Serum Globulin Is Associated with Endoscopic Findings and Mucosal Healing in Japanese Patients with Ulcerative Colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-02-04

AUTHORS

Kana Shiraishi, Shinya Furukawa, Sen Yagi, Kenichirou Mori, Tomoyuki Ninomiya, Keitarou Kawasaki, Yuji Mizukami, Seiyuu Suzuki, Masayoshi Uraoka, Naozumi Shibata, Sanae Nakamura, Satoshi Imamine, Hidehiro Murakami, Katsuhisa Ohashi, Masamoto Torisu, Makoto Yano, Aki Hasebe, Harumi Yano, Masato Murakami, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa

ABSTRACT

BackgroundSerum globulin is an inflammation marker. To date, no evidence regarding the association between serum globulin and disease activity in patients with ulcerative colitis has been reported. AimsWe evaluated the association between serum globulin and endoscopic activity in patients with ulcerative colitis.MethodsSerum globulin was divided into tertiles based on the distribution of study subjects (low globulin, ≤ 2.7 g/dl (reference); moderate globulin, 2.7–3.1 g/dl; and high globulin, > 3.1 g/dl). A single endoscopic specialist evaluated the endoscopic findings, and mucosal healing was based on Mayo endoscopic subscore.ResultsA total of 277 patients with ulcerative colitis were included in the study. Serum globulin was independently positively associated with diminished or absent vascular markings [moderate: adjusted odds ratio (OR) 3.70 (95% confidence interval, CI: 1.82–7.88) and high: adjusted OR 2.40 (95%CI: 1.20–4.94), p for trend = 0.005]. A similar positive association between globulin and erosion was found [high: adjusted OR 2.00 (95%CI: 1.05–3.86)]. Serum globulin was independently inversely associated with mucosal healing [moderate: adjusted OR 0.37 (95%CI: 0.18–0.73) and high: adjusted OR 0.31 (95%CI: 0.14–0.64), p for trend = 0.001] and adjusted partial mucosal healing [moderate: OR 0.51 (95%CI: 0.26–0.98), p for trend = 0.048]. The inverse association between globulin and mucosal healing was significant in the low but not the high C-reactive protein group.ConclusionsIn patients with ulcerative colitis, serum globulin was significantly positively associated with endoscopic activity, and was significantly inversely associated with mucosal healing, especially in the low C-reactive protein group. More... »

PAGES

233-240

References to SciGraph publications

  • 1978-02. The humoral immune system in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • Journal

    TITLE

    Digestive Diseases and Sciences

    ISSUE

    1

    VOLUME

    67

    Author Affiliations

  • Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
  • Health Services Center, Ehime University, Matsuyama, Bunkyo, Ehime, Japan
  • Department of Internal Medicine, Saiseikai Matsuyama Hospital, Yamanishi, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Ehime Prefectural Central Hospital, Kasuga, Matsuyama, Ehime, Japan
  • Department of Internal Medicine, Saiseikai Imabari Hospital, Kita, Imabari, Ehime, Japan
  • Department of Gastroenterology, Matsuyama Shimin Hospital, Ote, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Sumitomo Besshi Hospital, Oji, Niihama, Ehime, Japan
  • Uraoka Gastrointestinal Clinic, Ishite, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Ehime Prefectural Niihama Hospital, Hongo, Niihama, Ehime, Japan
  • Department of Gastroenterology, Shinsenkai Matsuyama Madonna Hospital, Kiyo, Matsuyama, Ehime, Japan
  • Department of Internal Medicine, Shiritsu Oozu Hospital, Nishioozu, Oozu, Ehime, Japan
  • Ohashi Clinic Participate in Gastro-Enterology and Ano-Proctology, Funaki, Niihama, Ehime, Japan
  • Department of Internal Medicine, Saiseikai Saijo Hospital, Tsuitachi, Saijo, Ehime, Japan
  • Yano Clinic, Higashinagato, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Shikoku Cancer Center, Minamiumenomoto, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Saijo City Shuso Hospital, Nyugawa, Saijo, Ehime, Japan
  • Department of Gastroenterology, Murakamikinen Hospital, Oomachi, Saijo, Ehime, Japan
  • Department of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
  • Endoscopy Center, Ehime University Hospital, Shitsukawa, Toon, Ehime, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10620-021-06834-5

    DOI

    http://dx.doi.org/10.1007/s10620-021-06834-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1135109788

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33537920


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