Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Kenji Ozawa, Kiyofumi Mochizuki, Yusuke Manabe, Nobuaki Yoshikura, Takayoshi Shimohata, Ichizo Nishino, Yu-ichi Goto

ABSTRACT

PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A > G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A > G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations. METHODS: The retinal structure and function of a 37-year-old woman who was referred to our clinic for of nyctalopia were studied. Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity, intraocular pressures, and slit-lamp biomicroscopy, ophthalmoscopy, fluorescein angiography, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and multifocal electroretinography (mfERG) were performed. RESULTS: Fundus examination showed bilateral hypopigmentary changes of the retinal pigment epithelium which extended from the posterior pole to the equator. Fluorescein angiography showed patchy hyperfluorescence due to window defects at the atrophic areas. Fundus autofluorescence demonstrated mild hyperfluorescent lesions in both eyes. SD-OCT showed that the interdigitation zone was indistinct in both eyes, and the inner nuclear layer was slightly thinner. The amplitudes of the rod, cone, and 30-Hz flicker ERGs were severely reduced, and the implicit times were prolonged. The a- and b-waves of the bright-flash mixed rod-cone ERGs were also reduced. The dark-adapted oscillatory potentials were reduced. The amplitudes of the mfERGs were severely depressed except at the fovea in both eyes. CONCLUSIONS: These findings indicate that the RPE atrophy was wider and the rod dysfunction was more severe affected than that of previously reported MELAS cases with the m.3243A > G mutation. More... »

PAGES

147-152

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y

DOI

http://dx.doi.org/10.1007/s10633-019-09673-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111779962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30701423


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozawa", 
        "givenName": "Kenji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochizuki", 
        "givenName": "Kiyofumi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manabe", 
        "givenName": "Yusuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshikura", 
        "givenName": "Nobuaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimohata", 
        "givenName": "Takayoshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center of Neurology and Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Departments of Neuromuscular Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishino", 
        "givenName": "Ichizo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center of Neurology and Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Mental Retardation and Birth Defect Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan", 
            "Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goto", 
        "givenName": "Yu-ichi", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archopht.1984.01040031057023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000210271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00417-002-0555-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001452609", 
          "https://doi.org/10.1007/s00417-002-0555-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-014-9473-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001655920", 
          "https://doi.org/10.1007/s10633-014-9473-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp-2012-303528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004840407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-011-9296-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010288819", 
          "https://doi.org/10.1007/s10633-011-9296-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90244-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011184920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90244-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011184920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.03-1090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012255790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/331717a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012494215", 
          "https://doi.org/10.1038/331717a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1962.00960030023005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021649283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410250611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023555532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s100380070004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027203910", 
          "https://doi.org/10.1007/s100380070004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/348651a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027941299", 
          "https://doi.org/10.1038/348651a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(93)90219-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033002182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(93)90219-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033002182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90356-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033348893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(99)90356-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033348893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wno.0b013e3180334cb0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033444272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wno.0b013e3180334cb0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033444272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2013.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036020287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(91)90042-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049992097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(91)90042-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049992097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-012-9351-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050631971", 
          "https://doi.org/10.1007/s10633-012-9351-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1987.01060070065030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052494048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3201231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062598995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000220197.36849.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.45.2.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064373056"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A\u2009>\u2009G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A\u2009>\u2009G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations.\nMETHODS: The retinal structure and function of a 37-year-old woman who was referred to our clinic for of nyctalopia were studied. Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity, intraocular pressures, and slit-lamp biomicroscopy, ophthalmoscopy, fluorescein angiography, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and multifocal electroretinography (mfERG) were performed.\nRESULTS: Fundus examination showed bilateral hypopigmentary changes of the retinal pigment epithelium which extended from the posterior pole to the equator. Fluorescein angiography showed patchy hyperfluorescence due to window defects at the atrophic areas. Fundus autofluorescence demonstrated mild hyperfluorescent lesions in both eyes. SD-OCT showed that the interdigitation zone was indistinct in both eyes, and the inner nuclear layer was slightly thinner. The amplitudes of the rod, cone, and 30-Hz flicker ERGs were severely reduced, and the implicit times were prolonged. The a- and b-waves of the bright-flash mixed rod-cone ERGs were also reduced. The dark-adapted oscillatory potentials were reduced. The amplitudes of the mfERGs were severely depressed except at the fovea in both eyes.\nCONCLUSIONS: These findings indicate that the RPE atrophy was wider and the rod dysfunction was more severe affected than that of previously reported MELAS cases with the m.3243A\u2009>\u2009G mutation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10633-019-09673-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017097", 
        "issn": [
          "0012-4486", 
          "1573-2622"
        ], 
        "name": "Documenta Ophthalmologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "138"
      }
    ], 
    "name": "Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome", 
    "pagination": "147-152", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e97b3cef307ee3ca54d068ac36606c6628c5fda970d0116b4dd9b68beb8c532e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30701423"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370667"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10633-019-09673-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111779962"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10633-019-09673-y", 
      "https://app.dimensions.ai/details/publication/pub.1111779962"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46757_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10633-019-09673-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10633-019-09673-y'


 

This table displays all metadata directly associated to this object as RDF triples.

183 TRIPLES      21 PREDICATES      51 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10633-019-09673-y schema:about anzsrc-for:11
2 anzsrc-for:1113
3 schema:author N8d887f50edff44d5a113e38aea178f9c
4 schema:citation sg:pub.10.1007/s00417-002-0555-y
5 sg:pub.10.1007/s100380070004
6 sg:pub.10.1007/s10633-011-9296-8
7 sg:pub.10.1007/s10633-012-9351-0
8 sg:pub.10.1007/s10633-014-9473-7
9 sg:pub.10.1038/331717a0
10 sg:pub.10.1038/348651a0
11 https://doi.org/10.1001/archopht.1962.00960030023005
12 https://doi.org/10.1001/archopht.1984.01040031057023
13 https://doi.org/10.1001/archopht.1987.01060070065030
14 https://doi.org/10.1002/ana.410250611
15 https://doi.org/10.1016/0022-510x(93)90219-o
16 https://doi.org/10.1016/0925-4439(91)90042-8
17 https://doi.org/10.1016/j.ophtha.2013.05.013
18 https://doi.org/10.1016/s0161-6420(99)90244-0
19 https://doi.org/10.1016/s0161-6420(99)90356-1
20 https://doi.org/10.1097/wno.0b013e3180334cb0
21 https://doi.org/10.1126/science.3201231
22 https://doi.org/10.1136/jnnp-2012-303528
23 https://doi.org/10.1167/iovs.03-1090
24 https://doi.org/10.1212/01.wnl.0000220197.36849.1e
25 https://doi.org/10.1212/wnl.45.2.286
26 schema:datePublished 2019-04
27 schema:datePublishedReg 2019-04-01
28 schema:description PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A > G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A > G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations. METHODS: The retinal structure and function of a 37-year-old woman who was referred to our clinic for of nyctalopia were studied. Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity, intraocular pressures, and slit-lamp biomicroscopy, ophthalmoscopy, fluorescein angiography, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and multifocal electroretinography (mfERG) were performed. RESULTS: Fundus examination showed bilateral hypopigmentary changes of the retinal pigment epithelium which extended from the posterior pole to the equator. Fluorescein angiography showed patchy hyperfluorescence due to window defects at the atrophic areas. Fundus autofluorescence demonstrated mild hyperfluorescent lesions in both eyes. SD-OCT showed that the interdigitation zone was indistinct in both eyes, and the inner nuclear layer was slightly thinner. The amplitudes of the rod, cone, and 30-Hz flicker ERGs were severely reduced, and the implicit times were prolonged. The a- and b-waves of the bright-flash mixed rod-cone ERGs were also reduced. The dark-adapted oscillatory potentials were reduced. The amplitudes of the mfERGs were severely depressed except at the fovea in both eyes. CONCLUSIONS: These findings indicate that the RPE atrophy was wider and the rod dysfunction was more severe affected than that of previously reported MELAS cases with the m.3243A > G mutation.
29 schema:genre research_article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf N7dd215a1f0814c64a3486a2740588f83
33 Nef53bdabc3f14ddeaf2eecb73d44bff2
34 sg:journal.1017097
35 schema:name Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome
36 schema:pagination 147-152
37 schema:productId N43b67f46bb824edf9695ee15876831b8
38 Na255659d028e4388a7bf06a89548e9c6
39 Na86e72b0800946c79e8451e2c70ee615
40 Nbd596dd972204343b04bd43e53cd3ffb
41 Nc58de6045ac54f459722da8c485bff8b
42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111779962
43 https://doi.org/10.1007/s10633-019-09673-y
44 schema:sdDatePublished 2019-04-11T13:31
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher Na471ff6ba77b4db0b34e00382f6ccb88
47 schema:url https://link.springer.com/10.1007%2Fs10633-019-09673-y
48 sgo:license sg:explorer/license/
49 sgo:sdDataset articles
50 rdf:type schema:ScholarlyArticle
51 N00174363cf2342cebe1c3c6ae12c38f4 rdf:first N78b963e0f7d84f99b7f547cf4c6d2943
52 rdf:rest Nb1ed0348fce34f32822ccc29e4a1b40b
53 N3d7a874153f447b28c06eb3ac2907b52 schema:affiliation https://www.grid.ac/institutes/grid.419280.6
54 schema:familyName Goto
55 schema:givenName Yu-ichi
56 rdf:type schema:Person
57 N43b67f46bb824edf9695ee15876831b8 schema:name nlm_unique_id
58 schema:value 0370667
59 rdf:type schema:PropertyValue
60 N552a1b4a65cb4b6eb0c4a83517b859ee schema:affiliation https://www.grid.ac/institutes/grid.256342.4
61 schema:familyName Yoshikura
62 schema:givenName Nobuaki
63 rdf:type schema:Person
64 N66458bad069045aababb763b55e9e092 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
65 schema:familyName Ozawa
66 schema:givenName Kenji
67 rdf:type schema:Person
68 N78b963e0f7d84f99b7f547cf4c6d2943 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
69 schema:familyName Shimohata
70 schema:givenName Takayoshi
71 rdf:type schema:Person
72 N7b282a8eb7d44186a8f7ac736ed14283 rdf:first N3d7a874153f447b28c06eb3ac2907b52
73 rdf:rest rdf:nil
74 N7dd215a1f0814c64a3486a2740588f83 schema:issueNumber 2
75 rdf:type schema:PublicationIssue
76 N8d887f50edff44d5a113e38aea178f9c rdf:first N66458bad069045aababb763b55e9e092
77 rdf:rest Nd2acd434e1f04313bbbfb0d840acc284
78 N981d21a95f3148f1952d0e2917a540f2 schema:affiliation https://www.grid.ac/institutes/grid.419280.6
79 schema:familyName Nishino
80 schema:givenName Ichizo
81 rdf:type schema:Person
82 Na255659d028e4388a7bf06a89548e9c6 schema:name readcube_id
83 schema:value e97b3cef307ee3ca54d068ac36606c6628c5fda970d0116b4dd9b68beb8c532e
84 rdf:type schema:PropertyValue
85 Na2d52bda12f84e1f9c18b26607687f7a schema:affiliation https://www.grid.ac/institutes/grid.256342.4
86 schema:familyName Mochizuki
87 schema:givenName Kiyofumi
88 rdf:type schema:Person
89 Na471ff6ba77b4db0b34e00382f6ccb88 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 Na86e72b0800946c79e8451e2c70ee615 schema:name pubmed_id
92 schema:value 30701423
93 rdf:type schema:PropertyValue
94 Nb1ed0348fce34f32822ccc29e4a1b40b rdf:first N981d21a95f3148f1952d0e2917a540f2
95 rdf:rest N7b282a8eb7d44186a8f7ac736ed14283
96 Nbd596dd972204343b04bd43e53cd3ffb schema:name dimensions_id
97 schema:value pub.1111779962
98 rdf:type schema:PropertyValue
99 Nc58de6045ac54f459722da8c485bff8b schema:name doi
100 schema:value 10.1007/s10633-019-09673-y
101 rdf:type schema:PropertyValue
102 Nd2acd434e1f04313bbbfb0d840acc284 rdf:first Na2d52bda12f84e1f9c18b26607687f7a
103 rdf:rest Nd942bc9f37704628965f8f2eb08a3e43
104 Nd942bc9f37704628965f8f2eb08a3e43 rdf:first Nf8f9f1fb810941e7a75a9009666b3e08
105 rdf:rest Ne65b8d8fbec84a2cb24adeadefd0312e
106 Ne65b8d8fbec84a2cb24adeadefd0312e rdf:first N552a1b4a65cb4b6eb0c4a83517b859ee
107 rdf:rest N00174363cf2342cebe1c3c6ae12c38f4
108 Nef53bdabc3f14ddeaf2eecb73d44bff2 schema:volumeNumber 138
109 rdf:type schema:PublicationVolume
110 Nf8f9f1fb810941e7a75a9009666b3e08 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
111 schema:familyName Manabe
112 schema:givenName Yusuke
113 rdf:type schema:Person
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
118 schema:name Ophthalmology and Optometry
119 rdf:type schema:DefinedTerm
120 sg:journal.1017097 schema:issn 0012-4486
121 1573-2622
122 schema:name Documenta Ophthalmologica
123 rdf:type schema:Periodical
124 sg:pub.10.1007/s00417-002-0555-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001452609
125 https://doi.org/10.1007/s00417-002-0555-y
126 rdf:type schema:CreativeWork
127 sg:pub.10.1007/s100380070004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027203910
128 https://doi.org/10.1007/s100380070004
129 rdf:type schema:CreativeWork
130 sg:pub.10.1007/s10633-011-9296-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010288819
131 https://doi.org/10.1007/s10633-011-9296-8
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s10633-012-9351-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050631971
134 https://doi.org/10.1007/s10633-012-9351-0
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/s10633-014-9473-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001655920
137 https://doi.org/10.1007/s10633-014-9473-7
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/331717a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012494215
140 https://doi.org/10.1038/331717a0
141 rdf:type schema:CreativeWork
142 sg:pub.10.1038/348651a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027941299
143 https://doi.org/10.1038/348651a0
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1001/archopht.1962.00960030023005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021649283
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1001/archopht.1984.01040031057023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000210271
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1001/archopht.1987.01060070065030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052494048
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1002/ana.410250611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023555532
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/0022-510x(93)90219-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1033002182
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0925-4439(91)90042-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049992097
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.ophtha.2013.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036020287
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0161-6420(99)90244-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011184920
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/s0161-6420(99)90356-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033348893
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1097/wno.0b013e3180334cb0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033444272
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1126/science.3201231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062598995
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1136/jnnp-2012-303528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004840407
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1167/iovs.03-1090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012255790
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1212/01.wnl.0000220197.36849.1e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348202
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1212/wnl.45.2.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064373056
174 rdf:type schema:CreativeWork
175 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
176 schema:name Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
177 Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, 501-1194, Gifu, Japan
178 rdf:type schema:Organization
179 https://www.grid.ac/institutes/grid.419280.6 schema:alternateName National Center of Neurology and Psychiatry
180 schema:name Departments of Neuromuscular Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
181 Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan
182 Mental Retardation and Birth Defect Research, National Institute of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
183 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...