema:DefinedTerm
    154 Nd27e2dc664a442d3b6bbd0aefbe95380 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Mercaptopurine
    156 rdf:type schema:DefinedTerm
    157 Nd700253da49f4dcea3e56ff92ed3a011 schema:name dimensions_id
    158 schema:value pub.1043851224
    159 rdf:type schema:PropertyValue
    160 Ne5fa9aba4e104f1a9844ea9ba2eb3f6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Animals
    162 rdf:type schema:DefinedTerm
    163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Medical and Health Sciences
    165 rdf:type schema:DefinedTerm
    166 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Pharmacology and Pharmaceutical Sciences
    168 rdf:type schema:DefinedTerm
    169 sg:journal.1094201 schema:issn 0167-6997
    170 1573-0646
    171 schema:name Investigational New Drugs
    172 schema:publisher Springer Nature
    173 rdf:type schema:Periodical
    174 sg:person.01245632127.83 schema:affiliation grid-institutes:grid.1006.7
    175 schema:familyName Hogarth
    176 schema:givenName Linda
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245632127.83
    178 rdf:type schema:Person
    179 sg:person.0576131213.97 schema:affiliation grid-institutes:grid.1006.7
    180 schema:familyName Coulthard
    181 schema:givenName Sally
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576131213.97
    183 rdf:type schema:Person
    184 sg:pub.10.1007/bf00253008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009761882
    185 https://doi.org/10.1007/bf00253008
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/bf00255484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014629242
    188 https://doi.org/10.1007/bf00255484
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/bf02220605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000863143
    191 https://doi.org/10.1007/bf02220605
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s00228-003-0617-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007561734
    194 https://doi.org/10.1007/s00228-003-0617-z
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s002280050457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019665476
    197 https://doi.org/10.1007/s002280050457
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1007/s002800050816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037384717
    200 https://doi.org/10.1007/s002800050816
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1007/s100380070020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050031173
    203 https://doi.org/10.1007/s100380070020
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1016/s0009-9236(97)90125-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032244265
    206 https://doi.org/10.1016/s0009-9236(97)90125-9
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1023/a:1011909315614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046367699
    209 https://doi.org/10.1023/a:1011909315614
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1023/a:1012111325397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030674820
    212 https://doi.org/10.1023/a:1012111325397
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/bjc.1993.311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033249097
    215 https://doi.org/10.1038/bjc.1993.311
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/clpt.1989.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045694510
    218 https://doi.org/10.1038/clpt.1989.119
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/sj.leu.2400928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046488609
    221 https://doi.org/10.1038/sj.leu.2400928
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/sj.leu.2401723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018637081
    224 https://doi.org/10.1038/sj.leu.2401723
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/sj.leu.2401974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027135078
    227 https://doi.org/10.1038/sj.leu.2401974
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/sj.leu.2402981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004860258
    230 https://doi.org/10.1038/sj.leu.2402981
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/sj.tpj.6500066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031895354
    233 https://doi.org/10.1038/sj.tpj.6500066
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1067/mcp.2000.108674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005506858
    236 https://doi.org/10.1067/mcp.2000.108674
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1067/mcp.2001.117284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008223166
    239 https://doi.org/10.1067/mcp.2001.117284
    240 rdf:type schema:CreativeWork
    241 grid-institutes:grid.1006.7 schema:alternateName Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle Upon Tyne, UK
    242 schema:name Leukaemia Research Group, Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle Upon Tyne, UK
    243 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...