Leukopenia Predicts Remission in Patients with Inflammatory Bowel Disease and Behcet’s Disease on Thiopurine Maintenance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Mi Sung Park, Dong Hyun Kim, Duk Hwan Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon

ABSTRACT

BACKGROUNDS: The thiopurine drugs, azathioprine (AZA), and 6-mercaptopurine (6-MP) are well-established drugs for the treatment of inflammatory bowel disease (IBD). Although leukopenia is a well-recognized side effect of AZA/6-MP treatment, its association with therapeutic effects has yet to be determined. We therefore evaluated the influences of thiopurine-induced leukopenia on the long-term prognosis of IBD. METHODS: We included 196 IBD patients [45 with ulcerative colitis (UC), 68 with Crohn's disease (CD), and 83 with intestinal Behçet's disease (BD)] who were treated with AZA/6-MP and achieved remission between January 2006 and December 2012. We retrospectively analyzed patient characteristics, AZA/6-MP maintenance dose (mg/kg), the lowest white blood cell (WBC) count during AZA/6-MP treatment, duration of remission, and the occurrence of relapse. We compared the clinical variables between leukopenic (n = 120, WBC count <4,000/μL) and nonleukopenic (n = 76, WBC count ≥ 4,000/μL) patients. RESULTS: The two groups were well matched for baseline clinical characteristics. The cumulative relapse-free survival rate was higher in the leukopenic group than the nonleukopenic group by Kaplan-Meier survival analysis (log-rank test, P < 0.001). On multivariate analysis, age, duration of AZA/6-MP treatment, presence of macrocytosis, and the presence of leukopenia were negatively associated with relapse (odds ratios 0.975, 0.988, 0.563, and 0.390, respectively). On subgroup analysis, the cumulative relapse-free survival rate was significantly higher in the leukopenic group than in the nonleukopenic group for all types of IBDs, including UC, CD, and intestinal BD (log-rank test, P = 0.032, 0.047, and 0.002, respectively). CONCLUSION: Leukopenia during thiopurine maintenance therapy was associated with prolonged remission in patients with IBD and Behcet's disease. More... »

PAGES

195-204

References to SciGraph publications

  • 2003-08. Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis in JOURNAL OF GASTROENTEROLOGY
  • 2010-02. Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs in JOURNAL OF HUMAN GENETICS
  • 1999-12. The immune S ystem in the elderly in IMMUNOLOGIC RESEARCH
  • 1999-11. Optimum duration of treatment with 6-mercaptopurine for Crohn's disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2003-07. The immunological and genetic basis of inflammatory bowel disease in NATURE REVIEWS IMMUNOLOGY
  • 2006-12. Thiopurine Methyltransferase (TPMT) Activity and Adverse Effects of Azathioprine in Inflammatory Bowel Disease: Long-Term Follow-Up Study of 394 Patients in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-07. Thiopurine-Induced Myelotoxicity in Patients With Inflammatory Bowel Disease: A Review in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-01. Outcome Predictors for Thiopurine Maintenance Therapy in Patients with Crohn’s Disease in DIGESTIVE DISEASES AND SCIENCES
  • 2007-09. Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach in JOURNAL OF GASTROENTEROLOGY
  • 2009-02. Gastrointestinal Manifestations of Behçet’s Disease in DIGESTIVE DISEASES AND SCIENCES
  • 2009-10. Development and Validation of Novel Diagnostic Criteria for Intestinal Behçet's Disease in Korean Patients With Ileocolonic Ulcers in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10620-014-3355-4

    DOI

    http://dx.doi.org/10.1007/s10620-014-3355-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005001053

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25239495


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