High C-Reactive Protein Is Associated with Poor Sleep Quality Independent of Nocturnal Symptoms in Patients with Inflammatory Bowel Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02-21

AUTHORS

Robin G. Wilson, Betsy W. Stevens, Abra Y. Guo, Caitlin N. Russell, Anna Thornton, Melissa A. Cohen, Holly C. Sturgeon, Cosmas Giallourakis, Hamed Khalili, Deanna D. Nguyen, Vijay Yajnik, Jenny Sauk, Ashwin N. Ananthakrishnan

ABSTRACT

BackgroundSleep disruption is common in inflammatory bowel diseases (IBD). However, studies demonstrating a similar prevalence in irritable bowel syndrome suggest that nighttime disruption due to diarrhea and abdominal pain may be key drivers of poor sleep quality. Whether inflammation is associated with poor sleep independently has not been examined previously.MethodsThis single-center study included subjects with IBD recruited to an ongoing prospective registry who completed a questionnaire assessing sleep quality and mood. Inflammatory marker levels [C-reactive protein (CRP), erythrocyte sedimentation rate] and clinical disease activity including nighttime disruption on the day of enrollment were obtained from the medical record. Logistic regression models were used to identify predictors of sleep quality.ResultsThe study included 131 subjects (72 women) with a median age of IBD diagnosis of 25 years. Twenty-three subjects (19 %) had a high C-reactive protein level (≥8 mg/dL). Poor sleep was more common in those with high CRP levels than with normal values (70 vs. 39 %, p = 0.009). This association remained significant on multivariate analysis [Odds ratio (OR) 4.12, 95 % confidence interval (CI) 1.38–12.29]. Adjusting for the presence of nighttime disruption did not significant alter this association (OR 3.16, 95 % CI 1.01–9.90). High CRP correlated with poor sleep even in patients not experiencing nocturnal symptoms (n = 101, OR 4.89, 95 % CI 1.24–19.36).ConclusionHigh CRP is associated with poor sleep quality in IBD independent of the presence of nighttime disruptions, suggesting that a relationship exists between circulating inflammatory markers and sleep. More... »

PAGES

2136-2143

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-015-3580-5

DOI

http://dx.doi.org/10.1007/s10620-015-3580-5

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https://app.dimensions.ai/details/publication/pub.1050300756

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25701321


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26 schema:description BackgroundSleep disruption is common in inflammatory bowel diseases (IBD). However, studies demonstrating a similar prevalence in irritable bowel syndrome suggest that nighttime disruption due to diarrhea and abdominal pain may be key drivers of poor sleep quality. Whether inflammation is associated with poor sleep independently has not been examined previously.MethodsThis single-center study included subjects with IBD recruited to an ongoing prospective registry who completed a questionnaire assessing sleep quality and mood. Inflammatory marker levels [C-reactive protein (CRP), erythrocyte sedimentation rate] and clinical disease activity including nighttime disruption on the day of enrollment were obtained from the medical record. Logistic regression models were used to identify predictors of sleep quality.ResultsThe study included 131 subjects (72 women) with a median age of IBD diagnosis of 25 years. Twenty-three subjects (19 %) had a high C-reactive protein level (≥8 mg/dL). Poor sleep was more common in those with high CRP levels than with normal values (70 vs. 39 %, p = 0.009). This association remained significant on multivariate analysis [Odds ratio (OR) 4.12, 95 % confidence interval (CI) 1.38–12.29]. Adjusting for the presence of nighttime disruption did not significant alter this association (OR 3.16, 95 % CI 1.01–9.90). High CRP correlated with poor sleep even in patients not experiencing nocturnal symptoms (n = 101, OR 4.89, 95 % CI 1.24–19.36).ConclusionHigh CRP is associated with poor sleep quality in IBD independent of the presence of nighttime disruptions, suggesting that a relationship exists between circulating inflammatory markers and sleep.
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33 C-reactive protein levels
34 CRP
35 CRP levels
36 IBD diagnosis
37 MethodsThis single-center study
38 ResultsThe study
39 abdominal pain
40 activity
41 age
42 alters
43 analysis
44 association
45 bowel disease
46 bowel syndrome
47 clinical disease activity
48 days
49 days of enrollment
50 diagnosis
51 diarrhea
52 disease
53 disease activity
54 disruption
55 drivers
56 enrollment
57 high CRP
58 higher C-reactive protein
59 higher C-reactive protein levels
60 higher CRP levels
61 independent
62 inflammation
63 inflammatory bowel disease
64 inflammatory marker levels
65 inflammatory markers
66 irritable bowel syndrome
67 key drivers
68 levels
69 logistic regression models
70 marker levels
71 markers
72 median age
73 medical records
74 model
75 mood
76 multivariate analysis
77 nighttime disruptions
78 nocturnal symptoms
79 normal values
80 ongoing prospective registry
81 pain
82 patients
83 poor sleep
84 poor sleep quality
85 predictors
86 presence
87 prevalence
88 prospective registry
89 protein
90 protein levels
91 quality
92 questionnaire
93 records
94 registry
95 regression models
96 relationship
97 significant alter
98 similar prevalence
99 single-center study
100 sleep
101 sleep quality
102 study
103 subjects
104 symptoms
105 syndrome
106 values
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