Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Tracey G. Simon, Kathleen E. Corey, Raymond T. Chung, Robert Giugliano

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disease or malignancy. The biologic mechanisms that link NAFLD to cardiovascular disease include expansion of visceral adipose tissue, atherogenic dyslipidemia, impaired insulin signaling, systemic inflammation, and endothelial dysfunction. Currently, there are no approved therapies for NAFLD. It has recently been hypothesized that reducing the delivery of dietary cholesterol using the hypolipidemic agent, ezetimibe, could benefit patients with NAFLD. By potently inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) sterol receptor on intestinal enterocytes and within the liver, ezetimibe blocks exogenous cholesterol absorption and has been shown to improve biochemical markers of NAFLD, improve insulin sensitivity and decrease hepatic steatosis. This review summarizes the clinical and epidemiological evidence for the relationship between NAFLD and cardiovascular risk and examines the potential therapeutic role of ezetimibe. More... »

PAGES

3425-3435

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-016-4330-z

DOI

http://dx.doi.org/10.1007/s10620-016-4330-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001798255

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27714510


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticholesteremic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atherosclerosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiovascular Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dyslipidemias", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ezetimibe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intra-Abdominal Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Non-alcoholic Fatty Liver Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity, Abdominal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Reduction Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombophilia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA", 
            "Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simon", 
        "givenName": "Tracey G.", 
        "id": "sg:person.01236301661.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236301661.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA", 
            "Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corey", 
        "givenName": "Kathleen E.", 
        "id": "sg:person.0733402201.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733402201.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA", 
            "Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Raymond T.", 
        "id": "sg:person.014222240037.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014222240037.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Harvard Medical School, Boston, MA, USA", 
            "Cardiovascular Division, Brigham and Women\u2019s Hospital, 350 Longwood Avenue, 1st Floor, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giugliano", 
        "givenName": "Robert", 
        "id": "sg:person.0702207604.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702207604.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/db09-0279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000807672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dld.2007.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001087147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacl.2014.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002218101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2010.01.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002620031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2011.02753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002719292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2006.05.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004684221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2003.50161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004861769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005767907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07853890.2010.518623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006316801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.28431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006499874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehl086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007522568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000443344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2157-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008748372", 
          "https://doi.org/10.1007/s00125-011-2157-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2157-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008748372", 
          "https://doi.org/10.1007/s00125-011-2157-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2006.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009143398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.11.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011070059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m006353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011813338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20080306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012333812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20080306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012333812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012902624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1160794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013064829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2008.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014053332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510230624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015022699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1872-034x.2010.00644.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015171113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1872-034x.2010.00644.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015171113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-010-0291-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015346058", 
          "https://doi.org/10.1007/s00535-010-0291-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dld.2011.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017182941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.107.152298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017760419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.107.152298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017760419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-511x-9-29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020544074", 
          "https://doi.org/10.1186/1476-511x-9-29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2446-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021177494", 
          "https://doi.org/10.1007/s00125-011-2446-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2446-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021177494", 
          "https://doi.org/10.1007/s00125-011-2446-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2015.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021481918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.17.10.1599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021718594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1135-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021740726", 
          "https://doi.org/10.1007/s00125-008-1135-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1135-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021740726", 
          "https://doi.org/10.1007/s00125-008-1135-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1135-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021740726", 
          "https://doi.org/10.1007/s00125-008-1135-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2013.06.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022101573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2008.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022305760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2010.230656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022452211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2016.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022691100", 
          "https://doi.org/10.1038/ajg.2016.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2016.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022691100", 
          "https://doi.org/10.1038/ajg.2016.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-1682-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023615563", 
          "https://doi.org/10.1007/s00125-005-1682-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-1682-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023615563", 
          "https://doi.org/10.1007/s00125-005-1682-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-1682-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023615563", 
          "https://doi.org/10.1007/s00125-005-1682-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024508992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.26156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024639671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-013-3149-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025013172", 
          "https://doi.org/10.1007/s00125-013-3149-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-013-3149-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025013172", 
          "https://doi.org/10.1007/s00125-013-3149-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-016-4040-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025859531", 
          "https://doi.org/10.1007/s10620-016-4040-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.552547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027187630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027475034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2011.242016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027519058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2016.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028408600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.107.147538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028504676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.107.147538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028504676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028574446", 
          "https://doi.org/10.1038/nm.2851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029035322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kws448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029502655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030253773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc06-2247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030511751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031012810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032251706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-007-0109-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033061267", 
          "https://doi.org/10.1007/s10620-007-0109-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu5051544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034356970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2014.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034411607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.108.814418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035377862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.27647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037724797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2010.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040084341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2008.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040148151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040397736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-010-3409-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040676479", 
          "https://doi.org/10.1007/s11745-010-3409-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-010-3409-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040676479", 
          "https://doi.org/10.1007/s11745-010-3409-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-007-2060-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042817238", 
          "https://doi.org/10.1007/s00535-007-2060-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-007-2060-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042817238", 
          "https://doi.org/10.1007/s00535-007-2060-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/imj.12706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043379243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2013.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044655885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.plipres.2012.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046015477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0912063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046126503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dld.2007.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046577904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.54.12.3541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046739232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.10.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047994983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.28506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048323060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.25731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2006.01023.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049702980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2013.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050129930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2012.04460.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050891311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61272-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051094801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2008.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051543971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051838476", 
          "https://doi.org/10.1038/ajg.2010.299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051838476", 
          "https://doi.org/10.1038/ajg.2010.299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2008.02034.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051861633", 
          "https://doi.org/10.1111/j.1572-0241.2008.02034.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.27869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052848419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc09-1765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053665014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0029-1222606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057193644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612811319170019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069168982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i27.4369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071364774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v13.i10.1579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071365570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075311782", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/84.1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077265816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/138.8.1452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077677657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077989049", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disease or malignancy. The biologic mechanisms that link NAFLD to cardiovascular disease include expansion of visceral adipose tissue, atherogenic dyslipidemia, impaired insulin signaling, systemic inflammation, and endothelial dysfunction. Currently, there are no approved therapies for NAFLD. It has recently been hypothesized that reducing the delivery of dietary cholesterol using the hypolipidemic agent, ezetimibe, could benefit patients with NAFLD. By potently inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) sterol receptor on intestinal enterocytes and within the liver, ezetimibe blocks exogenous cholesterol absorption and has been shown to improve biochemical markers of NAFLD, improve insulin sensitivity and decrease hepatic steatosis. This review summarizes the clinical and epidemiological evidence for the relationship between NAFLD and cardiovascular risk and examines the potential therapeutic role of ezetimibe.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-016-4330-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2419058", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2421067", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "61"
      }
    ], 
    "name": "Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe", 
    "pagination": "3425-3435", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0890c5830847baa1911e7e8cdf1dd7944daa3f52823e8e472df1072cecb289b4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27714510"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-016-4330-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001798255"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-016-4330-z", 
      "https://app.dimensions.ai/details/publication/pub.1001798255"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87078_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10620-016-4330-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4330-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4330-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4330-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4330-z'


 

This table displays all metadata directly associated to this object as RDF triples.

444 TRIPLES      21 PREDICATES      134 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-016-4330-z schema:about N186cceb5678143d48d893131223fd326
2 N264e44de4f6b45e28acfb852be87883d
3 N3460b254c22a40c28c39c56ab8d7c1da
4 N38bf9f74e18e4c0aa6d7d0efa670d18b
5 N49500ded42d04ed9be75be563e59d978
6 N57e29e06761345b3bbca59d150f0e98c
7 N5c8d7c32f6d74a8e9e0d162aff176e11
8 N6741d1dab0ee4842b1f07bbf4b642b60
9 N7b9fc716c3e94b74818f0e1db2f2fecb
10 N90d5061180e34529a45b604bc63b57f2
11 Ncb5fbb722393410d9d06d400c49bf7b1
12 Nd5624d271301409aab2e0b420559477f
13 Nde3d92a37b9840d4bb8867a702c3a6b8
14 Ne6ea5dab20684bd9aa1e2001527d4fad
15 Neee1abd05dea4544a762eecbac38880e
16 Nf1db5a47b8234243a1729bba109c40f4
17 Nf4748320d9084194a8226066320fece6
18 anzsrc-for:11
19 anzsrc-for:1102
20 schema:author N151d62011ba94e8bb38571ae21de27a7
21 schema:citation sg:pub.10.1007/s00125-005-1682-x
22 sg:pub.10.1007/s00125-008-1135-4
23 sg:pub.10.1007/s00125-011-2157-x
24 sg:pub.10.1007/s00125-011-2446-4
25 sg:pub.10.1007/s00125-013-3149-9
26 sg:pub.10.1007/s00535-007-2060-x
27 sg:pub.10.1007/s00535-010-0291-8
28 sg:pub.10.1007/s10620-007-0109-6
29 sg:pub.10.1007/s10620-016-4040-6
30 sg:pub.10.1007/s11745-010-3409-0
31 sg:pub.10.1038/ajg.2010.299
32 sg:pub.10.1038/ajg.2016.44
33 sg:pub.10.1038/nm.2851
34 sg:pub.10.1111/j.1572-0241.2008.02034.x
35 sg:pub.10.1186/1476-511x-9-29
36 https://app.dimensions.ai/details/publication/pub.1075311782
37 https://app.dimensions.ai/details/publication/pub.1077989049
38 https://doi.org/10.1002/hep.21171
39 https://doi.org/10.1002/hep.21327
40 https://doi.org/10.1002/hep.23135
41 https://doi.org/10.1002/hep.23314
42 https://doi.org/10.1002/hep.25731
43 https://doi.org/10.1002/hep.26156
44 https://doi.org/10.1002/hep.27647
45 https://doi.org/10.1002/hep.27869
46 https://doi.org/10.1002/hep.28431
47 https://doi.org/10.1002/hep.28506
48 https://doi.org/10.1002/hep.510230624
49 https://doi.org/10.1016/j.atherosclerosis.2006.04.006
50 https://doi.org/10.1016/j.atherosclerosis.2008.01.019
51 https://doi.org/10.1016/j.atherosclerosis.2010.01.049
52 https://doi.org/10.1016/j.atherosclerosis.2015.02.011
53 https://doi.org/10.1016/j.cgh.2008.11.005
54 https://doi.org/10.1016/j.cgh.2013.08.014
55 https://doi.org/10.1016/j.dld.2007.10.002
56 https://doi.org/10.1016/j.dld.2007.10.003
57 https://doi.org/10.1016/j.dld.2011.12.013
58 https://doi.org/10.1016/j.ejphar.2010.02.003
59 https://doi.org/10.1016/j.ijcard.2013.06.024
60 https://doi.org/10.1016/j.jacc.2013.11.002
61 https://doi.org/10.1016/j.jacl.2014.02.011
62 https://doi.org/10.1016/j.jhep.2008.06.012
63 https://doi.org/10.1016/j.jhep.2013.02.024
64 https://doi.org/10.1016/j.jhep.2014.08.013
65 https://doi.org/10.1016/j.jhep.2016.05.013
66 https://doi.org/10.1016/j.mehy.2006.05.041
67 https://doi.org/10.1016/j.plipres.2012.11.002
68 https://doi.org/10.1016/s0140-6736(10)61272-x
69 https://doi.org/10.1038/oby.2008.64
70 https://doi.org/10.1042/cs20080306
71 https://doi.org/10.1053/j.gastro.2005.04.014
72 https://doi.org/10.1053/j.gastro.2007.11.038
73 https://doi.org/10.1053/j.gastro.2008.10.052
74 https://doi.org/10.1053/j.gastro.2012.04.001
75 https://doi.org/10.1053/jhep.2003.50161
76 https://doi.org/10.1055/s-0029-1222606
77 https://doi.org/10.1056/nejmra0912063
78 https://doi.org/10.1093/ajcn/84.1.5
79 https://doi.org/10.1093/aje/kws448
80 https://doi.org/10.1093/eurheartj/ehl086
81 https://doi.org/10.1093/eurheartj/ehr112
82 https://doi.org/10.1093/eurheartj/ehr453
83 https://doi.org/10.1093/jn/138.8.1452
84 https://doi.org/10.1111/imj.12706
85 https://doi.org/10.1111/j.1365-2265.2012.04460.x
86 https://doi.org/10.1111/j.1478-3231.2011.02753.x
87 https://doi.org/10.1111/j.1742-1241.2006.01023.x
88 https://doi.org/10.1111/j.1872-034x.2010.00644.x
89 https://doi.org/10.1126/science.1160794
90 https://doi.org/10.1136/gut.2010.230656
91 https://doi.org/10.1136/gut.2011.242016
92 https://doi.org/10.1159/000443344
93 https://doi.org/10.1161/atvbaha.107.147538
94 https://doi.org/10.1161/atvbaha.107.152298
95 https://doi.org/10.1161/circulationaha.105.552547
96 https://doi.org/10.1161/circulationaha.108.814418
97 https://doi.org/10.1194/jlr.m006353
98 https://doi.org/10.1371/journal.pone.0031799
99 https://doi.org/10.1517/13543784.17.10.1599
100 https://doi.org/10.2174/1381612811319170019
101 https://doi.org/10.2337/db09-0279
102 https://doi.org/10.2337/dc06-2247
103 https://doi.org/10.2337/dc09-1765
104 https://doi.org/10.2337/diabetes.54.12.3541
105 https://doi.org/10.3109/07853890.2010.518623
106 https://doi.org/10.3390/nu5051544
107 https://doi.org/10.3748/wjg.v12.i27.4369
108 https://doi.org/10.3748/wjg.v13.i10.1579
109 schema:datePublished 2016-12
110 schema:datePublishedReg 2016-12-01
111 schema:description Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disease or malignancy. The biologic mechanisms that link NAFLD to cardiovascular disease include expansion of visceral adipose tissue, atherogenic dyslipidemia, impaired insulin signaling, systemic inflammation, and endothelial dysfunction. Currently, there are no approved therapies for NAFLD. It has recently been hypothesized that reducing the delivery of dietary cholesterol using the hypolipidemic agent, ezetimibe, could benefit patients with NAFLD. By potently inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) sterol receptor on intestinal enterocytes and within the liver, ezetimibe blocks exogenous cholesterol absorption and has been shown to improve biochemical markers of NAFLD, improve insulin sensitivity and decrease hepatic steatosis. This review summarizes the clinical and epidemiological evidence for the relationship between NAFLD and cardiovascular risk and examines the potential therapeutic role of ezetimibe.
112 schema:genre research_article
113 schema:inLanguage en
114 schema:isAccessibleForFree false
115 schema:isPartOf N92bbd9647db44636965f45f021569cc3
116 Na412a7fcf88c49d3bf99991875e9cc72
117 sg:journal.1018525
118 schema:name Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe
119 schema:pagination 3425-3435
120 schema:productId N87b63e32f8264ab6a8ee6704bb63bb57
121 N8ad75f62571c459abfe8ff2bef814bf6
122 Na8d361302fc24aeca32fbfa181182f12
123 Ncd02bc1c715f47fab9e0945076f09d57
124 Ndb8d5ecfc3fa48bbb1b1bfb37d576e0b
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001798255
126 https://doi.org/10.1007/s10620-016-4330-z
127 schema:sdDatePublished 2019-04-11T12:20
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher N8c408b03f4f649a6ab917923192a45d6
130 schema:url https://link.springer.com/10.1007%2Fs10620-016-4330-z
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N151d62011ba94e8bb38571ae21de27a7 rdf:first sg:person.01236301661.07
135 rdf:rest N9beda24f3dc146f9b65a322528d1803c
136 N186cceb5678143d48d893131223fd326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Non-alcoholic Fatty Liver Disease
138 rdf:type schema:DefinedTerm
139 N264e44de4f6b45e28acfb852be87883d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Metabolic Syndrome
141 rdf:type schema:DefinedTerm
142 N3460b254c22a40c28c39c56ab8d7c1da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Dyslipidemias
144 rdf:type schema:DefinedTerm
145 N38bf9f74e18e4c0aa6d7d0efa670d18b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Anticholesteremic Agents
147 rdf:type schema:DefinedTerm
148 N49500ded42d04ed9be75be563e59d978 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Insulin Resistance
150 rdf:type schema:DefinedTerm
151 N57e29e06761345b3bbca59d150f0e98c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Obesity
153 rdf:type schema:DefinedTerm
154 N5c8d7c32f6d74a8e9e0d162aff176e11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Risk Reduction Behavior
156 rdf:type schema:DefinedTerm
157 N6741d1dab0ee4842b1f07bbf4b642b60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Atherosclerosis
159 rdf:type schema:DefinedTerm
160 N7b9fc716c3e94b74818f0e1db2f2fecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Obesity, Abdominal
162 rdf:type schema:DefinedTerm
163 N87b63e32f8264ab6a8ee6704bb63bb57 schema:name pubmed_id
164 schema:value 27714510
165 rdf:type schema:PropertyValue
166 N8ad75f62571c459abfe8ff2bef814bf6 schema:name doi
167 schema:value 10.1007/s10620-016-4330-z
168 rdf:type schema:PropertyValue
169 N8c408b03f4f649a6ab917923192a45d6 schema:name Springer Nature - SN SciGraph project
170 rdf:type schema:Organization
171 N90d5061180e34529a45b604bc63b57f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Ezetimibe
173 rdf:type schema:DefinedTerm
174 N92bbd9647db44636965f45f021569cc3 schema:volumeNumber 61
175 rdf:type schema:PublicationVolume
176 N9beda24f3dc146f9b65a322528d1803c rdf:first sg:person.0733402201.70
177 rdf:rest Na43ca2b0e520468b9f61b372202e3c13
178 Na412a7fcf88c49d3bf99991875e9cc72 schema:issueNumber 12
179 rdf:type schema:PublicationIssue
180 Na43ca2b0e520468b9f61b372202e3c13 rdf:first sg:person.014222240037.63
181 rdf:rest Na9adf3a1d6b94bcd90e7fef8bd6ce9bb
182 Na8d361302fc24aeca32fbfa181182f12 schema:name readcube_id
183 schema:value 0890c5830847baa1911e7e8cdf1dd7944daa3f52823e8e472df1072cecb289b4
184 rdf:type schema:PropertyValue
185 Na9adf3a1d6b94bcd90e7fef8bd6ce9bb rdf:first sg:person.0702207604.00
186 rdf:rest rdf:nil
187 Ncb5fbb722393410d9d06d400c49bf7b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Cardiovascular Diseases
189 rdf:type schema:DefinedTerm
190 Ncd02bc1c715f47fab9e0945076f09d57 schema:name dimensions_id
191 schema:value pub.1001798255
192 rdf:type schema:PropertyValue
193 Nd5624d271301409aab2e0b420559477f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Intra-Abdominal Fat
195 rdf:type schema:DefinedTerm
196 Ndb8d5ecfc3fa48bbb1b1bfb37d576e0b schema:name nlm_unique_id
197 schema:value 7902782
198 rdf:type schema:PropertyValue
199 Nde3d92a37b9840d4bb8867a702c3a6b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Endothelium, Vascular
201 rdf:type schema:DefinedTerm
202 Ne6ea5dab20684bd9aa1e2001527d4fad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Humans
204 rdf:type schema:DefinedTerm
205 Neee1abd05dea4544a762eecbac38880e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Inflammation
207 rdf:type schema:DefinedTerm
208 Nf1db5a47b8234243a1729bba109c40f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Liver
210 rdf:type schema:DefinedTerm
211 Nf4748320d9084194a8226066320fece6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Thrombophilia
213 rdf:type schema:DefinedTerm
214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
215 schema:name Medical and Health Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
218 schema:name Cardiorespiratory Medicine and Haematology
219 rdf:type schema:DefinedTerm
220 sg:grant.2419058 http://pending.schema.org/fundedItem sg:pub.10.1007/s10620-016-4330-z
221 rdf:type schema:MonetaryGrant
222 sg:grant.2421067 http://pending.schema.org/fundedItem sg:pub.10.1007/s10620-016-4330-z
223 rdf:type schema:MonetaryGrant
224 sg:journal.1018525 schema:issn 0163-2116
225 1573-2568
226 schema:name Digestive Diseases and Sciences
227 rdf:type schema:Periodical
228 sg:person.01236301661.07 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
229 schema:familyName Simon
230 schema:givenName Tracey G.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236301661.07
232 rdf:type schema:Person
233 sg:person.014222240037.63 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
234 schema:familyName Chung
235 schema:givenName Raymond T.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014222240037.63
237 rdf:type schema:Person
238 sg:person.0702207604.00 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
239 schema:familyName Giugliano
240 schema:givenName Robert
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702207604.00
242 rdf:type schema:Person
243 sg:person.0733402201.70 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
244 schema:familyName Corey
245 schema:givenName Kathleen E.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733402201.70
247 rdf:type schema:Person
248 sg:pub.10.1007/s00125-005-1682-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023615563
249 https://doi.org/10.1007/s00125-005-1682-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s00125-008-1135-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021740726
252 https://doi.org/10.1007/s00125-008-1135-4
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s00125-011-2157-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008748372
255 https://doi.org/10.1007/s00125-011-2157-x
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s00125-011-2446-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177494
258 https://doi.org/10.1007/s00125-011-2446-4
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s00125-013-3149-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025013172
261 https://doi.org/10.1007/s00125-013-3149-9
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s00535-007-2060-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042817238
264 https://doi.org/10.1007/s00535-007-2060-x
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s00535-010-0291-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015346058
267 https://doi.org/10.1007/s00535-010-0291-8
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s10620-007-0109-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033061267
270 https://doi.org/10.1007/s10620-007-0109-6
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s10620-016-4040-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025859531
273 https://doi.org/10.1007/s10620-016-4040-6
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s11745-010-3409-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040676479
276 https://doi.org/10.1007/s11745-010-3409-0
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/ajg.2010.299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051838476
279 https://doi.org/10.1038/ajg.2010.299
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/ajg.2016.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022691100
282 https://doi.org/10.1038/ajg.2016.44
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nm.2851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028574446
285 https://doi.org/10.1038/nm.2851
286 rdf:type schema:CreativeWork
287 sg:pub.10.1111/j.1572-0241.2008.02034.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051861633
288 https://doi.org/10.1111/j.1572-0241.2008.02034.x
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/1476-511x-9-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020544074
291 https://doi.org/10.1186/1476-511x-9-29
292 rdf:type schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1075311782 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1077989049 schema:CreativeWork
295 https://doi.org/10.1002/hep.21171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030253773
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/hep.21327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029035322
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/hep.23135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024508992
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/hep.23314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032251706
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/hep.25731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048595612
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/hep.26156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024639671
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/hep.27647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037724797
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/hep.27869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052848419
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/hep.28431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006499874
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/hep.28506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048323060
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/hep.510230624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015022699
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.atherosclerosis.2006.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009143398
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.atherosclerosis.2008.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051543971
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.atherosclerosis.2010.01.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002620031
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.atherosclerosis.2015.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021481918
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.cgh.2008.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022305760
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.cgh.2013.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050129930
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.dld.2007.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046577904
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.dld.2007.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001087147
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.dld.2011.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017182941
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.ejphar.2010.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040084341
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.ijcard.2013.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022101573
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.jacc.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031012810
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.jacl.2014.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002218101
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.jhep.2008.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014053332
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.jhep.2013.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044655885
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.jhep.2014.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034411607
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.jhep.2016.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028408600
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.mehy.2006.05.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004684221
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.plipres.2012.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046015477
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/s0140-6736(10)61272-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051094801
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1038/oby.2008.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040148151
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1042/cs20080306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012333812
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1053/j.gastro.2005.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030511751
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1053/j.gastro.2007.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011070059
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1053/j.gastro.2008.10.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047994983
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1053/j.gastro.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040397736
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1053/jhep.2003.50161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004861769
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1055/s-0029-1222606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057193644
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1056/nejmra0912063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046126503
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/ajcn/84.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077265816
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/aje/kws448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029502655
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1093/eurheartj/ehl086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007522568
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/eurheartj/ehr112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005767907
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1093/eurheartj/ehr453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012902624
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1093/jn/138.8.1452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077677657
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1111/imj.12706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043379243
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1111/j.1365-2265.2012.04460.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050891311
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1111/j.1478-3231.2011.02753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002719292
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1111/j.1742-1241.2006.01023.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049702980
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1111/j.1872-034x.2010.00644.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015171113
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1126/science.1160794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013064829
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1136/gut.2010.230656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022452211
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1136/gut.2011.242016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027519058
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1159/000443344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007566436
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1161/atvbaha.107.147538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028504676
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1161/atvbaha.107.152298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017760419
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1161/circulationaha.105.552547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027187630
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1161/circulationaha.108.814418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035377862
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1194/jlr.m006353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011813338
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1371/journal.pone.0031799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027475034
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1517/13543784.17.10.1599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021718594
418 rdf:type schema:CreativeWork
419 https://doi.org/10.2174/1381612811319170019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069168982
420 rdf:type schema:CreativeWork
421 https://doi.org/10.2337/db09-0279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000807672
422 rdf:type schema:CreativeWork
423 https://doi.org/10.2337/dc06-2247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030503587
424 rdf:type schema:CreativeWork
425 https://doi.org/10.2337/dc09-1765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053665014
426 rdf:type schema:CreativeWork
427 https://doi.org/10.2337/diabetes.54.12.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046739232
428 rdf:type schema:CreativeWork
429 https://doi.org/10.3109/07853890.2010.518623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006316801
430 rdf:type schema:CreativeWork
431 https://doi.org/10.3390/nu5051544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034356970
432 rdf:type schema:CreativeWork
433 https://doi.org/10.3748/wjg.v12.i27.4369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364774
434 rdf:type schema:CreativeWork
435 https://doi.org/10.3748/wjg.v13.i10.1579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071365570
436 rdf:type schema:CreativeWork
437 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
438 schema:name Harvard Medical School, Boston, MA, USA
439 Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
440 rdf:type schema:Organization
441 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
442 schema:name Cardiovascular Division, Brigham and Women’s Hospital, 350 Longwood Avenue, 1st Floor, 02215, Boston, MA, USA
443 Harvard Medical School, Boston, MA, USA
444 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...