Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Kenji Ozawa, Kiyofumi Mochizuki, Yusuke Manabe, Nobuaki Yoshikura, Takayoshi Shimohata, Ichizo Nishino, Yu-ichi Goto

ABSTRACT

PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A > G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A > G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations. METHODS: The retinal structure and function of a 37-year-old woman who was referred to our clinic for of nyctalopia were studied. Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity, intraocular pressures, and slit-lamp biomicroscopy, ophthalmoscopy, fluorescein angiography, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and multifocal electroretinography (mfERG) were performed. RESULTS: Fundus examination showed bilateral hypopigmentary changes of the retinal pigment epithelium which extended from the posterior pole to the equator. Fluorescein angiography showed patchy hyperfluorescence due to window defects at the atrophic areas. Fundus autofluorescence demonstrated mild hyperfluorescent lesions in both eyes. SD-OCT showed that the interdigitation zone was indistinct in both eyes, and the inner nuclear layer was slightly thinner. The amplitudes of the rod, cone, and 30-Hz flicker ERGs were severely reduced, and the implicit times were prolonged. The a- and b-waves of the bright-flash mixed rod-cone ERGs were also reduced. The dark-adapted oscillatory potentials were reduced. The amplitudes of the mfERGs were severely depressed except at the fovea in both eyes. CONCLUSIONS: These findings indicate that the RPE atrophy was wider and the rod dysfunction was more severe affected than that of previously reported MELAS cases with the m.3243A > G mutation. More... »

PAGES

147-152

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y

DOI

http://dx.doi.org/10.1007/s10633-019-09673-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111779962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30701423


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozawa", 
        "givenName": "Kenji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochizuki", 
        "givenName": "Kiyofumi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manabe", 
        "givenName": "Yusuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshikura", 
        "givenName": "Nobuaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimohata", 
        "givenName": "Takayoshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center of Neurology and Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Departments of Neuromuscular Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishino", 
        "givenName": "Ichizo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center of Neurology and Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Mental Retardation and Birth Defect Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan", 
            "Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goto", 
        "givenName": "Yu-ichi", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archopht.1984.01040031057023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000210271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00417-002-0555-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001452609", 
          "https://doi.org/10.1007/s00417-002-0555-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-014-9473-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001655920", 
          "https://doi.org/10.1007/s10633-014-9473-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp-2012-303528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004840407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-011-9296-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010288819", 
          "https://doi.org/10.1007/s10633-011-9296-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90244-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011184920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90244-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011184920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.03-1090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012255790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/331717a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012494215", 
          "https://doi.org/10.1038/331717a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1962.00960030023005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021649283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410250611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023555532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s100380070004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027203910", 
          "https://doi.org/10.1007/s100380070004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/348651a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027941299", 
          "https://doi.org/10.1038/348651a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(93)90219-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033002182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(93)90219-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033002182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90356-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033348893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90356-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033348893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wno.0b013e3180334cb0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033444272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wno.0b013e3180334cb0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033444272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2013.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036020287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(91)90042-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049992097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(91)90042-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049992097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-012-9351-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050631971", 
          "https://doi.org/10.1007/s10633-012-9351-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1987.01060070065030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052494048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3201231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062598995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.45.2.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064373056"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A\u2009>\u2009G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A\u2009>\u2009G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations.\nMETHODS: The retinal structure and function of a 37-year-old woman who was referred to our clinic for of nyctalopia were studied. Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity, intraocular pressures, and slit-lamp biomicroscopy, ophthalmoscopy, fluorescein angiography, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and multifocal electroretinography (mfERG) were performed.\nRESULTS: Fundus examination showed bilateral hypopigmentary changes of the retinal pigment epithelium which extended from the posterior pole to the equator. Fluorescein angiography showed patchy hyperfluorescence due to window defects at the atrophic areas. Fundus autofluorescence demonstrated mild hyperfluorescent lesions in both eyes. SD-OCT showed that the interdigitation zone was indistinct in both eyes, and the inner nuclear layer was slightly thinner. The amplitudes of the rod, cone, and 30-Hz flicker ERGs were severely reduced, and the implicit times were prolonged. The a- and b-waves of the bright-flash mixed rod-cone ERGs were also reduced. The dark-adapted oscillatory potentials were reduced. The amplitudes of the mfERGs were severely depressed except at the fovea in both eyes.\nCONCLUSIONS: These findings indicate that the RPE atrophy was wider and the rod dysfunction was more severe affected than that of previously reported MELAS cases with the m.3243A\u2009>\u2009G mutation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10633-019-09673-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017097", 
        "issn": [
          "0012-4486", 
          "1573-2622"
        ], 
        "name": "Documenta Ophthalmologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "138"
      }
    ], 
    "name": "Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome", 
    "pagination": "147-152", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e97b3cef307ee3ca54d068ac36606c6628c5fda970d0116b4dd9b68beb8c532e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30701423"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370667"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10633-019-09673-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111779962"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10633-019-09673-y", 
      "https://app.dimensions.ai/details/publication/pub.1111779962"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46757_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10633-019-09673-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'


 

This table displays all metadata directly associated to this object as RDF triples.

183 TRIPLES      21 PREDICATES      51 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10633-019-09673-y schema:about anzsrc-for:11
2 anzsrc-for:1113
3 schema:author N754379aee43e4ae0885b2096664026fe
4 schema:citation sg:pub.10.1007/s00417-002-0555-y
5 sg:pub.10.1007/s100380070004
6 sg:pub.10.1007/s10633-011-9296-8
7 sg:pub.10.1007/s10633-012-9351-0
8 sg:pub.10.1007/s10633-014-9473-7
9 sg:pub.10.1038/331717a0
10 sg:pub.10.1038/348651a0
11 https://doi.org/10.1001/archopht.1962.00960030023005
12 https://doi.org/10.1001/archopht.1984.01040031057023
13 https://doi.org/10.1001/archopht.1987.01060070065030
14 https://doi.org/10.1002/ana.410250611
15 https://doi.org/10.1016/0022-510x(93)90219-o
16 https://doi.org/10.1016/0925-4439(91)90042-8
17 https://doi.org/10.1016/j.ophtha.2013.05.013
18 https://doi.org/10.1016/s0161-6420(99)90244-0
19 https://doi.org/10.1016/s0161-6420(99)90356-1
20 https://doi.org/10.1097/wno.0b013e3180334cb0
21 https://doi.org/10.1126/science.3201231
22 https://doi.org/10.1136/jnnp-2012-303528
23 https://doi.org/10.1167/iovs.03-1090
24 https://doi.org/10.1212/01.wnl.0000220197.36849.1e
25 https://doi.org/10.1212/wnl.45.2.286
26 schema:datePublished 2019-04
27 schema:datePublishedReg 2019-04-01
28 schema:description PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A > G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A > G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations. METHODS: The retinal structure and function of a 37-year-old woman who was referred to our clinic for of nyctalopia were studied. Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity, intraocular pressures, and slit-lamp biomicroscopy, ophthalmoscopy, fluorescein angiography, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and multifocal electroretinography (mfERG) were performed. RESULTS: Fundus examination showed bilateral hypopigmentary changes of the retinal pigment epithelium which extended from the posterior pole to the equator. Fluorescein angiography showed patchy hyperfluorescence due to window defects at the atrophic areas. Fundus autofluorescence demonstrated mild hyperfluorescent lesions in both eyes. SD-OCT showed that the interdigitation zone was indistinct in both eyes, and the inner nuclear layer was slightly thinner. The amplitudes of the rod, cone, and 30-Hz flicker ERGs were severely reduced, and the implicit times were prolonged. The a- and b-waves of the bright-flash mixed rod-cone ERGs were also reduced. The dark-adapted oscillatory potentials were reduced. The amplitudes of the mfERGs were severely depressed except at the fovea in both eyes. CONCLUSIONS: These findings indicate that the RPE atrophy was wider and the rod dysfunction was more severe affected than that of previously reported MELAS cases with the m.3243A > G mutation.
29 schema:genre research_article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf N47623b60f3ff4af59026f2ab870dbf20
33 Nf15c41ae68124fcd81431ffc8bdc2459
34 sg:journal.1017097
35 schema:name Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome
36 schema:pagination 147-152
37 schema:productId N1a38a5f9e7184da88d5dd3f1a62d5c9d
38 N272192fbcf9441a78131b2a3ec789b99
39 Nc5e05a402a4349bdab1b09c7b8daf360
40 Nf1d6665adec94aa39c303a6295f298d8
41 Nfd8db2f5930246878cb76174d95b428f
42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111779962
43 https://doi.org/10.1007/s10633-019-09673-y
44 schema:sdDatePublished 2019-04-11T13:31
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher N43aa4d8fb3ce4ac38be2605d93074176
47 schema:url https://link.springer.com/10.1007%2Fs10633-019-09673-y
48 sgo:license sg:explorer/license/
49 sgo:sdDataset articles
50 rdf:type schema:ScholarlyArticle
51 N05f703a487fa40928139f96a5b62e557 rdf:first N31369687ebb8456098af2dd0309eeb21
52 rdf:rest N8895981d2b594b048044ae73c11d05d5
53 N1a38a5f9e7184da88d5dd3f1a62d5c9d schema:name dimensions_id
54 schema:value pub.1111779962
55 rdf:type schema:PropertyValue
56 N272192fbcf9441a78131b2a3ec789b99 schema:name pubmed_id
57 schema:value 30701423
58 rdf:type schema:PropertyValue
59 N31369687ebb8456098af2dd0309eeb21 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
60 schema:familyName Shimohata
61 schema:givenName Takayoshi
62 rdf:type schema:Person
63 N372f2d52db414ca68a61789d9b0b95e6 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
64 schema:familyName Mochizuki
65 schema:givenName Kiyofumi
66 rdf:type schema:Person
67 N43aa4d8fb3ce4ac38be2605d93074176 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N4735269b193d406e8798b0ab08d27a57 schema:affiliation https://www.grid.ac/institutes/grid.419280.6
70 schema:familyName Nishino
71 schema:givenName Ichizo
72 rdf:type schema:Person
73 N47623b60f3ff4af59026f2ab870dbf20 schema:issueNumber 2
74 rdf:type schema:PublicationIssue
75 N754379aee43e4ae0885b2096664026fe rdf:first Nb0471124d52d48e7a336c9fbda61ee83
76 rdf:rest Nb95872f7e4e240d6ba5662b705386080
77 N786c3381df86466a9028de5955938380 rdf:first Neeb464091bc84ca687c9f79fe5afa921
78 rdf:rest Nacf47c55ba9946c5a808cff9297ebdc1
79 N8895981d2b594b048044ae73c11d05d5 rdf:first N4735269b193d406e8798b0ab08d27a57
80 rdf:rest Ne0759fafa3e6499caeec6cd6c4c80695
81 Nacf47c55ba9946c5a808cff9297ebdc1 rdf:first Ne7495c2030c44079b185d82b00139561
82 rdf:rest N05f703a487fa40928139f96a5b62e557
83 Nb0471124d52d48e7a336c9fbda61ee83 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
84 schema:familyName Ozawa
85 schema:givenName Kenji
86 rdf:type schema:Person
87 Nb95872f7e4e240d6ba5662b705386080 rdf:first N372f2d52db414ca68a61789d9b0b95e6
88 rdf:rest N786c3381df86466a9028de5955938380
89 Nc5e05a402a4349bdab1b09c7b8daf360 schema:name doi
90 schema:value 10.1007/s10633-019-09673-y
91 rdf:type schema:PropertyValue
92 Ncde2165a85764bd09820da63a3bc46a9 schema:affiliation https://www.grid.ac/institutes/grid.419280.6
93 schema:familyName Goto
94 schema:givenName Yu-ichi
95 rdf:type schema:Person
96 Ne0759fafa3e6499caeec6cd6c4c80695 rdf:first Ncde2165a85764bd09820da63a3bc46a9
97 rdf:rest rdf:nil
98 Ne7495c2030c44079b185d82b00139561 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
99 schema:familyName Yoshikura
100 schema:givenName Nobuaki
101 rdf:type schema:Person
102 Neeb464091bc84ca687c9f79fe5afa921 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
103 schema:familyName Manabe
104 schema:givenName Yusuke
105 rdf:type schema:Person
106 Nf15c41ae68124fcd81431ffc8bdc2459 schema:volumeNumber 138
107 rdf:type schema:PublicationVolume
108 Nf1d6665adec94aa39c303a6295f298d8 schema:name readcube_id
109 schema:value e97b3cef307ee3ca54d068ac36606c6628c5fda970d0116b4dd9b68beb8c532e
110 rdf:type schema:PropertyValue
111 Nfd8db2f5930246878cb76174d95b428f schema:name nlm_unique_id
112 schema:value 0370667
113 rdf:type schema:PropertyValue
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
118 schema:name Ophthalmology and Optometry
119 rdf:type schema:DefinedTerm
120 sg:journal.1017097 schema:issn 0012-4486
121 1573-2622
122 schema:name Documenta Ophthalmologica
123 rdf:type schema:Periodical
124 sg:pub.10.1007/s00417-002-0555-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001452609
125 https://doi.org/10.1007/s00417-002-0555-y
126 rdf:type schema:CreativeWork
127 sg:pub.10.1007/s100380070004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027203910
128 https://doi.org/10.1007/s100380070004
129 rdf:type schema:CreativeWork
130 sg:pub.10.1007/s10633-011-9296-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010288819
131 https://doi.org/10.1007/s10633-011-9296-8
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s10633-012-9351-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050631971
134 https://doi.org/10.1007/s10633-012-9351-0
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/s10633-014-9473-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001655920
137 https://doi.org/10.1007/s10633-014-9473-7
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/331717a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012494215
140 https://doi.org/10.1038/331717a0
141 rdf:type schema:CreativeWork
142 sg:pub.10.1038/348651a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027941299
143 https://doi.org/10.1038/348651a0
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1001/archopht.1962.00960030023005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021649283
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1001/archopht.1984.01040031057023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000210271
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1001/archopht.1987.01060070065030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052494048
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1002/ana.410250611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023555532
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/0022-510x(93)90219-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1033002182
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0925-4439(91)90042-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049992097
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.ophtha.2013.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036020287
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0161-6420(99)90244-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011184920
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/s0161-6420(99)90356-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033348893
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1097/wno.0b013e3180334cb0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033444272
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1126/science.3201231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062598995
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1136/jnnp-2012-303528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004840407
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1167/iovs.03-1090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012255790
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1212/01.wnl.0000220197.36849.1e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348202
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1212/wnl.45.2.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064373056
174 rdf:type schema:CreativeWork
175 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
176 schema:name Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
177 Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan
178 rdf:type schema:Organization
179 https://www.grid.ac/institutes/grid.419280.6 schema:alternateName National Center of Neurology and Psychiatry
180 schema:name Departments of Neuromuscular Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
181 Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan
182 Mental Retardation and Birth Defect Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
183 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...