Effects of Pristine C60 Fullerenes on Liver and Pancreas in α-Naphthylisothiocyanate-Induced Cholangitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-16

AUTHORS

Halyna M. Kuznietsova, Natalia V. Dziubenko, Oksana V. Lynchak, Tetyana S. Herheliuk, Dmytro K. Zavalny, Olga V. Remeniak, Yuriy I. Prylutskyy, Uwe Ritter

ABSTRACT

BackgroundA significant role in pathogenesis of cholangitis is attributed to excessive reactive oxygen species production and oxidative stress. Therefore, antioxidants could be promising therapeutics.AimsThe effects of powerful free radical scavenger C60 fullerene on hepatic and pancreatic manifestations of acute and chronic cholangitis in rats were aimed to be discovered.MethodsAcute (AC, 3 days) and chronic (CC, 28 days) cholangitis models were simulated by single (AC) and 4 weekly (CC) α-naphthylisothiocyanate per os administrations. Pristine C60 fullerene aqueous colloid solution (C60FAS, 0.15 mg/ml, size of aggregates 1.2–100 nm) was administered either per os or intraperitoneally at a dose of 0.5 mg/kg C60 fullerene daily (AC) and every other day (CC). Prednisolone was used as a reference. Liver and pancreas autopsies were analyzed, and blood serum biochemical markers were measured. Pan-cytokeratin expression in HepG2 cells was assessed after 48-h incubation with C60FAS.ResultsOn AC, C60FAS normalized elevated bilirubin, alkaline phosphatase, and triglycerides, diminished fibrotic alterations in liver, and improved pancreas state when applied by both ways. Additionally, C60FAS per os significantly reduced the signs of inflammation in liver and pancreas. On CC, C60FAS also mitigated liver fibrosis and inflammation, improved pancreas state, and normalized alkaline phosphatase and triglycerides. The remedy effect of C60FAS was more expressed compared to that of prednisolone on both models. Furthermore, C60FAS inhibited pan-cytokeratin expression in HepG2 cells in a dose-dependent manner.ConclusionPristine C60 fullerene inhibits liver inflammation and fibrogenesis and partially improved liver and pancreas state under acute and chronic cholangitis. More... »

PAGES

215-224

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-019-05730-3

DOI

http://dx.doi.org/10.1007/s10620-019-05730-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1118039874

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31312992


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35 schema:description BackgroundA significant role in pathogenesis of cholangitis is attributed to excessive reactive oxygen species production and oxidative stress. Therefore, antioxidants could be promising therapeutics.AimsThe effects of powerful free radical scavenger C60 fullerene on hepatic and pancreatic manifestations of acute and chronic cholangitis in rats were aimed to be discovered.MethodsAcute (AC, 3 days) and chronic (CC, 28 days) cholangitis models were simulated by single (AC) and 4 weekly (CC) α-naphthylisothiocyanate per os administrations. Pristine C60 fullerene aqueous colloid solution (C60FAS, 0.15 mg/ml, size of aggregates 1.2–100 nm) was administered either per os or intraperitoneally at a dose of 0.5 mg/kg C60 fullerene daily (AC) and every other day (CC). Prednisolone was used as a reference. Liver and pancreas autopsies were analyzed, and blood serum biochemical markers were measured. Pan-cytokeratin expression in HepG2 cells was assessed after 48-h incubation with C60FAS.ResultsOn AC, C60FAS normalized elevated bilirubin, alkaline phosphatase, and triglycerides, diminished fibrotic alterations in liver, and improved pancreas state when applied by both ways. Additionally, C60FAS per os significantly reduced the signs of inflammation in liver and pancreas. On CC, C60FAS also mitigated liver fibrosis and inflammation, improved pancreas state, and normalized alkaline phosphatase and triglycerides. The remedy effect of C60FAS was more expressed compared to that of prednisolone on both models. Furthermore, C60FAS inhibited pan-cytokeratin expression in HepG2 cells in a dose-dependent manner.ConclusionPristine C60 fullerene inhibits liver inflammation and fibrogenesis and partially improved liver and pancreas state under acute and chronic cholangitis.
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42 AimsThe effects
43 C60
44 C60 fullerene
45 C60FAS
46 CC
47 HepG2 cells
48 MethodsAcute
49 OS
50 administration
51 alkaline phosphatase
52 alterations
53 antioxidants
54 aqueous colloid solution
55 autopsies
56 bilirubin
57 biochemical markers
58 cells
59 cholangitis
60 cholangitis model
61 chronic cholangitis
62 colloid solution
63 days
64 dose
65 dose-dependent manner
66 effect
67 elevated bilirubin
68 excessive reactive oxygen species (ROS) production
69 expression
70 fibrogenesis
71 fibrosis
72 fibrotic alterations
73 fullerenes
74 improved liver
75 incubation
76 inflammation
77 inhibits
78 liver
79 liver fibrosis
80 manifestations
81 manner
82 markers
83 model
84 oxidative stress
85 oxygen species production
86 pan-cytokeratin expression
87 pancreas
88 pancreatic manifestation
89 pathogenesis
90 pathogenesis of cholangitis
91 phosphatase
92 prednisolone
93 pristine C60
94 pristine C60 fullerene
95 production
96 promising therapeutics
97 rats
98 reactive oxygen species production
99 reference
100 remedy effects
101 role
102 serum biochemical markers
103 significant role
104 signs
105 signs of inflammation
106 solution
107 species production
108 state
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111 triglycerides
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