Aberrant p53 Immunostaining in Barrett’s Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-26

AUTHORS

Patrick Snyder, Kerry Dunbar, Daisha J. Cipher, Rhonda F. Souza, Stuart Jon Spechler, Vani J. A. Konda

ABSTRACT

Risk stratification of patients with Barrett's esophagus (BE) presently relies on the histopathologic grade of dysplasia found in esophageal biopsies, which is limited by sampling error and inter-pathologist variability. p53 immunostaining of BE biopsies has shown promise as an adjunct tool but is not recommended by American gastroenterology societies, who cite insufficient evidence of its prognostic value. We have conducted a systematic review and meta-analyses to clarify this value. We searched for studies that: (1) used immunohistochemistry to assess p53 expression in esophageal biopsies of BE patients and (2) reported subsequent neoplastic progression. We performed separate meta-analyses of case-control studies and cohort studies. We identified 14 relevant reports describing 8 case-control studies comprising 1435 patients and 7 cohort studies comprising 582 patients. In the case-control study meta-analysis of the risk of neoplasia with aberrant p53 expression, the fixed- and random-effect estimates of average effect size with aberrant p53 expression were OR 3.84, p < .001 (95% CI 2.79-5.27) and OR 5.95, p < .001 (95% CI 2.68-13.22), respectively. In the cohort study meta-analysis, the fixed- and random-effect estimates of average effect size were RR = 17.31, p < .001 (95% CI 9.35-32.08) and RR = 14.25, p < .001 (95% CI 6.76-30.02), respectively. Separate meta-analyses of case-control and cohort studies of BE patients who had baseline biopsies with p53 immunostaining revealed consistent, strong, and significant associations between aberrant p53 immunostaining and progression to high-grade dysplasia or esophageal adenocarcinoma. These findings support the use of p53 immunostaining as an adjunct to routine clinical diagnosis for dysplasia in BE patients. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-019-05586-7

DOI

http://dx.doi.org/10.1007/s10620-019-05586-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112992780

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30911864


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Baylor University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411588.1", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Snyder", 
        "givenName": "Patrick", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA North Texas Health Care System", 
          "id": "https://www.grid.ac/institutes/grid.422201.7", 
          "name": [
            "Esophageal Diseases Center, University of Texas Southwestern Medical Center, Dallas, TX, USA", 
            "Veterans Affairs North Texas Health Care System, 4500 S. Lancaster Road, 75216, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dunbar", 
        "givenName": "Kerry", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas at Arlington", 
          "id": "https://www.grid.ac/institutes/grid.267315.4", 
          "name": [
            "College of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive, Mailbox 19407, 76019, Arlington, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cipher", 
        "givenName": "Daisha J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor Scott & White Health", 
          "id": "https://www.grid.ac/institutes/grid.486749.0", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA", 
            "Center for Esophageal Diseases, Baylor University Medical Center, Dallas, TX, USA", 
            "Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Souza", 
        "givenName": "Rhonda F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor Scott & White Health", 
          "id": "https://www.grid.ac/institutes/grid.486749.0", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA", 
            "Center for Esophageal Diseases, Baylor University Medical Center, Dallas, TX, USA", 
            "Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spechler", 
        "givenName": "Stuart Jon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor Scott & White Health", 
          "id": "https://www.grid.ac/institutes/grid.486749.0", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA", 
            "Center for Esophageal Diseases, Baylor University Medical Center, Dallas, TX, USA", 
            "Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konda", 
        "givenName": "Vani J. A.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1053/j.gastro.2016.09.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000051739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2010.03715.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000838941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2010.03715.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000838941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0033-1344617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003696703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2002.06032.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004113941", 
          "https://doi.org/10.1111/j.1572-0241.2002.06032.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365520510011533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005854582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008099601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(93)91058-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009225825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.07.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009549503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2015-309642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014497999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018828207371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015324800", 
          "https://doi.org/10.1023/a:1018828207371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(88)90613-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015535271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2001.04236.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016386294", 
          "https://doi.org/10.1111/j.1572-0241.2001.04236.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gie.2016.09.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018565625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019171748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028630481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.16.1316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029959048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2011.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030311092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.083295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032669253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gie.2012.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034429943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035442401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-0028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035506825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-10-0012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037590129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038478569", 
          "https://doi.org/10.1038/sj.onc.1208598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038478569", 
          "https://doi.org/10.1038/sj.onc.1208598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038478569", 
          "https://doi.org/10.1038/sj.onc.1208598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313029800169076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038710974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313029800169076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038710974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313029800169076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038710974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2013-305372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038835120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2015.322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040555271", 
          "https://doi.org/10.1038/ajg.2015.322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2015.322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040555271", 
          "https://doi.org/10.1038/ajg.2015.322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041143429", 
          "https://doi.org/10.1038/ajg.2010.171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041143429", 
          "https://doi.org/10.1038/ajg.2010.171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2001.03851.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041575339", 
          "https://doi.org/10.1111/j.1572-0241.2001.03851.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044911879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044911879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.06.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050028367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2012-303594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050646471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gastro/gov045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050992318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018891923998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052582030", 
          "https://doi.org/10.1023/a:1018891923998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(94)90053-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052938294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074557715", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/cbm-2008-4101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077618582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083080875", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.13193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083856837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.10484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084009311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2017-313815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086134406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0186305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092334999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2018.03.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101841806"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-26", 
    "datePublishedReg": "2019-03-26", 
    "description": "Risk stratification of patients with Barrett's esophagus (BE) presently relies on the histopathologic grade of dysplasia found in esophageal biopsies, which is limited by sampling error and inter-pathologist variability. p53 immunostaining of BE biopsies has shown promise as an adjunct tool but is not recommended by American gastroenterology societies, who cite insufficient evidence of its prognostic value. We have conducted a systematic review and meta-analyses to clarify this value. We searched for studies that: (1) used immunohistochemistry to assess p53 expression in esophageal biopsies of BE patients and (2) reported subsequent neoplastic progression. We performed separate meta-analyses of case-control studies and cohort studies. We identified 14 relevant reports describing 8 case-control studies comprising 1435 patients and 7 cohort studies comprising 582 patients. In the case-control study meta-analysis of the risk of neoplasia with aberrant p53 expression, the fixed- and random-effect estimates of average effect size with aberrant p53 expression were OR 3.84, p\u2009<\u2009.001 (95% CI 2.79-5.27) and OR 5.95, p\u2009<\u2009.001 (95% CI 2.68-13.22), respectively. In the cohort study meta-analysis, the fixed- and random-effect estimates of average effect size were RR\u2009=\u200917.31, p\u2009<\u2009.001 (95% CI 9.35-32.08) and RR\u2009=\u200914.25, p\u2009<\u2009.001 (95% CI 6.76-30.02), respectively. Separate meta-analyses of case-control and cohort studies of BE patients who had baseline biopsies with p53 immunostaining revealed consistent, strong, and significant associations between aberrant p53 immunostaining and progression to high-grade dysplasia or esophageal adenocarcinoma. These findings support the use of p53 immunostaining as an adjunct to routine clinical diagnosis for dysplasia in BE patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-019-05586-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }
    ], 
    "name": "Aberrant p53 Immunostaining in Barrett\u2019s Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bf54e9445b524e3856b8972fb507a5131e039914e0e8683359af10c86172398c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30911864"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-019-05586-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112992780"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-019-05586-7", 
      "https://app.dimensions.ai/details/publication/pub.1112992780"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88217_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10620-019-05586-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-019-05586-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-019-05586-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-019-05586-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-019-05586-7'


 

This table displays all metadata directly associated to this object as RDF triples.

236 TRIPLES      21 PREDICATES      68 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-019-05586-7 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author Na9f7197a757047f79f081bdaee38932a
4 schema:citation sg:pub.10.1023/a:1018828207371
5 sg:pub.10.1023/a:1018891923998
6 sg:pub.10.1038/ajg.2010.171
7 sg:pub.10.1038/ajg.2015.322
8 sg:pub.10.1038/sj.onc.1208598
9 sg:pub.10.1111/j.1572-0241.2001.03851.x
10 sg:pub.10.1111/j.1572-0241.2001.04236.x
11 sg:pub.10.1111/j.1572-0241.2002.06032.x
12 https://app.dimensions.ai/details/publication/pub.1074557715
13 https://app.dimensions.ai/details/publication/pub.1083080875
14 https://doi.org/10.1002/bjs.10484
15 https://doi.org/10.1002/gcc.22220
16 https://doi.org/10.1016/0002-9610(94)90053-1
17 https://doi.org/10.1016/0016-5085(88)90613-0
18 https://doi.org/10.1016/0016-5085(93)91058-p
19 https://doi.org/10.1016/j.gie.2012.08.004
20 https://doi.org/10.1016/j.gie.2016.09.022
21 https://doi.org/10.1053/j.gastro.2004.07.061
22 https://doi.org/10.1053/j.gastro.2011.01.031
23 https://doi.org/10.1053/j.gastro.2012.06.041
24 https://doi.org/10.1053/j.gastro.2016.09.040
25 https://doi.org/10.1053/j.gastro.2018.03.047
26 https://doi.org/10.1055/s-0033-1344617
27 https://doi.org/10.1056/nejmoa0808145
28 https://doi.org/10.1056/nejmoa1103042
29 https://doi.org/10.1080/00313029800169076
30 https://doi.org/10.1080/00365520510011533
31 https://doi.org/10.1093/gastro/gov045
32 https://doi.org/10.1093/jnci/92.16.1316
33 https://doi.org/10.1097/pas.0000000000000598
34 https://doi.org/10.1111/his.13193
35 https://doi.org/10.1111/j.1365-2559.2010.03715.x
36 https://doi.org/10.1136/gut.2005.083295
37 https://doi.org/10.1136/gutjnl-2012-303594
38 https://doi.org/10.1136/gutjnl-2013-305372
39 https://doi.org/10.1136/gutjnl-2015-309642
40 https://doi.org/10.1136/gutjnl-2017-313815
41 https://doi.org/10.1158/0008-5472.can-04-1738
42 https://doi.org/10.1158/0008-5472.can-09-0028
43 https://doi.org/10.1158/1055-9965.epi-10-0012
44 https://doi.org/10.1371/journal.pone.0186305
45 https://doi.org/10.3233/cbm-2008-4101
46 schema:datePublished 2019-03-26
47 schema:datePublishedReg 2019-03-26
48 schema:description Risk stratification of patients with Barrett's esophagus (BE) presently relies on the histopathologic grade of dysplasia found in esophageal biopsies, which is limited by sampling error and inter-pathologist variability. p53 immunostaining of BE biopsies has shown promise as an adjunct tool but is not recommended by American gastroenterology societies, who cite insufficient evidence of its prognostic value. We have conducted a systematic review and meta-analyses to clarify this value. We searched for studies that: (1) used immunohistochemistry to assess p53 expression in esophageal biopsies of BE patients and (2) reported subsequent neoplastic progression. We performed separate meta-analyses of case-control studies and cohort studies. We identified 14 relevant reports describing 8 case-control studies comprising 1435 patients and 7 cohort studies comprising 582 patients. In the case-control study meta-analysis of the risk of neoplasia with aberrant p53 expression, the fixed- and random-effect estimates of average effect size with aberrant p53 expression were OR 3.84, p < .001 (95% CI 2.79-5.27) and OR 5.95, p < .001 (95% CI 2.68-13.22), respectively. In the cohort study meta-analysis, the fixed- and random-effect estimates of average effect size were RR = 17.31, p < .001 (95% CI 9.35-32.08) and RR = 14.25, p < .001 (95% CI 6.76-30.02), respectively. Separate meta-analyses of case-control and cohort studies of BE patients who had baseline biopsies with p53 immunostaining revealed consistent, strong, and significant associations between aberrant p53 immunostaining and progression to high-grade dysplasia or esophageal adenocarcinoma. These findings support the use of p53 immunostaining as an adjunct to routine clinical diagnosis for dysplasia in BE patients.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf sg:journal.1018525
53 schema:name Aberrant p53 Immunostaining in Barrett’s Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses
54 schema:pagination 1-9
55 schema:productId N12500b72906a4d028d511a4616f4c988
56 N4801a657be0c4ad09d8495ea433755e5
57 N8bd0e425404a426b8ddb53335e4f2b14
58 Nbcc1537e8ede420d93c15958a38fa052
59 Nc42bd7a893ea4ef99ce1ec09594fefd4
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112992780
61 https://doi.org/10.1007/s10620-019-05586-7
62 schema:sdDatePublished 2019-04-11T13:06
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N168c999cf1cc473e86cdc94cdce89657
65 schema:url https://link.springer.com/10.1007%2Fs10620-019-05586-7
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N12500b72906a4d028d511a4616f4c988 schema:name dimensions_id
70 schema:value pub.1112992780
71 rdf:type schema:PropertyValue
72 N168c999cf1cc473e86cdc94cdce89657 schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N1ae6f2a3bc7046fdb080d63118fce814 schema:affiliation https://www.grid.ac/institutes/grid.486749.0
75 schema:familyName Souza
76 schema:givenName Rhonda F.
77 rdf:type schema:Person
78 N350cd7de9df9499e833dbf0161ad52b6 rdf:first N5791565e86ff43da9fd31625430c18cf
79 rdf:rest N9a17053a23d948c982449700521442da
80 N43092c7b4d164e26a052d574637cd047 schema:affiliation https://www.grid.ac/institutes/grid.411588.1
81 schema:familyName Snyder
82 schema:givenName Patrick
83 rdf:type schema:Person
84 N4801a657be0c4ad09d8495ea433755e5 schema:name nlm_unique_id
85 schema:value 7902782
86 rdf:type schema:PropertyValue
87 N4f41ae3004174448b86e8710ab403b38 rdf:first N847b9a25757d4d33b3f3578793190e01
88 rdf:rest rdf:nil
89 N5791565e86ff43da9fd31625430c18cf schema:affiliation https://www.grid.ac/institutes/grid.422201.7
90 schema:familyName Dunbar
91 schema:givenName Kerry
92 rdf:type schema:Person
93 N6ab2dc36a2ba4a7dbd8347bd0a356cc2 schema:affiliation https://www.grid.ac/institutes/grid.486749.0
94 schema:familyName Spechler
95 schema:givenName Stuart Jon
96 rdf:type schema:Person
97 N847b9a25757d4d33b3f3578793190e01 schema:affiliation https://www.grid.ac/institutes/grid.486749.0
98 schema:familyName Konda
99 schema:givenName Vani J. A.
100 rdf:type schema:Person
101 N8bd0e425404a426b8ddb53335e4f2b14 schema:name pubmed_id
102 schema:value 30911864
103 rdf:type schema:PropertyValue
104 N9962326716754d479dabf4a8f915ea80 rdf:first N1ae6f2a3bc7046fdb080d63118fce814
105 rdf:rest Na933e1d821114af1a8a8dad287306908
106 N9a17053a23d948c982449700521442da rdf:first N9bf73b60d5644fc3a2428b3dea65e5eb
107 rdf:rest N9962326716754d479dabf4a8f915ea80
108 N9bf73b60d5644fc3a2428b3dea65e5eb schema:affiliation https://www.grid.ac/institutes/grid.267315.4
109 schema:familyName Cipher
110 schema:givenName Daisha J.
111 rdf:type schema:Person
112 Na933e1d821114af1a8a8dad287306908 rdf:first N6ab2dc36a2ba4a7dbd8347bd0a356cc2
113 rdf:rest N4f41ae3004174448b86e8710ab403b38
114 Na9f7197a757047f79f081bdaee38932a rdf:first N43092c7b4d164e26a052d574637cd047
115 rdf:rest N350cd7de9df9499e833dbf0161ad52b6
116 Nbcc1537e8ede420d93c15958a38fa052 schema:name readcube_id
117 schema:value bf54e9445b524e3856b8972fb507a5131e039914e0e8683359af10c86172398c
118 rdf:type schema:PropertyValue
119 Nc42bd7a893ea4ef99ce1ec09594fefd4 schema:name doi
120 schema:value 10.1007/s10620-019-05586-7
121 rdf:type schema:PropertyValue
122 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
123 schema:name Medical and Health Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
126 schema:name Public Health and Health Services
127 rdf:type schema:DefinedTerm
128 sg:journal.1018525 schema:issn 0163-2116
129 1573-2568
130 schema:name Digestive Diseases and Sciences
131 rdf:type schema:Periodical
132 sg:pub.10.1023/a:1018828207371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015324800
133 https://doi.org/10.1023/a:1018828207371
134 rdf:type schema:CreativeWork
135 sg:pub.10.1023/a:1018891923998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052582030
136 https://doi.org/10.1023/a:1018891923998
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/ajg.2010.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041143429
139 https://doi.org/10.1038/ajg.2010.171
140 rdf:type schema:CreativeWork
141 sg:pub.10.1038/ajg.2015.322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040555271
142 https://doi.org/10.1038/ajg.2015.322
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/sj.onc.1208598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038478569
145 https://doi.org/10.1038/sj.onc.1208598
146 rdf:type schema:CreativeWork
147 sg:pub.10.1111/j.1572-0241.2001.03851.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041575339
148 https://doi.org/10.1111/j.1572-0241.2001.03851.x
149 rdf:type schema:CreativeWork
150 sg:pub.10.1111/j.1572-0241.2001.04236.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016386294
151 https://doi.org/10.1111/j.1572-0241.2001.04236.x
152 rdf:type schema:CreativeWork
153 sg:pub.10.1111/j.1572-0241.2002.06032.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004113941
154 https://doi.org/10.1111/j.1572-0241.2002.06032.x
155 rdf:type schema:CreativeWork
156 https://app.dimensions.ai/details/publication/pub.1074557715 schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1083080875 schema:CreativeWork
158 https://doi.org/10.1002/bjs.10484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084009311
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1002/gcc.22220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019171748
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/0002-9610(94)90053-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052938294
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/0016-5085(88)90613-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015535271
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/0016-5085(93)91058-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1009225825
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.gie.2012.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034429943
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.gie.2016.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018565625
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1053/j.gastro.2004.07.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009549503
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1053/j.gastro.2011.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030311092
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1053/j.gastro.2012.06.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050028367
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1053/j.gastro.2016.09.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000051739
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1053/j.gastro.2018.03.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101841806
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1055/s-0033-1344617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003696703
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1056/nejmoa0808145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035442401
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1056/nejmoa1103042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028630481
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1080/00313029800169076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038710974
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1080/00365520510011533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005854582
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1093/gastro/gov045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050992318
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1093/jnci/92.16.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029959048
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/pas.0000000000000598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044911879
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1111/his.13193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083856837
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1111/j.1365-2559.2010.03715.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000838941
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1136/gut.2005.083295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032669253
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1136/gutjnl-2012-303594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050646471
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1136/gutjnl-2013-305372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038835120
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1136/gutjnl-2015-309642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014497999
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1136/gutjnl-2017-313815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086134406
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1158/0008-5472.can-04-1738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008099601
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1158/0008-5472.can-09-0028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035506825
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1158/1055-9965.epi-10-0012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037590129
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1371/journal.pone.0186305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092334999
219 rdf:type schema:CreativeWork
220 https://doi.org/10.3233/cbm-2008-4101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077618582
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.267315.4 schema:alternateName The University of Texas at Arlington
223 schema:name College of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive, Mailbox 19407, 76019, Arlington, TX, USA
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.411588.1 schema:alternateName Baylor University Medical Center
226 schema:name Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.422201.7 schema:alternateName VA North Texas Health Care System
229 schema:name Esophageal Diseases Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
230 Veterans Affairs North Texas Health Care System, 4500 S. Lancaster Road, 75216, Dallas, TX, USA
231 rdf:type schema:Organization
232 https://www.grid.ac/institutes/grid.486749.0 schema:alternateName Baylor Scott & White Health
233 schema:name Center for Esophageal Diseases, Baylor University Medical Center, Dallas, TX, USA
234 Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA
235 Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA
236 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...