Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10-31

AUTHORS

Elsa Kermorvant-Duchemin, Przemyslaw Sapieha, Mirna Sirinyan, Martin Beauchamp, Daniella Checchin, Pierre Hardy, Florian Sennlaub, Pierre Lachapelle, Sylvain Chemtob

ABSTRACT

Ischemic retinopathies, such as retinopathy of prematurity and diabetic retinopathy are characterized by an initial microvascular degeneration, followed by an abnormal hypoxia-induced neovascularization. Oxygen-induced retinopathy (OIR) is a well-established in vivo model of ischemic retinopathies, which, although the triggering insult varies, all share a common end result of capillary loss. Understanding the mechanisms of normal retinal vascular development as well as the pathophysiological processes leading to the primary vascular loss is the key to develop treatments to prevent the sight-threatening neovascularization associated with human ischemic retinopathies. The importance of oxygen-dependant vascular endothelial growth factor in the pathophysiology of both phases of OIR has long been recognized. However, recent studies point out that OIR is a multifactorial disease, resulting from additive effects of an unbalanced expression of pro- and anti-angiogenic factors, interrelated with protective effects of nutritional factors and cytotoxic effects of oxidative and nitro-oxidative stress-dependant mediators. This review summarizes the most recent aspects of the research on OIR conducted in our laboratory and others, with a particular focus on the role of new mediators of nitro-oxidative stress, the trans-arachidonic acids, in microvascular degeneration, and on a novel pathway of metabolic signaling where hypoxia-driven succinate, via receptor GPR91, governs normal and pathological retinal angiogenesis. More... »

PAGES

51-60

References to SciGraph publications

  • 2004-07-02. An increase in superoxide dismutase ameliorates oxygen-induced retinopathy in transgenic mice in EYE
  • 1991-03. Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation in PEDIATRIC RESEARCH
  • 1999-12-01. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor in NATURE MEDICINE
  • 1996-03. Role of essential fatty acids in the function of the developing nervous system in LIPIDS
  • 2005-11-27. Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration in NATURE MEDICINE
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2005-12-14. Retinal angiogenesis in development and disease in NATURE
  • 2000-01. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1 in NATURE MEDICINE
  • 2007-06-24. Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis in NATURE MEDICINE
  • 2005-06. Emerging biological roles for erythropoietin in the nervous system in NATURE REVIEWS NEUROSCIENCE
  • 1995-10. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity in NATURE MEDICINE
  • 2001-09. Essential fatty acids in visual and brain development in LIPIDS
  • 2004-05. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors in NATURE
  • 1997-05. Therapeutic Effect of Liposomal Superoxide Dismutase in an Animal Model of Retinopathy of Prematurity in NEUROCHEMICAL RESEARCH
  • 2008-10-05. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis in NATURE MEDICINE
  • 2001-03. A study of metabolites as intermediate effectors in angiogenesis in ANGIOGENESIS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10633-009-9201-x

    DOI

    http://dx.doi.org/10.1007/s10633-009-9201-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018867733

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19882183


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Ophthalmology and Optometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetic Retinopathy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ischemia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidative Stress", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxygen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retinal Vessels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retinopathy of Prematurity", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "INSERM UMRS872, Paris, France", 
                "Paris Descartes University, Paris, France", 
                "AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kermorvant-Duchemin", 
            "givenName": "Elsa", 
            "id": "sg:person.0753071624.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753071624.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.411418.9", 
              "name": [
                "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sapieha", 
            "givenName": "Przemyslaw", 
            "id": "sg:person.01325524165.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325524165.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.411418.9", 
              "name": [
                "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sirinyan", 
            "givenName": "Mirna", 
            "id": "sg:person.01361357717.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361357717.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.411418.9", 
              "name": [
                "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beauchamp", 
            "givenName": "Martin", 
            "id": "sg:person.01166051467.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166051467.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.411418.9", 
              "name": [
                "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Checchin", 
            "givenName": "Daniella", 
            "id": "sg:person.0705131544.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705131544.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Montreal, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14848.31", 
              "name": [
                "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada", 
                "University of Montreal, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hardy", 
            "givenName": "Pierre", 
            "id": "sg:person.01006442417.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006442417.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "INSERM UMRS872, Paris, France", 
                "AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sennlaub", 
            "givenName": "Florian", 
            "id": "sg:person.01356263054.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Ophthalmology, McGill University-Montreal Children\u2019s Hospital, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.416084.f", 
              "name": [
                "Department of Ophthalmology, McGill University-Montreal Children\u2019s Hospital, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lachapelle", 
            "givenName": "Pierre", 
            "id": "sg:person.01255254002.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255254002.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics and Pharmacology, Research Center, Sainte-Justine Hospital, University of Montreal, H3T 1C5, Montreal, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.411418.9", 
              "name": [
                "Paris Descartes University, Paris, France", 
                "Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada", 
                "University of Montreal, Montreal, QC, Canada", 
                "Department of Pediatrics and Pharmacology, Research Center, Sainte-Justine Hospital, University of Montreal, H3T 1C5, Montreal, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chemtob", 
            "givenName": "Sylvain", 
            "id": "sg:person.0723576657.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723576657.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1023/a:1022474120512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007972256", 
              "https://doi.org/10.1023/a:1022474120512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006269942", 
              "https://doi.org/10.1038/nature02488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/70963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050822067", 
              "https://doi.org/10.1038/70963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034420089", 
              "https://doi.org/10.1038/nm1336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016792319207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009878216", 
              "https://doi.org/10.1023/a:1016792319207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042392994", 
              "https://doi.org/10.1038/nm1591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022770960", 
              "https://doi.org/10.1038/71517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005736593", 
              "https://doi.org/10.1038/nm.1873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002517591", 
              "https://doi.org/10.1038/nrn1687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02637071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020703030", 
              "https://doi.org/10.1007/bf02637071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1095-1024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011626141", 
              "https://doi.org/10.1038/nm1095-1024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10456-007-9066-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011809546", 
              "https://doi.org/10.1007/s10456-007-9066-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11745-001-0798-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038131277", 
              "https://doi.org/10.1007/s11745-001-0798-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.eye.6701424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037476817", 
              "https://doi.org/10.1038/sj.eye.6701424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/00006450-199103000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007263039", 
              "https://doi.org/10.1203/00006450-199103000-00001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010896038", 
              "https://doi.org/10.1038/nature04482"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-10-31", 
        "datePublishedReg": "2009-10-31", 
        "description": "Ischemic retinopathies, such as retinopathy of prematurity and diabetic retinopathy are characterized by an initial microvascular degeneration, followed by an abnormal hypoxia-induced neovascularization. Oxygen-induced retinopathy (OIR) is a well-established in vivo model of ischemic retinopathies, which, although the triggering insult varies, all share a common end result of capillary loss. Understanding the mechanisms of normal retinal vascular development as well as the pathophysiological processes leading to the primary vascular loss is the key to develop treatments to prevent the sight-threatening neovascularization associated with human ischemic retinopathies. The importance of oxygen-dependant vascular endothelial growth factor in the pathophysiology of both phases of OIR has long been recognized. However, recent studies point out that OIR is a multifactorial disease, resulting from additive effects of an unbalanced expression of pro- and anti-angiogenic factors, interrelated with protective effects of nutritional factors and cytotoxic effects of oxidative and nitro-oxidative stress-dependant mediators. This review summarizes the most recent aspects of the research on OIR conducted in our laboratory and others, with a particular focus on the role of new mediators of nitro-oxidative stress, the trans-arachidonic acids, in microvascular degeneration, and on a novel pathway of metabolic signaling where hypoxia-driven succinate, via receptor GPR91, governs normal and pathological retinal angiogenesis.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10633-009-9201-x", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1017097", 
            "issn": [
              "0012-4486", 
              "1573-2622"
            ], 
            "name": "Documenta Ophthalmologica", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "120"
          }
        ], 
        "keywords": [
          "oxygen-induced retinopathy", 
          "ischemic retinopathy", 
          "microvascular degeneration", 
          "normal retinal vascular development", 
          "hypoxia-induced neovascularization", 
          "pathological retinal angiogenesis", 
          "retinopathy of prematurity", 
          "retinal vascular development", 
          "vascular endothelial growth factor", 
          "anti-angiogenic factors", 
          "common end result", 
          "endothelial growth factor", 
          "vascular loss", 
          "capillary loss", 
          "nitro-oxidative stress", 
          "diabetic retinopathy", 
          "protective effect", 
          "retinal angiogenesis", 
          "retinopathy", 
          "receptor GPR91", 
          "vivo model", 
          "multifactorial disease", 
          "pathophysiological processes", 
          "growth factor", 
          "nutritional factors", 
          "cytotoxic effects", 
          "trans-arachidonic acids", 
          "neovascularization", 
          "additive effect", 
          "degeneration", 
          "new mediator", 
          "unbalanced expression", 
          "vascular development", 
          "Recent studies", 
          "novel pathway", 
          "mediators", 
          "end result", 
          "prematurity", 
          "pathophysiology", 
          "GPR91", 
          "factors", 
          "disease", 
          "angiogenesis", 
          "Metabolic", 
          "treatment", 
          "effect", 
          "recent aspects", 
          "loss", 
          "review", 
          "expression", 
          "oxidative", 
          "pathway", 
          "particular focus", 
          "study", 
          "role", 
          "succinate", 
          "acid", 
          "mechanism", 
          "stress", 
          "laboratory", 
          "development", 
          "varies", 
          "importance", 
          "focus", 
          "results", 
          "aspects", 
          "research", 
          "model", 
          "phase", 
          "process", 
          "key", 
          "concept"
        ], 
        "name": "Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy", 
        "pagination": "51-60", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1018867733"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10633-009-9201-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19882183"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10633-009-9201-x", 
          "https://app.dimensions.ai/details/publication/pub.1018867733"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_482.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10633-009-9201-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10633-009-9201-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10633-009-9201-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10633-009-9201-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10633-009-9201-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    314 TRIPLES      22 PREDICATES      125 URIs      101 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10633-009-9201-x schema:about N063a2ec26359402e88b3bb2c347f647d
    2 N2a12b70e8a6440dc9feb1cffd6bc9707
    3 N32bf24d5bfb44154a6df445b1a79fac4
    4 N530a436155cd41b4b314562bfca82652
    5 N62007984024347bdbb5626098829b8d5
    6 N6b5ab783cbf94f768c70d5b425a80028
    7 N810b983f773f4042ae4674ee7980a4a1
    8 N9d0d714fd9ec4029b4fc0eb72b2ff0a9
    9 Nd91e030040274a4cba08ca39527af40b
    10 Ne7284df5c57c49a883a2d8ed471dff6d
    11 Neac83936dbf449fa9a6d29647522181c
    12 anzsrc-for:11
    13 anzsrc-for:1113
    14 schema:author N7916bfa0689843468c7af8c47053b601
    15 schema:citation sg:pub.10.1007/bf02637071
    16 sg:pub.10.1007/s10456-007-9066-0
    17 sg:pub.10.1007/s11745-001-0798-1
    18 sg:pub.10.1023/a:1016792319207
    19 sg:pub.10.1023/a:1022474120512
    20 sg:pub.10.1038/70963
    21 sg:pub.10.1038/71517
    22 sg:pub.10.1038/nature02488
    23 sg:pub.10.1038/nature04482
    24 sg:pub.10.1038/nm.1873
    25 sg:pub.10.1038/nm1095-1024
    26 sg:pub.10.1038/nm1336
    27 sg:pub.10.1038/nm1591
    28 sg:pub.10.1038/nrn1687
    29 sg:pub.10.1038/sj.eye.6701424
    30 sg:pub.10.1203/00006450-199103000-00001
    31 schema:datePublished 2009-10-31
    32 schema:datePublishedReg 2009-10-31
    33 schema:description Ischemic retinopathies, such as retinopathy of prematurity and diabetic retinopathy are characterized by an initial microvascular degeneration, followed by an abnormal hypoxia-induced neovascularization. Oxygen-induced retinopathy (OIR) is a well-established in vivo model of ischemic retinopathies, which, although the triggering insult varies, all share a common end result of capillary loss. Understanding the mechanisms of normal retinal vascular development as well as the pathophysiological processes leading to the primary vascular loss is the key to develop treatments to prevent the sight-threatening neovascularization associated with human ischemic retinopathies. The importance of oxygen-dependant vascular endothelial growth factor in the pathophysiology of both phases of OIR has long been recognized. However, recent studies point out that OIR is a multifactorial disease, resulting from additive effects of an unbalanced expression of pro- and anti-angiogenic factors, interrelated with protective effects of nutritional factors and cytotoxic effects of oxidative and nitro-oxidative stress-dependant mediators. This review summarizes the most recent aspects of the research on OIR conducted in our laboratory and others, with a particular focus on the role of new mediators of nitro-oxidative stress, the trans-arachidonic acids, in microvascular degeneration, and on a novel pathway of metabolic signaling where hypoxia-driven succinate, via receptor GPR91, governs normal and pathological retinal angiogenesis.
    34 schema:genre article
    35 schema:inLanguage en
    36 schema:isAccessibleForFree false
    37 schema:isPartOf N7839cd6075184d8c9d06ed1c7b207152
    38 Ndaf5b92abad44bb98daea86d8caa1322
    39 sg:journal.1017097
    40 schema:keywords GPR91
    41 Metabolic
    42 Recent studies
    43 acid
    44 additive effect
    45 angiogenesis
    46 anti-angiogenic factors
    47 aspects
    48 capillary loss
    49 common end result
    50 concept
    51 cytotoxic effects
    52 degeneration
    53 development
    54 diabetic retinopathy
    55 disease
    56 effect
    57 end result
    58 endothelial growth factor
    59 expression
    60 factors
    61 focus
    62 growth factor
    63 hypoxia-induced neovascularization
    64 importance
    65 ischemic retinopathy
    66 key
    67 laboratory
    68 loss
    69 mechanism
    70 mediators
    71 microvascular degeneration
    72 model
    73 multifactorial disease
    74 neovascularization
    75 new mediator
    76 nitro-oxidative stress
    77 normal retinal vascular development
    78 novel pathway
    79 nutritional factors
    80 oxidative
    81 oxygen-induced retinopathy
    82 particular focus
    83 pathological retinal angiogenesis
    84 pathophysiological processes
    85 pathophysiology
    86 pathway
    87 phase
    88 prematurity
    89 process
    90 protective effect
    91 recent aspects
    92 receptor GPR91
    93 research
    94 results
    95 retinal angiogenesis
    96 retinal vascular development
    97 retinopathy
    98 retinopathy of prematurity
    99 review
    100 role
    101 stress
    102 study
    103 succinate
    104 trans-arachidonic acids
    105 treatment
    106 unbalanced expression
    107 varies
    108 vascular development
    109 vascular endothelial growth factor
    110 vascular loss
    111 vivo model
    112 schema:name Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy
    113 schema:pagination 51-60
    114 schema:productId N19f4132f27204a70a75c145f5786d30d
    115 N372bf3dd345c423e95cbae31c850d0ca
    116 Nd9865eac5aa94ce4bce6ff8b8ddee139
    117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018867733
    118 https://doi.org/10.1007/s10633-009-9201-x
    119 schema:sdDatePublished 2022-05-20T07:25
    120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    121 schema:sdPublisher Nd1650d898d444143a1d3e4f328588269
    122 schema:url https://doi.org/10.1007/s10633-009-9201-x
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset articles
    125 rdf:type schema:ScholarlyArticle
    126 N063a2ec26359402e88b3bb2c347f647d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Ischemia
    128 rdf:type schema:DefinedTerm
    129 N0d957eadb222405fbf44596d6dd68c3f rdf:first sg:person.01356263054.39
    130 rdf:rest N7bf927518b104d7d90a8deb53050e388
    131 N17670ac7c6d24285be6ecb48651cefdc rdf:first sg:person.01361357717.48
    132 rdf:rest N8f6bc24cce634931a0a87052a1248c0a
    133 N17e452ee7a9c413890fe5888abdcf775 rdf:first sg:person.0723576657.87
    134 rdf:rest rdf:nil
    135 N19f4132f27204a70a75c145f5786d30d schema:name doi
    136 schema:value 10.1007/s10633-009-9201-x
    137 rdf:type schema:PropertyValue
    138 N2a12b70e8a6440dc9feb1cffd6bc9707 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Disease Models, Animal
    140 rdf:type schema:DefinedTerm
    141 N32bf24d5bfb44154a6df445b1a79fac4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Rats
    143 rdf:type schema:DefinedTerm
    144 N34e20899609a4c768772c9dd9e910090 rdf:first sg:person.0705131544.47
    145 rdf:rest N917253c255964ace8599f622f063ee4d
    146 N372bf3dd345c423e95cbae31c850d0ca schema:name pubmed_id
    147 schema:value 19882183
    148 rdf:type schema:PropertyValue
    149 N530a436155cd41b4b314562bfca82652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Animals
    151 rdf:type schema:DefinedTerm
    152 N62007984024347bdbb5626098829b8d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Oxygen
    154 rdf:type schema:DefinedTerm
    155 N6b5ab783cbf94f768c70d5b425a80028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Diabetic Retinopathy
    157 rdf:type schema:DefinedTerm
    158 N7839cd6075184d8c9d06ed1c7b207152 schema:volumeNumber 120
    159 rdf:type schema:PublicationVolume
    160 N7916bfa0689843468c7af8c47053b601 rdf:first sg:person.0753071624.51
    161 rdf:rest Nc281d64e8e9b42beb23f4190f845471d
    162 N7bf927518b104d7d90a8deb53050e388 rdf:first sg:person.01255254002.16
    163 rdf:rest N17e452ee7a9c413890fe5888abdcf775
    164 N810b983f773f4042ae4674ee7980a4a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Retinopathy of Prematurity
    166 rdf:type schema:DefinedTerm
    167 N8f6bc24cce634931a0a87052a1248c0a rdf:first sg:person.01166051467.92
    168 rdf:rest N34e20899609a4c768772c9dd9e910090
    169 N917253c255964ace8599f622f063ee4d rdf:first sg:person.01006442417.41
    170 rdf:rest N0d957eadb222405fbf44596d6dd68c3f
    171 N9d0d714fd9ec4029b4fc0eb72b2ff0a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Humans
    173 rdf:type schema:DefinedTerm
    174 Nc281d64e8e9b42beb23f4190f845471d rdf:first sg:person.01325524165.20
    175 rdf:rest N17670ac7c6d24285be6ecb48651cefdc
    176 Nd1650d898d444143a1d3e4f328588269 schema:name Springer Nature - SN SciGraph project
    177 rdf:type schema:Organization
    178 Nd91e030040274a4cba08ca39527af40b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Infant, Newborn
    180 rdf:type schema:DefinedTerm
    181 Nd9865eac5aa94ce4bce6ff8b8ddee139 schema:name dimensions_id
    182 schema:value pub.1018867733
    183 rdf:type schema:PropertyValue
    184 Ndaf5b92abad44bb98daea86d8caa1322 schema:issueNumber 1
    185 rdf:type schema:PublicationIssue
    186 Ne7284df5c57c49a883a2d8ed471dff6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Oxidative Stress
    188 rdf:type schema:DefinedTerm
    189 Neac83936dbf449fa9a6d29647522181c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Retinal Vessels
    191 rdf:type schema:DefinedTerm
    192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    193 schema:name Medical and Health Sciences
    194 rdf:type schema:DefinedTerm
    195 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
    196 schema:name Ophthalmology and Optometry
    197 rdf:type schema:DefinedTerm
    198 sg:journal.1017097 schema:issn 0012-4486
    199 1573-2622
    200 schema:name Documenta Ophthalmologica
    201 schema:publisher Springer Nature
    202 rdf:type schema:Periodical
    203 sg:person.01006442417.41 schema:affiliation grid-institutes:grid.14848.31
    204 schema:familyName Hardy
    205 schema:givenName Pierre
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006442417.41
    207 rdf:type schema:Person
    208 sg:person.01166051467.92 schema:affiliation grid-institutes:grid.411418.9
    209 schema:familyName Beauchamp
    210 schema:givenName Martin
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166051467.92
    212 rdf:type schema:Person
    213 sg:person.01255254002.16 schema:affiliation grid-institutes:grid.416084.f
    214 schema:familyName Lachapelle
    215 schema:givenName Pierre
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255254002.16
    217 rdf:type schema:Person
    218 sg:person.01325524165.20 schema:affiliation grid-institutes:grid.411418.9
    219 schema:familyName Sapieha
    220 schema:givenName Przemyslaw
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325524165.20
    222 rdf:type schema:Person
    223 sg:person.01356263054.39 schema:affiliation grid-institutes:grid.50550.35
    224 schema:familyName Sennlaub
    225 schema:givenName Florian
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39
    227 rdf:type schema:Person
    228 sg:person.01361357717.48 schema:affiliation grid-institutes:grid.411418.9
    229 schema:familyName Sirinyan
    230 schema:givenName Mirna
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361357717.48
    232 rdf:type schema:Person
    233 sg:person.0705131544.47 schema:affiliation grid-institutes:grid.411418.9
    234 schema:familyName Checchin
    235 schema:givenName Daniella
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705131544.47
    237 rdf:type schema:Person
    238 sg:person.0723576657.87 schema:affiliation grid-institutes:grid.411418.9
    239 schema:familyName Chemtob
    240 schema:givenName Sylvain
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723576657.87
    242 rdf:type schema:Person
    243 sg:person.0753071624.51 schema:affiliation grid-institutes:grid.50550.35
    244 schema:familyName Kermorvant-Duchemin
    245 schema:givenName Elsa
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753071624.51
    247 rdf:type schema:Person
    248 sg:pub.10.1007/bf02637071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020703030
    249 https://doi.org/10.1007/bf02637071
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s10456-007-9066-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011809546
    252 https://doi.org/10.1007/s10456-007-9066-0
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s11745-001-0798-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038131277
    255 https://doi.org/10.1007/s11745-001-0798-1
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1023/a:1016792319207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009878216
    258 https://doi.org/10.1023/a:1016792319207
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1023/a:1022474120512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007972256
    261 https://doi.org/10.1023/a:1022474120512
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/70963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050822067
    264 https://doi.org/10.1038/70963
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/71517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022770960
    267 https://doi.org/10.1038/71517
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature02488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006269942
    270 https://doi.org/10.1038/nature02488
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature04482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010896038
    273 https://doi.org/10.1038/nature04482
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nm.1873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005736593
    276 https://doi.org/10.1038/nm.1873
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nm1095-1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011626141
    279 https://doi.org/10.1038/nm1095-1024
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nm1336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034420089
    282 https://doi.org/10.1038/nm1336
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nm1591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042392994
    285 https://doi.org/10.1038/nm1591
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nrn1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002517591
    288 https://doi.org/10.1038/nrn1687
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/sj.eye.6701424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037476817
    291 https://doi.org/10.1038/sj.eye.6701424
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1203/00006450-199103000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007263039
    294 https://doi.org/10.1203/00006450-199103000-00001
    295 rdf:type schema:CreativeWork
    296 grid-institutes:grid.14848.31 schema:alternateName University of Montreal, Montreal, QC, Canada
    297 schema:name Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada
    298 University of Montreal, Montreal, QC, Canada
    299 rdf:type schema:Organization
    300 grid-institutes:grid.411418.9 schema:alternateName Department of Pediatrics and Pharmacology, Research Center, Sainte-Justine Hospital, University of Montreal, H3T 1C5, Montreal, QC, Canada
    301 Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada
    302 schema:name Department of Pediatrics and Pharmacology, Research Center, Sainte-Justine Hospital, University of Montreal, H3T 1C5, Montreal, QC, Canada
    303 Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center, Sainte-Justine Hospital, Montreal, QC, Canada
    304 Paris Descartes University, Paris, France
    305 University of Montreal, Montreal, QC, Canada
    306 rdf:type schema:Organization
    307 grid-institutes:grid.416084.f schema:alternateName Department of Ophthalmology, McGill University-Montreal Children’s Hospital, Montreal, QC, Canada
    308 schema:name Department of Ophthalmology, McGill University-Montreal Children’s Hospital, Montreal, QC, Canada
    309 rdf:type schema:Organization
    310 grid-institutes:grid.50550.35 schema:alternateName AP-HP, Paris, France
    311 schema:name AP-HP, Paris, France
    312 INSERM UMRS872, Paris, France
    313 Paris Descartes University, Paris, France
    314 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...