The Genetics of Barrett’s Esophagus: A Familial and Population-Based Perspective View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

Henry To, Nicholas J. Clemons, Cuong P. Duong, Alison H. Trainer, Wayne A. Phillips

ABSTRACT

Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but the exact biological mechanisms have been difficult to determine. BE is generally thought to be an acquired condition that develops secondarily to chronic gastroesophageal reflux. However, multiple reports of familial clustering of patients with BE and/or EAC suggest a possible inherited predisposition to BE may be driving this condition, at least in a subset of patients. Identifying the genetic variants that predispose to BE in these families would open up the possibility for blood-based screening tests that could inform decision-making in regard to surveillance strategies, particularly for relatives of patients with BE and/or EAC. Perhaps more importantly, understanding the genetic mechanisms that predispose to BE may provide valuable insights into the biology of this condition and potentially identify novel targets for therapeutic intervention. Here we review the current evidence for a genetic predisposition to BE and discuss the potential implications of these findings. More... »

PAGES

1826-1834

References to SciGraph publications

  • 2011-08. Epidemiology and Natural History of Intestinal Metaplasia of the Gastroesophageal Junction and Barrett's Esophagus: A Population-Based Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-07. Predictors for Neoplastic Progression in Patients With Barrett's Esophagus: A Prospective Cohort Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-03. Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett's Esophagus in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2005-12. Mortality Associated with Barrett's Esophagus and Gastroesophageal Reflux Disease Diagnoses—A Population-Based Cohort Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2007-05-25. Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus in JOURNAL OF HUMAN GENETICS
  • 2014-04. Symptoms and Endoscopic Features at Barrett's Esophagus Diagnosis: Implications for Neoplastic Progression Risk in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-08. Assessment of Familiality, Obesity, and Other Risk Factors for Early Age of Cancer Diagnosis in Adenocarcinomas of the Esophagus and Gastroesophageal Junction in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2002-05. Barrett's esophagus: prevalence in symptomatic relatives in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-11. Identification of Barrett's Esophagus in Relatives by Endoscopic Screening in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-09. Increasing incidence of Barrett’s oesophagus: a population-based study in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2013-12. A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus in NATURE GENETICS
  • 2011-06. Comparison of Endoscopic and Clinical Characteristics of Patients with Familial and Sporadic Barrett’s Esophagus in DIGESTIVE DISEASES AND SCIENCES
  • 2012-10. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus in NATURE GENETICS
  • 2015-09. Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma in NATURE GENETICS
  • 2006-03. Familial Barrett's Adenocarcinoma in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2015-09. Paired exome analysis of Barrett's esophagus and adenocarcinoma in NATURE GENETICS
  • 2012-01. Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma in JOURNAL OF HUMAN GENETICS
  • 2014-12. Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis in NATURE COMMUNICATIONS
  • 2012-09. Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10620-016-4109-2

    DOI

    http://dx.doi.org/10.1007/s10620-016-4109-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016374374

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26971090


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Barrett Esophagus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Family", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Division of Cancer Surgery, Peter MacCallum Cancer Centre, A\u2019Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia", 
                "Department of Surgery (St. Vincent\u2019s Hospital), University of Melbourne, Fitzroy, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "To", 
            "givenName": "Henry", 
            "id": "sg:person.011454532141.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011454532141.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Division of Cancer Research, Peter MacCallum Cancer Centre, A\u2019Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia", 
                "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clemons", 
            "givenName": "Nicholas J.", 
            "id": "sg:person.01353025150.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353025150.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peter MacCallum Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.1055.1", 
              "name": [
                "Division of Cancer Surgery, Peter MacCallum Cancer Centre, A\u2019Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duong", 
            "givenName": "Cuong P.", 
            "id": "sg:person.01133501561.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133501561.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Familial Cancer Centre, Peter MacCallum Cancer Centre, A\u2019Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia", 
                "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trainer", 
            "givenName": "Alison H.", 
            "id": "sg:person.01321737230.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321737230.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Division of Cancer Surgery, Peter MacCallum Cancer Centre, A\u2019Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia", 
                "Division of Cancer Research, Peter MacCallum Cancer Centre, A\u2019Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia", 
                "Department of Surgery (St. Vincent\u2019s Hospital), University of Melbourne, Fitzroy, VIC, Australia", 
                "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Phillips", 
            "givenName": "Wayne A.", 
            "id": "sg:person.0705640631.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705640631.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1097/mcg.0b013e31809e7126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000111364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcg.0b013e31809e7126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000111364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcg.0b013e31809e7126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000111364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cgh.2009.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000113413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2002.31879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000158018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000896957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwn121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001147801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2004.063685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002177696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2005.083600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002487988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2008.01835.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002800875", 
              "https://doi.org/10.1111/j.1572-0241.2008.01835.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.40.9.651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003141475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humimm.2013.06.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003722045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.39.1.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004752675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0361-090x(03)00033-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004900432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0361-090x(03)00033-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004900432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2005.08.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004983501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2010.06529.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005810169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-06-0293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006401086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5107(04)02589-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006931401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10620-011-1620-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007831430", 
              "https://doi.org/10.1007/s10620-011-1620-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008165994", 
              "https://doi.org/10.1038/ng.3357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008686233", 
              "https://doi.org/10.1038/ajg.2012.134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008686233", 
              "https://doi.org/10.1038/ajg.2012.134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.02846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009891319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00365520510023189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010122007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00365520510023189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010122007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2011.1029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010570717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gie.2007.07.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011509023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2005.089144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011752248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(92)90784-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012751992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(92)90784-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012751992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jhg.2011.124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013068160", 
              "https://doi.org/10.1038/jhg.2011.124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2009.176701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013416853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2002.05665.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014276377", 
              "https://doi.org/10.1111/j.1572-0241.2002.05665.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2011.01.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016914673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwi218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019806848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019888748", 
              "https://doi.org/10.1038/ng.3343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.01.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020553165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcg.0b013e3180329015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020622488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcg.0b013e3180329015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020622488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcg.0b013e3180329015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020622488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcg.0b013e3180329015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020622488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2007.145177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020645587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2004.40464.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021054426", 
              "https://doi.org/10.1111/j.1572-0241.2004.40464.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-11-0927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021273755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021629896", 
              "https://doi.org/10.1038/ajg.2009.241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021629896", 
              "https://doi.org/10.1038/ajg.2009.241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-09-1136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022540982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023884331", 
              "https://doi.org/10.1038/ncomms6224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2006.04448.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024142753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/ceg.s32610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025148708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2005.00340.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025643644", 
              "https://doi.org/10.1111/j.1572-0241.2005.00340.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2005.00340.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025643644", 
              "https://doi.org/10.1111/j.1572-0241.2005.00340.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2012.04.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026006211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027075303", 
              "https://doi.org/10.1038/ng.2796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1103042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028630481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2036.2004.02230.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029926850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2011.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030311092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1442-2050.2010.01054.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030343697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1442-2050.2010.01054.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030343697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.med.59.061206.112706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032317408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004836-198306000-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032404157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004836-198306000-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032404157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032980656", 
              "https://doi.org/10.1038/ajg.2011.130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032980656", 
              "https://doi.org/10.1038/ajg.2011.130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033234133", 
              "https://doi.org/10.1038/ng.2408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mds181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033719280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2011.06042.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033803236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2011.06042.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033803236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(15)30107-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034247661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cgh.2014.01.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036939824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004836-198308000-00015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037124902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004836-198308000-00015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037124902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10038-007-0148-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038013244", 
              "https://doi.org/10.1007/s10038-007-0148-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039960969", 
              "https://doi.org/10.1038/ajg.2011.153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039960969", 
              "https://doi.org/10.1038/ajg.2011.153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2010.06602.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041534481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2006.473_7.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041883407", 
              "https://doi.org/10.1111/j.1572-0241.2006.473_7.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043227521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.51.3.323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044580848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365521.2011.650192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045508872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.giec.2010.09.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047252108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-011-9596-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047285770", 
              "https://doi.org/10.1007/s10654-011-9596-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1442-2050.2007.00651.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047494977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4103/1477-3163.157441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048407791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2014.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048423881", 
              "https://doi.org/10.1038/ajg.2014.10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2014.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048423881", 
              "https://doi.org/10.1038/ajg.2014.10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cgh.2006.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048533393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci66603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048613369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2008.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049186107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2003.09.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049222334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.52.8.1081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049523823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049815626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.25362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050765705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2011-300730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051795402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v19.i46.8770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071370089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-103-1-52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073690229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076958954", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079916203", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082763733", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082768434", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082957073", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-07", 
        "datePublishedReg": "2016-07-01", 
        "description": "Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but the exact biological mechanisms have been difficult to determine. BE is generally thought to be an acquired condition that develops secondarily to chronic gastroesophageal reflux. However, multiple reports of familial clustering of patients with BE and/or EAC suggest a possible inherited predisposition to BE may be driving this condition, at least in a subset of patients. Identifying the genetic variants that predispose to BE in these families would open up the possibility for blood-based screening tests that could inform decision-making in regard to surveillance strategies, particularly for relatives of patients with BE and/or EAC. Perhaps more importantly, understanding the genetic mechanisms that predispose to BE may provide valuable insights into the biology of this condition and potentially identify novel targets for therapeutic intervention. Here we review the current evidence for a genetic predisposition to BE and discuss the potential implications of these findings.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10620-016-4109-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6732284", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018525", 
            "issn": [
              "0163-2116", 
              "1573-2568"
            ], 
            "name": "Digestive Diseases and Sciences", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "61"
          }
        ], 
        "name": "The Genetics of Barrett\u2019s Esophagus: A Familial and Population-Based Perspective", 
        "pagination": "1826-1834", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4e04e64469382e4c07be4bc8a02a954b5e8dc1cb32beb80a9ca3599f0364c346"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26971090"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7902782"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10620-016-4109-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1016374374"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10620-016-4109-2", 
          "https://app.dimensions.ai/details/publication/pub.1016374374"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000487.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s10620-016-4109-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4109-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4109-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4109-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-016-4109-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    396 TRIPLES      21 PREDICATES      119 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10620-016-4109-2 schema:about N14b6c16898f94c29be668b2788713286
    2 N52b0b4ad277b4a4b8d5a4e77027e6dd5
    3 N9d586406288e4c87a57132962f6a0b14
    4 Na2f7df26a90d430a9f3980cea5a7a0e5
    5 Nad02bb074a884748accae83a72d69dce
    6 Nbffd45363e9f4891a8f89fa8e3438ad1
    7 anzsrc-for:11
    8 anzsrc-for:1117
    9 schema:author N9e302bf3e6834a49bba477b841ea6d73
    10 schema:citation sg:pub.10.1007/s10038-007-0148-z
    11 sg:pub.10.1007/s10620-011-1620-3
    12 sg:pub.10.1007/s10654-011-9596-z
    13 sg:pub.10.1038/ajg.2009.241
    14 sg:pub.10.1038/ajg.2011.130
    15 sg:pub.10.1038/ajg.2011.153
    16 sg:pub.10.1038/ajg.2012.134
    17 sg:pub.10.1038/ajg.2014.10
    18 sg:pub.10.1038/jhg.2011.124
    19 sg:pub.10.1038/ncomms6224
    20 sg:pub.10.1038/ng.2408
    21 sg:pub.10.1038/ng.2796
    22 sg:pub.10.1038/ng.3343
    23 sg:pub.10.1038/ng.3357
    24 sg:pub.10.1111/j.1572-0241.2002.05665.x
    25 sg:pub.10.1111/j.1572-0241.2004.40464.x
    26 sg:pub.10.1111/j.1572-0241.2005.00340.x
    27 sg:pub.10.1111/j.1572-0241.2006.473_7.x
    28 sg:pub.10.1111/j.1572-0241.2008.01835.x
    29 https://app.dimensions.ai/details/publication/pub.1076958954
    30 https://app.dimensions.ai/details/publication/pub.1079916203
    31 https://app.dimensions.ai/details/publication/pub.1082763733
    32 https://app.dimensions.ai/details/publication/pub.1082768434
    33 https://app.dimensions.ai/details/publication/pub.1082957073
    34 https://doi.org/10.1001/jama.2011.1029
    35 https://doi.org/10.1016/0016-5085(92)90784-v
    36 https://doi.org/10.1016/j.cgh.2006.03.001
    37 https://doi.org/10.1016/j.cgh.2009.10.010
    38 https://doi.org/10.1016/j.cgh.2014.01.028
    39 https://doi.org/10.1016/j.gie.2007.07.019
    40 https://doi.org/10.1016/j.giec.2010.09.011
    41 https://doi.org/10.1016/j.humimm.2013.06.026
    42 https://doi.org/10.1016/j.humpath.2008.06.008
    43 https://doi.org/10.1016/s0016-5085(15)30107-4
    44 https://doi.org/10.1016/s0016-5107(04)02589-1
    45 https://doi.org/10.1016/s0361-090x(03)00033-3
    46 https://doi.org/10.1053/gast.2002.31879
    47 https://doi.org/10.1053/j.gastro.2003.09.030
    48 https://doi.org/10.1053/j.gastro.2005.08.053
    49 https://doi.org/10.1053/j.gastro.2010.01.002
    50 https://doi.org/10.1053/j.gastro.2010.01.048
    51 https://doi.org/10.1053/j.gastro.2010.04.014
    52 https://doi.org/10.1053/j.gastro.2011.01.030
    53 https://doi.org/10.1053/j.gastro.2011.01.031
    54 https://doi.org/10.1053/j.gastro.2012.04.032
    55 https://doi.org/10.1056/nejmoa1103042
    56 https://doi.org/10.1080/00365520510023189
    57 https://doi.org/10.1093/aje/kwi218
    58 https://doi.org/10.1093/aje/kwn121
    59 https://doi.org/10.1093/annonc/mds181
    60 https://doi.org/10.1097/00004836-198306000-00011
    61 https://doi.org/10.1097/00004836-198308000-00015
    62 https://doi.org/10.1097/mcg.0b013e3180329015
    63 https://doi.org/10.1097/mcg.0b013e31809e7126
    64 https://doi.org/10.1111/j.1365-2036.2004.02230.x
    65 https://doi.org/10.1111/j.1440-1746.2006.04448.x
    66 https://doi.org/10.1111/j.1440-1746.2010.06529.x
    67 https://doi.org/10.1111/j.1440-1746.2010.06602.x
    68 https://doi.org/10.1111/j.1442-2050.2007.00651.x
    69 https://doi.org/10.1111/j.1442-2050.2010.01054.x
    70 https://doi.org/10.1111/j.1749-6632.2011.06042.x
    71 https://doi.org/10.1136/gut.2004.063685
    72 https://doi.org/10.1136/gut.2005.083600
    73 https://doi.org/10.1136/gut.2005.089144
    74 https://doi.org/10.1136/gut.2007.145177
    75 https://doi.org/10.1136/gut.2009.176701
    76 https://doi.org/10.1136/gut.39.1.5
    77 https://doi.org/10.1136/gut.51.3.323
    78 https://doi.org/10.1136/gut.52.8.1081
    79 https://doi.org/10.1136/gutjnl-2011-300730
    80 https://doi.org/10.1136/jmg.40.9.651
    81 https://doi.org/10.1146/annurev.med.59.061206.112706
    82 https://doi.org/10.1158/1055-9965.epi-06-0293
    83 https://doi.org/10.1158/1055-9965.epi-09-1136
    84 https://doi.org/10.1158/1055-9965.epi-11-0927
    85 https://doi.org/10.1172/jci66603
    86 https://doi.org/10.1242/dev.02846
    87 https://doi.org/10.2147/ceg.s32610
    88 https://doi.org/10.3109/00365521.2011.650192
    89 https://doi.org/10.3322/caac.21185
    90 https://doi.org/10.3748/wjg.v19.i46.8770
    91 https://doi.org/10.4103/1477-3163.157441
    92 https://doi.org/10.4161/cbt.25362
    93 https://doi.org/10.7326/0003-4819-103-1-52
    94 schema:datePublished 2016-07
    95 schema:datePublishedReg 2016-07-01
    96 schema:description Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but the exact biological mechanisms have been difficult to determine. BE is generally thought to be an acquired condition that develops secondarily to chronic gastroesophageal reflux. However, multiple reports of familial clustering of patients with BE and/or EAC suggest a possible inherited predisposition to BE may be driving this condition, at least in a subset of patients. Identifying the genetic variants that predispose to BE in these families would open up the possibility for blood-based screening tests that could inform decision-making in regard to surveillance strategies, particularly for relatives of patients with BE and/or EAC. Perhaps more importantly, understanding the genetic mechanisms that predispose to BE may provide valuable insights into the biology of this condition and potentially identify novel targets for therapeutic intervention. Here we review the current evidence for a genetic predisposition to BE and discuss the potential implications of these findings.
    97 schema:genre research_article
    98 schema:inLanguage en
    99 schema:isAccessibleForFree false
    100 schema:isPartOf Nec48b2b4231545ee86240e9f33bbd569
    101 Nf3781987da6648b99b4124a0c2d1378e
    102 sg:journal.1018525
    103 schema:name The Genetics of Barrett’s Esophagus: A Familial and Population-Based Perspective
    104 schema:pagination 1826-1834
    105 schema:productId N71f59de3bc114240a3f48c8f56d9c57b
    106 N7df2f488b1a14a37a0a177e111a0ba5b
    107 Nef4713d949ae41eabb10891ac2b3bc66
    108 Nf7eabee930274cddaf36ce99afec3a09
    109 Nfa2cddfc781445b18221af78165468ba
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016374374
    111 https://doi.org/10.1007/s10620-016-4109-2
    112 schema:sdDatePublished 2019-04-10T23:18
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N4a5baa934fff4ff0a1775e158ab43732
    115 schema:url http://link.springer.com/10.1007/s10620-016-4109-2
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N14b6c16898f94c29be668b2788713286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Humans
    121 rdf:type schema:DefinedTerm
    122 N4a5baa934fff4ff0a1775e158ab43732 schema:name Springer Nature - SN SciGraph project
    123 rdf:type schema:Organization
    124 N52b0b4ad277b4a4b8d5a4e77027e6dd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Barrett Esophagus
    126 rdf:type schema:DefinedTerm
    127 N6a7f3ad11b4b42109df5715ea983d9a1 rdf:first sg:person.0705640631.51
    128 rdf:rest rdf:nil
    129 N6adbde5795c2483ea24c66e1e5b29c0c rdf:first sg:person.01321737230.67
    130 rdf:rest N6a7f3ad11b4b42109df5715ea983d9a1
    131 N71f59de3bc114240a3f48c8f56d9c57b schema:name readcube_id
    132 schema:value 4e04e64469382e4c07be4bc8a02a954b5e8dc1cb32beb80a9ca3599f0364c346
    133 rdf:type schema:PropertyValue
    134 N7332bf0a905e4a02845184fe2a91e0e2 rdf:first sg:person.01133501561.34
    135 rdf:rest N6adbde5795c2483ea24c66e1e5b29c0c
    136 N769e171a34204e11a4fbede6315195a3 rdf:first sg:person.01353025150.09
    137 rdf:rest N7332bf0a905e4a02845184fe2a91e0e2
    138 N7df2f488b1a14a37a0a177e111a0ba5b schema:name dimensions_id
    139 schema:value pub.1016374374
    140 rdf:type schema:PropertyValue
    141 N9d586406288e4c87a57132962f6a0b14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Gene Expression Regulation
    143 rdf:type schema:DefinedTerm
    144 N9e302bf3e6834a49bba477b841ea6d73 rdf:first sg:person.011454532141.07
    145 rdf:rest N769e171a34204e11a4fbede6315195a3
    146 Na2f7df26a90d430a9f3980cea5a7a0e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Risk Factors
    148 rdf:type schema:DefinedTerm
    149 Nad02bb074a884748accae83a72d69dce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Genetic Predisposition to Disease
    151 rdf:type schema:DefinedTerm
    152 Nbffd45363e9f4891a8f89fa8e3438ad1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Family
    154 rdf:type schema:DefinedTerm
    155 Nec48b2b4231545ee86240e9f33bbd569 schema:volumeNumber 61
    156 rdf:type schema:PublicationVolume
    157 Nef4713d949ae41eabb10891ac2b3bc66 schema:name doi
    158 schema:value 10.1007/s10620-016-4109-2
    159 rdf:type schema:PropertyValue
    160 Nf3781987da6648b99b4124a0c2d1378e schema:issueNumber 7
    161 rdf:type schema:PublicationIssue
    162 Nf7eabee930274cddaf36ce99afec3a09 schema:name pubmed_id
    163 schema:value 26971090
    164 rdf:type schema:PropertyValue
    165 Nfa2cddfc781445b18221af78165468ba schema:name nlm_unique_id
    166 schema:value 7902782
    167 rdf:type schema:PropertyValue
    168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Medical and Health Sciences
    170 rdf:type schema:DefinedTerm
    171 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Public Health and Health Services
    173 rdf:type schema:DefinedTerm
    174 sg:grant.6732284 http://pending.schema.org/fundedItem sg:pub.10.1007/s10620-016-4109-2
    175 rdf:type schema:MonetaryGrant
    176 sg:journal.1018525 schema:issn 0163-2116
    177 1573-2568
    178 schema:name Digestive Diseases and Sciences
    179 rdf:type schema:Periodical
    180 sg:person.01133501561.34 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
    181 schema:familyName Duong
    182 schema:givenName Cuong P.
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133501561.34
    184 rdf:type schema:Person
    185 sg:person.011454532141.07 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    186 schema:familyName To
    187 schema:givenName Henry
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011454532141.07
    189 rdf:type schema:Person
    190 sg:person.01321737230.67 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    191 schema:familyName Trainer
    192 schema:givenName Alison H.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321737230.67
    194 rdf:type schema:Person
    195 sg:person.01353025150.09 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    196 schema:familyName Clemons
    197 schema:givenName Nicholas J.
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353025150.09
    199 rdf:type schema:Person
    200 sg:person.0705640631.51 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    201 schema:familyName Phillips
    202 schema:givenName Wayne A.
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705640631.51
    204 rdf:type schema:Person
    205 sg:pub.10.1007/s10038-007-0148-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1038013244
    206 https://doi.org/10.1007/s10038-007-0148-z
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/s10620-011-1620-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007831430
    209 https://doi.org/10.1007/s10620-011-1620-3
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s10654-011-9596-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1047285770
    212 https://doi.org/10.1007/s10654-011-9596-z
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/ajg.2009.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021629896
    215 https://doi.org/10.1038/ajg.2009.241
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/ajg.2011.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032980656
    218 https://doi.org/10.1038/ajg.2011.130
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/ajg.2011.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039960969
    221 https://doi.org/10.1038/ajg.2011.153
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/ajg.2012.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008686233
    224 https://doi.org/10.1038/ajg.2012.134
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/ajg.2014.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048423881
    227 https://doi.org/10.1038/ajg.2014.10
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/jhg.2011.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013068160
    230 https://doi.org/10.1038/jhg.2011.124
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/ncomms6224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023884331
    233 https://doi.org/10.1038/ncomms6224
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/ng.2408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033234133
    236 https://doi.org/10.1038/ng.2408
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/ng.2796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027075303
    239 https://doi.org/10.1038/ng.2796
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ng.3343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888748
    242 https://doi.org/10.1038/ng.3343
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ng.3357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008165994
    245 https://doi.org/10.1038/ng.3357
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1111/j.1572-0241.2002.05665.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014276377
    248 https://doi.org/10.1111/j.1572-0241.2002.05665.x
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1111/j.1572-0241.2004.40464.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021054426
    251 https://doi.org/10.1111/j.1572-0241.2004.40464.x
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1111/j.1572-0241.2005.00340.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025643644
    254 https://doi.org/10.1111/j.1572-0241.2005.00340.x
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1111/j.1572-0241.2006.473_7.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041883407
    257 https://doi.org/10.1111/j.1572-0241.2006.473_7.x
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1111/j.1572-0241.2008.01835.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002800875
    260 https://doi.org/10.1111/j.1572-0241.2008.01835.x
    261 rdf:type schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1076958954 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1079916203 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1082763733 schema:CreativeWork
    265 https://app.dimensions.ai/details/publication/pub.1082768434 schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1082957073 schema:CreativeWork
    267 https://doi.org/10.1001/jama.2011.1029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010570717
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/0016-5085(92)90784-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1012751992
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.cgh.2006.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048533393
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.cgh.2009.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000113413
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.cgh.2014.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036939824
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.gie.2007.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011509023
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.giec.2010.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047252108
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.humimm.2013.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003722045
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.humpath.2008.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049186107
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s0016-5085(15)30107-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034247661
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/s0016-5107(04)02589-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006931401
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s0361-090x(03)00033-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004900432
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1053/gast.2002.31879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000158018
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1053/j.gastro.2003.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049222334
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1053/j.gastro.2005.08.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004983501
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1053/j.gastro.2010.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049815626
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1053/j.gastro.2010.01.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020553165
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1053/j.gastro.2010.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043227521
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1053/j.gastro.2011.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016914673
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1053/j.gastro.2011.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030311092
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1053/j.gastro.2012.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026006211
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1056/nejmoa1103042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028630481
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1080/00365520510023189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010122007
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/aje/kwi218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019806848
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1093/aje/kwn121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001147801
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1093/annonc/mds181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033719280
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1097/00004836-198306000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032404157
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1097/00004836-198308000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037124902
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1097/mcg.0b013e3180329015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020622488
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1097/mcg.0b013e31809e7126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000111364
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1111/j.1365-2036.2004.02230.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029926850
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1111/j.1440-1746.2006.04448.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024142753
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1111/j.1440-1746.2010.06529.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005810169
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1111/j.1440-1746.2010.06602.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041534481
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1111/j.1442-2050.2007.00651.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047494977
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1111/j.1442-2050.2010.01054.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343697
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1111/j.1749-6632.2011.06042.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033803236
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1136/gut.2004.063685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002177696
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1136/gut.2005.083600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002487988
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1136/gut.2005.089144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011752248
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1136/gut.2007.145177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020645587
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1136/gut.2009.176701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013416853
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1136/gut.39.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004752675
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1136/gut.51.3.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044580848
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1136/gut.52.8.1081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049523823
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1136/gutjnl-2011-300730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051795402
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1136/jmg.40.9.651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003141475
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1146/annurev.med.59.061206.112706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032317408
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1158/1055-9965.epi-06-0293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006401086
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1158/1055-9965.epi-09-1136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022540982
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1158/1055-9965.epi-11-0927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021273755
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1172/jci66603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048613369
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1242/dev.02846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009891319
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.2147/ceg.s32610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025148708
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.3109/00365521.2011.650192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045508872
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.3322/caac.21185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000896957
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.3748/wjg.v19.i46.8770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071370089
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.4103/1477-3163.157441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048407791
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.4161/cbt.25362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050765705
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.7326/0003-4819-103-1-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073690229
    386 rdf:type schema:CreativeWork
    387 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
    388 schema:name Department of Surgery (St. Vincent’s Hospital), University of Melbourne, Fitzroy, VIC, Australia
    389 Division of Cancer Research, Peter MacCallum Cancer Centre, A’Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia
    390 Division of Cancer Surgery, Peter MacCallum Cancer Centre, A’Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia
    391 Familial Cancer Centre, Peter MacCallum Cancer Centre, A’Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia
    392 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia
    393 rdf:type schema:Organization
    394 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
    395 schema:name Division of Cancer Surgery, Peter MacCallum Cancer Centre, A’Beckett Street, Locked bag 1, 8006, East Melbourne, VIC, Australia
    396 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...