Liver Function Assessment Using Albumin–Bilirubin Grade for Patients with Very Early-Stage Hepatocellular Carcinoma Treated with Radiofrequency Ablation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10-05

AUTHORS

In Soo Oh, Dong Hyun Sinn, Tae Wook Kang, Min Woo Lee, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik

ABSTRACT

Background/AimAssessment of liver function is essential for management of hepatocellular carcinoma (HCC). Recently, albumin–bilirubin (ALBI) grade has been reported as a useful tool for assessing hepatic reserve in patients with HCC. The objective of this study was to determine whether ALBI grade could be used to predict the overall survival of very early-stage HCC patients treated with radiofrequency ablation (RF ablation).MethodsA cohort of 368 patients with very early-stage HCC treated with RF ablation was retrospectively analyzed. The overall survival and recurrence-free survival were calculated in groups classified by ALBI grade and Child–Pugh score.ResultsOverall survival of patients with ALBI grade 1 was better than that of patients with ALBI grade 2 (5-year survival rate 88.5 vs. 73.8%, P < 0.001). In multivariable-adjusted model, ALBI grade was found to be an independent factor associated with overall survival (hazard ratio 2.44; 95% confidence interval 1.43–4.15). ALBI grade was able to stratify patients with distinct overall survival among patients within the same Child–Pugh score (5-year survival rate for Child–Pugh score 5: 88.5 vs. 76.6%, P = 0.002; for Child–Pugh score 6: 88.9 vs. 70.1%, P = 0.064). In contrast, Child–Pugh score was unable to stratify patients with distinct overall survival within the same ALBI grade.ConclusionsAmong patients with very early-stage HCC treated with RF ablation, ALBI grade was a good stratifying biomarker. ALBI grade was better tool for assessing liver function than Child–Pugh score for very early-stage HCC treated with RF ablation. More... »

PAGES

3235-3242

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-017-4775-8

DOI

http://dx.doi.org/10.1007/s10620-017-4775-8

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https://app.dimensions.ai/details/publication/pub.1092101186

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28983724


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33 schema:description Background/AimAssessment of liver function is essential for management of hepatocellular carcinoma (HCC). Recently, albumin–bilirubin (ALBI) grade has been reported as a useful tool for assessing hepatic reserve in patients with HCC. The objective of this study was to determine whether ALBI grade could be used to predict the overall survival of very early-stage HCC patients treated with radiofrequency ablation (RF ablation).MethodsA cohort of 368 patients with very early-stage HCC treated with RF ablation was retrospectively analyzed. The overall survival and recurrence-free survival were calculated in groups classified by ALBI grade and Child–Pugh score.ResultsOverall survival of patients with ALBI grade 1 was better than that of patients with ALBI grade 2 (5-year survival rate 88.5 vs. 73.8%, P < 0.001). In multivariable-adjusted model, ALBI grade was found to be an independent factor associated with overall survival (hazard ratio 2.44; 95% confidence interval 1.43–4.15). ALBI grade was able to stratify patients with distinct overall survival among patients within the same Child–Pugh score (5-year survival rate for Child–Pugh score 5: 88.5 vs. 76.6%, P = 0.002; for Child–Pugh score 6: 88.9 vs. 70.1%, P = 0.064). In contrast, Child–Pugh score was unable to stratify patients with distinct overall survival within the same ALBI grade.ConclusionsAmong patients with very early-stage HCC treated with RF ablation, ALBI grade was a good stratifying biomarker. ALBI grade was better tool for assessing liver function than Child–Pugh score for very early-stage HCC treated with RF ablation.
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48 MethodsA cohort
49 RF ablation
50 ResultsOverall survival
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52 albumin-bilirubin (ALBI) grade
53 assessment
54 biomarkers
55 carcinoma
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57 contrast
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59 early-stage HCC patients
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