Proteomic Analysis of Serum Amyloid A as a Potential Marker in Intestinal Behçet’s Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

Hyun Jung Lee, Jae Hyun Kim, Seung Won Kim, Hyun Ah Joo, Hye Won Lee, You Sun Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Young-Ho Kim, Jae Hee Cheon

ABSTRACT

BACKGROUND/AIMS: Data regarding biomarkers to understand disease pathogenesis and to assess disease activity of intestinal Behçet's disease (BD) are limited. Therefore, we aimed to investigate the differentially expressed proteins in sera from patients with intestinal BD and to search for biomarkers using mass spectrometry-based proteomic analysis. METHODS: Serum samples were pooled for the screening study, and two-dimensional electrophoresis (2-DE) was performed to characterize the proteins present in intestinal BD patients. Candidate protein spots were identified using matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF MS) and bioinformatic analysis. To validate the proteomic results, serum samples from an independent cohort were assessed by enzyme-linked immunosorbent assay. RESULTS: Pooled serum samples were used for 2-DE, and approximately 400 protein spots were detected in the sera of intestinal BD patients. Of the 22 differentially expressed proteins, 3 were successfully identified using MALDI-TOF/TOF MS. The three up-regulated proteins identified in the intestinal BD group included fibrin, apolipoprotein A-IV, and serum amyloid A (SAA). Serum SAA in intestinal BD patients (2.76 ± 2.50 ng/ml) was significantly higher than that in controls (1.68 ± 0.90 ng/ml, p = 0.007), which is consistent with the proteomic results. In addition, the level of IL-1β in patients with intestinal BD (8.96 ± 1.23 pg/ml) was higher than that in controls (5.40 ± 0.15 pg/ml, p = 0.009). SAA released by HT-29 cells was markedly increased by tumor necrosis factor-α (TNF-α) and lipopolysaccharides stimulation. CONCLUSIONS: Our proteomic analysis revealed that SAA was up-regulated in intestinal BD patients. More... »

PAGES

1953-1962

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-017-4606-y

DOI

http://dx.doi.org/10.1007/s10620-017-4606-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085432702

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28523576


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apolipoproteins A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Behcet Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HT29 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mass Spectrometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum Amyloid A Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyun Jung", 
        "id": "sg:person.011242043254.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea", 
            "Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jae Hyun", 
        "id": "sg:person.01362027676.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362027676.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea", 
            "Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea", 
            "Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Seung Won", 
        "id": "sg:person.01051737174.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051737174.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Biochemistry, Yonsei University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joo", 
        "givenName": "Hyun Ah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hye Won", 
        "id": "sg:person.0604617375.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604617375.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "You Sun", 
        "id": "sg:person.01165177162.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165177162.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Soo Jung", 
        "id": "sg:person.0733275532.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733275532.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Sung Pil", 
        "id": "sg:person.01120052374.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120052374.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae Il", 
        "id": "sg:person.015302742440.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015302742440.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Won Ho", 
        "id": "sg:person.012071233174.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012071233174.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sungkyunkwan University", 
          "id": "https://www.grid.ac/institutes/grid.264381.a", 
          "name": [
            "Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 135-710, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young-Ho", 
        "id": "sg:person.013173012204.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013173012204.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea", 
            "Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea", 
            "Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheon", 
        "givenName": "Jae Hee", 
        "id": "sg:person.01361111112.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361111112.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ibd.21313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000220980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000220980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000220980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3182431d56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002774957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3182431d56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002774957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2015.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003063783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5217/ir.2013.11.3.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003074607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.181.1.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003655142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0407203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004445708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-007-2090-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005161377", 
          "https://doi.org/10.1007/s00535-007-2090-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-007-2090-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005161377", 
          "https://doi.org/10.1007/s00535-007-2090-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1222669110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006819825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1999.00657.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007730303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2009.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008020262", 
          "https://doi.org/10.1038/ajg.2009.331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2008.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010916352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.069476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012521428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10254-003-0012-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014406362", 
          "https://doi.org/10.1007/s10254-003-0012-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199910213411707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014703943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10350-006-0706-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015334354", 
          "https://doi.org/10.1007/s10350-006-0706-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-006-0706-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015334354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2002.33204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016138932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017025034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017025034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13075-016-1009-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017347489", 
          "https://doi.org/10.1186/s13075-016-1009-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-008-0337-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019478942", 
          "https://doi.org/10.1007/s10620-008-0337-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020538572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020538572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020538572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1100500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020826367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.02.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021170740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021380813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021380813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023182499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023182499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2362.1987.tb01143.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023560365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2006.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025434927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14789450.2016.1182431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029357641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35015709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030361158", 
          "https://doi.org/10.1038/35015709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35015709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030361158", 
          "https://doi.org/10.1038/35015709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.r200007-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030622889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-012-2291-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033580098", 
          "https://doi.org/10.1007/s10620-012-2291-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034427996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034427996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200300558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037698699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037783927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037783927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2008.148395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038181741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2009.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039111223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200425688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043497969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2010.142240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046195497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000115516.54550.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048639376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365529850171927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048994698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2011.238477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052165030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14789450.5.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052728509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3349/ymj.2016.57.1.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053690324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr0500657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056290683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr800279m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056294397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200003000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200003000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200003000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.080755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071541600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4291/wjgp.v7.i1.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072443499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-20.1295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077107200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1002843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078385155"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08", 
    "datePublishedReg": "2017-08-01", 
    "description": "BACKGROUND/AIMS: Data regarding biomarkers to understand disease pathogenesis and to assess disease activity of intestinal Beh\u00e7et's disease (BD) are limited. Therefore, we aimed to investigate the differentially expressed proteins in sera from patients with intestinal BD and to search for biomarkers using mass spectrometry-based proteomic analysis.\nMETHODS: Serum samples were pooled for the screening study, and two-dimensional electrophoresis (2-DE) was performed to characterize the proteins present in intestinal BD patients. Candidate protein spots were identified using matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF MS) and bioinformatic analysis. To validate the proteomic results, serum samples from an independent cohort were assessed by enzyme-linked immunosorbent assay.\nRESULTS: Pooled serum samples were used for 2-DE, and approximately 400 protein spots were detected in the sera of intestinal BD patients. Of the 22 differentially expressed proteins, 3 were successfully identified using MALDI-TOF/TOF MS. The three up-regulated proteins identified in the intestinal BD group included fibrin, apolipoprotein A-IV, and serum amyloid A (SAA). Serum SAA in intestinal BD patients (2.76\u00a0\u00b1\u00a02.50\u00a0ng/ml) was significantly higher than that in controls (1.68\u00a0\u00b1\u00a00.90\u00a0ng/ml, p\u00a0=\u00a00.007), which is consistent with the proteomic results. In addition, the level of IL-1\u03b2 in patients with intestinal BD (8.96\u00a0\u00b1\u00a01.23\u00a0pg/ml) was higher than that in controls (5.40\u00a0\u00b1\u00a00.15\u00a0pg/ml, p\u00a0=\u00a00.009). SAA released by HT-29 cells was markedly increased by tumor necrosis factor-\u03b1 (TNF-\u03b1) and lipopolysaccharides stimulation.\nCONCLUSIONS: Our proteomic analysis revealed that SAA was up-regulated in intestinal BD patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-017-4606-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7487785", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7490126", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "62"
      }
    ], 
    "name": "Proteomic Analysis of Serum Amyloid A as a Potential Marker in Intestinal Beh\u00e7et\u2019s Disease", 
    "pagination": "1953-1962", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "75b571a2c723b101ebb07b4b5fb358084a3dc5bd6455d60e8b679001bfa81e49"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28523576"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-017-4606-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085432702"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-017-4606-y", 
      "https://app.dimensions.ai/details/publication/pub.1085432702"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89786_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10620-017-4606-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-017-4606-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-017-4606-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-017-4606-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-017-4606-y'


 

This table displays all metadata directly associated to this object as RDF triples.

387 TRIPLES      21 PREDICATES      97 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-017-4606-y schema:about N0d6ab82bbfdc442798eb31c2200dbb75
2 N3f19d9eefffd42b6b8761fd68b85b07d
3 N44767155c16d419e87f99247f623b775
4 N4f36f7b9341d4439909f5690b506acad
5 N53c2a021d32f4551867e1905a9fd5aa4
6 N548bca5952854b7db0f5d1f406e904aa
7 N5a360113b10c4e6f8590f810619a6752
8 N5e915930e637485e911d50201f2aa2b4
9 N8d8f555e794c4ca3a8b317871baebf11
10 N9736c4fb888744ea953a2ea52aadbea7
11 N99025566c61748429c0c66c70f34d425
12 N9a07923005a7472f9f884fdf71793072
13 Naa3e6c76559a44f1b9955ece6143eaa7
14 Nbc0b355cd24744bda9323883ac6cddec
15 Nd58138b35fdc45ec82960fa50d044369
16 Ndd6fec26f2fd407ca7dcb5399da184f6
17 Ne181e50cb4694cabbec3932a477a497e
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N2cb4089cc2784ca0b410a9e75f0914d5
21 schema:citation sg:pub.10.1007/s00535-007-2090-4
22 sg:pub.10.1007/s10254-003-0012-2
23 sg:pub.10.1007/s10350-006-0706-z
24 sg:pub.10.1007/s10620-008-0337-4
25 sg:pub.10.1007/s10620-012-2291-4
26 sg:pub.10.1038/35015709
27 sg:pub.10.1038/ajg.2009.331
28 sg:pub.10.1186/s13075-016-1009-y
29 https://doi.org/10.1002/eji.200425688
30 https://doi.org/10.1002/ibd.20078
31 https://doi.org/10.1002/ibd.20110
32 https://doi.org/10.1002/ibd.21212
33 https://doi.org/10.1002/ibd.21263
34 https://doi.org/10.1002/ibd.21313
35 https://doi.org/10.1002/ibd.21600
36 https://doi.org/10.1002/pmic.200300558
37 https://doi.org/10.1007/s10350-006-0706-z
38 https://doi.org/10.1016/j.autrev.2006.03.006
39 https://doi.org/10.1016/j.cytogfr.2012.04.001
40 https://doi.org/10.1016/j.jchromb.2009.08.003
41 https://doi.org/10.1016/j.thromres.2008.04.004
42 https://doi.org/10.1021/pr0500657
43 https://doi.org/10.1021/pr800279m
44 https://doi.org/10.1046/j.1432-1327.1999.00657.x
45 https://doi.org/10.1053/j.gastro.2005.02.053
46 https://doi.org/10.1053/j.gastro.2015.07.003
47 https://doi.org/10.1053/jhep.2002.33204
48 https://doi.org/10.1056/nejm199910213411707
49 https://doi.org/10.1073/pnas.1222669110
50 https://doi.org/10.1074/mcp.r200007-mcp200
51 https://doi.org/10.1080/00365529850171927
52 https://doi.org/10.1080/14789450.2016.1182431
53 https://doi.org/10.1097/00004836-200003000-00006
54 https://doi.org/10.1097/mcg.0b013e3182431d56
55 https://doi.org/10.1111/j.1365-2362.1987.tb01143.x
56 https://doi.org/10.1136/ard.2010.142240
57 https://doi.org/10.1136/gut.2005.069476
58 https://doi.org/10.1136/gut.2008.148395
59 https://doi.org/10.1136/gut.2011.238477
60 https://doi.org/10.1161/01.cir.0000115516.54550.b1
61 https://doi.org/10.1172/jci21233
62 https://doi.org/10.1189/jlb.0407203
63 https://doi.org/10.14670/hh-20.1295
64 https://doi.org/10.1586/14789450.5.1.1
65 https://doi.org/10.3349/ymj.2016.57.1.22
66 https://doi.org/10.3899/jrheum.080755
67 https://doi.org/10.4049/jimmunol.1002843
68 https://doi.org/10.4049/jimmunol.1100500
69 https://doi.org/10.4049/jimmunol.181.1.22
70 https://doi.org/10.4291/wjgp.v7.i1.27
71 https://doi.org/10.5217/ir.2013.11.3.155
72 schema:datePublished 2017-08
73 schema:datePublishedReg 2017-08-01
74 schema:description BACKGROUND/AIMS: Data regarding biomarkers to understand disease pathogenesis and to assess disease activity of intestinal Behçet's disease (BD) are limited. Therefore, we aimed to investigate the differentially expressed proteins in sera from patients with intestinal BD and to search for biomarkers using mass spectrometry-based proteomic analysis. METHODS: Serum samples were pooled for the screening study, and two-dimensional electrophoresis (2-DE) was performed to characterize the proteins present in intestinal BD patients. Candidate protein spots were identified using matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF MS) and bioinformatic analysis. To validate the proteomic results, serum samples from an independent cohort were assessed by enzyme-linked immunosorbent assay. RESULTS: Pooled serum samples were used for 2-DE, and approximately 400 protein spots were detected in the sera of intestinal BD patients. Of the 22 differentially expressed proteins, 3 were successfully identified using MALDI-TOF/TOF MS. The three up-regulated proteins identified in the intestinal BD group included fibrin, apolipoprotein A-IV, and serum amyloid A (SAA). Serum SAA in intestinal BD patients (2.76 ± 2.50 ng/ml) was significantly higher than that in controls (1.68 ± 0.90 ng/ml, p = 0.007), which is consistent with the proteomic results. In addition, the level of IL-1β in patients with intestinal BD (8.96 ± 1.23 pg/ml) was higher than that in controls (5.40 ± 0.15 pg/ml, p = 0.009). SAA released by HT-29 cells was markedly increased by tumor necrosis factor-α (TNF-α) and lipopolysaccharides stimulation. CONCLUSIONS: Our proteomic analysis revealed that SAA was up-regulated in intestinal BD patients.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree false
78 schema:isPartOf N20d32e346cee46fab527290605f2b0fe
79 N918439389c80447bb4113b3875415479
80 sg:journal.1018525
81 schema:name Proteomic Analysis of Serum Amyloid A as a Potential Marker in Intestinal Behçet’s Disease
82 schema:pagination 1953-1962
83 schema:productId N0228ca46d56742659bd39bd7666b8e21
84 N6879ece280434202bc1a464f7a9aacbd
85 N7e5f7ed8d1684cde99d58733c7d17e0a
86 N8283a5427fc54cb1bfc9af641a8f105a
87 Nce22a59a27d243c8ba494204956a16e0
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085432702
89 https://doi.org/10.1007/s10620-017-4606-y
90 schema:sdDatePublished 2019-04-11T09:50
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nbcf4ba89cd394154bb6b953ea4d88743
93 schema:url https://link.springer.com/10.1007%2Fs10620-017-4606-y
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0228ca46d56742659bd39bd7666b8e21 schema:name dimensions_id
98 schema:value pub.1085432702
99 rdf:type schema:PropertyValue
100 N0d6ab82bbfdc442798eb31c2200dbb75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Male
102 rdf:type schema:DefinedTerm
103 N0d8bbf564ebd4a3699d588817d1f1496 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
104 schema:familyName Joo
105 schema:givenName Hyun Ah
106 rdf:type schema:Person
107 N20d32e346cee46fab527290605f2b0fe schema:issueNumber 8
108 rdf:type schema:PublicationIssue
109 N2cb4089cc2784ca0b410a9e75f0914d5 rdf:first sg:person.011242043254.34
110 rdf:rest N75cdc0782e2d436bb508c581c4127903
111 N32a769678c2646da899069f6a64f00df rdf:first sg:person.0604617375.89
112 rdf:rest Nc2744d41a9a646b08f6880fcb75ca96b
113 N3ce918c73477411bbaf80f4f511766ee rdf:first sg:person.01051737174.28
114 rdf:rest N6126ee7465244e6e9a6fd3308b568dc0
115 N3f19d9eefffd42b6b8761fd68b85b07d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name HT29 Cells
117 rdf:type schema:DefinedTerm
118 N44767155c16d419e87f99247f623b775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Intestinal Diseases
120 rdf:type schema:DefinedTerm
121 N4f36f7b9341d4439909f5690b506acad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mass Spectrometry
123 rdf:type schema:DefinedTerm
124 N53c2a021d32f4551867e1905a9fd5aa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Serum Amyloid A Protein
126 rdf:type schema:DefinedTerm
127 N548bca5952854b7db0f5d1f406e904aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N5a360113b10c4e6f8590f810619a6752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Proteomics
132 rdf:type schema:DefinedTerm
133 N5e915930e637485e911d50201f2aa2b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Apolipoproteins A
135 rdf:type schema:DefinedTerm
136 N6126ee7465244e6e9a6fd3308b568dc0 rdf:first N0d8bbf564ebd4a3699d588817d1f1496
137 rdf:rest N32a769678c2646da899069f6a64f00df
138 N667890dfb0e34c9e8b98d82a81fa616b rdf:first sg:person.012071233174.13
139 rdf:rest Ne153326ec65f4478a600a74d28957465
140 N6879ece280434202bc1a464f7a9aacbd schema:name nlm_unique_id
141 schema:value 7902782
142 rdf:type schema:PropertyValue
143 N75cdc0782e2d436bb508c581c4127903 rdf:first sg:person.01362027676.58
144 rdf:rest N3ce918c73477411bbaf80f4f511766ee
145 N7e5f7ed8d1684cde99d58733c7d17e0a schema:name pubmed_id
146 schema:value 28523576
147 rdf:type schema:PropertyValue
148 N7eb9601845fc4a4a96979d844574e8f1 rdf:first sg:person.01120052374.02
149 rdf:rest Ncfe4ba55dd924e3ebdb0d6054575ce4c
150 N8283a5427fc54cb1bfc9af641a8f105a schema:name readcube_id
151 schema:value 75b571a2c723b101ebb07b4b5fb358084a3dc5bd6455d60e8b679001bfa81e49
152 rdf:type schema:PropertyValue
153 N853a0c71f4d44d40844986e13ed833be rdf:first sg:person.01361111112.51
154 rdf:rest rdf:nil
155 N8d8f555e794c4ca3a8b317871baebf11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 N918439389c80447bb4113b3875415479 schema:volumeNumber 62
159 rdf:type schema:PublicationVolume
160 N9736c4fb888744ea953a2ea52aadbea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adult
162 rdf:type schema:DefinedTerm
163 N99025566c61748429c0c66c70f34d425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Behcet Syndrome
165 rdf:type schema:DefinedTerm
166 N9a07923005a7472f9f884fdf71793072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Biomarkers
168 rdf:type schema:DefinedTerm
169 Naa3e6c76559a44f1b9955ece6143eaa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Case-Control Studies
171 rdf:type schema:DefinedTerm
172 Nbc0b355cd24744bda9323883ac6cddec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Interleukin-1beta
174 rdf:type schema:DefinedTerm
175 Nbcf4ba89cd394154bb6b953ea4d88743 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nc2744d41a9a646b08f6880fcb75ca96b rdf:first sg:person.01165177162.38
178 rdf:rest Ne7571256bd584bc4b6bb15dde08acdc6
179 Nce22a59a27d243c8ba494204956a16e0 schema:name doi
180 schema:value 10.1007/s10620-017-4606-y
181 rdf:type schema:PropertyValue
182 Ncfe4ba55dd924e3ebdb0d6054575ce4c rdf:first sg:person.015302742440.35
183 rdf:rest N667890dfb0e34c9e8b98d82a81fa616b
184 Nd58138b35fdc45ec82960fa50d044369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Middle Aged
186 rdf:type schema:DefinedTerm
187 Ndd6fec26f2fd407ca7dcb5399da184f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Fibrin
189 rdf:type schema:DefinedTerm
190 Ne153326ec65f4478a600a74d28957465 rdf:first sg:person.013173012204.30
191 rdf:rest N853a0c71f4d44d40844986e13ed833be
192 Ne181e50cb4694cabbec3932a477a497e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Enzyme-Linked Immunosorbent Assay
194 rdf:type schema:DefinedTerm
195 Ne7571256bd584bc4b6bb15dde08acdc6 rdf:first sg:person.0733275532.51
196 rdf:rest N7eb9601845fc4a4a96979d844574e8f1
197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
198 schema:name Biological Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biochemistry and Cell Biology
202 rdf:type schema:DefinedTerm
203 sg:grant.7487785 http://pending.schema.org/fundedItem sg:pub.10.1007/s10620-017-4606-y
204 rdf:type schema:MonetaryGrant
205 sg:grant.7490126 http://pending.schema.org/fundedItem sg:pub.10.1007/s10620-017-4606-y
206 rdf:type schema:MonetaryGrant
207 sg:journal.1018525 schema:issn 0163-2116
208 1573-2568
209 schema:name Digestive Diseases and Sciences
210 rdf:type schema:Periodical
211 sg:person.01051737174.28 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
212 schema:familyName Kim
213 schema:givenName Seung Won
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051737174.28
215 rdf:type schema:Person
216 sg:person.01120052374.02 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
217 schema:familyName Hong
218 schema:givenName Sung Pil
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120052374.02
220 rdf:type schema:Person
221 sg:person.011242043254.34 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
222 schema:familyName Lee
223 schema:givenName Hyun Jung
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34
225 rdf:type schema:Person
226 sg:person.01165177162.38 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
227 schema:familyName Kim
228 schema:givenName You Sun
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165177162.38
230 rdf:type schema:Person
231 sg:person.012071233174.13 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
232 schema:familyName Kim
233 schema:givenName Won Ho
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012071233174.13
235 rdf:type schema:Person
236 sg:person.013173012204.30 schema:affiliation https://www.grid.ac/institutes/grid.264381.a
237 schema:familyName Kim
238 schema:givenName Young-Ho
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013173012204.30
240 rdf:type schema:Person
241 sg:person.01361111112.51 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
242 schema:familyName Cheon
243 schema:givenName Jae Hee
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361111112.51
245 rdf:type schema:Person
246 sg:person.01362027676.58 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
247 schema:familyName Kim
248 schema:givenName Jae Hyun
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362027676.58
250 rdf:type schema:Person
251 sg:person.015302742440.35 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
252 schema:familyName Kim
253 schema:givenName Tae Il
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015302742440.35
255 rdf:type schema:Person
256 sg:person.0604617375.89 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
257 schema:familyName Lee
258 schema:givenName Hye Won
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604617375.89
260 rdf:type schema:Person
261 sg:person.0733275532.51 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
262 schema:familyName Park
263 schema:givenName Soo Jung
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733275532.51
265 rdf:type schema:Person
266 sg:pub.10.1007/s00535-007-2090-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005161377
267 https://doi.org/10.1007/s00535-007-2090-4
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s10254-003-0012-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014406362
270 https://doi.org/10.1007/s10254-003-0012-2
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s10350-006-0706-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015334354
273 https://doi.org/10.1007/s10350-006-0706-z
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s10620-008-0337-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019478942
276 https://doi.org/10.1007/s10620-008-0337-4
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s10620-012-2291-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033580098
279 https://doi.org/10.1007/s10620-012-2291-4
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/35015709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030361158
282 https://doi.org/10.1038/35015709
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/ajg.2009.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008020262
285 https://doi.org/10.1038/ajg.2009.331
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/s13075-016-1009-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017347489
288 https://doi.org/10.1186/s13075-016-1009-y
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/eji.200425688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043497969
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1002/ibd.20078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021380813
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1002/ibd.20110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023182499
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1002/ibd.21212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020538572
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1002/ibd.21263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037783927
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1002/ibd.21313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000220980
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1002/ibd.21600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034427996
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1002/pmic.200300558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037698699
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1007/s10350-006-0706-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015334354
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.autrev.2006.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025434927
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.cytogfr.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017025034
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.jchromb.2009.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039111223
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.thromres.2008.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010916352
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1021/pr0500657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056290683
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1021/pr800279m schema:sameAs https://app.dimensions.ai/details/publication/pub.1056294397
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1046/j.1432-1327.1999.00657.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007730303
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1053/j.gastro.2005.02.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021170740
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1053/j.gastro.2015.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003063783
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1053/jhep.2002.33204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016138932
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1056/nejm199910213411707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014703943
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.1222669110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006819825
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/mcp.r200007-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030622889
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1080/00365529850171927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048994698
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1080/14789450.2016.1182431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029357641
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1097/00004836-200003000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060191935
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1097/mcg.0b013e3182431d56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002774957
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1111/j.1365-2362.1987.tb01143.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023560365
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1136/ard.2010.142240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046195497
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1136/gut.2005.069476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012521428
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1136/gut.2008.148395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038181741
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1136/gut.2011.238477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052165030
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1161/01.cir.0000115516.54550.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048639376
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1172/jci21233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416606
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1189/jlb.0407203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004445708
357 rdf:type schema:CreativeWork
358 https://doi.org/10.14670/hh-20.1295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077107200
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1586/14789450.5.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052728509
361 rdf:type schema:CreativeWork
362 https://doi.org/10.3349/ymj.2016.57.1.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053690324
363 rdf:type schema:CreativeWork
364 https://doi.org/10.3899/jrheum.080755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071541600
365 rdf:type schema:CreativeWork
366 https://doi.org/10.4049/jimmunol.1002843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078385155
367 rdf:type schema:CreativeWork
368 https://doi.org/10.4049/jimmunol.1100500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020826367
369 rdf:type schema:CreativeWork
370 https://doi.org/10.4049/jimmunol.181.1.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003655142
371 rdf:type schema:CreativeWork
372 https://doi.org/10.4291/wjgp.v7.i1.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072443499
373 rdf:type schema:CreativeWork
374 https://doi.org/10.5217/ir.2013.11.3.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003074607
375 rdf:type schema:CreativeWork
376 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
377 schema:name Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
378 Department of Biochemistry, Yonsei University, Seoul, Korea
379 Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea
380 Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.264381.a schema:alternateName Sungkyunkwan University
383 schema:name Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 135-710, Seoul, Republic of Korea
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.411612.1 schema:alternateName Inje University
386 schema:name Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea
387 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...