Differential Metabolomic Signatures in Patients with Weight Regain and Sustained Weight Loss After Gastric Bypass Surgery: A Pilot Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-08-05

AUTHORS

Wasif Abidi, Eirini Nestoridi, Henry Feldman, Margaret Stefater, Clary Clish, Christopher C. Thompson, Nicholas Stylopoulos

ABSTRACT

BackgroundWhile Roux-en-Y gastric bypass (RYGB) is one of the most effective and durable treatment options for obesity and its comorbidities, it is complicated by long-term weight regain in over 20% of patients.AimsWe sought to determine the metabolite signatures of serum samples of patients with weight regain (RYGB-WR) after RYGB and features distinguishing these patients from patients with sustained weight loss (RYGB-SWL).MethodsWe prospectively analyzed serum samples from 21 RYGB-WR patients, 14 RYGB-SWL patients, and 11 unoperated controls. The main outcome measure was their serum metabolite profile.ResultsWeight regain after RYGB was associated with a unique serum metabolomic fingerprint. Most of the statistically different metabolites were involved in amino acid metabolism, one-carbon metabolism, and related nucleotide metabolism. A principal component analysis identified groups of metabolites that correlate with weight regain. Specifically, weight regain was associated with lower serum levels of metabolites related to the serine, glycine and threonine pathway, phenylalanine metabolism, tricyclic acid cycle, alanine and glutamate metabolism, and higher levels of other amino acids.ConclusionsWeight regain after RYGB is associated with unique serum metabolite signatures. Metabolite profiling may eventually help us to identify markers that could differentiate the patients who will regain weight versus those who will likely sustain weight loss. More... »

PAGES

1144-1154

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-019-05714-3

DOI

http://dx.doi.org/10.1007/s10620-019-05714-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120147268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31385097


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